Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines.

abstract：BACKGROUND:Dental pulp stem cells (DPSCs) can be driven into odontoblast, osteoblast, and chondrocyte lineages in different inductive media. However, the differentiation potential of naive DPSCs after serial passaging in the routine culture system has not been fully elucidated. RESULTS:DPSCs were isolated from human/r...

journal_title：BMC cell biology

authors： Yu J,He H,Tang C,Zhang G,Li Y,Wang R,Shi J,Jin Y

更新日期：2010-05-08 00:00:00

abstract：BACKGROUND:Golgins are coiled-coil proteins associated with the Golgi apparatus, that are believed to be involved in the tethering of vesicles and the stacking of cisternae, as well as other functions such as cytoskeletal association. Many are peripheral membrane proteins recruited by GTPases. Several have been describ...

journal_title：BMC cell biology

authors： Fridmann-Sirkis Y,Siniossoglou S,Pelham HR

更新日期：2004-05-05 00:00:00

abstract：BACKGROUND:Ubiquitination serves multiple cellular functions, including proteasomal degradation and the control of stability, function, and intracellular localization of a wide variety of proteins. NEDD4L is a member of the HECT class of E3 ubiquitin ligases. A defining feature of NEDD4L protein isoforms is the presenc...

journal_title：BMC cell biology

authors： Garrone NF,Blazer-Yost BL,Weiss RB,Lalouel JM,Rohrwasser A

更新日期：2009-04-13 00:00:00

abstract：BACKGROUND:Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A gene in cellular processes are u...

journal_title：BMC cell biology

authors： Funakoshi E,Hori T,Haraguchi T,Hiraoka Y,Kudoh J,Shimizu N,Ito F

更新日期：2003-09-10 00:00:00

abstract：:The 2006 International Workshop on Multiscale Biological Imaging, Data Mining and Informatics was held at Santa Barbara, on Sept 7-8, 2006. Based on the presentations at the workshop, we selected and compiled this collection of research articles related to novel algorithms and enabling techniques for bio- and biomedic...

journal_title：BMC cell biology

authors：

更新日期：2007-07-10 00:00:00

abstract：BACKGROUND:We have previously obtained a clonal population of cells from human foreskin that is able to differentiate into mesodermal, ectodermal and endodermal progenies. It is of great interest to know whether these cells could be further differentiated into functional insulin-producing cells. RESULTS:Sixty-one sing...

journal_title：BMC cell biology

authors： Bi D,Chen FG,Zhang WJ,Zhou GD,Cui L,Liu W,Cao Y

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:The mammalian inner ear contains the organ of Corti which is responsible for the conversion of sound into neuronal signals. This specialised epithelial tissue is the product of a complex developmental process where a common precursor cell type differentiates into the sound transducing hair cells and the non-...

journal_title：BMC cell biology

authors： Brunetta I,Casalotti SO,Hart IR,Forge A,Reynolds LE

更新日期：2012-03-17 00:00:00

abstract：BACKGROUND:The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. RESULTS:MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50...

journal_title：BMC cell biology

authors： Barteneva NS,Fasler-Kan E,Bernimoulin M,Stern JN,Ponomarev ED,Duckett L,Vorobjev IA

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on the microenvironment of the specific vascular bed and on interact...

journal_title：BMC cell biology

authors： Beese M,Wyss K,Haubitz M,Kirsch T

更新日期：2010-09-07 00:00:00

abstract：BACKGROUND:During cytokinesis, the cell's equator contracts against the cell's global stiffness. Identifying the biochemical basis for these mechanical parameters is essential for understanding how cells divide. To achieve this goal, the distribution and flux of the cell division machinery must be quantified. Here we r...

journal_title：BMC cell biology

authors： Robinson DN,Cavet G,Warrick HM,Spudich JA

更新日期：2002-01-01 00:00:00

abstract：:Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. At present these proteins are named Shroom, APX, APXL, and KI...

journal_title：BMC cell biology

authors： Hagens O,Ballabio A,Kalscheuer V,Kraehenbuhl JP,Schiaffino MV,Smith P,Staub O,Hildebrand J,Wallingford JB

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant. Because heterogeneity among endothelial cells from different tissues, has been demonstrated, the purpose of this study was to determine, if Fa...

journal_title：BMC cell biology

authors： Filippatos G,Ang E,Gidea C,Dincer E,Wang R,Uhal BD

更新日期：2004-01-22 00:00:00

abstract：BACKGROUND:The c-Cbl-associated protein (CAP), also known as ponsin, localizes to focal adhesions and stress fibers and is involved in signaling events. Phosphorylation has been described for the other two members of the sorbin homology family, vinexin and ArgBP2, but no data exist about the putative phosphorylation of...

journal_title：BMC cell biology

authors： Fernow I,Tomasovic A,Siehoff-Icking A,Tikkanen R

更新日期：2009-11-05 00:00:00

abstract：BACKGROUND:The therapeutic efficacy of human mesenchymal stem cells (hMSCs) for the treatment of hypoxic-ischemic diseases is closely related to level of hypoxia in the damaged tissues. To elucidate the potential therapeutic applications and limitations of hMSCs derived from human umbilical cords, the effects of hypoxi...

journal_title：BMC cell biology

authors： Zeng HL,Zhong Q,Qin YL,Bu QQ,Han XA,Jia HT,Liu HW

更新日期：2011-08-09 00:00:00

abstract：BACKGROUND:Mutations in the gene encoding for dysferlin cause recessive autosomal muscular dystrophies called dysferlinopathies. These mutations induce several alterations in skeletal muscles, including, inflammation, increased membrane permeability and cell death. Despite the fact that the etiology of dysferlinopathie...

journal_title：BMC cell biology

authors： Cea LA,Bevilacqua JA,Arriagada C,Cárdenas AM,Bigot A,Mouly V,Sáez JC,Caviedes P

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:Lipid droplets are a class of eukaryotic cell organelles for storage of neutral fat such as triacylglycerol (TAG) and cholesterol ester (CE). We and others have recently reported that lysosome-related organelles (LROs) are not fat storage structures in the nematode C. elegans. We also reported the formation ...

journal_title：BMC cell biology

authors： Zhang SO,Trimble R,Guo F,Mak HY

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:The adaptive response of bone cells to mechanical strain is a primary determinant of skeletal architecture and bone mass. In vivo mechanical loading induces new bone formation and increases bone mineral density whereas disuse, immobilisation and weightlessness induce bone loss. The potency of mechanical stra...

journal_title：BMC cell biology

authors： Spencer GJ,Genever PG

更新日期：2003-07-31 00:00:00

abstract：BACKGROUND:The envelope protein of lentiviruses are type I transmembrane proteins, and their transmembrane domain contains conserved potentially charged residues. This highly unusual feature would be expected to cause endoplasmic reticulum (ER) localization. The aim of this study was to determine by which means the HIV...

journal_title：BMC cell biology

authors： Perrin J,Bary A,Vernay A,Cosson P

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:Clathrin-mediated vesicular trafficking, the mechanism by which proteins and lipids are transported between membrane-bound organelles, accounts for a large proportion of import from the plasma membrane (endocytosis) and transport from the trans-Golgi network towards the endosomal system. Clathrin-mediated ev...

journal_title：BMC cell biology

authors： Kalb LC,Frederico YC,Batista CM,Eger I,Fragoso SP,Soares MJ

更新日期：2014-06-19 00:00:00

abstract：BACKGROUND:The tissue accumulation of protein-bound advanced glycation endproducts (AGE) may be involved in the etiology of diabetic chronic complications, including osteopenia. The aim of this study was to investigate the effect of an AGE-modified type I collagen substratum on the adhesion, spreading, proliferation an...

journal_title：BMC cell biology

authors： McCarthy AD,Etcheverry SB,Bruzzone L,Lettieri G,Barrio DA,Cortizo AM

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:The mechanism involved in the maintenance and differentiation of embryonic stem (ES) cells is incompletely understood. RESULTS:To address this issue, we have developed a retroviral gene trap vector that can target genes expressed in undifferentiated ES cells. This gene trap vector harbors both GFP and Neo r...

journal_title：BMC cell biology

authors： Li X,Leder P

更新日期：2007-08-28 00:00:00

abstract：BACKGROUND:In this study, we have investigated the viscoelastic behaviour of individual human adult bone marrow-derived mesenchymal stem cells (hMSCs) and the role of F-actin filaments in maintaining these properties, using micropipette aspiration technique together with a standard linear viscoelastic solid model. RES...

journal_title：BMC cell biology

authors： Tan SC,Pan WX,Ma G,Cai N,Leong KW,Liao K

更新日期：2008-07-22 00:00:00

abstract：BACKGROUND:Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role in muscle development. Genetic and biochemical studies in C. elegans have demonstrated that Unc-45 facilitates the process of myosin folding and assembly in body wall muscles. Loss or overexpression of Unc-45 in C. elegans results in...

journal_title：BMC cell biology

authors： Bernick EP,Zhang PJ,Du S

更新日期：2010-09-17 00:00:00

abstract：BACKGROUND:In endothelial cells (EC), transforming growth factor-beta (TGF-beta) can bind to and transduce signals through ALK1 and ALK5. The TGF-beta/ALK5 and TGF-beta/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor binding, the duration of TGF-beta signaling is an important specific...

journal_title：BMC cell biology

authors： Valdimarsdottir G,Goumans MJ,Itoh F,Itoh S,Heldin CH,ten Dijke P

更新日期：2006-03-29 00:00:00

abstract：BACKGROUND:Transport of macromolecules into and out of the nucleus is a highly regulated process. The RanGTP/RanGDP gradient controls the trafficking of molecules exceeding the diffusion limit of the nuclear pore across the nuclear envelope. RESULTS:We found genetic interaction between genes establishing the Ran gradi...

journal_title：BMC cell biology

authors： Minakhina S,Myers R,Druzhinina M,Steward R

更新日期：2005-08-24 00:00:00

abstract：BACKGROUND:In the bone marrow, hematopietic and mesenchymal stem cells form a unique niche in which the oxygen tension is low. Hypoxia may have a role in maintaining stem cell fate, self renewal and multipotency. However, whereas most studies addressed the effect of transient in vitro exposure of MSC to hypoxia, perman...

journal_title：BMC cell biology

authors： Basciano L,Nemos C,Foliguet B,de Isla N,de Carvalho M,Tran N,Dalloul A

更新日期：2011-03-30 00:00:00

abstract：BACKGROUND:The regulatory mechanisms of motor protein-dependent intracellular transport are still not fully understood. The kinesin-1-binding protein, JIP1, can function as an adaptor protein that links kinesin-1 and other JIP1-binding "cargo" proteins. However, it is unknown whether these "cargo" proteins influence th...

journal_title：BMC cell biology

authors： Satake T,Otsuki K,Banba Y,Suenaga J,Hirano H,Yamanaka Y,Ohno S,Hirai S

更新日期：2013-03-04 00:00:00

abstract：BACKGROUND:Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis. RESULTS:In the current study, we investigated the effect of melatonin on DNA strand breaks using the alkaline DNA comet as...

journal_title：BMC cell biology

authors： Liu R,Fu A,Hoffman AE,Zheng T,Zhu Y

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:Mitochondrial homeostasis has been increasingly viewed as a potential target of cancer therapy, and mitochondrial fission is a novel regulator of mitochondrial function and apoptosis. The aim of our study was to determine the detailed role of mitochondrial fission in SW837 colorectal cancer cell viability, m...

journal_title：BMC cell biology

authors： Jieensinue S,Zhu H,Li G,Dong K,Liang M,Li Y

更新日期：2018-09-25 00:00:00

abstract：BACKGROUND:SPARC is a matricellular protein involved in cell-matrix interactions. From expression patterns at the wound site and in vitro studies, SPARC has been implicated in the control of wound healing. Here we examined the function of SPARC in cutaneous wound healing using SPARC-null mice and dermal fibroblasts der...

journal_title：BMC cell biology

authors： Basu A,Kligman LH,Samulewicz SJ,Howe CC

更新日期：2001-01-01 00:00:00