Tissue and subcellular distribution of CLIC1.

abstract：BACKGROUND:Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant. Because heterogeneity among endothelial cells from different tissues, has been demonstrated, the purpose of this study was to determine, if Fa...

journal_title：BMC cell biology

authors： Filippatos G,Ang E,Gidea C,Dincer E,Wang R,Uhal BD

更新日期：2004-01-22 00:00:00

abstract：BACKGROUND:Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. In order to monitor the organisation of chromatin in live cells we have engineered fluorescent fusio...

journal_title：BMC cell biology

authors： Dickerson D,Gierliński M,Singh V,Kitamura E,Ball G,Tanaka TU,Owen-Hughes T

更新日期：2016-09-08 00:00:00

abstract：BACKGROUND:Bone morphogenetic proteins (BMPs) contribute to many different aspects of development including mesoderm formation, heart development, neurogenesis, skeletal development, and axis formation. They have previously been recognized only as secreted growth factors, but the present study detected Bmp2, Bmp4, and ...

journal_title：BMC cell biology

authors： Felin JE,Mayo JL,Loos TJ,Jensen JD,Sperry DK,Gaufin SL,Meinhart CA,Moss JB,Bridgewater LC

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:In interferon-γ-stimulated cells, the dimeric transcription factor STAT1 (signal transducer and activator of transcription 1) recognizes semi-palindromic motifs in the promoter regions of cytokine-driven target genes termed GAS (gamma-activated sites). However, the molecular steps that facilitate GAS binding...

journal_title：BMC cell biology

authors： Koch V,Staab J,Ruppert V,Meyer T

更新日期：2012-08-24 00:00:00

abstract：BACKGROUND:In the bone marrow, hematopietic and mesenchymal stem cells form a unique niche in which the oxygen tension is low. Hypoxia may have a role in maintaining stem cell fate, self renewal and multipotency. However, whereas most studies addressed the effect of transient in vitro exposure of MSC to hypoxia, perman...

journal_title：BMC cell biology

authors： Basciano L,Nemos C,Foliguet B,de Isla N,de Carvalho M,Tran N,Dalloul A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:Fetal mesenchymal stem/stromal cells (MSC) represent a developmentally-advantageous cell type with translational potential.To enhance adult MSC migration, studies have focussed on the role of the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12), but more recent work implicates an intricate system of CX...

journal_title：BMC cell biology

authors： Pelekanos RA,Ting MJ,Sardesai VS,Ryan JM,Lim YC,Chan JK,Fisk NM

更新日期：2014-05-16 00:00:00

abstract：BACKGROUND:Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of the HECT class of E3 ubiquitin ligases. A defining feature of NEDD4L protein isoforms is the presenc...

journal_title：BMC cell biology

authors： Garrone NF,Blazer-Yost BL,Weiss RB,Lalouel JM,Rohrwasser A

更新日期：2009-04-13 00:00:00

abstract：BACKGROUND:Acrosomal proteins play crucial roles in the physiology of fertilization. Identification of proteins localizing to the acrosome is fundamental to the understanding of its contribution to fertilization. Novel proteins are still being reported from acrosome. In order to capture yet unreported proteins localizi...

journal_title：BMC cell biology

authors： Bhattacharya R,Devi MS,Dhople VM,Jesudasan RA

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:Clathrin-mediated vesicular trafficking, the mechanism by which proteins and lipids are transported between membrane-bound organelles, accounts for a large proportion of import from the plasma membrane (endocytosis) and transport from the trans-Golgi network towards the endosomal system. Clathrin-mediated ev...

journal_title：BMC cell biology

authors： Kalb LC,Frederico YC,Batista CM,Eger I,Fragoso SP,Soares MJ

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:Induced pluripotent stem cells (iPSC) are generated by reprogramming somatic cells into embryonic like state (ESC) using defined factors. There is great interest in these cells because of their potential for application in regenerative medicine. RESULTS:iPSC reprogrammed from murine tail tip fibroblasts wer...

journal_title：BMC cell biology

authors： Li F,Niyibizi C

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A gene in cellular processes are u...

journal_title：BMC cell biology

authors： Funakoshi E,Hori T,Haraguchi T,Hiraoka Y,Kudoh J,Shimizu N,Ito F

更新日期：2003-09-10 00:00:00

abstract：BACKGROUND:There is evidence that several messenger RNAs (mRNAs) are bifunctional RNAs, i.e. RNA transcript carrying both protein-coding capacity and activity as functional non-coding RNA via 5' and 3' untranslated regions (UTRs). RESULTS:In this study, we identified a novel bifunctional RNA that is transcribed from i...

journal_title：BMC cell biology

authors： Nagano H,Yamagishi N,Tomida C,Yano C,Aibara K,Kohno S,Abe T,Ohno A,Hirasaka K,Okumura Y,Mills EM,Nikawa T,Teshima-Kondo S

更新日期：2015-03-11 00:00:00

abstract：BACKGROUND:Multilineage differentiation, immunomodulation and secretion of trophic factors render mesenchymal stromal cells (MSC) highly attractive for clinical application. Human platelet derivatives such as pooled human platelet lysate (pHPL) and thrombin-activated platelet releasate in plasma (tPRP) have been introd...

journal_title：BMC cell biology

authors： Kinzebach S,Dietz L,Klüter H,Thierse HJ,Bieback K

更新日期：2013-10-30 00:00:00

abstract：BACKGROUND:The direction of cytokine secretion from polarized cells determines the cytokine's cellular targets. Leukemia inhibitory factor (LIF) belongs to the interleukin-6 (IL-6) family of cytokines and signals through LIFR/gp130. Three factors which may regulate the direction of LIF secretion were studied: the site ...

journal_title：BMC cell biology

authors： Hill EJ,Vernallis AB

更新日期：2008-09-18 00:00:00

abstract：BACKGROUND:Neuronal ceroid lipofuscinoses (NCLs) are collectively the most common type of recessively inherited childhood encephalopathies. The most severe form of NCL, infantile neuronal ceroid lipofuscinosis (INCL), is caused by mutations in the CLN1 gene, resulting in a deficiency of the lysosomal enzyme, palmitoyl ...

journal_title：BMC cell biology

authors： Lyly A,von Schantz C,Salonen T,Kopra O,Saarela J,Jauhiainen M,Kyttälä A,Jalanko A

更新日期：2007-06-12 00:00:00

abstract：BACKGROUND:A breakthrough in the understanding of centriole assembly was provided by the characterization of the UNI3 gene in Chlamydomonas. Deletion of this gene, found to encode a novel member of the tubulin superfamily, delta-tubulin, results in the loss of the C-tubule, in the nine microtubule triplets which are th...

journal_title：BMC cell biology

authors： Garreau de Loubresse N,Ruiz F,Beisson J,Klotz C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process prepares the cells to actively participate in the inflammatory and immune responses, and many factors...

journal_title：BMC cell biology

authors： Zhou J,Zhu P,Jiang JL,Zhang Q,Wu ZB,Yao XY,Tang H,Lu N,Yang Y,Chen ZN

更新日期：2005-05-17 00:00:00

abstract：BACKGROUND:Epithelial tight junction (TJ) and adherens junction (AJ) form the apical junctional complex (AJC) which regulates cell-cell adhesion, paracellular permeability and cell polarity. The AJC is anchored on cytoskeletal structures including actin microfilaments and microtubules. Such cytoskeletal interactions ar...

journal_title：BMC cell biology

authors： Ivanov AI,McCall IC,Babbin B,Samarin SN,Nusrat A,Parkos CA

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Fallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro models of this tissue type available for use in studies of FTSEC biology and malignant transformation. In vitro three-dimensi...

journal_title：BMC cell biology

authors： Lawrenson K,Notaridou M,Lee N,Benjamin E,Jacobs IJ,Jones C,Gayther SA

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:The mammalian inner ear contains the organ of Corti which is responsible for the conversion of sound into neuronal signals. This specialised epithelial tissue is the product of a complex developmental process where a common precursor cell type differentiates into the sound transducing hair cells and the non-...

journal_title：BMC cell biology

authors： Brunetta I,Casalotti SO,Hart IR,Forge A,Reynolds LE

更新日期：2012-03-17 00:00:00

abstract：BACKGROUND:The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature would be expected to cause endoplasmic reticulum (ER) localization. The aim of this study was to determine by which means the HIV...

journal_title：BMC cell biology

authors： Perrin J,Bary A,Vernay A,Cosson P

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Golgins are coiled-coil proteins associated with the Golgi apparatus, that are believed to be involved in the tethering of vesicles and the stacking of cisternae, as well as other functions such as cytoskeletal association. Many are peripheral membrane proteins recruited by GTPases. Several have been describ...

journal_title：BMC cell biology

authors： Fridmann-Sirkis Y,Siniossoglou S,Pelham HR

更新日期：2004-05-05 00:00:00

abstract：BACKGROUND:Recent interest in the function of the nuclear lamina has been provoked by the discovery of lamin A/C mutations in the laminopathy diseases. However, it is not understood why mutations in lamin A give such a range of tissue-specific phenotypes. Part of the problem in rationalising genotype-phenotype correlat...

journal_title：BMC cell biology

authors： Gilchrist S,Gilbert N,Perry P,Ostlund C,Worman HJ,Bickmore WA

更新日期：2004-12-13 00:00:00

abstract：BACKGROUND:Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on the microenvironment of the specific vascular bed and on interact...

journal_title：BMC cell biology

authors： Beese M,Wyss K,Haubitz M,Kirsch T

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:The discovery of the importance of angiogenesis in tumor growth has emphasized the need to find specific vascular targets for tumor-targeted therapies. Previously, using phage display technology, we identified the peptide GX1 as having the ability to target the gastric cancer vasculature. The present study i...

journal_title：BMC cell biology

authors： Chen B,Cao S,Zhang Y,Wang X,Liu J,Hui X,Wan Y,Du W,Wang L,Wu K,Fan D

更新日期：2009-09-09 00:00:00

abstract：BACKGROUND:Chromatin insulators or boundary elements are a class of functional elements in the eukaryotic genome. They regulate gene transcription by interfering with promoter-enhancer communication. The Cp190 protein of Drosophila melanogaster is essential to the function of at least three-types of chromatin insulator...

journal_title：BMC cell biology

authors： Oliver D,Sheehan B,South H,Akbari O,Pai CY

更新日期：2010-12-31 00:00:00

abstract：BACKGROUND:Recently, mast cells have been recognized to express several Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was reported to be able to alter expression of TLRs and cytokine production in neutrophils. However, whether GM-CSF modulates the e...

journal_title：BMC cell biology

authors： Yang H,Wei J,Zhang H,Lin L,Zhang W,He S

更新日期：2009-05-09 00:00:00

abstract：BACKGROUND:Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role in muscle development. Genetic and biochemical studies in C. elegans have demonstrated that Unc-45 facilitates the process of myosin folding and assembly in body wall muscles. Loss or overexpression of Unc-45 in C. elegans results in...

journal_title：BMC cell biology

authors： Bernick EP,Zhang PJ,Du S

更新日期：2010-09-17 00:00:00

abstract：BACKGROUND:There is a growing awareness of the importance of intracellular events in determining the outcome of infectious disease. To improve the understanding of such events, like phagosome maturation, we set out to develop a versatile technique for phagosome isolation that is rapid and widely applicable to different...

journal_title：BMC cell biology

authors： Lönnbro P,Nordenfelt P,Tapper H

更新日期：2008-06-27 00:00:00

abstract：BACKGROUND:Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis. RESULTS:In the current study, we investigated the effect of melatonin on DNA strand breaks using the alkaline DNA comet as...

journal_title：BMC cell biology

authors： Liu R,Fu A,Hoffman AE,Zheng T,Zhu Y

更新日期：2013-01-07 00:00:00