Abstract:
BACKGROUND:The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. RESULTS:MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50 and 1000 nm. MPs are capable of transferring peptides, proteins, lipid components, microRNA, mRNA, and DNA from one cell to another without direct cell-to-cell contact. Growing evidence suggests that MPs present in peripheral blood and body fluids contribute to the development and progression of cancer, and are of pathophysiological relevance for autoimmune, inflammatory, infectious, cardiovascular, hematological, and other diseases. MPs have large diagnostic potential as biomarkers; however, due to current technological limitations in purification of MPs and an absence of standardized methods of MP detection, challenges remain in validating the potential of MPs as a non-invasive and early diagnostic platform. CONCLUSIONS:Improvements in the effective deciphering of MP molecular signatures will be critical not only for diagnostics, but also for the evaluation of treatment regimens and predicting disease outcomes.
journal_name
BMC Cell Bioljournal_title
BMC cell biologyauthors
Barteneva NS,Fasler-Kan E,Bernimoulin M,Stern JN,Ponomarev ED,Duckett L,Vorobjev IAdoi
10.1186/1471-2121-14-23subject
Has Abstractpub_date
2013-04-22 00:00:00pages
23issn
1471-2121pii
1471-2121-14-23journal_volume
14pub_type
杂志文章,评审相关文献
BMC CELL BIOLOGY文献大全abstract::BACKGROUND Alternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differently. Chimeric IGF-I precursors were made with green fluorescent protein (GFP) cloned between the ...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-3-17
更新日期:2002-07-02 00:00:00
abstract:BACKGROUND:Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of the HECT class of E3 ubiquitin ligases. A defining feature of NEDD4L protein isoforms is the presenc...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-10-26
更新日期:2009-04-13 00:00:00
abstract:BACKGROUND:One of the problems associated with osteosarcoma is the frequent formation of micrometastases in the lung prior to diagnosis because the development of metastatic lesions often causes a fatal outcome. Therefore, the prevention of pulmonary metastases during the early stage of tumor development is critical fo...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-13-24
更新日期:2012-09-26 00:00:00
abstract:BACKGROUND:During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process prepares the cells to actively participate in the inflammatory and immune responses, and many factors...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-6-25
更新日期:2005-05-17 00:00:00
abstract:BACKGROUND:In cancer cells the three-dimensional (3D) telomere organization of interphase nuclei into a telomeric disk is heavily distorted and aggregates are found. In Hodgkin's lymphoma quantitative FISH (3D Q-FISH) reveals a major impact of nuclear telomere dynamics during the transition form mononuclear Hodgkin (H)...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-11-99
更新日期:2010-12-14 00:00:00
abstract:BACKGROUND:There is evidence that several messenger RNAs (mRNAs) are bifunctional RNAs, i.e. RNA transcript carrying both protein-coding capacity and activity as functional non-coding RNA via 5' and 3' untranslated regions (UTRs). RESULTS:In this study, we identified a novel bifunctional RNA that is transcribed from i...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/s12860-015-0054-8
更新日期:2015-03-11 00:00:00
abstract:BACKGROUND:The regulatory mechanisms of motor protein-dependent intracellular transport are still not fully understood. The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and other JIP1-binding "cargo" proteins. However, it is unknown whether these "cargo" proteins influence th...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-14-12
更新日期:2013-03-04 00:00:00
abstract:BACKGROUND:Xanthurenic acid is an endogenous molecule produced by tryptophan degradation, produced in the cytoplasm and mitochondria. Its accumulation can be observed in aging-related diseases, e.g. senile cataract and infectious disease. We previously reported that xanthurenic acid provokes apoptosis, and now present ...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-5-14
更新日期:2004-04-06 00:00:00
abstract:BACKGROUND:About 20 % of nemaline myopathies are thus far related to skeletal muscle alpha-actin. Seven actin mutants located in different parts of the actin molecule and linked to different forms of the disease were selected and expressed as EGFP-tagged constructs in differentiated C2C12 mytoubes. Results were compare...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-8-2
更新日期:2007-01-16 00:00:00
abstract:BACKGROUND:The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therapeutic applications and limitations of hMSCs derived from human umbilical cords, the effects of hypoxi...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-12-32
更新日期:2011-08-09 00:00:00
abstract:BACKGROUND:Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration, and in the cleavage furrow during cytokinesis. Filament assembly in turn is regulated by phosphorylation in the tail region of the myosin heavy chain (MHC). Early studies have revea...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-3-19
更新日期:2002-07-24 00:00:00
abstract:BACKGROUND:The estrogen receptor alpha (ERα) is found predominately in the nucleus, both in hormone stimulated and untreated cells. Intracellular distribution of the ERα changes in the presence of agonists but the impact of different antiestrogens on the fate of ERα is a matter of debate. RESULTS:A MCF-7 cell line sta...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-11-98
更新日期:2010-12-10 00:00:00
abstract:BACKGROUND:The discovery of the importance of angiogenesis in tumor growth has emphasized the need to find specific vascular targets for tumor-targeted therapies. Previously, using phage display technology, we identified the peptide GX1 as having the ability to target the gastric cancer vasculature. The present study i...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-10-63
更新日期:2009-09-09 00:00:00
abstract:BACKGROUND:Fallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro models of this tissue type available for use in studies of FTSEC biology and malignant transformation. In vitro three-dimensi...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-14-43
更新日期:2013-09-27 00:00:00
abstract:BACKGROUND:Proteins linking intermediate filaments to other cytoskeletal components have important functions in maintaining tissue integrity and cell shape. RESULTS:We found a set of monoclonal antibodies raised against specific human sarcomeric myosin heavy chain (MyHC) isoforms labels cells in distinct regions of th...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-4-10
更新日期:2003-08-04 00:00:00
abstract:BACKGROUND:Angiogenesis is the main therapeutic mechanism of cell therapy for cardiovascular diseases, but diabetes is reported to reduce the function and number of progenitor cells. Therefore, we studied the effect of streptozotocin-induced diabetes on the bone marrow-mesenchymal stem cell (MSC) function, and examined...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-14-38
更新日期:2013-09-11 00:00:00
abstract:BACKGROUND:DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinokitiol and DNA methylat...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/s12860-017-0130-3
更新日期:2017-02-27 00:00:00
abstract:BACKGROUND:The nucleolus is a multi-domain enriched with proteins involved in ribosome biogenesis, cell cycle and apoptosis control, viral replication and differentiation of stem cells. Several authors have suggested a role for the nucleolus also in malignant transformation. We have recently demonstrated that under spe...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/s12860-015-0073-5
更新日期:2015-11-17 00:00:00
abstract:BACKGROUND:Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis. RESULTS:In the current study, we investigated the effect of melatonin on DNA strand breaks using the alkaline DNA comet as...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-14-1
更新日期:2013-01-07 00:00:00
abstract:BACKGROUND:Epithelial tight junction (TJ) and adherens junction (AJ) form the apical junctional complex (AJC) which regulates cell-cell adhesion, paracellular permeability and cell polarity. The AJC is anchored on cytoskeletal structures including actin microfilaments and microtubules. Such cytoskeletal interactions ar...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-7-12
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:In endothelial cells (EC), transforming growth factor-beta (TGF-beta) can bind to and transduce signals through ALK1 and ALK5. The TGF-beta/ALK5 and TGF-beta/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-beta signaling is an important specific...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-7-16
更新日期:2006-03-29 00:00:00
abstract:BACKGROUND:Multilineage differentiation, immunomodulation and secretion of trophic factors render mesenchymal stromal cells (MSC) highly attractive for clinical application. Human platelet derivatives such as pooled human platelet lysate (pHPL) and thrombin-activated platelet releasate in plasma (tPRP) have been introd...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-14-48
更新日期:2013-10-30 00:00:00
abstract:BACKGROUND:Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A gene in cellular processes are u...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-4-12
更新日期:2003-09-10 00:00:00
abstract:BACKGROUND:Mutations in the gene encoding for dysferlin cause recessive autosomal muscular dystrophies called dysferlinopathies. These mutations induce several alterations in skeletal muscles, including, inflammation, increased membrane permeability and cell death. Despite the fact that the etiology of dysferlinopathie...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/s12860-016-0096-6
更新日期:2016-05-24 00:00:00
abstract:BACKGROUND:In most cells glucocorticoid receptors (GR) reside predominantly in the cytoplasm. Upon hormone binding, the GR translocates into the nucleus, where the hormone-activated GR-complex regulates the transcription of GR-responsive genes. Serine/threonine protein phosphatase type 5 (PP5) associates with the GR-he...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-2-6
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Bone morphogenetic proteins (BMPs) contribute to many different aspects of development including mesoderm formation, heart development, neurogenesis, skeletal development, and axis formation. They have previously been recognized only as secreted growth factors, but the present study detected Bmp2, Bmp4, and ...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-11-20
更新日期:2010-03-15 00:00:00
abstract:BACKGROUND:Dental pulp stem cells (DPSCs) can be driven into odontoblast, osteoblast, and chondrocyte lineages in different inductive media. However, the differentiation potential of naive DPSCs after serial passaging in the routine culture system has not been fully elucidated. RESULTS:DPSCs were isolated from human/r...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-11-32
更新日期:2010-05-08 00:00:00
abstract:BACKGROUND:There is a growing interest in cord blood as a source of primitive stem cells with the capacity for multilineage differentiation. Pure cell fractions are needed for the characterization and in vitro expansion of stem cells as well as for their use in preclinical research. However, enrichment of stem cells is...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-7-30
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Recently, mast cells have been recognized to express several Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was reported to be able to alter expression of TLRs and cytokine production in neutrophils. However, whether GM-CSF modulates the e...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-10-37
更新日期:2009-05-09 00:00:00
abstract:BACKGROUND:A breakthrough in the understanding of centriole assembly was provided by the characterization of the UNI3 gene in Chlamydomonas. Deletion of this gene, found to encode a novel member of the tubulin superfamily, delta-tubulin, results in the loss of the C-tubule, in the nine microtubule triplets which are th...
journal_title:BMC cell biology
pub_type: 杂志文章
doi:10.1186/1471-2121-2-4
更新日期:2001-01-01 00:00:00