Abstract:
:Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association of IL-17 F( rs763780), IL-17 A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese and lean Egyptian females, and to find out whether these gene polymorphisms affect the women’s serum levels. One hundred and twenty patients with RPL and 120 fertile volunteers with no history of pregnancy loss were genotyped for leptin (2548 G/A), IL-17 A (rs2275913), and IL-17 F (rs763780) polymorphisms by RFLP. The serum level of IL-17 was measured by ELISA, while serum leptin level was measured by HPLC. We found that IL-17 F (rs763780) polymorphism was associated with a decreased risk of RPL in Egyptian females, and we also found that IL-17 A (rs2275913) and LEP (2548 G/A) SNP were associated with an increased risk of RPL. We also demonstrated that both the IL-17 and leptin levels were elevated in the women with RPL and in an obese subgroup within RPL in comparison to a lean one.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Zidan HE,Rezk NA,Alnemr AA,Moniem MIdoi
10.1007/s00251-015-0876-8subject
Has Abstractpub_date
2015-11-01 00:00:00pages
665-73issue
11-12eissn
0093-7711issn
1432-1211pii
10.1007/s00251-015-0876-8journal_volume
67pub_type
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