abstract：:Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of diseases have been the subject of research for decades. In particular, the associations of autoimmune disorders to allelic variants and candidate genes encoding the MHC are we...

journal_title：Immunogenetics

authors： Al Naqbi H,Mawart A,Alshamsi J,Al Safar H,Tay GK

更新日期：2021-02-02 00:00:00

abstract：:An optimized alignment of related protein sequences helps to see their important shared features and to deduce their phylogenetic relationships. At low levels of sequence similarity, there are no suitable computer programs for making the best possible alignment. This review summarizes some guidelines for how in such i...

journal_title：Immunogenetics

authors： Dijkstra JM

更新日期：2021-01-29 00:00:00

abstract：:Genetic and functional analyses of the inflammasome suggest a role for this multiprotein complex in the biological mechanisms leading to the onset and progression of multiple sclerosis (MS). Nucleotide-binding, leucine-rich repeat (NLR) receptors trigger the activation and assembly of specific inflammasomes in respons...

journal_title：Immunogenetics

authors： Popplewell LF,Encarnacion M,Bernales CQ,Sadovnick AD,Traboulsee AL,Quandt JA,Vilariño-Güell C

更新日期：2020-09-01 00:00:00

abstract：:Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...

journal_title：Immunogenetics

authors： Zhang J,Goto RM,Miller MM

更新日期：2020-07-01 00:00:00

abstract：:Toll-interleukin-1R resistance (TIR) domains are ubiquitously present in all forms of cellular life. They are most commonly found in signaling proteins, as units responsible for signal-dependent formation of protein complexes that enable amplification and spatial propagation of the signal. A less common function of TI...

journal_title：Immunogenetics

authors： Toshchakov VY,Neuwald AF

更新日期：2020-04-01 00:00:00

abstract：:Among the genes with the highest allelic polymorphism and sequence diversity are those encoding the classical class I and class II molecules of the major histocompatibility complex (MHC). Although many thousands of MHC sequences have been deposited in general sequence databases like GenBank, the availability of curate...

journal_title：Immunogenetics

authors： Afrache H,Tregaskes CA,Kaufman J

更新日期：2020-02-01 00:00:00

abstract：:Celiac disease is a chronic inflammatory condition of the small intestine caused by aberrant adaptive immune response to gluten protein from wheat and related cereal plants. Over 90% of celiac disease patients carry the HLA-DQ2.5 allotype and HLA-DQ2.5 presents gluten peptides to gluten-reactive CD4+ T cells in celiac...

journal_title：Immunogenetics

authors： Qiao SW,Sollid LM

更新日期：2019-11-01 00:00:00

abstract：:The major histocompatibility complex (MHC) is critical to host-pathogen interactions. Class II MHC is a heterodimer, with α and β subunits encoded by different genes. The peptide-binding groove is formed by the first domain of both subunits (α1 and β1), but studies of class II variation or natural selection focus prim...

journal_title：Immunogenetics

authors： Rand LM,Woodward C,May R,Ackerman RA,Tweedie B,Zicarelli TB,Dearborn DC

更新日期：2019-09-01 00:00:00

abstract：:The common fruit fly Drosophila melanogaster is a powerful model for studying signaling pathway regulation. Conserved signaling pathways underlying physiological processes signify evolutionary relationship between organisms and the nature of the mechanisms they control. This study explores the cross-talk between the w...

journal_title：Immunogenetics

authors： Patrnogic J,Heryanto C,Ozakman Y,Eleftherianos I

更新日期：2019-07-01 00:00:00

abstract：:Cathepsins are key mammalian proteases that play an important role in the immune response. Several studies have revealed the versatile and critical functions of cathepsins. Here, we obtained ten kinds of cathepsin homologs and identified seven homologs with complete coding sequences. Phylogenetic analysis verified the...

journal_title：Immunogenetics

authors： Wang D,Su P,Wang X,Liu K,Li C,Gao X,Lu J,Sun F,Li Q,Pang Y

更新日期：2019-05-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...

journal_title：Immunogenetics

authors： Dijkstra JM,Yamaguchi T

更新日期：2019-03-01 00:00:00

abstract：:Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell tolerance to self and to recognition of foreign antigens. Antigen uptake and processing pathways as well as expression of the peptide exchange factors HLA-DM and HLA-DO differ among the various professional and non-professional...

journal_title：Immunogenetics

authors： Jurewicz MM,Stern LJ

更新日期：2019-03-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I-related molecule, MR1, presents vitamin B metabolites from bacteria and yeast to mucosal-associated invariant T (MAIT) cells. Despite the evolutionary conservation of MR1, we do not know whether different allele variants of MR1 exist within the nonhuman primate (NHP) ...

journal_title：Immunogenetics

authors： Ellis-Connell AL,Kannal NM,Balgeman AJ,O'Connor SL

更新日期：2019-02-01 00:00:00

abstract：:The authors regret that an error was present in the Fig. 5 of the above article; some digits in the DRB allele-designations in Fig. 5 have been lost, and are incorrectly presented by only two digits. The correct allele-designations should have been four (or six) digits. The correct Figure is now presented correctly. ...

journal_title：Immunogenetics

authors： Otting N,de Groot NG,Bontrop RE

更新日期：2018-11-01 00:00:00

abstract：:MHC genes are key components in disease resistance and an excellent system for studying selection acting on genetic variation in natural populations. Current patterns of variation in MHC genes are likely to be influenced by past and ongoing selection as well as demographic fluctuations in population size such as those...

journal_title：Immunogenetics

authors： Cortázar-Chinarro M,Meyer-Lucht Y,Laurila A,Höglund J

更新日期：2018-07-01 00:00:00

abstract：:The cluster of differentiation 4 (CD4) molecule functions as a co-receptor for MHC class II binding to TCR in T helper cells. A CD4 epitope deficiency was identified in the swine MeLiM (melanoblastoma-bearing Libechov minipig) strain, a model for spontaneous cutaneous melanoma development and regression. Extensive seq...

journal_title：Immunogenetics

authors： Blanc F,Créchet F,Bruneau N,Piton G,Leplat JJ,Andréoletti F,Egidy G,Vincent-Naulleau S,Bourneuf E

更新日期：2018-04-01 00:00:00

abstract：:The immune systems of all mammals include populations of B cells producing antibodies with incredibly diverse specificities. Repertoire diversity has been described as the "miracle of immunology," and it was long thought to be the result of essentially stochastic processes. Recently, however, analysis of high throughp...

journal_title：Immunogenetics

authors： Collins AM,Jackson KJL

更新日期：2018-03-01 00:00:00

abstract：:Sickle cell anemia (SCA) is characterized by chronic hemolysis, severe vasoocclusive crises (VOCs), and recurrent often severe infections. A cohort of 95 SCA pediatric patients was the background for genotype-to-phenotype association of the patient's infectious disease phenotype and three non-coding polymorphic region...

journal_title：Immunogenetics

authors： David S,Aguiar P,Antunes L,Dias A,Morais A,Sakuntabhai A,Lavinha J

更新日期：2018-01-01 00:00:00

abstract：:Many fishes express high levels of intraspecific variability, often linked to resource partitioning. Several studies show that a species' evolutionary trajectory of adaptive divergence can undergo reversals caused by changes in its environment. Such a reversal in neutral genetic and morphological variation among lake ...

journal_title：Immunogenetics

authors： Baillie SM,Hemstock RR,Muir AM,Krueger CC,Bentzen P

更新日期：2018-01-01 00:00:00

abstract：:The ability of NK cells to specifically recognize cells lacking expression of self-MHC class I molecules was discovered over 30 years ago. It provided the foundation for the "missing self" hypothesis. Research in the two past decades has contributed to a detailed understanding of the molecular mechanisms that determin...

journal_title：Immunogenetics

authors： Malmberg KJ,Sohlberg E,Goodridge JP,Ljunggren HG

更新日期：2017-08-01 00:00:00

abstract：:Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has been implicated in population declines and species extinctions of amphibians around the world. Susceptibility to the disease varies both within and among species, most likely attributable to heritable immunogenetic variation. Anal...

journal_title：Immunogenetics

authors： Fu M,Waldman B

更新日期：2017-08-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T), a rare inherited disorder, usually affects the nervous and immune systems, and occasionally other organs. A-T is associated mainly with mutations in the ataxia telangiectasia mutated (ATM) gene, which encodes a protein kinase that has a major role in the cellular response to DNA damage. We...

journal_title：Immunogenetics

authors： Mortaz E,Marashian SM,Ghaffaripour H,Varahram M,Mehrian P,Dorudinia A,Garssen J,Adcock IM,Taylor M,Mahdaviani SA

更新日期：2017-07-01 00:00:00

abstract：:Phenotypic variability is often observed in cynomolgus monkeys on preclinical studies and may, in part, be driven by genetic variability. However, the role of monkey genetic variation remains largely unexplored in the context of drug response. This study evaluated genetic variation in cynomolgus monkey FcγR3A and TAP1...

journal_title：Immunogenetics

authors： Sanford JC,Wu H,Abdiche Y,Harney JA,Chaparro-Riggers J,Adkins K

更新日期：2017-04-01 00:00:00

abstract：:The polymorphism of major histocompatibility complex (MHC) class II DQ and DR genes in five common equine leukocyte antigen (ELA) haplotypes was determined through sequencing of mRNA transcripts isolated from lymphocytes of eight ELA homozygous horses. Ten expressed MHC class II genes were detected in horses of the EL...

journal_title：Immunogenetics

authors： Miller D,Tallmadge RL,Binns M,Zhu B,Mohamoud YA,Ahmed A,Brooks SA,Antczak DF

更新日期：2017-03-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules are responsible for the antigen presentation to T lymphocytes. High recombination rates in the MHC genes, as observed in humans, are believed to serve the evolutionary goal to achieve a high genetic diversity, allowing for a broad and efficient immune response. In a coh...

journal_title：Immunogenetics

authors： Gimsa U,Ho CS,Hammer SE

更新日期：2017-01-01 00:00:00

abstract：:Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-1...

journal_title：Immunogenetics

authors： Gröndahl-Yli-Hannuksela K,Vahlberg T,Ilonen J,Mertsola J,He Q

更新日期：2016-10-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) represent the most polymorphic genes responsible for natural killer cell function, while human leukocyte antigen (HLA) class I molecules define and restrict cytotoxic T lymphocyte responses. Specific KIR, HLA, or KIR-HLA combinations have been implicated in the outcome ...

journal_title：Immunogenetics

authors： Garrido-Rodríguez D,Ávila-Ríos S,García-Morales C,Valenzuela-Ponce H,Ormsby C,Reyes-Gopar H,Fernandez-Lopez JC,Reyes-Terán G

更新日期：2016-10-01 00:00:00

abstract：:Type II natural killer T cells (NKT) are a subset of the innate-like CD1d-restricted lymphocytes that are reactive to lipid antigens. Unlike the type I NKT cells, which express a semi-invariant TCR, type II NKT cells express a broader TCR repertoire. Additionally, other features, such as their predominance over type I...

journal_title：Immunogenetics

authors： Dasgupta S,Kumar V

更新日期：2016-08-01 00:00:00

abstract：:Immunity-related genes are a suitable model for studying effects of selection at the genomic level. Some of them are highly conserved due to functional constraints and purifying selection, while others are variable and change quickly to cope with the variation of pathogens. The SLC11A1 gene encodes a transporter prote...

journal_title：Immunogenetics

authors： Bayerova Z,Janova E,Matiasovic J,Orlando L,Horin P

更新日期：2016-05-01 00:00:00

abstract：:As the only native insular Newfoundland canid between the extinction of the wolf in the 1930s and the recent arrival of coyotes, the red fox (Vulpes vulpes deletrix Bangs 1898) poses interesting questions about genetic distinctiveness and the post-glacial colonization history of the island's depauperate mammalian faun...

journal_title：Immunogenetics

authors： Marshall HD,Langille BL,Hann CA,Whitney HG

更新日期：2016-05-01 00:00:00

abstract：:Human leukocyte antigen (HLA)-E molecules are potent inhibitors of NK cell-mediated killing. Low in polymorphisms, two alleles are widely expressed among diverse populations: HLA-E*01:01 and HLA-E*01:03. Both alleles are distinguished by one SNP resulting in the substitution Arg107Gly. Both alleles present a limited s...

journal_title：Immunogenetics

authors： Celik AA,Kraemer T,Huyton T,Blasczyk R,Bade-Döding C

更新日期：2016-01-01 00:00:00

abstract：:Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association of IL-17 F( rs763780), IL-17 A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese and lean Egyptian females, and to find out whether these gene polymorphisms affect th...

journal_title：Immunogenetics

authors： Zidan HE,Rezk NA,Alnemr AA,Moniem MI

更新日期：2015-11-01 00:00:00

abstract：:Infection of humans and chimpanzees with Hepatitis C virus (HCV) results in either the resolution of the acute infection or its progression to a persistent infection associated with chronic liver disease. In cohorts of human patients, resolution of HCV infection has been associated with homozygosity for both C1(+)HLA-...

journal_title：Immunogenetics

authors： Abi-Rached L,Guethlein LA,Norman PJ,Parham P

更新日期：2015-10-01 00:00:00

abstract：:The gray short-tailed opossum Monodelphis domestica is one of the few marsupial species for which a high quality whole genome sequence is available and the major histocompatibility complex (MHC) region has been annotated. Previous analyses revealed only a single locus within the opossum MHC region, designated Modo-UA1...

journal_title：Immunogenetics

authors： Krasnec KV,Sharp AR,Williams TL,Miller RD

更新日期：2015-04-01 00:00:00

abstract：:We studied the relationship between human leukocyte antigen (HLA) class I alleles and cervical cancer among Indian women. Seventy-five cervical cancer cases were compared with 175 noncancer controls. Cervical biopsy tissue specimen from cancer cases and cervical swab specimen from controls were collected for HPV detec...

journal_title：Immunogenetics

authors： Gokhale P,Mania-Pramanik J,Sonawani A,Idicula-Thomas S,Kerkar S,Tongaonkar H,Chaudhari H,Warke H,Salvi V

更新日期：2014-12-01 00:00:00

abstract：:The interleukin-1 gene family encodes a group of related proteins that exhibit a remarkable pleiotropy in the context of health and disease. The set of indispensable functions they control suggests that these genes should be found in all eukaryotic species. The ligands and receptors of this family have been primarily ...

journal_title：Immunogenetics

authors： Gibson MS,Kaiser P,Fife M

更新日期：2014-08-01 00:00:00

abstract：:Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...

journal_title：Immunogenetics

authors： Nguyen DC,Sanghvi R,Scinicariello F,Pulit-Penaloza J,Hill N,Attanasio R

更新日期：2014-06-01 00:00:00

abstract：:Recent genome-wide association studies (GWAs) have identified several new genetic risk factors for asthma; however, their influence on disease behavior and treatment response is still unclear. The aim of our study was the association analysis of the most significant single nucleotide polymorphisms (SNPs) recently repo...

journal_title：Immunogenetics

authors： Perin P,Potočnik U

更新日期：2014-03-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILR) are cell surface molecules that regulate the activities of myelomonocytic cells through the balance of inhibitory and activation signals. LILR genes are located within the leukocyte receptor complex (LRC) on chromosome 19q13.4 adjacent to KIR genes, which are subject to a...

journal_title：Immunogenetics

authors： López-Álvarez MR,Jones DC,Jiang W,Traherne JA,Trowsdale J

更新日期：2014-02-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through ...

journal_title：Immunogenetics

authors： Bashirova AA,Apps R,Vince N,Mochalova Y,Yu XG,Carrington M

更新日期：2014-01-01 00:00:00