Polarized secretion of leukemia inhibitory factor.

abstract：BACKGROUND:The discovery of the importance of angiogenesis in tumor growth has emphasized the need to find specific vascular targets for tumor-targeted therapies. Previously, using phage display technology, we identified the peptide GX1 as having the ability to target the gastric cancer vasculature. The present study i...

journal_title：BMC cell biology

authors： Chen B,Cao S,Zhang Y,Wang X,Liu J,Hui X,Wan Y,Du W,Wang L,Wu K,Fan D

更新日期：2009-09-09 00:00:00

abstract：BACKGROUND:Fallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro models of this tissue type available for use in studies of FTSEC biology and malignant transformation. In vitro three-dimensi...

journal_title：BMC cell biology

authors： Lawrenson K,Notaridou M,Lee N,Benjamin E,Jacobs IJ,Jones C,Gayther SA

更新日期：2013-09-27 00:00:00

abstract：BACKGROUND:During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process prepares the cells to actively participate in the inflammatory and immune responses, and many factors...

journal_title：BMC cell biology

authors： Zhou J,Zhu P,Jiang JL,Zhang Q,Wu ZB,Yao XY,Tang H,Lu N,Yang Y,Chen ZN

更新日期：2005-05-17 00:00:00

abstract：BACKGROUND:The interleukin-8 chemokine (IL-8) G-protein coupled receptor CXCR2 governs pro-inflammatory and pro-angiogenic responses in leukocytes and endothelial cells. At a molecular standpoint, CXCR2 is widely reported to operate through calcium flux, phosphoinoisitide 3 kinase (PI3K) and mitogen-activated protein k...

journal_title：BMC cell biology

authors： Leclair HM,Dubois SM,Azzi S,Dwyer J,Bidère N,Gavard J

更新日期：2014-10-22 00:00:00

abstract：BACKGROUND:In this study, we have investigated the viscoelastic behaviour of individual human adult bone marrow-derived mesenchymal stem cells (hMSCs) and the role of F-actin filaments in maintaining these properties, using micropipette aspiration technique together with a standard linear viscoelastic solid model. RES...

journal_title：BMC cell biology

authors： Tan SC,Pan WX,Ma G,Cai N,Leong KW,Liao K

更新日期：2008-07-22 00:00:00

abstract：BACKGROUND:One of the problems associated with osteosarcoma is the frequent formation of micrometastases in the lung prior to diagnosis because the development of metastatic lesions often causes a fatal outcome. Therefore, the prevention of pulmonary metastases during the early stage of tumor development is critical fo...

journal_title：BMC cell biology

authors： Nakamura A,Aizawa J,Sakayama K,Kidani T,Takata T,Norimatsu Y,Miura H,Masuno H

更新日期：2012-09-26 00:00:00

abstract：BACKGROUND:The mechanism involved in the maintenance and differentiation of embryonic stem (ES) cells is incompletely understood. RESULTS:To address this issue, we have developed a retroviral gene trap vector that can target genes expressed in undifferentiated ES cells. This gene trap vector harbors both GFP and Neo r...

journal_title：BMC cell biology

authors： Li X,Leder P

更新日期：2007-08-28 00:00:00

abstract：BACKGROUND:The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. RESULTS:MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50...

journal_title：BMC cell biology

authors： Barteneva NS,Fasler-Kan E,Bernimoulin M,Stern JN,Ponomarev ED,Duckett L,Vorobjev IA

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:CLIC1 is a chloride channel whose cellular role remains uncertain. The distribution of CLIC1 in normal tissues is largely unknown and conflicting data have been reported regarding the cellular membrane fraction in which CLIC1 resides. RESULTS:New antisera to CLIC1 were generated and were found to be sensiti...

journal_title：BMC cell biology

authors： Ulmasov B,Bruno J,Woost PG,Edwards JC

更新日期：2007-02-27 00:00:00

abstract：BACKGROUND:DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinokitiol and DNA methylat...

journal_title：BMC cell biology

authors： Seo JS,Choi YH,Moon JW,Kim HS,Park SH

更新日期：2017-02-27 00:00:00

abstract：BACKGROUND:We have previously obtained a clonal population of cells from human foreskin that is able to differentiate into mesodermal, ectodermal and endodermal progenies. It is of great interest to know whether these cells could be further differentiated into functional insulin-producing cells. RESULTS:Sixty-one sing...

journal_title：BMC cell biology

authors： Bi D,Chen FG,Zhang WJ,Zhou GD,Cui L,Liu W,Cao Y

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therapeutic applications and limitations of hMSCs derived from human umbilical cords, the effects of hypoxi...

journal_title：BMC cell biology

authors： Zeng HL,Zhong Q,Qin YL,Bu QQ,Han XA,Jia HT,Liu HW

更新日期：2011-08-09 00:00:00

abstract：BACKGROUND:In cytokinesis, when the cleavage furrow has been formed, the two centrioles in each daughter cell separate. It has been suggested that the centrioles facilitate and regulate cytokinesis to some extent. It has been postulated that termination of cytokinesis (abscission) depends on the migration of a centriol...

journal_title：BMC cell biology

authors： Jonsdottir AB,Dirks RW,Vrolijk J,Ogmundsdottir HM,Tanke HJ,Eyfjörd JE,Szuhai K

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on the microenvironment of the specific vascular bed and on interact...

journal_title：BMC cell biology

authors： Beese M,Wyss K,Haubitz M,Kirsch T

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:Bone morphogenetic proteins (BMPs) contribute to many different aspects of development including mesoderm formation, heart development, neurogenesis, skeletal development, and axis formation. They have previously been recognized only as secreted growth factors, but the present study detected Bmp2, Bmp4, and ...

journal_title：BMC cell biology

authors： Felin JE,Mayo JL,Loos TJ,Jensen JD,Sperry DK,Gaufin SL,Meinhart CA,Moss JB,Bridgewater LC

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:Recently, mast cells have been recognized to express several Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was reported to be able to alter expression of TLRs and cytokine production in neutrophils. However, whether GM-CSF modulates the e...

journal_title：BMC cell biology

authors： Yang H,Wei J,Zhang H,Lin L,Zhang W,He S

更新日期：2009-05-09 00:00:00

abstract：BACKGROUND:Golgins are coiled-coil proteins associated with the Golgi apparatus, that are believed to be involved in the tethering of vesicles and the stacking of cisternae, as well as other functions such as cytoskeletal association. Many are peripheral membrane proteins recruited by GTPases. Several have been describ...

journal_title：BMC cell biology

authors： Fridmann-Sirkis Y,Siniossoglou S,Pelham HR

更新日期：2004-05-05 00:00:00

abstract：BACKGROUND:Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural proteins were upregulated when murine embryonic stem (ES) cells differentiated to primitive endoder...

journal_title：BMC cell biology

authors： Smith ER,Meng Y,Moore R,Tse JD,Xu AG,Xu XX

更新日期：2017-01-14 00:00:00

abstract：BACKGROUND:SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examined the function of SPARC in cutaneous wound healing using SPARC-null mice and dermal fibroblasts der...

journal_title：BMC cell biology

authors： Basu A,Kligman LH,Samulewicz SJ,Howe CC

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The tissue accumulation of protein-bound advanced glycation endproducts (AGE) may be involved in the etiology of diabetic chronic complications, including osteopenia. The aim of this study was to investigate the effect of an AGE-modified type I collagen substratum on the adhesion, spreading, proliferation an...

journal_title：BMC cell biology

authors： McCarthy AD,Etcheverry SB,Bruzzone L,Lettieri G,Barrio DA,Cortizo AM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats. RESULTS:Cisplatin increased GC apoptosis from 0.59% to 13.04% in the control and cisplatin treatment groups, respectively, which was significantly reduced u...

journal_title：BMC cell biology

authors： Guo JQ,Gao X,Lin ZJ,Wu WZ,Huang LH,Dong HY,Chen J,Lu J,Fu YF,Wang J,Ma YJ,Chen XW,Wu ZX,He FQ,Yang SL,Liao LM,Zheng F,Tan JM

更新日期：2013-03-19 00:00:00

abstract：BACKGROUND:Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration, and in the cleavage furrow during cytokinesis. Filament assembly in turn is regulated by phosphorylation in the tail region of the myosin heavy chain (MHC). Early studies have revea...

journal_title：BMC cell biology

authors： Liang W,Licate L,Warrick H,Spudich J,Egelhoff T

更新日期：2002-07-24 00:00:00

abstract：BACKGROUND:There is evidence that several messenger RNAs (mRNAs) are bifunctional RNAs, i.e. RNA transcript carrying both protein-coding capacity and activity as functional non-coding RNA via 5' and 3' untranslated regions (UTRs). RESULTS:In this study, we identified a novel bifunctional RNA that is transcribed from i...

journal_title：BMC cell biology

authors： Nagano H,Yamagishi N,Tomida C,Yano C,Aibara K,Kohno S,Abe T,Ohno A,Hirasaka K,Okumura Y,Mills EM,Nikawa T,Teshima-Kondo S

更新日期：2015-03-11 00:00:00

abstract：BACKGROUND:The adaptive response of bone cells to mechanical strain is a primary determinant of skeletal architecture and bone mass. In vivo mechanical loading induces new bone formation and increases bone mineral density whereas disuse, immobilisation and weightlessness induce bone loss. The potency of mechanical stra...

journal_title：BMC cell biology

authors： Spencer GJ,Genever PG

更新日期：2003-07-31 00:00:00

abstract：BACKGROUND:Endocytosis of activated EGF receptor (EGFR) to specific endocytic compartments is required to terminate EGF signaling. Trafficking of EGFR relies on microtubule tracks that transport the cargo vesicle to their intermediate and final destinations and can be modulated through posttranslational modification of...

journal_title：BMC cell biology

authors： Lee SJ,Li Z,Litan A,Yoo S,Langhans SA

更新日期：2015-09-18 00:00:00

abstract：:BACKGROUND Alternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differently. Chimeric IGF-I precursors were made with green fluorescent protein (GFP) cloned between the ...

journal_title：BMC cell biology

authors： Tan DS,Cook A,Chew SL

更新日期：2002-07-02 00:00:00

abstract：BACKGROUND:Bone morphogenetic proteins (BMPs) and transforming growth factor-betas (TGF-betas) are important regulators of bone repair and regeneration. BMP-2 and TGF-beta1 have been shown to inhibit gap junctional intercellular communication (GJIC) in MC3T3-E1 cells. Connexin 43 (Cx43) has been shown to mediate GJIC i...

journal_title：BMC cell biology

authors： Wyatt LE,Chung CY,Carlsen B,Iida-Klein A,Rudkin GH,Ishida K,Yamaguchi DT,Miller TA

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Primary cilia are flagella-like projections from the centriole of mammalian cells that have a key role in cell signaling. Human diseases are linked to defects in primary cilia. Microtubules make up the axoneme of cilia and are selectively acetylated and this is thought to contribute to the stability of the s...

journal_title：BMC cell biology

authors： Wang W,Brautigan DL

更新日期：2008-11-26 00:00:00

abstract：BACKGROUND:Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of the HECT class of E3 ubiquitin ligases. A defining feature of NEDD4L protein isoforms is the presenc...

journal_title：BMC cell biology

authors： Garrone NF,Blazer-Yost BL,Weiss RB,Lalouel JM,Rohrwasser A

更新日期：2009-04-13 00:00:00

abstract：BACKGROUND:Mutations in the gene encoding for dysferlin cause recessive autosomal muscular dystrophies called dysferlinopathies. These mutations induce several alterations in skeletal muscles, including, inflammation, increased membrane permeability and cell death. Despite the fact that the etiology of dysferlinopathie...

journal_title：BMC cell biology

authors： Cea LA,Bevilacqua JA,Arriagada C,Cárdenas AM,Bigot A,Mouly V,Sáez JC,Caviedes P

更新日期：2016-05-24 00:00:00