Identification and characterization of the lamprey cathepsin genes.

abstract：:Genetic variation in the major histocompatibility complex (MHC) is directly correlated to differences in disease resistance. Immunity is greatly dependent on highly polymorphic genes in the MHC, such as class I, class II, and class III complement genes. Preliminary studies of wild turkey populations show extreme polym...

journal_title：Immunogenetics

authors： Bauer MM,Reed KM

更新日期：2011-04-01 00:00:00

abstract：:The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...

journal_title：Immunogenetics

authors： Suzan M,Valsted F,Boned A,Rubin B

更新日期：1982-01-01 00:00:00

abstract：:The sheep immunoglobulin heavy chain Igh-J locus has been characterized in order to determine the genomic organization of JH segments and their contribution to heavy chain diversity. The locus contains six segments, of which two are functional and four are apparently pseudogenes. These segments span a 1.8 kilobase (kb...

journal_title：Immunogenetics

authors： Dufour V,Nau F

更新日期：1997-01-01 00:00:00

abstract：:The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified with the canonical st...

journal_title：Immunogenetics

authors： Golub R,Fellah JS,Charlemagne J

更新日期：1997-01-01 00:00:00

abstract：:The human major histocompatibility complex (MHC) is located within a 4 megabase segment on chromosome 6p21.3. Recently, a highly divergent MHC class I chain-related gene family, MIC was identified within the class I region. The MICA and MICB genes in this family have unique patterns of tissue expression. The MICA gene...

journal_title：Immunogenetics

authors： Ando H,Mizuki N,Ota M,Yamazaki M,Ohno S,Goto K,Miyata Y,Wakisaka K,Bahram S,Inoko H

更新日期：1997-01-01 00:00:00

abstract：:In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...

journal_title：Immunogenetics

authors： Siemens I,Brenden M,Mauff G,Abbal M,Du Toit E,Bertrams J,Geserick G

更新日期：1992-01-01 00:00:00

abstract：:The ability of NK cells to specifically recognize cells lacking expression of self-MHC class I molecules was discovered over 30 years ago. It provided the foundation for the "missing self" hypothesis. Research in the two past decades has contributed to a detailed understanding of the molecular mechanisms that determin...

journal_title：Immunogenetics

authors： Malmberg KJ,Sohlberg E,Goodridge JP,Ljunggren HG

更新日期：2017-08-01 00:00:00

abstract：:Celiac disease is a chronic inflammatory condition of the small intestine caused by aberrant adaptive immune response to gluten protein from wheat and related cereal plants. Over 90% of celiac disease patients carry the HLA-DQ2.5 allotype and HLA-DQ2.5 presents gluten peptides to gluten-reactive CD4+ T cells in celiac...

journal_title：Immunogenetics

authors： Qiao SW,Sollid LM

更新日期：2019-11-01 00:00:00

abstract：:Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles w...

journal_title：Immunogenetics

authors： Hill A,Takiguchi M,McMichael A

更新日期：1993-01-01 00:00:00

abstract：:On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...

journal_title：Immunogenetics

authors： Blackwell JM

更新日期：1983-01-01 00:00:00

abstract：:Early and late primary IgM antibody responses of mice to Thy-1.1 antigens showed different antigenic and cellular requirements. We studied genetic controls of the early primary responses, which could be induced by subcellular thymocyte antigens independently of host T-cell activity. All Thy-1.2 mouse strains of Igha (...

journal_title：Immunogenetics

authors： Isobe K,Nakashima I,Nagase F,Yoshida T,Ando K,Inagi R,Kato N,Ohashi K

更新日期：1984-01-01 00:00:00

abstract：:A graft-vs-host reaction (GVHR) develops after major histocompatibility complex (MHC)-compatible bone marrow-transplantation. In the genetic combination studied, B10.D2 donor cells differed from those of (DBA/2 x B10.D2)F1 mice for multiple DBA/2 minor histocompatibility antigens (mHAg) and minor lymphocyte stimulatin...

journal_title：Immunogenetics

authors： Miconnet I,de la Selle V,Tucek C,Huchet R,Bonardelle D,Bruley-Rosset M

更新日期：1994-01-01 00:00:00

abstract：:We analyzed the genetic regulation of spontaneous autoimmune thyroiditis (SAT) by means of crosses between Obese strain (OS) chickens with the disease, and healthy inbred chicken of line CB. Mononuclear cell infiltration of the thyroid was used as a criterion for the disease. We confirmed the existence of one recessiv...

journal_title：Immunogenetics

authors： Vasícek D,Vasícková K,Kaiser P,Drozenová R,Cítek J,Hala K

更新日期：2001-12-01 00:00:00

abstract：:Earlier studies suggest that end-stage renal disease (ESRD) is associated with inflammatory state and have become a major cause of morbidity and mortality worldwide. This study speculated the role of interleukins (IL)-2, -4, and -6 cytokines gene polymorphism with risk of susceptibility to ESRD. Polymorphism in IL-2 (...

journal_title：Immunogenetics

authors： Mittal RD,Manchanda PK

更新日期：2007-02-01 00:00:00

abstract：:Sixteen microsatellite markers, including two described here, were used to construct a high-resolution map of the 1q32 region encompassing the regulator of the complement activation (RCA) gene cluster. The RCA genes are a group of related genes coding for plasma and membrane associated proteins that collectively contr...

journal_title：Immunogenetics

authors： Heine-Suñer D,Díaz-Guillén MA,de Villena FP,Robledo M,Benítez J,Rodríguez de Córdoba S

更新日期：1997-01-01 00:00:00

abstract：:Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes ar...

journal_title：Immunogenetics

authors： de Groot NG,Heijmans CM,de Ru AH,Hassan C,Otting N,Doxiadis GG,Koning F,van Veelen PA,Bontrop RE

更新日期：2013-12-01 00:00:00

abstract：:Footpad swelling response was used to measure the alloantigenicity of epidermal cells (ECs) in delayed-type hypersensitivity (DTH). Strong footpad swelling was observed 3 h after the challenge, and it continued for 48 h after the challenge. Genetical incompatibility between the recipients and the ECs was required to i...

journal_title：Immunogenetics

authors： Ishii N,Nakajima H,Aoki I,Ishii T,Takahashi T,Okuda K

更新日期：1986-01-01 00:00:00

abstract：:Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority ...

journal_title：Immunogenetics

authors： Schwartz JC,Lefranc MP,Murtaugh MP

更新日期：2012-04-01 00:00:00

abstract：:A large number of HLA-Cw4 (Cw *0402) peptides were purified, sequenced, and identified from breast and ovarian carcinoma cell lines. HLA-Cw4 molecules were expressed in these cells as soluble, secreted HLA (sHLA) and recovered from the growth medium. The peptides were separated by capillary reversed-phase HPLC and ana...

journal_title：Immunogenetics

authors： Buchsbaum S,Barnea E,Dassau L,Beer I,Milner E,Admon A

更新日期：2003-06-01 00:00:00

abstract：:The major histocompatibility complex (MHC) includes highly polymorphic gene families encoding proteins crucial to the vertebrate acquired immune system. Classical MHC class I (MHCI) genes code for molecules expressed on the surfaces of most nucleated cells and are associated with defense against intracellular pathogen...

journal_title：Immunogenetics

authors： Buehler DM,Verkuil YI,Tavares ES,Baker AJ

更新日期：2013-03-01 00:00:00

abstract：:We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4. We also studied the distribution of MICA ...

journal_title：Immunogenetics

authors： Lopez-Vazquez A,Rodrigo L,Fuentes D,Riestra S,Bousoño C,Garcia-Fernandez S,Martinez-Borra J,Gonzalez S,Lopez-Larrea C

更新日期：2002-02-01 00:00:00

abstract：:The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic ...

journal_title：Immunogenetics

authors： Ferrier P,Fontecilla-Camps JC,Bucchini D,Caillol DH,Jordan BR,Lemonnier FA

更新日期：1985-01-01 00:00:00

abstract：:Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and dou...

journal_title：Immunogenetics

authors： Reveille JD,Arnett FC,Wilson RW,Bias WB,McLean RH

更新日期：1985-01-01 00:00:00

abstract：:The A15, L6, and S5.7(TAPA1) proteins are members of the transmembrane 4 superfamily (TM4SF). The A15 is expressed in immature human T cells and in the human brain. The MXS1(CCG-B7) gene which codes for A15 contains triplet nucleotide repeats which have been associated with neuropsychiatric diseases such as Huntington...

journal_title：Immunogenetics

authors： Virtaneva KI,Emi N,Marken JS,Aruffo A,Jones C,Spurr NK,Schröder JP

更新日期：1994-01-01 00:00:00

abstract：:The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...

journal_title：Immunogenetics

authors： Melvold RW,Kohn HI,Dunn GR

更新日期：1982-01-01 00:00:00

abstract：:The immune response to bovine insulin (BI) in the rat is controlled by the major histocompatibility complex (Mhc)-linked immune response gene (Ir-BI) and immune suppression gene (Is-BI). In the present study, we investigated the low responsiveness to BI in the WKAH rat (RT1k) and attempted to explore the functional li...

journal_title：Immunogenetics

authors： Mizuno K,Tsuchimoto S,Matsuno Y,Niiyama T,Fujii H,Natori T,Aizawa M

更新日期：1988-01-01 00:00:00

abstract：:The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequences showed the expected evolutionary...

journal_title：Immunogenetics

authors： Grossberger D,Parham P

更新日期：1992-01-01 00:00:00

abstract：:Genetically anemic W/Wv mice and lethally irradiated wild-type mice were cured and populated by grafted marrow cells from donor mice of three congenic lines that differed at non-H-2 histocompatibility loci. Tail skin from mice of the same congenic lines was grafted 3-4 weeks later. In two cases, the recipients behaved...

journal_title：Immunogenetics

authors： Harrison DE,Mobraaten LE

更新日期：1984-01-01 00:00:00

abstract：:The polymorphic major histocompatibility complex (MHC) has gained a specific relevance in pathogen resistance and mate choice. Particularly the antigen-binding site (ABS), encoded by exon 2 of the DRB class II gene, exhibits numerous alleles and extensive sequence variations between alleles. A lack of MHC variability ...

journal_title：Immunogenetics

authors： Becker L,Nieberg C,Jahreis K,Peters E

更新日期：2009-04-01 00:00:00

abstract：:Genetic and functional analyses of the inflammasome suggest a role for this multiprotein complex in the biological mechanisms leading to the onset and progression of multiple sclerosis (MS). Nucleotide-binding, leucine-rich repeat (NLR) receptors trigger the activation and assembly of specific inflammasomes in respons...

journal_title：Immunogenetics

authors： Popplewell LF,Encarnacion M,Bernales CQ,Sadovnick AD,Traboulsee AL,Quandt JA,Vilariño-Güell C

更新日期：2020-09-01 00:00:00