Abstract:
:We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed in South American Indians, compared with 16 that were found in North American Caucasians, suggesting a more restricted allelic distribution of MICA in these tribes. In South American Indians, MICA*00201 was the most frequent allele, with a gene frequency of 33% in Toba, 47% in Wichi and 44% in Terena. MICA*00201, MICA*027 (external domain sequence like MICA*008/TM allele A5) and MICA*010 accounted for more than 90% of all the MICA genes in South American Indians. In North American Caucasians, MICA*00801 (*008/A5.1) accounted for 42% of the genes and was the most common allele. We observed a high degree of linkage disequilibrium between certain alleles of MICA and of HLA-B in the South American Indian populations. Phylogenetic trees constructed using gene frequencies of the transmembrane short tandem repeats in the populations reported here, and in other populations taken from published reports, suggest that South American Indians are more closely related to Asians than to Europeans.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Zhang Y,Lazaro AM,Zou Y,Lavingia B,Moraes EM,Moraes RJ,Stastny Pdoi
10.1007/s00251-001-0426-4subject
Has Abstractpub_date
2002-02-01 00:00:00pages
900-6issue
10-11eissn
0093-7711issn
1432-1211journal_volume
53pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000276
更新日期:2001-01-01 00:00:00
abstract::Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates predictions of proteaso...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0441-4
更新日期:2010-06-01 00:00:00
abstract::Multiple sclerosis (MS) is a common disease of the central nervous system characterized by myelin loss and progressive neurological dysfunction. An underlying genetic susceptibility plays a clear role in the etiology of MS, likely acting in concert with an undefined environmental exposure. Full-genome screenings in mu...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050621
更新日期:2000-04-01 00:00:00
abstract::Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0459-7
更新日期:2010-08-01 00:00:00
abstract::The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00621950
更新日期:1982-01-01 00:00:00
abstract::Two proteasome activators PA28alpha and beta, which have been implicated in antigen processing for loading class I MHC molecules, are synthesized in response to Ifn-gamma. The human genes encoding these activators (PSME1 and PSME2, respectively) were analyzed by sequencing. Each gene comprised 11 exons, consistent wit...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050517
更新日期:1999-05-01 00:00:00
abstract::Mouse Ly6A and Ly6C cDNA probes were hybridized to total RNA of rat tissues and, as in mouse, the highest level of Ly6-related transcripts was detected in kidney. Therefore, Ly6-related cDNA clones were isolated from a commercial rat kidney cDNA library in lambda gt11. Four of these (RK3, RK6, RK10, and RK11) have bee...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00661220
更新日期:1990-01-01 00:00:00
abstract::Natural killer (NK) cells constitute the third major population of lymphocytes. They possess the inherent capacity to kill various tumor and virally infected cells and mediate the rejection of bone-marrow grafts in lethally irradiated animals. A large family of NK cell receptors belong to the C-type lectin superfamily...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050679
更新日期:1999-10-01 00:00:00
abstract::Natural-killer group 2 member D (NKG2D) is an activating receptor that plays an important role in the immune response mediated by NK cells, γδ(+) T cells, and CD8(+) T cells. In humans, MHC class I chain-related genes and UL-16 binding protein (ULBP)/retinoic acid early transcript 1 (REAT1) gene family encode ligands ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0531-y
更新日期:2011-08-01 00:00:00
abstract::In order to determine the extent of the repertoire of the immunoglobulin light chain V-region locus (Igl-V) in the laboratory rat (Rattus norvegicus), we constructed a specifically primed cDNA library from lipopolysaccharide-stimulated DA strain rat spleens. The library was screened with a rat Igl-C2-specific probe, a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00223543
更新日期:1992-01-01 00:00:00
abstract::Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes ar...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0734-5
更新日期:2013-12-01 00:00:00
abstract::In the mouse three lymphocyte gene families have been positioned on the proximal region of chromosome 6. Originally the immunoglobulin kappa light chain (Igk) and the thymocyte surface antigens Lyt-2 and Lyt-3 were assigned to chromosome 6, and recently the beta chain of the T-cell receptor for antigen was positioned ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00404487
更新日期:1985-01-01 00:00:00
abstract::Parasites exert a selection pressure on their hosts and are accountable for driving diversity within gene families and immune gene polymorphisms in a host population. The overwhelming response of regulatory T cells during infectious challenges directs the host immune system to lose the ability to mount parasite specif...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0524-x
更新日期:2011-07-01 00:00:00
abstract::Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-020-01166-6
更新日期:2020-07-01 00:00:00
abstract::The factors which influence expression of autoimmune disease in the central nervous system are still poorly understood. We determined the characteristics of experimental autoimmune encephalomyelitis (EAE) in twelve different inbred strains of mice using either mouse spinal cord homogenate or synthetic peptides as the ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02602559
更新日期:1996-01-01 00:00:00
abstract::We have analyzed genomic DNA in a large number of independent examples of five HLA-DQw2-bearing extended haplotypes for their associated subtypes by restriction fragment length polymorphism (RFLP) using DRB, DQA, and DQB probes after Taq I and Pst I digestion and Southern blotting. In addition to three previously desc...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00210445
更新日期:1990-01-01 00:00:00
abstract::Segregation distortion was found for a haplotype of the equine lymphocyte antigen (ELA) system in an extended family of American Standardbred horses. In one sire family, consisting of a stallion and his 17 sons and grandsons, the gene for ELA-A10 (A10) was transmitted to 57.7% of 638 offspring scored (P = 0.001). Sign...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364526
更新日期:1986-01-01 00:00:00
abstract::The common fruit fly Drosophila melanogaster is a powerful model for studying signaling pathway regulation. Conserved signaling pathways underlying physiological processes signify evolutionary relationship between organisms and the nature of the mechanisms they control. This study explores the cross-talk between the w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-019-01119-8
更新日期:2019-07-01 00:00:00
abstract::Protein tyrosine phosphorylation is an important regulatory mechanism in cell physiology. While the protein tyrosine kinase (PTKase) family has been extensively studied, only six protein tyrosine phosphatases (PTPases) have been described. By Southern blot analysis, genomic DNA from several different phyla were found ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00211693
更新日期:1991-01-01 00:00:00
abstract::Mice bearing the H-2w7 haplotype have five C4-related genes, one C4, one Slp, and three C4/Slp hybrid genes. The expression of these five genes in the liver of H-2w7 mice was estimated at the steady state level of their respective mRNA. We have amplified by the polymerase chain reaction (PCR) three regions of the C4/S...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216695
更新日期:1991-01-01 00:00:00
abstract::We have performed an extensive analysis of Th1/Th2 cytokine receptors IL2Ralpha, IL4Ralpha, IL10Ralpha, and IFNgammaR1 gene polymorphisms to evaluate their impact on AIDS progression. The coding regions and promoters of these genes were sequenced in the genetics of resistance to immunodeficiency virus cohort, composed...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0072-3
更新日期:2006-04-01 00:00:00
abstract::The class I genes of the major histocompatibility complex (Mhc) are here investigated for the first time in a passerine bird. The great reed warbler is a rare species in Sweden with a few semi-isolated populations. Yet, we found extensive Mhc class I variation in the study population. The variable exon 3, correspondin...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050477
更新日期:1999-03-01 00:00:00
abstract::The incidence of arthritis and the antibody response to mouse and to rat type II collagen after immunization with native rat type II collagen was studied in different mouse strains, including wild mouse-derived strains belonging to the H-2p/H-2q family. High serum levels of antibodies to mouse and rat type II collagen...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00373114
更新日期:1986-01-01 00:00:00
abstract::The human major histocompatibility complex (MHC) is located within a 4 megabase segment on chromosome 6p21.3. Recently, a highly divergent MHC class I chain-related gene family, MIC was identified within the class I region. The MICA and MICB genes in this family have unique patterns of tissue expression. The MICA gene...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050311
更新日期:1997-01-01 00:00:00
abstract::Lentinan, a beta-1,6;1,3-glucan, is tumor-specific for transplantable mouse solid-type tumors and it also stimulates the production of acute phase proteins (APPs). The APP response to lentinan is of the delayed type (DT-APR) and differs from that to lipopolysaccharide, which is acute. We found that the responses were ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00587302
更新日期:1996-01-01 00:00:00
abstract::The CCL4 chemokine is secreted by a variety of cells following stimulation. CCL4 affects several different types of cells that are important for acute inflammatory responses and are critical for the development of specific immune responses to foreign antigens. The human genome contains two genes for the CCL4 chemokine...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0636-z
更新日期:2004-01-01 00:00:00
abstract::Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561675
更新日期:1981-01-01 00:00:00
abstract::Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345403
更新日期:1984-01-01 00:00:00
abstract::CD4 has a central role in thymocyte differentiation and cell-mediated immunity. We isolated and analyzed chicken CD4. The gene spans 11.5 kb and is composed of ten exons. The promoter is TATA-less and similar to the mouse and human CD4 promoters, with two transcription start sites as determined by 5'RACE analysis. In ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0490-4
更新日期:2002-10-01 00:00:00
abstract::Drosophila larvae react against eggs from the endoparasitoid wasp Leptopilina boulardi by surrounding them in a multilayered cellular capsule. Once a wasp egg is recognized as foreign, circulating macrophage-like cells, known as plasmatocytes, adhere to the invader. After spreading around the wasp egg, plasmatocytes f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-011-0571-3
更新日期:2012-02-01 00:00:00