Identification of expressed bovine class I MHC genes at two loci and demonstration of physical linkage.

abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...

journal_title：Immunogenetics

authors： van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JG

更新日期：2003-07-01 00:00:00

abstract：:Wild mice captured in Texas, Scotland, Federal Republic of Germany, Denmark, Spain, Greece, Israel, Egypt, and Chile were mated to inbred strains and through successive backcross matings and H-2 typing lines homozygous for wild-derived H-2, haplotypes were established. The lines, which are neither congenic nor inbred,...

journal_title：Immunogenetics

authors： Zaleska-Rutczynska Z,Figueroa F,Klein J

更新日期：1983-01-01 00:00:00

abstract：:Four cDNA probes for the human major histocompatibility complex (MHC) were used to investigate the sheep MHC, in conjunction with serological typing for ovine lymphocyte antigen (OLA). Lymphocytes from a family (two parents and five offspring) of Romanov sheep were subjected to genomic DNA digestion by the restriction...

journal_title：Immunogenetics

authors： Chardon P,Kirszenbaum M,Cullen PR,Geffrotin C,Auffray C,Strominger JL,Cohen D,Vaiman M

更新日期：1985-01-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILR) are cell surface molecules that regulate the activities of myelomonocytic cells through the balance of inhibitory and activation signals. LILR genes are located within the leukocyte receptor complex (LRC) on chromosome 19q13.4 adjacent to KIR genes, which are subject to a...

journal_title：Immunogenetics

authors： López-Álvarez MR,Jones DC,Jiang W,Traherne JA,Trowsdale J

更新日期：2014-02-01 00:00:00

abstract：:Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes ha...

journal_title：Immunogenetics

authors： Delgado JC,Leung JY,Baena A,Clavijo OP,Vittinghoff E,Buchbinder S,Wolinsky S,Addo M,Walker BD,Yunis EJ,Goldfeld AE

更新日期：2003-10-01 00:00:00

abstract：:Two proteasome activators PA28alpha and beta, which have been implicated in antigen processing for loading class I MHC molecules, are synthesized in response to Ifn-gamma. The human genes encoding these activators (PSME1 and PSME2, respectively) were analyzed by sequencing. Each gene comprised 11 exons, consistent wit...

journal_title：Immunogenetics

authors： McCusker D,Wilson M,Trowsdale J

更新日期：1999-05-01 00:00:00

abstract：:To describe the polymorphism of the DRA gene in Macaca fascicularis, we have studied 141 animals either at cDNA level (78 animals from Mauritius, the Philippines, and Vietnam) or genomic level (63 animals from the Philippines, Indonesia, and Vietnam). In total, we characterized 22 cDNA DRA alleles, 13 of which had not...

journal_title：Immunogenetics

authors： Aarnink A,Estrade L,Apoil PA,Kita YF,Saitou N,Shiina T,Blancher A

更新日期：2010-03-01 00:00:00

abstract：:The interleukin-1 gene family encodes a group of related proteins that exhibit a remarkable pleiotropy in the context of health and disease. The set of indispensable functions they control suggests that these genes should be found in all eukaryotic species. The ligands and receptors of this family have been primarily ...

journal_title：Immunogenetics

authors： Gibson MS,Kaiser P,Fife M

更新日期：2014-08-01 00:00:00

abstract：:Many fishes express high levels of intraspecific variability, often linked to resource partitioning. Several studies show that a species' evolutionary trajectory of adaptive divergence can undergo reversals caused by changes in its environment. Such a reversal in neutral genetic and morphological variation among lake ...

journal_title：Immunogenetics

authors： Baillie SM,Hemstock RR,Muir AM,Krueger CC,Bentzen P

更新日期：2018-01-01 00:00:00

abstract：:Development of an accurate and efficient molecular-based equine MHC class I typing method would facilitate the study of T lymphocyte immune responses in horses. Here, a DNA microarray was designed to detect expressed classical MHC class I genes comprising serologically defined equine leukocyte antigen (ELA)-A haplotyp...

journal_title：Immunogenetics

authors： Ramsay JD,Leib SR,Orfe L,Call DR,Tallmadge RL,Fraser DG,Mealey RH

更新日期：2010-09-01 00:00:00

abstract：:The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...

journal_title：Immunogenetics

authors： Kikuchi A,Sakaguchi T,Miwa K,Takamiya Y,Rammensee HG,Kaneko Y,Takiguchi M

更新日期：1996-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...

journal_title：Immunogenetics

authors： Dijkstra JM,Yamaguchi T

更新日期：2019-03-01 00:00:00

abstract：:As the only native insular Newfoundland canid between the extinction of the wolf in the 1930s and the recent arrival of coyotes, the red fox (Vulpes vulpes deletrix Bangs 1898) poses interesting questions about genetic distinctiveness and the post-glacial colonization history of the island's depauperate mammalian faun...

journal_title：Immunogenetics

authors： Marshall HD,Langille BL,Hann CA,Whitney HG

更新日期：2016-05-01 00:00:00

abstract：:In mammals, there are MHC class II molecules with distinctive sequence features, such as the classical isotypes DR, DQ and DP. These particular isotypes have not been reported in non-mammalian vertebrates. We have isolated the class II (B-L) alpha chain from outbred chickens as the basis for the cloning and sequencing...

journal_title：Immunogenetics

authors： Salomonsen J,Marston D,Avila D,Bumstead N,Johansson B,Juul-Madsen H,Olesen GD,Riegert P,Skjødt K,Vainio O,Wiles MV,Kaufman J

更新日期：2003-12-01 00:00:00

abstract：:Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of diseases have been the subject of research for decades. In particular, the associations of autoimmune disorders to allelic variants and candidate genes encoding the MHC are we...

journal_title：Immunogenetics

authors： Al Naqbi H,Mawart A,Alshamsi J,Al Safar H,Tay GK

更新日期：2021-02-02 00:00:00

abstract：:We studied the relationship between human leukocyte antigen (HLA) class I alleles and cervical cancer among Indian women. Seventy-five cervical cancer cases were compared with 175 noncancer controls. Cervical biopsy tissue specimen from cancer cases and cervical swab specimen from controls were collected for HPV detec...

journal_title：Immunogenetics

authors： Gokhale P,Mania-Pramanik J,Sonawani A,Idicula-Thomas S,Kerkar S,Tongaonkar H,Chaudhari H,Warke H,Salvi V

更新日期：2014-12-01 00:00:00

abstract：:Several lines of evidence have confirmed the importance of Nod2 mutations for disease susceptibility in Crohn's disease. For tracing Nod2 evolution, exons 4a, 4e, 8, and 12 mutations were screened in a collection of 1,064 DNA samples from 52 worldwide populations. The overall allele frequency was 7.5% for single nucle...

journal_title：Immunogenetics

authors： Gasche C,Nemeth M,Grundtner P,Willheim-Polli C,Ferenci P,Schwarzenbacher R

更新日期：2008-02-01 00:00:00

abstract：:Ranatuerins are antimicrobial peptides of the innate immune system found in ranid frogs. We previously presented evidence that a positive selective sweep had fixed a single allele at the Ranatuerin2 locus in the northern leopard frog (Rana pipiens). In this paper, we further investigate the evolutionary history of ran...

journal_title：Immunogenetics

authors： Tennessen JA,Blouin MS

更新日期：2010-05-01 00:00:00

abstract：:The interaction of bacterial pathogens with their hosts' innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate im...

journal_title：Immunogenetics

authors： Persson J,Vance RE

更新日期：2007-10-01 00:00:00

abstract：:Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

journal_title：Immunogenetics

authors： Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

更新日期：1995-01-01 00:00:00

abstract：:Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...

journal_title：Immunogenetics

authors： Schwienbacher C,De Grandi A,Fuchsberger C,Facheris MF,Svaldi M,Wjst M,Pramstaller PP,Hicks AA

更新日期：2010-08-01 00:00:00

abstract：:Dendritic cells (DC) are specialist antigen presenting cells which capture antigens in the periphery, migrate centrally, and present the processed antigens in the context of major histocompatibility complex and appropriate co-stimulatory molecules to T lymphocytes for the initiation of an immune response. DEC-205 has ...

journal_title：Immunogenetics

authors： Kato M,Neil TK,Clark GJ,Morris CM,Sorg RV,Hart DN

更新日期：1998-05-01 00:00:00

abstract：:Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gen...

journal_title：Immunogenetics

authors： Kikuchi T,Naruse TK,Onizuka M,Li S,Kimura T,Oka A,Morishima Y,Kulski JK,Ichimiya S,Sato N,Inoko H

更新日期：2007-02-01 00:00:00

abstract：:As part of an investigation of the immune system in the developing zebrafish, Danio rerio, we cloned and characterized a genomic V(H) segment and a number of cDNAs encoding IgM heavy chains. The genomic V(H) has the characteristic features of V(H) in other vertebrates, including a leader segment interrupted by a short...

journal_title：Immunogenetics

authors： Danilova N,Hohman VS,Kim EH,Steiner LA

更新日期：2000-11-01 00:00:00

abstract：:Infection of humans and chimpanzees with Hepatitis C virus (HCV) results in either the resolution of the acute infection or its progression to a persistent infection associated with chronic liver disease. In cohorts of human patients, resolution of HCV infection has been associated with homozygosity for both C1(+)HLA-...

journal_title：Immunogenetics

authors： Abi-Rached L,Guethlein LA,Norman PJ,Parham P

更新日期：2015-10-01 00:00:00

abstract：:T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...

journal_title：Immunogenetics

authors： Li J,Li J,You Y,Chen S

更新日期：2012-05-01 00:00:00

abstract：:Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and dou...

journal_title：Immunogenetics

authors： Reveille JD,Arnett FC,Wilson RW,Bias WB,McLean RH

更新日期：1985-01-01 00:00:00

abstract：:Rearrangements of the immunoglobulin heavy chain joining region (JH) genes occur in some T lymphocytes, probably because the mechanism for assembly of T-cell receptor encoded genes is very similar to that for immunoglobulins. Two such rearrangements described previously represented proper fusion of a DH and JH gene. W...

journal_title：Immunogenetics

authors： Gerondakis S,Bernard O,Cory S,Adams JM

更新日期：1988-01-01 00:00:00

abstract：:The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...

journal_title：Immunogenetics

authors： Mehta IK,Wang J,Roland J,Margulies DH,Yokoyama WM

更新日期：2001-09-01 00:00:00

abstract：:Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by microsatellites reve...

journal_title：Immunogenetics

authors： Aarnink A,Dereuddre-Bosquet N,Vaslin B,Le Grand R,Winterton P,Apoil PA,Blancher A

更新日期：2011-05-01 00:00:00