Induction of MMP-9 release from human dermal fibroblasts by thrombin: involvement of JAK/STAT3 signaling pathway in MMP-9 release.

abstract：BACKGROUND:During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue macrophages. The maturation process prepares the cells to actively participate in the inflammatory and immune responses, and many factors...

journal_title：BMC cell biology

authors： Zhou J,Zhu P,Jiang JL,Zhang Q,Wu ZB,Yao XY,Tang H,Lu N,Yang Y,Chen ZN

更新日期：2005-05-17 00:00:00

abstract：BACKGROUND:The adaptive response of bone cells to mechanical strain is a primary determinant of skeletal architecture and bone mass. In vivo mechanical loading induces new bone formation and increases bone mineral density whereas disuse, immobilisation and weightlessness induce bone loss. The potency of mechanical stra...

journal_title：BMC cell biology

authors： Spencer GJ,Genever PG

更新日期：2003-07-31 00:00:00

abstract：BACKGROUND:Angiogenesis is the main therapeutic mechanism of cell therapy for cardiovascular diseases, but diabetes is reported to reduce the function and number of progenitor cells. Therefore, we studied the effect of streptozotocin-induced diabetes on the bone marrow-mesenchymal stem cell (MSC) function, and examined...

journal_title：BMC cell biology

authors： Kim YS,Kwon JS,Hong MH,Kang WS,Jeong HY,Kang HJ,Jeong Mh,Ahn Y

更新日期：2013-09-11 00:00:00

abstract：BACKGROUND:Spermatogenesis is comprised of a series of highly regulated developmental changes that transform the precursor germ cell into a highly specialized spermatozoon. The last phase of spermatogenesis, termed spermiogenesis, involves dramatic morphological change including formation of the acrosome, elongation an...

journal_title：BMC cell biology

authors： Wang R,Sperry AO

更新日期：2008-01-31 00:00:00

abstract：BACKGROUND:Golgins are coiled-coil proteins associated with the Golgi apparatus, that are believed to be involved in the tethering of vesicles and the stacking of cisternae, as well as other functions such as cytoskeletal association. Many are peripheral membrane proteins recruited by GTPases. Several have been describ...

journal_title：BMC cell biology

authors： Fridmann-Sirkis Y,Siniossoglou S,Pelham HR

更新日期：2004-05-05 00:00:00

abstract：BACKGROUND:Primary cilia are flagella-like projections from the centriole of mammalian cells that have a key role in cell signaling. Human diseases are linked to defects in primary cilia. Microtubules make up the axoneme of cilia and are selectively acetylated and this is thought to contribute to the stability of the s...

journal_title：BMC cell biology

authors： Wang W,Brautigan DL

更新日期：2008-11-26 00:00:00

abstract：BACKGROUND:Mutations in the gene encoding for dysferlin cause recessive autosomal muscular dystrophies called dysferlinopathies. These mutations induce several alterations in skeletal muscles, including, inflammation, increased membrane permeability and cell death. Despite the fact that the etiology of dysferlinopathie...

journal_title：BMC cell biology

authors： Cea LA,Bevilacqua JA,Arriagada C,Cárdenas AM,Bigot A,Mouly V,Sáez JC,Caviedes P

更新日期：2016-05-24 00:00:00

abstract：BACKGROUND:Endocytosis of activated EGF receptor (EGFR) to specific endocytic compartments is required to terminate EGF signaling. Trafficking of EGFR relies on microtubule tracks that transport the cargo vesicle to their intermediate and final destinations and can be modulated through posttranslational modification of...

journal_title：BMC cell biology

authors： Lee SJ,Li Z,Litan A,Yoo S,Langhans SA

更新日期：2015-09-18 00:00:00

abstract：BACKGROUND:We have previously obtained a clonal population of cells from human foreskin that is able to differentiate into mesodermal, ectodermal and endodermal progenies. It is of great interest to know whether these cells could be further differentiated into functional insulin-producing cells. RESULTS:Sixty-one sing...

journal_title：BMC cell biology

authors： Bi D,Chen FG,Zhang WJ,Zhou GD,Cui L,Liu W,Cao Y

更新日期：2010-06-25 00:00:00

abstract：BACKGROUND:Fetal mesenchymal stem/stromal cells (MSC) represent a developmentally-advantageous cell type with translational potential.To enhance adult MSC migration, studies have focussed on the role of the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12), but more recent work implicates an intricate system of CX...

journal_title：BMC cell biology

authors： Pelekanos RA,Ting MJ,Sardesai VS,Ryan JM,Lim YC,Chan JK,Fisk NM

更新日期：2014-05-16 00:00:00

abstract：:Shroom is a recently-described regulator of cell shape changes in the developing nervous system. This protein is a member of a small family of related proteins that are defined by sequence similarity and in most cases by some link to the actin cytoskeleton. At present these proteins are named Shroom, APX, APXL, and KI...

journal_title：BMC cell biology

authors： Hagens O,Ballabio A,Kalscheuer V,Kraehenbuhl JP,Schiaffino MV,Smith P,Staub O,Hildebrand J,Wallingford JB

更新日期：2006-04-14 00:00:00

abstract：BACKGROUND:The MAL2 gene, encoding a four-transmembrane protein of the MAL family, is amplified and overexpressed in breast and other cancers, yet the significance of this is unknown. MAL-like proteins have trafficking functions, but their molecular roles are largely obscure, partly due to a lack of known binding partn...

journal_title：BMC cell biology

authors： Fanayan S,Shehata M,Agterof AP,McGuckin MA,Alonso MA,Byrne JA

更新日期：2009-01-28 00:00:00

abstract：BACKGROUND:Adipose-Derived Stromal Cells have been shown to have multiple lineage differentiation properties and to be suitable for tissues regeneration in many degenerative processes. Their use has been proposed for the therapy of joint diseases and tendon injuries in the horse. In the present report the genetic manip...

journal_title：BMC cell biology

authors： Donofrio G,Capocefalo A,Franceschi V,Morini G,Del Bue M,Conti V,Cavirani S,Grolli S

更新日期：2010-09-23 00:00:00

abstract：BACKGROUND:Unc-45 is a myosin chaperone and a Hsp90 co-chaperone that plays a key role in muscle development. Genetic and biochemical studies in C. elegans have demonstrated that Unc-45 facilitates the process of myosin folding and assembly in body wall muscles. Loss or overexpression of Unc-45 in C. elegans results in...

journal_title：BMC cell biology

authors： Bernick EP,Zhang PJ,Du S

更新日期：2010-09-17 00:00:00

abstract：BACKGROUND:Bone morphogenetic proteins (BMPs) contribute to many different aspects of development including mesoderm formation, heart development, neurogenesis, skeletal development, and axis formation. They have previously been recognized only as secreted growth factors, but the present study detected Bmp2, Bmp4, and ...

journal_title：BMC cell biology

authors： Felin JE,Mayo JL,Loos TJ,Jensen JD,Sperry DK,Gaufin SL,Meinhart CA,Moss JB,Bridgewater LC

更新日期：2010-03-15 00:00:00

abstract：BACKGROUND:Induced pluripotent stem cells (iPSC) are generated by reprogramming somatic cells into embryonic like state (ESC) using defined factors. There is great interest in these cells because of their potential for application in regenerative medicine. RESULTS:iPSC reprogrammed from murine tail tip fibroblasts wer...

journal_title：BMC cell biology

authors： Li F,Niyibizi C

更新日期：2012-12-15 00:00:00

abstract：BACKGROUND:In cytokinesis, when the cleavage furrow has been formed, the two centrioles in each daughter cell separate. It has been suggested that the centrioles facilitate and regulate cytokinesis to some extent. It has been postulated that termination of cytokinesis (abscission) depends on the migration of a centriol...

journal_title：BMC cell biology

authors： Jonsdottir AB,Dirks RW,Vrolijk J,Ogmundsdottir HM,Tanke HJ,Eyfjörd JE,Szuhai K

更新日期：2010-05-21 00:00:00

abstract：BACKGROUND:In most cells glucocorticoid receptors (GR) reside predominantly in the cytoplasm. Upon hormone binding, the GR translocates into the nucleus, where the hormone-activated GR-complex regulates the transcription of GR-responsive genes. Serine/threonine protein phosphatase type 5 (PP5) associates with the GR-he...

journal_title：BMC cell biology

authors： Dean DA,Urban G,Aragon IV,Swingle M,Miller B,Rusconi S,Bueno M,Dean NM,Honkanen RE

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Acrosomal proteins play crucial roles in the physiology of fertilization. Identification of proteins localizing to the acrosome is fundamental to the understanding of its contribution to fertilization. Novel proteins are still being reported from acrosome. In order to capture yet unreported proteins localizi...

journal_title：BMC cell biology

authors： Bhattacharya R,Devi MS,Dhople VM,Jesudasan RA

更新日期：2013-11-20 00:00:00

abstract：BACKGROUND:The mechanism involved in the maintenance and differentiation of embryonic stem (ES) cells is incompletely understood. RESULTS:To address this issue, we have developed a retroviral gene trap vector that can target genes expressed in undifferentiated ES cells. This gene trap vector harbors both GFP and Neo r...

journal_title：BMC cell biology

authors： Li X,Leder P

更新日期：2007-08-28 00:00:00

abstract：BACKGROUND:Acacia honey (AH) has been proven to improve skin wound healing, but its therapeutic effects on corneal epithelium has not been elucidated to date. This study aimed to investigate the effects of AH on cultured corneal epithelial cells (CEC) on in vitro corneal abrasion wound healing model. Six New Zealand wh...

journal_title：BMC cell biology

authors： Ker-Woon C,Abd Ghafar N,Hui CK,Mohd Yusof YA,Wan Ngah WZ

更新日期：2015-02-18 00:00:00

abstract：BACKGROUND:The nucleolus is a multi-domain enriched with proteins involved in ribosome biogenesis, cell cycle and apoptosis control, viral replication and differentiation of stem cells. Several authors have suggested a role for the nucleolus also in malignant transformation. We have recently demonstrated that under spe...

journal_title：BMC cell biology

authors： Ponti D,Bastianelli D,Rosa P,Pacini L,Ibrahim M,Rendina EA,Ragona G,Calogero A

更新日期：2015-11-17 00:00:00

abstract：BACKGROUND:Transport of macromolecules into and out of the nucleus is a highly regulated process. The RanGTP/RanGDP gradient controls the trafficking of molecules exceeding the diffusion limit of the nuclear pore across the nuclear envelope. RESULTS:We found genetic interaction between genes establishing the Ran gradi...

journal_title：BMC cell biology

authors： Minakhina S,Myers R,Druzhinina M,Steward R

更新日期：2005-08-24 00:00:00

abstract：BACKGROUND:DNA hypermethylation is a key epigenetic mechanism for the silencing of many genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce apoptosis and cell cycle arrest and has anti-inflammatory and anti-tumor activities. However, the relationship between hinokitiol and DNA methylat...

journal_title：BMC cell biology

authors： Seo JS,Choi YH,Moon JW,Kim HS,Park SH

更新日期：2017-02-27 00:00:00

abstract：BACKGROUND:Lipid droplets are a class of eukaryotic cell organelles for storage of neutral fat such as triacylglycerol (TAG) and cholesterol ester (CE). We and others have recently reported that lysosome-related organelles (LROs) are not fat storage structures in the nematode C. elegans. We also reported the formation ...

journal_title：BMC cell biology

authors： Zhang SO,Trimble R,Guo F,Mak HY

更新日期：2010-12-08 00:00:00

abstract：BACKGROUND:Experimental models are inevitably a compromise between accurately reproducing a pathological situation and schematically simplifying it, which is intended to provide both relevance and conclusiveness. In-vivo models are very relevant, but multiple cell-types undergoing various changes may hinder the observa...

journal_title：BMC cell biology

authors： Legouis D,Bataille A,Hertig A,Vandermeersch S,Simon N,Rondeau E,Galichon P

更新日期：2015-03-25 00:00:00

abstract：BACKGROUND:Pluripotent stem cells that are capable of differentiating into different cell types and develop robust hallmark cellular features are useful tools for clarifying the impact of developmental events on neurodegenerative diseases such as Huntington's disease. Additionally, a Huntington's cell model that develo...

journal_title：BMC cell biology

authors： Laowtammathron C,Cheng ECh,Cheng PH,Snyder BR,Yang SH,Johnson Z,Lorthongpanich C,Kuo HC,Parnpai R,Chan AW

更新日期：2010-02-05 00:00:00

abstract：BACKGROUND:In this study, we have investigated the viscoelastic behaviour of individual human adult bone marrow-derived mesenchymal stem cells (hMSCs) and the role of F-actin filaments in maintaining these properties, using micropipette aspiration technique together with a standard linear viscoelastic solid model. RES...

journal_title：BMC cell biology

authors： Tan SC,Pan WX,Ma G,Cai N,Leong KW,Liao K

更新日期：2008-07-22 00:00:00

abstract：BACKGROUND:The discovery of the importance of angiogenesis in tumor growth has emphasized the need to find specific vascular targets for tumor-targeted therapies. Previously, using phage display technology, we identified the peptide GX1 as having the ability to target the gastric cancer vasculature. The present study i...

journal_title：BMC cell biology

authors： Chen B,Cao S,Zhang Y,Wang X,Liu J,Hui X,Wan Y,Du W,Wang L,Wu K,Fan D

更新日期：2009-09-09 00:00:00

abstract：BACKGROUND:Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant. Because heterogeneity among endothelial cells from different tissues, has been demonstrated, the purpose of this study was to determine, if Fa...

journal_title：BMC cell biology

authors： Filippatos G,Ang E,Gidea C,Dincer E,Wang R,Uhal BD

更新日期：2004-01-22 00:00:00