Lipid droplets as ubiquitous fat storage organelles in C. elegans.

abstract：BACKGROUND:About 20 % of nemaline myopathies are thus far related to skeletal muscle alpha-actin. Seven actin mutants located in different parts of the actin molecule and linked to different forms of the disease were selected and expressed as EGFP-tagged constructs in differentiated C2C12 mytoubes. Results were compare...

journal_title：BMC cell biology

authors： Bathe FS,Rommelaere H,Machesky LM

更新日期：2007-01-16 00:00:00

abstract：:The 2006 International Workshop on Multiscale Biological Imaging, Data Mining and Informatics was held at Santa Barbara, on Sept 7-8, 2006. Based on the presentations at the workshop, we selected and compiled this collection of research articles related to novel algorithms and enabling techniques for bio- and biomedic...

journal_title：BMC cell biology

authors：

更新日期：2007-07-10 00:00:00

abstract：:Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. At present these proteins are named Shroom, APX, APXL, and KI...

journal_title：BMC cell biology

authors： Hagens O,Ballabio A,Kalscheuer V,Kraehenbuhl JP,Schiaffino MV,Smith P,Staub O,Hildebrand J,Wallingford JB

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:The present review summarizes current knowledge about microparticles (MPs) and provides a systematic overview of last 20 years of research on circulating MPs, with particular focus on their clinical relevance. RESULTS:MPs are a heterogeneous population of cell-derived vesicles, with sizes ranging between 50...

journal_title：BMC cell biology

authors： Barteneva NS,Fasler-Kan E,Bernimoulin M,Stern JN,Ponomarev ED,Duckett L,Vorobjev IA

更新日期：2013-04-22 00:00:00

abstract：BACKGROUND:Angiogenesis is the main therapeutic mechanism of cell therapy for cardiovascular diseases, but diabetes is reported to reduce the function and number of progenitor cells. Therefore, we studied the effect of streptozotocin-induced diabetes on the bone marrow-mesenchymal stem cell (MSC) function, and examined...

journal_title：BMC cell biology

authors： Kim YS,Kwon JS,Hong MH,Kang WS,Jeong HY,Kang HJ,Jeong Mh,Ahn Y

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate the effect of bone marrow mesenchymal stem cells (BMSCs) on the apoptosis of granulosa cells (GCs) in rats. RESULTS:Cisplatin increased GC apoptosis from 0.59% to 13.04% in the control and cisplatin treatment groups, respectively, which was significantly reduced u...

journal_title：BMC cell biology

authors： Guo JQ,Gao X,Lin ZJ,Wu WZ,Huang LH,Dong HY,Chen J,Lu J,Fu YF,Wang J,Ma YJ,Chen XW,Wu ZX,He FQ,Yang SL,Liao LM,Zheng F,Tan JM

更新日期：2013-03-19 00:00:00

abstract：BACKGROUND:Golgins are coiled-coil proteins associated with the Golgi apparatus, that are believed to be involved in the tethering of vesicles and the stacking of cisternae, as well as other functions such as cytoskeletal association. Many are peripheral membrane proteins recruited by GTPases. Several have been describ...

journal_title：BMC cell biology

authors： Fridmann-Sirkis Y,Siniossoglou S,Pelham HR

更新日期：2004-05-05 00:00:00

abstract：BACKGROUND:Transport of macromolecules into and out of the nucleus is a highly regulated process. The RanGTP/RanGDP gradient controls the trafficking of molecules exceeding the diffusion limit of the nuclear pore across the nuclear envelope. RESULTS:We found genetic interaction between genes establishing the Ran gradi...

journal_title：BMC cell biology

authors： Minakhina S,Myers R,Druzhinina M,Steward R

更新日期：2005-08-24 00:00:00

abstract：BACKGROUND:Fallopian tube secretory epithelial cells (FTSECs) have been implicated as a cell-of-origin for high-grade serous epithelial ovarian cancer. However, there are relatively few in vitro models of this tissue type available for use in studies of FTSEC biology and malignant transformation. In vitro three-dimensi...

journal_title：BMC cell biology

authors： Lawrenson K,Notaridou M,Lee N,Benjamin E,Jacobs IJ,Jones C,Gayther SA

更新日期：2013-09-27 00:00:00

abstract：:BACKGROUND Alternative exons encode different isoforms of the human insulin-like growth factor-I (IGF-I) precursor without altering mature IGF-I. We hypothesized that the various IGF-I precursors may traffic IGF-I differently. Chimeric IGF-I precursors were made with green fluorescent protein (GFP) cloned between the ...

journal_title：BMC cell biology

authors： Tan DS,Cook A,Chew SL

更新日期：2002-07-02 00:00:00

abstract：BACKGROUND:The adaptive response of bone cells to mechanical strain is a primary determinant of skeletal architecture and bone mass. In vivo mechanical loading induces new bone formation and increases bone mineral density whereas disuse, immobilisation and weightlessness induce bone loss. The potency of mechanical stra...

journal_title：BMC cell biology

authors： Spencer GJ,Genever PG

更新日期：2003-07-31 00:00:00

abstract：BACKGROUND:In interferon-γ-stimulated cells, the dimeric transcription factor STAT1 (signal transducer and activator of transcription 1) recognizes semi-palindromic motifs in the promoter regions of cytokine-driven target genes termed GAS (gamma-activated sites). However, the molecular steps that facilitate GAS binding...

journal_title：BMC cell biology

authors： Koch V,Staab J,Ruppert V,Meyer T

更新日期：2012-08-24 00:00:00

abstract：BACKGROUND:Ras proteins are guanine-nucleotide-binding enzymes that couple cell surface receptors to intracellular signaling pathways controlling cell proliferation and differentiation, both in lower and higher eukaryotes. They act as molecular switches by cycling between active GTP and inactive GDP-bound states, throu...

journal_title：BMC cell biology

authors： Arigoni M,Bracco E,Lusche DF,Kae H,Weeks G,Bozzaro S

更新日期：2005-12-07 00:00:00

abstract：BACKGROUND:The mammalian inner ear contains the organ of Corti which is responsible for the conversion of sound into neuronal signals. This specialised epithelial tissue is the product of a complex developmental process where a common precursor cell type differentiates into the sound transducing hair cells and the non-...

journal_title：BMC cell biology

authors： Brunetta I,Casalotti SO,Hart IR,Forge A,Reynolds LE

更新日期：2012-03-17 00:00:00

abstract：BACKGROUND:In most cells glucocorticoid receptors (GR) reside predominantly in the cytoplasm. Upon hormone binding, the GR translocates into the nucleus, where the hormone-activated GR-complex regulates the transcription of GR-responsive genes. Serine/threonine protein phosphatase type 5 (PP5) associates with the GR-he...

journal_title：BMC cell biology

authors： Dean DA,Urban G,Aragon IV,Swingle M,Miller B,Rusconi S,Bueno M,Dean NM,Honkanen RE

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinokitiol and DNA methylat...

journal_title：BMC cell biology

authors： Seo JS,Choi YH,Moon JW,Kim HS,Park SH

更新日期：2017-02-27 00:00:00

abstract：BACKGROUND:Melatonin, a hormone-like substance involved in the regulation of the circadian rhythm, has been demonstrated to protect cells against oxidative DNA damage and to inhibit tumorigenesis. RESULTS:In the current study, we investigated the effect of melatonin on DNA strand breaks using the alkaline DNA comet as...

journal_title：BMC cell biology

authors： Liu R,Fu A,Hoffman AE,Zheng T,Zhu Y

更新日期：2013-01-07 00:00:00

abstract：BACKGROUND:A breakthrough in the understanding of centriole assembly was provided by the characterization of the UNI3 gene in Chlamydomonas. Deletion of this gene, found to encode a novel member of the tubulin superfamily, delta-tubulin, results in the loss of the C-tubule, in the nine microtubule triplets which are th...

journal_title：BMC cell biology

authors： Garreau de Loubresse N,Ruiz F,Beisson J,Klotz C

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:There is a growing awareness of the importance of intracellular events in determining the outcome of infectious disease. To improve the understanding of such events, like phagosome maturation, we set out to develop a versatile technique for phagosome isolation that is rapid and widely applicable to different...

journal_title：BMC cell biology

authors： Lönnbro P,Nordenfelt P,Tapper H

更新日期：2008-06-27 00:00:00

abstract：BACKGROUND:There is a growing interest in cord blood as a source of primitive stem cells with the capacity for multilineage differentiation. Pure cell fractions are needed for the characterization and in vitro expansion of stem cells as well as for their use in preclinical research. However, enrichment of stem cells is...

journal_title：BMC cell biology

authors： Kekarainen T,Mannelin S,Laine J,Jaatinen T

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:In cancer cells the three-dimensional (3D) telomere organization of interphase nuclei into a telomeric disk is heavily distorted and aggregates are found. In Hodgkin's lymphoma quantitative FISH (3D Q-FISH) reveals a major impact of nuclear telomere dynamics during the transition form mononuclear Hodgkin (H)...

journal_title：BMC cell biology

authors： Knecht H,Brüderlein S,Wegener S,Lichtensztejn D,Lichtensztejn Z,Lemieux B,Möller P,Mai S

更新日期：2010-12-14 00:00:00

abstract：BACKGROUND:One of the problems associated with osteosarcoma is the frequent formation of micrometastases in the lung prior to diagnosis because the development of metastatic lesions often causes a fatal outcome. Therefore, the prevention of pulmonary metastases during the early stage of tumor development is critical fo...

journal_title：BMC cell biology

authors： Nakamura A,Aizawa J,Sakayama K,Kidani T,Takata T,Norimatsu Y,Miura H,Masuno H

更新日期：2012-09-26 00:00:00

abstract：BACKGROUND:Mutations in the gene encoding for dysferlin cause recessive autosomal muscular dystrophies called dysferlinopathies. These mutations induce several alterations in skeletal muscles, including, inflammation, increased membrane permeability and cell death. Despite the fact that the etiology of dysferlinopathie...

journal_title：BMC cell biology

authors： Cea LA,Bevilacqua JA,Arriagada C,Cárdenas AM,Bigot A,Mouly V,Sáez JC,Caviedes P

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:Acacia honey (AH) has been proven to improve skin wound healing, but its therapeutic effects on corneal epithelium has not been elucidated to date. This study aimed to investigate the effects of AH on cultured corneal epithelial cells (CEC) on in vitro corneal abrasion wound healing model. Six New Zealand wh...

journal_title：BMC cell biology

authors： Ker-Woon C,Abd Ghafar N,Hui CK,Mohd Yusof YA,Wan Ngah WZ

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:There is evidence that several messenger RNAs (mRNAs) are bifunctional RNAs, i.e. RNA transcript carrying both protein-coding capacity and activity as functional non-coding RNA via 5' and 3' untranslated regions (UTRs). RESULTS:In this study, we identified a novel bifunctional RNA that is transcribed from i...

journal_title：BMC cell biology

authors： Nagano H,Yamagishi N,Tomida C,Yano C,Aibara K,Kohno S,Abe T,Ohno A,Hirasaka K,Okumura Y,Mills EM,Nikawa T,Teshima-Kondo S

更新日期：2015-03-11 00:00:00

abstract：BACKGROUND:Spermatogenesis is comprised of a series of highly regulated developmental changes that transform the precursor germ cell into a highly specialized spermatozoon. The last phase of spermatogenesis, termed spermiogenesis, involves dramatic morphological change including formation of the acrosome, elongation an...

journal_title：BMC cell biology

authors： Wang R,Sperry AO

更新日期：2008-01-31 00:00:00

abstract：BACKGROUND:Bone morphogenetic proteins (BMPs) and transforming growth factor-betas (TGF-betas) are important regulators of bone repair and regeneration. BMP-2 and TGF-beta1 have been shown to inhibit gap junctional intercellular communication (GJIC) in MC3T3-E1 cells. Connexin 43 (Cx43) has been shown to mediate GJIC i...

journal_title：BMC cell biology

authors： Wyatt LE,Chung CY,Carlsen B,Iida-Klein A,Rudkin GH,Ishida K,Yamaguchi DT,Miller TA

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Previously we cloned the human MNB/DYRK1A gene from the "Down syndrome critical region" on chromosome 21. This gene encodes a dual specificity protein kinase that catalyzes its autophosphorylation on serine/threonine and tyrosine residues. But, the functions of the MNB/DYRK1A gene in cellular processes are u...

journal_title：BMC cell biology

authors： Funakoshi E,Hori T,Haraguchi T,Hiraoka Y,Kudoh J,Shimizu N,Ito F

更新日期：2003-09-10 00:00:00

abstract：BACKGROUND:Genomes of eukaryotes exist as chromatin, and it is known that different chromatin states can influence gene regulation. Chromatin is not a static structure, but is known to be dynamic and vary between cells. In order to monitor the organisation of chromatin in live cells we have engineered fluorescent fusio...

journal_title：BMC cell biology

authors： Dickerson D,Gierliński M,Singh V,Kitamura E,Ball G,Tanaka TU,Owen-Hughes T

更新日期：2016-09-08 00:00:00

abstract：BACKGROUND:The mechanism involved in the maintenance and differentiation of embryonic stem (ES) cells is incompletely understood. RESULTS:To address this issue, we have developed a retroviral gene trap vector that can target genes expressed in undifferentiated ES cells. This gene trap vector harbors both GFP and Neo r...

journal_title：BMC cell biology

authors： Li X,Leder P

更新日期：2007-08-28 00:00:00