Virally and physically transgenized equine adipose-derived stromal cells as a cargo for paracrine secreted factors.

abstract：BACKGROUND:Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of the HECT class of E3 ubiquitin ligases. A defining feature of NEDD4L protein isoforms is the presenc...

journal_title：BMC cell biology

authors： Garrone NF,Blazer-Yost BL,Weiss RB,Lalouel JM,Rohrwasser A

更新日期：2009-04-13 00:00:00

abstract：BACKGROUND:In cytokinesis, when the cleavage furrow has been formed, the two centrioles in each daughter cell separate. It has been suggested that the centrioles facilitate and regulate cytokinesis to some extent. It has been postulated that termination of cytokinesis (abscission) depends on the migration of a centriol...

journal_title：BMC cell biology

authors： Jonsdottir AB,Dirks RW,Vrolijk J,Ogmundsdottir HM,Tanke HJ,Eyfjörd JE,Szuhai K

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:One of the problems associated with osteosarcoma is the frequent formation of micrometastases in the lung prior to diagnosis because the development of metastatic lesions often causes a fatal outcome. Therefore, the prevention of pulmonary metastases during the early stage of tumor development is critical fo...

journal_title：BMC cell biology

authors： Nakamura A,Aizawa J,Sakayama K,Kidani T,Takata T,Norimatsu Y,Miura H,Masuno H

更新日期：2012-09-26 00:00:00

abstract：BACKGROUND:Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role in muscle development. Genetic and biochemical studies in C. elegans have demonstrated that Unc-45 facilitates the process of myosin folding and assembly in body wall muscles. Loss or overexpression of Unc-45 in C. elegans results in...

journal_title：BMC cell biology

authors： Bernick EP,Zhang PJ,Du S

更新日期：2010-09-17 00:00:00

abstract：BACKGROUND:During cytokinesis, the cell's equator contracts against the cell's global stiffness. Identifying the biochemical basis for these mechanical parameters is essential for understanding how cells divide. To achieve this goal, the distribution and flux of the cell division machinery must be quantified. Here we r...

journal_title：BMC cell biology

authors： Robinson DN,Cavet G,Warrick HM,Spudich JA

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Dental pulp stem cells (DPSCs) can be driven into odontoblast, osteoblast, and chondrocyte lineages in different inductive media. However, the differentiation potential of naive DPSCs after serial passaging in the routine culture system has not been fully elucidated. RESULTS:DPSCs were isolated from human/r...

journal_title：BMC cell biology

authors： Yu J,He H,Tang C,Zhang G,Li Y,Wang R,Shi J,Jin Y

更新日期：2010-05-08 00:00:00

abstract：BACKGROUND:Primary cilia are flagella-like projections from the centriole of mammalian cells that have a key role in cell signaling. Human diseases are linked to defects in primary cilia. Microtubules make up the axoneme of cilia and are selectively acetylated and this is thought to contribute to the stability of the s...

journal_title：BMC cell biology

authors： Wang W,Brautigan DL

更新日期：2008-11-26 00:00:00

abstract：BACKGROUND:Fallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro models of this tissue type available for use in studies of FTSEC biology and malignant transformation. In vitro three-dimensi...

journal_title：BMC cell biology

authors： Lawrenson K,Notaridou M,Lee N,Benjamin E,Jacobs IJ,Jones C,Gayther SA

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:In endothelial cells (EC), transforming growth factor-beta (TGF-beta) can bind to and transduce signals through ALK1 and ALK5. The TGF-beta/ALK5 and TGF-beta/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-beta signaling is an important specific...

journal_title：BMC cell biology

authors： Valdimarsdottir G,Goumans MJ,Itoh F,Itoh S,Heldin CH,ten Dijke P

更新日期：2006-03-29 00:00:00

abstract：BACKGROUND:SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examined the function of SPARC in cutaneous wound healing using SPARC-null mice and dermal fibroblasts der...

journal_title：BMC cell biology

authors： Basu A,Kligman LH,Samulewicz SJ,Howe CC

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Transport of macromolecules into and out of the nucleus is a highly regulated process. The RanGTP/RanGDP gradient controls the trafficking of molecules exceeding the diffusion limit of the nuclear pore across the nuclear envelope. RESULTS:We found genetic interaction between genes establishing the Ran gradi...

journal_title：BMC cell biology

authors： Minakhina S,Myers R,Druzhinina M,Steward R

更新日期：2005-08-24 00:00:00

abstract：BACKGROUND:Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural proteins were upregulated when murine embryonic stem (ES) cells differentiated to primitive endoder...

journal_title：BMC cell biology

authors： Smith ER,Meng Y,Moore R,Tse JD,Xu AG,Xu XX

更新日期：2017-01-14 00:00:00

abstract：BACKGROUND:The tissue accumulation of protein-bound advanced glycation endproducts (AGE) may be involved in the etiology of diabetic chronic complications, including osteopenia. The aim of this study was to investigate the effect of an AGE-modified type I collagen substratum on the adhesion, spreading, proliferation an...

journal_title：BMC cell biology

authors： McCarthy AD,Etcheverry SB,Bruzzone L,Lettieri G,Barrio DA,Cortizo AM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis. RESULTS:In the current study, we investigated the effect of melatonin on DNA strand breaks using the alkaline DNA comet as...

journal_title：BMC cell biology

authors： Liu R,Fu A,Hoffman AE,Zheng T,Zhu Y

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:The interleukin-8 chemokine (IL-8) G-protein coupled receptor CXCR2 governs pro-inflammatory and pro-angiogenic responses in leukocytes and endothelial cells. At a molecular standpoint, CXCR2 is widely reported to operate through calcium flux, phosphoinoisitide 3 kinase (PI3K) and mitogen-activated protein k...

journal_title：BMC cell biology

authors： Leclair HM,Dubois SM,Azzi S,Dwyer J,Bidère N,Gavard J

更新日期：2014-10-22 00:00:00

abstract：BACKGROUND:Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A gene in cellular processes are u...

journal_title：BMC cell biology

authors： Funakoshi E,Hori T,Haraguchi T,Hiraoka Y,Kudoh J,Shimizu N,Ito F

更新日期：2003-09-10 00:00:00

abstract：BACKGROUND:Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant. Because heterogeneity among endothelial cells from different tissues, has been demonstrated, the purpose of this study was to determine, if Fa...

journal_title：BMC cell biology

authors： Filippatos G,Ang E,Gidea C,Dincer E,Wang R,Uhal BD

更新日期：2004-01-22 00:00:00

abstract：BACKGROUND:The estrogen receptor alpha (ERα) is found predominately in the nucleus, both in hormone stimulated and untreated cells. Intracellular distribution of the ERα changes in the presence of agonists but the impact of different antiestrogens on the fate of ERα is a matter of debate. RESULTS:A MCF-7 cell line sta...

journal_title：BMC cell biology

authors： Kocanova S,Mazaheri M,Caze-Subra S,Bystricky K

更新日期：2010-12-10 00:00:00

abstract：BACKGROUND:Experimental models are inevitably a compromise between accurately reproducing a pathological situation and schematically simplifying it, which is intended to provide both relevance and conclusiveness. In-vivo models are very relevant, but multiple cell-types undergoing various changes may hinder the observa...

journal_title：BMC cell biology

authors： Legouis D,Bataille A,Hertig A,Vandermeersch S,Simon N,Rondeau E,Galichon P

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes. Part of the problem in rationalising genotype-phenotype correlat...

journal_title：BMC cell biology

authors： Gilchrist S,Gilbert N,Perry P,Ostlund C,Worman HJ,Bickmore WA

更新日期：2004-12-13 00:00:00

abstract：BACKGROUND:Endocytosis of activated EGF receptor (EGFR) to specific endocytic compartments is required to terminate EGF signaling. Trafficking of EGFR relies on microtubule tracks that transport the cargo vesicle to their intermediate and final destinations and can be modulated through posttranslational modification of...

journal_title：BMC cell biology

authors： Lee SJ,Li Z,Litan A,Yoo S,Langhans SA

更新日期：2015-09-18 00:00:00

abstract：BACKGROUND:Acrosomal proteins play crucial roles in the physiology of fertilization. Identification of proteins localizing to the acrosome is fundamental to the understanding of its contribution to fertilization. Novel proteins are still being reported from acrosome. In order to capture yet unreported proteins localizi...

journal_title：BMC cell biology

authors： Bhattacharya R,Devi MS,Dhople VM,Jesudasan RA

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:In the bone marrow, hematopietic and mesenchymal stem cells form a unique niche in which the oxygen tension is low. Hypoxia may have a role in maintaining stem cell fate, self renewal and multipotency. However, whereas most studies addressed the effect of transient in vitro exposure of MSC to hypoxia, perman...

journal_title：BMC cell biology

authors： Basciano L,Nemos C,Foliguet B,de Isla N,de Carvalho M,Tran N,Dalloul A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Cellular senescence plays important roles in the aging process of complex organisms, in tumor suppression and in response to stress. Several markers can be used to identify senescent cells, of which the most widely used is the senescence-associated β-galactosidase (SABG) activity. The main advantage of SABG ...

journal_title：BMC cell biology

authors： Shlush LI,Itzkovitz S,Cohen A,Rutenberg A,Berkovitz R,Yehezkel S,Shahar H,Selig S,Skorecki K

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therapeutic applications and limitations of hMSCs derived from human umbilical cords, the effects of hypoxi...

journal_title：BMC cell biology

authors： Zeng HL,Zhong Q,Qin YL,Bu QQ,Han XA,Jia HT,Liu HW

更新日期：2011-08-09 00:00:00

abstract：BACKGROUND:Fetal mesenchymal stem/stromal cells (MSC) represent a developmentally-advantageous cell type with translational potential.To enhance adult MSC migration, studies have focussed on the role of the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12), but more recent work implicates an intricate system of CX...

journal_title：BMC cell biology

authors： Pelekanos RA,Ting MJ,Sardesai VS,Ryan JM,Lim YC,Chan JK,Fisk NM

更新日期：2014-05-16 00:00:00

abstract：BACKGROUND:The nucleolus is a multi-domain enriched with proteins involved in ribosome biogenesis, cell cycle and apoptosis control, viral replication and differentiation of stem cells. Several authors have suggested a role for the nucleolus also in malignant transformation. We have recently demonstrated that under spe...

journal_title：BMC cell biology

authors： Ponti D,Bastianelli D,Rosa P,Pacini L,Ibrahim M,Rendina EA,Ragona G,Calogero A

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats. RESULTS:Cisplatin increased GC apoptosis from 0.59% to 13.04% in the control and cisplatin treatment groups, respectively, which was significantly reduced u...

journal_title：BMC cell biology

authors： Guo JQ,Gao X,Lin ZJ,Wu WZ,Huang LH,Dong HY,Chen J,Lu J,Fu YF,Wang J,Ma YJ,Chen XW,Wu ZX,He FQ,Yang SL,Liao LM,Zheng F,Tan JM

更新日期：2013-03-19 00:00:00

abstract：BACKGROUND:Bone morphogenetic proteins (BMPs) and transforming growth factor-betas (TGF-betas) are important regulators of bone repair and regeneration. BMP-2 and TGF-beta1 have been shown to inhibit gap junctional intercellular communication (GJIC) in MC3T3-E1 cells. Connexin 43 (Cx43) has been shown to mediate GJIC i...

journal_title：BMC cell biology

authors： Wyatt LE,Chung CY,Carlsen B,Iida-Klein A,Rudkin GH,Ishida K,Yamaguchi DT,Miller TA

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Multilineage differentiation, immunomodulation and secretion of trophic factors render mesenchymal stromal cells (MSC) highly attractive for clinical application. Human platelet derivatives such as pooled human platelet lysate (pHPL) and thrombin-activated platelet releasate in plasma (tPRP) have been introd...

journal_title：BMC cell biology

authors： Kinzebach S,Dietz L,Klüter H,Thierse HJ,Bieback K

更新日期：2013-10-30 00:00:00