Bone morphogenetic protein-2 (BMP-2) and transforming growth factor-beta1 (TGF-beta1) alter connexin 43 phosphorylation in MC3T3-E1 Cells.

abstract：BACKGROUND:Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes. Part of the problem in rationalising genotype-phenotype correlat...

journal_title：BMC cell biology

authors： Gilchrist S,Gilbert N,Perry P,Ostlund C,Worman HJ,Bickmore WA

更新日期：2004-12-13 00:00:00

abstract：BACKGROUND:Stimulation of Dictyostelium discoideum with cAMP evokes an elevation of the cytosolic free Ca2+ concentration ([Ca2+]i). The [Ca2+]i-change is composed of liberation of stored Ca2+ and extracellular Ca2+-entry. The significance of the [Ca2+]i-transient for chemotaxis is under debate. Abolition of chemotacti...

journal_title：BMC cell biology

authors： Schaloske RH,Lusche DF,Bezares-Roder K,Happle K,Malchow D,Schlatterer C

更新日期：2005-03-11 00:00:00

abstract：BACKGROUND:During cytokinesis, the cell's equator contracts against the cell's global stiffness. Identifying the biochemical basis for these mechanical parameters is essential for understanding how cells divide. To achieve this goal, the distribution and flux of the cell division machinery must be quantified. Here we r...

journal_title：BMC cell biology

authors： Robinson DN,Cavet G,Warrick HM,Spudich JA

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Dental pulp stem cells (DPSCs) can be driven into odontoblast, osteoblast, and chondrocyte lineages in different inductive media. However, the differentiation potential of naive DPSCs after serial passaging in the routine culture system has not been fully elucidated. RESULTS:DPSCs were isolated from human/r...

journal_title：BMC cell biology

authors： Yu J,He H,Tang C,Zhang G,Li Y,Wang R,Shi J,Jin Y

更新日期：2010-05-08 00:00:00

abstract：BACKGROUND:CLIC1 is a chloride channel whose cellular role remains uncertain. The distribution of CLIC1 in normal tissues is largely unknown and conflicting data have been reported regarding the cellular membrane fraction in which CLIC1 resides. RESULTS:New antisera to CLIC1 were generated and were found to be sensiti...

journal_title：BMC cell biology

authors： Ulmasov B,Bruno J,Woost PG,Edwards JC

更新日期：2007-02-27 00:00:00

abstract：BACKGROUND:Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis. The aim of our study was to determine the detailed role of mitochondrial fission in SW837 colorectal cancer cell viability, m...

journal_title：BMC cell biology

authors： Jieensinue S,Zhu H,Li G,Dong K,Liang M,Li Y

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:Transport of macromolecules into and out of the nucleus is a highly regulated process. The RanGTP/RanGDP gradient controls the trafficking of molecules exceeding the diffusion limit of the nuclear pore across the nuclear envelope. RESULTS:We found genetic interaction between genes establishing the Ran gradi...

journal_title：BMC cell biology

authors： Minakhina S,Myers R,Druzhinina M,Steward R

更新日期：2005-08-24 00:00:00

abstract：:The 2006 International Workshop on Multiscale Biological Imaging, Data Mining and Informatics was held at Santa Barbara, on Sept 7-8, 2006. Based on the presentations at the workshop, we selected and compiled this collection of research articles related to novel algorithms and enabling techniques for bio- and biomedic...

journal_title：BMC cell biology

authors：

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:Clathrin-mediated vesicular trafficking, the mechanism by which proteins and lipids are transported between membrane-bound organelles, accounts for a large proportion of import from the plasma membrane (endocytosis) and transport from the trans-Golgi network towards the endosomal system. Clathrin-mediated ev...

journal_title：BMC cell biology

authors： Kalb LC,Frederico YC,Batista CM,Eger I,Fragoso SP,Soares MJ

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Chromatin insulators or boundary elements are a class of functional elements in the eukaryotic genome. They regulate gene transcription by interfering with promoter-enhancer communication. The Cp190 protein of Drosophila melanogaster is essential to the function of at least three-types of chromatin insulator...

journal_title：BMC cell biology

authors： Oliver D,Sheehan B,South H,Akbari O,Pai CY

更新日期：2010-12-31 00:00:00

abstract：BACKGROUND:Adipose-Derived Stromal Cells have been shown to have multiple lineage differentiation properties and to be suitable for tissues regeneration in many degenerative processes. Their use has been proposed for the therapy of joint diseases and tendon injuries in the horse. In the present report the genetic manip...

journal_title：BMC cell biology

authors： Donofrio G,Capocefalo A,Franceschi V,Morini G,Del Bue M,Conti V,Cavirani S,Grolli S

更新日期：2010-09-23 00:00:00

abstract：BACKGROUND:Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. In order to monitor the organisation of chromatin in live cells we have engineered fluorescent fusio...

journal_title：BMC cell biology

authors： Dickerson D,Gierliński M,Singh V,Kitamura E,Ball G,Tanaka TU,Owen-Hughes T

更新日期：2016-09-08 00:00:00

abstract：BACKGROUND:DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinokitiol and DNA methylat...

journal_title：BMC cell biology

authors： Seo JS,Choi YH,Moon JW,Kim HS,Park SH

更新日期：2017-02-27 00:00:00

abstract：BACKGROUND:The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. RESULTS:MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50...

journal_title：BMC cell biology

authors： Barteneva NS,Fasler-Kan E,Bernimoulin M,Stern JN,Ponomarev ED,Duckett L,Vorobjev IA

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:The adaptive response of bone cells to mechanical strain is a primary determinant of skeletal architecture and bone mass. In vivo mechanical loading induces new bone formation and increases bone mineral density whereas disuse, immobilisation and weightlessness induce bone loss. The potency of mechanical stra...

journal_title：BMC cell biology

authors： Spencer GJ,Genever PG

更新日期：2003-07-31 00:00:00

abstract：BACKGROUND:Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration, and in the cleavage furrow during cytokinesis. Filament assembly in turn is regulated by phosphorylation in the tail region of the myosin heavy chain (MHC). Early studies have revea...

journal_title：BMC cell biology

authors： Liang W,Licate L,Warrick H,Spudich J,Egelhoff T

更新日期：2002-07-24 00:00:00

abstract：:Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. At present these proteins are named Shroom, APX, APXL, and KI...

journal_title：BMC cell biology

authors： Hagens O,Ballabio A,Kalscheuer V,Kraehenbuhl JP,Schiaffino MV,Smith P,Staub O,Hildebrand J,Wallingford JB

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:In endothelial cells (EC), transforming growth factor-beta (TGF-beta) can bind to and transduce signals through ALK1 and ALK5. The TGF-beta/ALK5 and TGF-beta/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-beta signaling is an important specific...

journal_title：BMC cell biology

authors： Valdimarsdottir G,Goumans MJ,Itoh F,Itoh S,Heldin CH,ten Dijke P

更新日期：2006-03-29 00:00:00

abstract：BACKGROUND:Ras proteins are guanine-nucleotide-binding enzymes that couple cell surface receptors to intracellular signaling pathways controlling cell proliferation and differentiation, both in lower and higher eukaryotes. They act as molecular switches by cycling between active GTP and inactive GDP-bound states, throu...

journal_title：BMC cell biology

authors： Arigoni M,Bracco E,Lusche DF,Kae H,Weeks G,Bozzaro S

更新日期：2005-12-07 00:00:00

abstract：BACKGROUND:Experimental models are inevitably a compromise between accurately reproducing a pathological situation and schematically simplifying it, which is intended to provide both relevance and conclusiveness. In-vivo models are very relevant, but multiple cell-types undergoing various changes may hinder the observa...

journal_title：BMC cell biology

authors： Legouis D,Bataille A,Hertig A,Vandermeersch S,Simon N,Rondeau E,Galichon P

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on the microenvironment of the specific vascular bed and on interact...

journal_title：BMC cell biology

authors： Beese M,Wyss K,Haubitz M,Kirsch T

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:The Scar/WAVE family of proteins mediates signals to actin assembly by direct activation of the Arp2/3 complex. These proteins have been characterised as major regulators of lamellipodia formation downstream of Rac activation and as members of large protein complexes. RESULTS:We have investigated the intera...

journal_title：BMC cell biology

authors： Stovold CF,Millard TH,Machesky LM

更新日期：2005-03-07 00:00:00

abstract：BACKGROUND:The mechanism involved in the maintenance and differentiation of embryonic stem (ES) cells is incompletely understood. RESULTS:To address this issue, we have developed a retroviral gene trap vector that can target genes expressed in undifferentiated ES cells. This gene trap vector harbors both GFP and Neo r...

journal_title：BMC cell biology

authors： Li X,Leder P

更新日期：2007-08-28 00:00:00

abstract：BACKGROUND:The transcription factor STAT3 (signal transducer and activator of transcription 3) is frequently activated in tumor cells. Activated STAT3 forms homodimers, or heterodimers with other TFs such as NF-κB, which becomes activated. Cytoplasmic STAT3 dimers are activated by tyrosine phosphorylation; they interac...

journal_title：BMC cell biology

authors： Souissi I,Najjar I,Ah-Koon L,Schischmanoff PO,Lesage D,Le Coquil S,Roger C,Dusanter-Fourt I,Varin-Blank N,Cao A,Metelev V,Baran-Marszak F,Fagard R

更新日期：2011-04-12 00:00:00

abstract：BACKGROUND:There is a growing interest in cord blood as a source of primitive stem cells with the capacity for multilineage differentiation. Pure cell fractions are needed for the characterization and in vitro expansion of stem cells as well as for their use in preclinical research. However, enrichment of stem cells is...

journal_title：BMC cell biology

authors： Kekarainen T,Mannelin S,Laine J,Jaatinen T

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant. Because heterogeneity among endothelial cells from different tissues, has been demonstrated, the purpose of this study was to determine, if Fa...

journal_title：BMC cell biology

authors： Filippatos G,Ang E,Gidea C,Dincer E,Wang R,Uhal BD

更新日期：2004-01-22 00:00:00

abstract：BACKGROUND:Proteins linking intermediate filaments to other cytoskeletal components have important functions in maintaining tissue integrity and cell shape. RESULTS:We found a set of monoclonal antibodies raised against specific human sarcomeric myosin heavy chain (MyHC) isoforms labels cells in distinct regions of th...

journal_title：BMC cell biology

authors： Jazwinska A,Ehler E,Hughes SM

更新日期：2003-08-04 00:00:00

abstract：BACKGROUND:Lipid droplets are a class of eukaryotic cell organelles for storage of neutral fat such as triacylglycerol (TAG) and cholesterol ester (CE). We and others have recently reported that lysosome-related organelles (LROs) are not fat storage structures in the nematode C. elegans. We also reported the formation ...

journal_title：BMC cell biology

authors： Zhang SO,Trimble R,Guo F,Mak HY

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:Filamin (FLN) and non-muscle alpha-actinin are members of a family of F-actin cross-linking proteins that utilize Calponin Homology domains (CH-domain) for actin binding. Although these two proteins have been extensively characterized, little is known about what regulates their binding to F-actin filaments i...

journal_title：BMC cell biology

authors： Washington RW,Knecht DA

更新日期：2008-02-13 00:00:00

abstract：BACKGROUND:The regulatory mechanisms of motor protein-dependent intracellular transport are still not fully understood. The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and other JIP1-binding "cargo" proteins. However, it is unknown whether these "cargo" proteins influence th...

journal_title：BMC cell biology

authors： Satake T,Otsuki K,Banba Y,Suenaga J,Hirano H,Yamanaka Y,Ohno S,Hirai S

更新日期：2013-03-04 00:00:00