Phosphatase inhibitor 2 promotes acetylation of tubulin in the primary cilium of human retinal epithelial cells.

abstract：BACKGROUND:Cellular senescence plays important roles in the aging process of complex organisms, in tumor suppression and in response to stress. Several markers can be used to identify senescent cells, of which the most widely used is the senescence-associated β-galactosidase (SABG) activity. The main advantage of SABG ...

journal_title：BMC cell biology

authors： Shlush LI,Itzkovitz S,Cohen A,Rutenberg A,Berkovitz R,Yehezkel S,Shahar H,Selig S,Skorecki K

更新日期：2011-04-15 00:00:00

abstract：BACKGROUND:Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role in muscle development. Genetic and biochemical studies in C. elegans have demonstrated that Unc-45 facilitates the process of myosin folding and assembly in body wall muscles. Loss or overexpression of Unc-45 in C. elegans results in...

journal_title：BMC cell biology

authors： Bernick EP,Zhang PJ,Du S

更新日期：2010-09-17 00:00:00

abstract：BACKGROUND:In cytokinesis, when the cleavage furrow has been formed, the two centrioles in each daughter cell separate. It has been suggested that the centrioles facilitate and regulate cytokinesis to some extent. It has been postulated that termination of cytokinesis (abscission) depends on the migration of a centriol...

journal_title：BMC cell biology

authors： Jonsdottir AB,Dirks RW,Vrolijk J,Ogmundsdottir HM,Tanke HJ,Eyfjörd JE,Szuhai K

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:It has been recognized that dermal fibroblasts and matrix metalloproteases (MMP) play crucial roles in wound healing process in skin. Thrombin was found to stimulate IL-8 release from human dermal fibroblasts (HDFs). However, little is known of the effect of thrombin on secretion of MMPs from dermal fibrobla...

journal_title：BMC cell biology

authors： Wang L,Luo J,He S

更新日期：2007-05-07 00:00:00

abstract：BACKGROUND:About 20 % of nemaline myopathies are thus far related to skeletal muscle alpha-actin. Seven actin mutants located in different parts of the actin molecule and linked to different forms of the disease were selected and expressed as EGFP-tagged constructs in differentiated C2C12 mytoubes. Results were compare...

journal_title：BMC cell biology

authors： Bathe FS,Rommelaere H,Machesky LM

更新日期：2007-01-16 00:00:00

abstract：BACKGROUND:Stimulation of Dictyostelium discoideum with cAMP evokes an elevation of the cytosolic free Ca2+ concentration ([Ca2+]i). The [Ca2+]i-change is composed of liberation of stored Ca2+ and extracellular Ca2+-entry. The significance of the [Ca2+]i-transient for chemotaxis is under debate. Abolition of chemotacti...

journal_title：BMC cell biology

authors： Schaloske RH,Lusche DF,Bezares-Roder K,Happle K,Malchow D,Schlatterer C

更新日期：2005-03-11 00:00:00

abstract：BACKGROUND:Hedgehog (Hh) signaling is a conserved morphogenetic pathway which plays critical roles in embryonic development, with emerging evidence also supporting a role in healing and repair processes and tumorigenesis. The Gli family of transcription factors (Gli1, 2 and 3) mediate the Hedgehog morphogenetic signal ...

journal_title：BMC cell biology

authors： Lipinski RJ,Bijlsma MF,Gipp JJ,Podhaizer DJ,Bushman W

更新日期：2008-09-13 00:00:00

abstract：BACKGROUND:In interferon-γ-stimulated cells, the dimeric transcription factor STAT1 (signal transducer and activator of transcription 1) recognizes semi-palindromic motifs in the promoter regions of cytokine-driven target genes termed GAS (gamma-activated sites). However, the molecular steps that facilitate GAS binding...

journal_title：BMC cell biology

authors： Koch V,Staab J,Ruppert V,Meyer T

更新日期：2012-08-24 00:00:00

abstract：BACKGROUND:Xanthurenic acid is an endogenous molecule produced by tryptophan degradation, produced in the cytoplasm and mitochondria. Its accumulation can be observed in aging-related diseases, e.g. senile cataract and infectious disease. We previously reported that xanthurenic acid provokes apoptosis, and now present ...

journal_title：BMC cell biology

authors： Malina HZ,Hess OM

更新日期：2004-04-06 00:00:00

abstract：BACKGROUND:Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A gene in cellular processes are u...

journal_title：BMC cell biology

authors： Funakoshi E,Hori T,Haraguchi T,Hiraoka Y,Kudoh J,Shimizu N,Ito F

更新日期：2003-09-10 00:00:00

abstract：BACKGROUND:The MAL2 gene, encoding a four-transmembrane protein of the MAL family, is amplified and overexpressed in breast and other cancers, yet the significance of this is unknown. MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partn...

journal_title：BMC cell biology

authors： Fanayan S,Shehata M,Agterof AP,McGuckin MA,Alonso MA,Byrne JA

更新日期：2009-01-28 00:00:00

abstract：BACKGROUND:Cortical myosin-II filaments in Dictyostelium discoideum display enrichment in the posterior of the cell during cell migration, and in the cleavage furrow during cytokinesis. Filament assembly in turn is regulated by phosphorylation in the tail region of the myosin heavy chain (MHC). Early studies have revea...

journal_title：BMC cell biology

authors： Liang W,Licate L,Warrick H,Spudich J,Egelhoff T

更新日期：2002-07-24 00:00:00

abstract：:Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. At present these proteins are named Shroom, APX, APXL, and KI...

journal_title：BMC cell biology

authors： Hagens O,Ballabio A,Kalscheuer V,Kraehenbuhl JP,Schiaffino MV,Smith P,Staub O,Hildebrand J,Wallingford JB

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:The mammalian inner ear contains the organ of Corti which is responsible for the conversion of sound into neuronal signals. This specialised epithelial tissue is the product of a complex developmental process where a common precursor cell type differentiates into the sound transducing hair cells and the non-...

journal_title：BMC cell biology

authors： Brunetta I,Casalotti SO,Hart IR,Forge A,Reynolds LE

更新日期：2012-03-17 00:00:00

abstract：BACKGROUND:Bone morphogenetic proteins (BMPs) contribute to many different aspects of development including mesoderm formation, heart development, neurogenesis, skeletal development, and axis formation. They have previously been recognized only as secreted growth factors, but the present study detected Bmp2, Bmp4, and ...

journal_title：BMC cell biology

authors： Felin JE,Mayo JL,Loos TJ,Jensen JD,Sperry DK,Gaufin SL,Meinhart CA,Moss JB,Bridgewater LC

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:Chromatin insulators or boundary elements are a class of functional elements in the eukaryotic genome. They regulate gene transcription by interfering with promoter-enhancer communication. The Cp190 protein of Drosophila melanogaster is essential to the function of at least three-types of chromatin insulator...

journal_title：BMC cell biology

authors： Oliver D,Sheehan B,South H,Akbari O,Pai CY

更新日期：2010-12-31 00:00:00

abstract：BACKGROUND:In cancer cells the three-dimensional (3D) telomere organization of interphase nuclei into a telomeric disk is heavily distorted and aggregates are found. In Hodgkin's lymphoma quantitative FISH (3D Q-FISH) reveals a major impact of nuclear telomere dynamics during the transition form mononuclear Hodgkin (H)...

journal_title：BMC cell biology

authors： Knecht H,Brüderlein S,Wegener S,Lichtensztejn D,Lichtensztejn Z,Lemieux B,Möller P,Mai S

更新日期：2010-12-14 00:00:00

abstract：BACKGROUND:A breakthrough in the understanding of centriole assembly was provided by the characterization of the UNI3 gene in Chlamydomonas. Deletion of this gene, found to encode a novel member of the tubulin superfamily, delta-tubulin, results in the loss of the C-tubule, in the nine microtubule triplets which are th...

journal_title：BMC cell biology

authors： Garreau de Loubresse N,Ruiz F,Beisson J,Klotz C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Proteins linking intermediate filaments to other cytoskeletal components have important functions in maintaining tissue integrity and cell shape. RESULTS:We found a set of monoclonal antibodies raised against specific human sarcomeric myosin heavy chain (MyHC) isoforms labels cells in distinct regions of th...

journal_title：BMC cell biology

authors： Jazwinska A,Ehler E,Hughes SM

更新日期：2003-08-04 00:00:00

abstract：BACKGROUND:Spermatogenesis is comprised of a series of highly regulated developmental changes that transform the precursor germ cell into a highly specialized spermatozoon. The last phase of spermatogenesis, termed spermiogenesis, involves dramatic morphological change including formation of the acrosome, elongation an...

journal_title：BMC cell biology

authors： Wang R,Sperry AO

更新日期：2008-01-31 00:00:00

abstract：BACKGROUND:Angiogenesis is the main therapeutic mechanism of cell therapy for cardiovascular diseases, but diabetes is reported to reduce the function and number of progenitor cells. Therefore, we studied the effect of streptozotocin-induced diabetes on the bone marrow-mesenchymal stem cell (MSC) function, and examined...

journal_title：BMC cell biology

authors： Kim YS,Kwon JS,Hong MH,Kang WS,Jeong HY,Kang HJ,Jeong Mh,Ahn Y

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:There is a growing awareness of the importance of intracellular events in determining the outcome of infectious disease. To improve the understanding of such events, like phagosome maturation, we set out to develop a versatile technique for phagosome isolation that is rapid and widely applicable to different...

journal_title：BMC cell biology

authors： Lönnbro P,Nordenfelt P,Tapper H

更新日期：2008-06-27 00:00:00

abstract：BACKGROUND:The regulatory mechanisms of motor protein-dependent intracellular transport are still not fully understood. The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and other JIP1-binding "cargo" proteins. However, it is unknown whether these "cargo" proteins influence th...

journal_title：BMC cell biology

authors： Satake T,Otsuki K,Banba Y,Suenaga J,Hirano H,Yamanaka Y,Ohno S,Hirai S

更新日期：2013-03-04 00:00:00

abstract：BACKGROUND:We have previously obtained a clonal population of cells from human foreskin that is able to differentiate into mesodermal, ectodermal and endodermal progenies. It is of great interest to know whether these cells could be further differentiated into functional insulin-producing cells. RESULTS:Sixty-one sing...

journal_title：BMC cell biology

authors： Bi D,Chen FG,Zhang WJ,Zhou GD,Cui L,Liu W,Cao Y

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examined the function of SPARC in cutaneous wound healing using SPARC-null mice and dermal fibroblasts der...

journal_title：BMC cell biology

authors： Basu A,Kligman LH,Samulewicz SJ,Howe CC

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis. RESULTS:In the current study, we investigated the effect of melatonin on DNA strand breaks using the alkaline DNA comet as...

journal_title：BMC cell biology

authors： Liu R,Fu A,Hoffman AE,Zheng T,Zhu Y

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Nuclear size and shape are specific to a cell type, function, and location, and can serve as indicators of disease and development. We previously found that lamin A/C and associated nuclear envelope structural proteins were upregulated when murine embryonic stem (ES) cells differentiated to primitive endoder...

journal_title：BMC cell biology

authors： Smith ER,Meng Y,Moore R,Tse JD,Xu AG,Xu XX

更新日期：2017-01-14 00:00:00

abstract：BACKGROUND:During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process prepares the cells to actively participate in the inflammatory and immune responses, and many factors...

journal_title：BMC cell biology

authors： Zhou J,Zhu P,Jiang JL,Zhang Q,Wu ZB,Yao XY,Tang H,Lu N,Yang Y,Chen ZN

更新日期：2005-05-17 00:00:00

abstract：BACKGROUND:Pluripotent stem cells that are capable of differentiating into different cell types and develop robust hallmark cellular features are useful tools for clarifying the impact of developmental events on neurodegenerative diseases such as Huntington's disease. Additionally, a Huntington's cell model that develo...

journal_title：BMC cell biology

authors： Laowtammathron C,Cheng ECh,Cheng PH,Snyder BR,Yang SH,Johnson Z,Lorthongpanich C,Kuo HC,Parnpai R,Chan AW

更新日期：2010-02-05 00:00:00

abstract：BACKGROUND:Recently, mast cells have been recognized to express several Toll-like receptors (TLRs) on their membrane surfaces, and granulocyte-macrophage colony-stimulating factor (GM-CSF) was reported to be able to alter expression of TLRs and cytokine production in neutrophils. However, whether GM-CSF modulates the e...

journal_title：BMC cell biology

authors： Yang H,Wei J,Zhang H,Lin L,Zhang W,He S

更新日期：2009-05-09 00:00:00