当前位置： SCI文献检索 > IMMUNOGENETICS期刊下所有文献 > Null alleles of the fourth component of complement and HLA haplotypes in familial systemic lupus erythematosus.

Null alleles of the fourth component of complement and HLA haplotypes in familial systemic lupus erythematosus.

Abstract：

:Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and double-stranded anti-DNA, anti-SM, anti-nRNP, anti-Ro [SS-A], anti-La [SS-B], and biological false-positive tests for syphilis and clinical features. Fifteen members had SLE, and 19 had other immune diseases (subacute cutaneous lupus erythematosus, discoid lupus erythematosus, hypothyroidism, insulin-dependent diabetes mellitus, primary Sjogren's syndrome, immune thrombocytopenic purpura, rheumatoid arthritis, and multiple sclerosis). Twenty-three healthy relatives (seroreactors) had significant titers of circulating antibodies, as did 2 of 17 spouses. There was an increased frequency of null C4 alleles in those individuals with SLE (60%) and healthy relatives (50%) as compared with spouses (24%). Multivariate analysis showed a significant association between SLE and female sex (P =.006), whereas there was no significant association revealed between female sex and other immune diseases. Patients with SLE also had a higher frequency of either C4A or C4B null alleles (P = .01) than those with immune diseases. The C4A homozygous null phenotype was more common in SLE patients than in seroreactors (P = .02). There was a higher frequency of HLA-DR2 and DR3 in individuals with SLE than in those with immune disease (P = .08), seroreactors (P = .02) and normal relatives (P = .002). One totally C4-deficient patient with SLE was identified. These families demonstrate an important association between SLE and the C4 null allele and the HLA-DR2 and DR3. These risk factors, however, cannot account for the development of disease in all individuals.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Reveille JD,Arnett FC,Wilson RW,Bias WB,McLean RH

doi

10.1007/BF00430796

subject

Has Abstract

pub_date

1985-01-01 00:00:00

pages

299-311

issue

4

eissn

0093-7711

issn

1432-1211

journal_volume

21

pub_type

杂志文章

相关文献

IMMUNOGENETICS文献大全
  • Gm and Km immunoglobulin allotypes in Sicily.

    abstract：:The aim of this study was to evaluate the intra- and inter-population variability of the Gm/Km system in the Madonie Mountains, one of the main geographical barriers in north-central Sicily. We analysed 392 samples: 145 from Alia, 128 from Valledolmo, 25 from Cerda and 94 from Palermo. Serum samples were tested for G1...

    journal_title：Immunogenetics

    pub_type： 历史文章,杂志文章

    doi：10.1007/s00251-003-0628-z

    authors： Cerutti N,Dugoujon JM,Guitard E,Rabino Massa E

    更新日期：2004-01-01 00:00:00

  • Paucity of class I MHC gene heterogeneity between individuals in the endangered Hawaiian monk seal population.

    abstract：:The Hawaiian monk seal population has experienced precipitous declines in the last 50 years. In this study, we provide evidence that individuals from remaining endangered population exhibit alarming uniformity in class I major histocompatibility (MHC) genes. The peripheral blood leukocyte-derived mRNA of six captive a...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-005-0069-y

    authors： Aldridge BM,Bowen L,Smith BR,Antonelis GA,Gulland F,Stott JL

    更新日期：2006-04-01 00:00:00

  • A single amino-acid polymorphism in pocket A of HLA-A*6602 alters the auxiliary anchors compared with HLA-A*6601 ligands.

    abstract：:In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-004-0677-y

    authors： Bade-Doeding C,Elsner HA,Eiz-Vesper B,Seltsam A,Holtkamp U,Blasczyk R

    更新日期：2004-05-01 00:00:00

  • Haplotype-specific sequence encoding the protein kinase, interferon-inducible double-stranded RNA-dependent activator in the human leukocyte antigen class II region.

    abstract：:The protein kinase, interferon-inducible double-stranded (ds)RNA-dependent activator (PRKRA) is a dsRNA-binding protein which activates a protein kinase participating in the antiviral activity of interferon. Our previous studies indicated that the nucleotide sequence encoding PRKRA, which appeared to be an intronless ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510000270

    authors： Chida S,Hohjoh H,Hirai M,Tokunaga K

    更新日期：2001-01-01 00:00:00

  • Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2.

    abstract：:TAP1 and TAP2 are two major histocompatibility complex (MHC) genes, located between HLA-DP and -DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in both genes and, in this study, we have identified another polymorphic site within the ade...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00216802

    authors： Powis SH,Tonks S,Mockridge I,Kelly AP,Bodmer JG,Trowsdale J

    更新日期：1993-01-01 00:00:00

  • Polymorphism in the regulatory region of HLA-DRB genes correlating with haplotype evolution.

    abstract：:Class II genes of the human major histocompatibility complex (MHC) are polymorphic. Allelic variation of the coding region of these genes is involved in the antigen presentation and is associated with susceptibility to certain autoimmune diseases. The DR region is unique among human class II regions in that multiple D...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00216386

    authors： Louis P,Eliaou JF,Kerlan-Candon S,Pinet V,Vincent R,Clot J

    更新日期：1993-01-01 00:00:00

  • Sixteen new H-2 haplotypes derived from wild mice.

    abstract：:Wild mice captured in Texas, Scotland, Federal Republic of Germany, Denmark, Spain, Greece, Israel, Egypt, and Chile were mated to inbred strains and through successive backcross matings and H-2 typing lines homozygous for wild-derived H-2, haplotypes were established. The lines, which are neither congenic nor inbred,...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00952959

    authors： Zaleska-Rutczynska Z,Figueroa F,Klein J

    更新日期：1983-01-01 00:00:00

  • Genetic controls of T cell-independent Thy-1 alloantibody responses.

    abstract：:Early and late primary IgM antibody responses of mice to Thy-1.1 antigens showed different antigenic and cellular requirements. We studied genetic controls of the early primary responses, which could be induced by subcellular thymocyte antigens independently of host T-cell activity. All Thy-1.2 mouse strains of Igha (...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00364214

    authors： Isobe K,Nakashima I,Nagase F,Yoshida T,Ando K,Inagi R,Kato N,Ohashi K

    更新日期：1984-01-01 00:00:00

  • Codon usage bias and base composition in MHC genes in humans and common chimpanzees.

    abstract：:Codon bias and base composition in major histocompatibility complex (MHC) sequences have been studied for both class I and II loci in Homo sapiens and Pan troglodytes. There is low to moderate codon bias for the MHC of humans and chimpanzees. In the class I loci, the same level of moderate codon bias is seen for HLA-B...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050493

    authors： McWeeney SK,Valdes AM

    更新日期：1999-04-01 00:00:00

  • Unusually limited nucleotide sequence variation of the expressed major histocompatibility complex class I genes of a New World primate species (Saguinus oedipus).

    abstract：:Although major histocompatibility complex (MHC) class I molecules are, as a rule, highly polymorphic in mammalian species, those of the New World primate Saguinus oedipus (cotton-top tamarin) exhibit limited polymorphism. We have cloned and sequenced twelve MHC class I cDNAs from this species. Since cloned cotton-top ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00210819

    authors： Watkins DI,Garber TL,Chen ZW,Toukatly G,Hughes AL,Letvin NL

    更新日期：1991-01-01 00:00:00

  • What to do with HLA-DO?

    abstract：:Antigenic peptide binding to MHC class II molecules in the endocytic pathway occurs via a multifactorial process that requires the support of a specialized lysosomal chaperone called HLA-DM. DM shows both in primary amino acid sequence and quaternary structure a high homology to both MHC class I and class II molecules...

    journal_title：Immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1007/s002510000208

    authors： van Ham M,van Lith M,Griekspoor A,Neefjes J

    更新日期：2000-08-01 00:00:00

  • Genomic organization of the mouse Tla locus: study of an endogenous retroviruslike locus reveals polymorphisms related to different Tla haplotypes.

    abstract：:A retrovirus element (TLev1) is located within the Thymus leukemia antigen (Tla) locus of the C57BL/10 mouse major histocompatibility complex. Low-copy probes have been isolated from sequences flanking the TLev1 integration site to examine the distribution of TLev1 among inbred mouse strains having genotypically deter...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00345501

    authors： Pampeno C,Meruelo D

    更新日期：1988-01-01 00:00:00

  • Channel catfish leukocyte immune-type receptors contain a putative MHC class I binding site.

    abstract：:The recent identification of a large and diverse family of leukocyte immune-type receptors (IpLITRs) in channel catfish (Ictalurus punctatus) indicates that immunoglobulin superfamily (IgSF) members related to both mammalian Fc receptors (FcRs) and leukocyte receptor complex (LRC)-encoded proteins exist in fish. In th...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-006-0169-3

    authors： Stafford JL,Bengtén E,Du Pasquier L,Miller NW,Wilson M

    更新日期：2007-01-01 00:00:00

  • Molecular identification of human Ia antigens coded for by a gene locus closely linked to HLA-DR locus.

    abstract：:Human Ia(-like) specificities controlled by gene loci other than HLA-DR were searched for at the molecular level in cells of human B-cell-type cell lines which carry two established DR specificities. Chevalier cells of DRw3 and 7 and U698M cells of DRw2 and 4 were used. Their Ia molecules were partially purified, radi...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF01561564

    authors： Tanigaki N,Tosi R,Pressman D,Ferrara GB

    更新日期：1980-01-01 00:00:00

  • MICA polymorphism in South American Indians.

    abstract：:We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-001-0426-4

    authors： Zhang Y,Lazaro AM,Zou Y,Lavingia B,Moraes EM,Moraes RJ,Stastny P

    更新日期：2002-02-01 00:00:00

  • Structure, chromosomal localization, and expression of 12 genes of the MAGE family.

    abstract：:We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized on a melanoma by autologous cytolytic T lymphocytes. Probing cosmid libraries with a MAGE-1 sequence, we identified 11 closely related genes. The analysis of hamster-human somatic cell hybrids indicated that the 12 MAGE ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF01246677

    authors： De Plaen E,Arden K,Traversari C,Gaforio JJ,Szikora JP,De Smet C,Brasseur F,van der Bruggen P,Lethé B,Lurquin C

    更新日期：1994-01-01 00:00:00

  • Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes.

    abstract：:The non-major histocompatibility complex (MHC)-encoded CD1 family has recently emerged as a new antigen-presenting system that is distinct from either MHC class I or class II molecules. In the present study, we determined the genomic structure of the rat CD1 locus. It was extremely similar to mouse CD1 genes, especial...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050396

    authors： Katabami S,Matsuura A,Chen HZ,Imai K,Kikuchi K

    更新日期：1998-06-01 00:00:00

  • H-2 influences phenytoin binding and inhibition of prostaglandin synthesis.

    abstract：:We have reported that susceptibility to glucocorticoid- and phenytoin-induced cleft palate and glucocorticoid receptor levels in mice are influenced by the H-2 histocompatibility complex on chromosome 17. Phenytoin competes with glucocorticoids for the glucocorticoid receptor and inhibits production of prostaglandins ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00430325

    authors： Gupta C,Katsumata M,Goldman AS

    更新日期：1984-01-01 00:00:00

  • Antigen-specific helper T cells recognize determinants encoded in the H-2D region of the H-2 gene complex.

    abstract：:Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00345403

    authors： Pilarski LM,Wegmann TG

    更新日期：1984-01-01 00:00:00

  • Activation of immunoglobulin control elements in transgenic mice.

    abstract：:To assess the role interleukins and mitogens play in regulating immunoglobulin (Ig) gene expression via the Ig enhancer and promoter, transgenic mice carrying two different Ig gene regulatory regions were generated. One, EmukCAT, contains the Ig heavy chain enhancer (Emu) and the kappa light chain promoter driving the...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00216623

    authors： Miller AE,Ennist DL,Ozato K,Westphal H

    更新日期：1992-01-01 00:00:00

  • "Natural" antibodies to chicken MHC antigens are present in mice, rats, humans, alligators and allogeneic chickens.

    abstract：:In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is direct...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF01567795

    authors： Longenecker BM,Mosmann TR

    更新日期：1980-01-01 00:00:00

  • MHC class II polymorphism is associated with a canine SLE-related disease complex.

    abstract：:Nova Scotia duck tolling retrievers are predisposed to a SLE-related disease complex including immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). IMRD involves symptoms that resemble those seen in systemic autoimmune rheumatic diseases, such as systemic lupus erythematosus, SL...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-009-0387-6

    authors： Wilbe M,Jokinen P,Hermanrud C,Kennedy LJ,Strandberg E,Hansson-Hamlin H,Lohi H,Andersson G

    更新日期：2009-08-01 00:00:00

  • Binding of nonamer peptides to three HLA-B51 molecules which differ by a single amino acid substitution in the A-pocket.

    abstract：:The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF02440994

    authors： Kikuchi A,Sakaguchi T,Miwa K,Takamiya Y,Rammensee HG,Kaneko Y,Takiguchi M

    更新日期：1996-01-01 00:00:00

  • The spatial relationship of the viral and H-2 antigens recognized by anti-viral CTLs.

    abstract：:With the use of monospecific rabbit anti-G protein and mouse monoclonal anti-H-2Kk, we have analyzed the spatial relationship of the serologically defined H-2Kk antigens and the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) to those antigens recognized by B10.A (k, d) anti-VSV cytotoxic T ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF01572582

    authors： Hale AH

    更新日期：1980-01-01 00:00:00

  • Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.

    abstract：:Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response leading to the rapid depletion of peripheral NK cells and lymphocytes. A critical...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-010-0480-x

    authors： Wauquier N,Padilla C,Becquart P,Leroy E,Vieillard V

    更新日期：2010-12-01 00:00:00

  • Nucleotide sequence of a rabbit IgG heavy chain from the recombinant F-I haplotype.

    abstract：:We report the sequence of a cDNA encoding a rabbit immunoglobulin gamma heavy chain of d12 and e14 allotypes with high homology to partial cDNA sequences from rabbits of d11 and e15 allotypes. The encoded rabbit protein shows homologies with human (68-70%) and mouse (60-63%) gamma chains. The nucleotide sequence homol...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00372471

    authors： Bernstein KE,Alexander CB,Mage RG

    更新日期：1983-01-01 00:00:00

  • Transcript analysis reveals the involvement of NF-κB transcription factors for the activation of TGF-β signaling in nematode-infected Drosophila.

    abstract：:The common fruit fly Drosophila melanogaster is a powerful model for studying signaling pathway regulation. Conserved signaling pathways underlying physiological processes signify evolutionary relationship between organisms and the nature of the mechanisms they control. This study explores the cross-talk between the w...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-019-01119-8

    authors： Patrnogic J,Heryanto C,Ozakman Y,Eleftherianos I

    更新日期：2019-07-01 00:00:00

  • Major histocompatibility complex variation and the evolution of resistance to amphibian chytridiomycosis.

    abstract：:Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has been implicated in population declines and species extinctions of amphibians around the world. Susceptibility to the disease varies both within and among species, most likely attributable to heritable immunogenetic variation. Anal...

    journal_title：Immunogenetics

    pub_type： 杂志文章,评审

    doi：10.1007/s00251-017-1008-4

    authors： Fu M,Waldman B

    更新日期：2017-08-01 00:00:00

  • Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice.

    abstract：:Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00179398

    authors： Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

    更新日期：1995-01-01 00:00:00

  • Heavy-chain antibodies in Camelidae; a case of evolutionary innovation.

    abstract：:The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-002-0433-0

    authors： Nguyen VK,Su C,Muyldermans S,van der Loo W

    更新日期：2002-04-01 00:00:00