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Expression of ia antigens by murine keratinizing epithelial langerhans cells.

Abstract：

:Immunofluorescent and immunoelectron-microscopic staining methods were utilized to investigate the localization of Ia antigens in murine keratinizing epithelia. Approximately 3-5% of epidermal cells were shown to be Ia positive. Only dendritic Langerhans cells in the interfollicular epidermis and outer root sheaths were found to express Ia antigens. These Ia determinants were shown to be controlled by both theI- A andI- EC subregions of theH-2 complex. The results were confirmed by identifying positively stained cells containing Langerhans cell granules at the ultrastructural level. No staining was noted on the surface of keratinocytes, melanocytes, or immigrant lymphocytes. The results presented are in close agreement with those previously reported for Ia-bearing Langerhans cells in human and guinea pig epidermis.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Rowden G,Phillips TM,Delovitch TL

doi

10.1007/BF01844036

subject

Has Abstract

pub_date

1978-12-01 00:00:00

pages

465-78

issue

1

eissn

0093-7711

issn

1432-1211

journal_volume

7

pub_type

杂志文章

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