High antibody response to autologous type II collagen is restricted to H-2q.

abstract：:The effect of the H-2dm1 mutation on Qa-m2 expression was examined. The mutant strain B10.D2-H-2dm1 showed a fourfold increase in Qa-m2 expression when compared with the parental strain B10.D2. Qa-m2 molecules immunoprecipitated from B10.D2-H-2dm1, C57BL/10, and B10.D2 spleen cells were identical by two-dimensional (2...

journal_title：Immunogenetics

authors： Hogarth PM,Walker ID,Rigby AJ,McKenzie IF

更新日期：1983-01-01 00:00:00

abstract：:Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...

journal_title：Immunogenetics

authors： Garlepp MJ,Wilton AN,Dawkins RL,White PC

更新日期：1986-01-01 00:00:00

abstract：:Loss of major histocompatibility complex class II (MHCII) antigen expression on diffuse large B cell lymphoma (DLBCL) corresponds closely with significant decreases in patient survival. However, the mechanisms accounting for MHCII loss in DLBCL have not been thoroughly characterized to date. In this report, we demonst...

journal_title：Immunogenetics

authors： Bushway M,Cycon KA,Mulvaney K,Murphy SP

更新日期：2010-02-01 00:00:00

abstract：:Natural-killer group 2 member D (NKG2D) is an activating receptor that plays an important role in the immune response mediated by NK cells, γδ(+) T cells, and CD8(+) T cells. In humans, MHC class I chain-related genes and UL-16 binding protein (ULBP)/retinoic acid early transcript 1 (REAT1) gene family encode ligands ...

journal_title：Immunogenetics

authors： Naruse TK,Okuda Y,Mori K,Akari H,Matano T,Kimura A

更新日期：2011-08-01 00:00:00

abstract：:In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...

journal_title：Immunogenetics

authors： Siemens I,Brenden M,Mauff G,Abbal M,Du Toit E,Bertrams J,Geserick G

更新日期：1992-01-01 00:00:00

abstract：:Although major histocompatibility complex (MHC) class I molecules are, as a rule, highly polymorphic in mammalian species, those of the New World primate Saguinus oedipus (cotton-top tamarin) exhibit limited polymorphism. We have cloned and sequenced twelve MHC class I cDNAs from this species. Since cloned cotton-top ...

journal_title：Immunogenetics

authors： Watkins DI,Garber TL,Chen ZW,Toukatly G,Hughes AL,Letvin NL

更新日期：1991-01-01 00:00:00

abstract：:Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) ...

journal_title：Immunogenetics

authors： Bacon LD,Polley CR,Cole RK,Rose NR

更新日期：1981-01-01 00:00:00

abstract：:We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequ...

journal_title：Immunogenetics

authors： Kaufman J,Salomonsen J,Skjødt K

更新日期：1989-01-01 00:00:00

abstract：:Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...

journal_title：Immunogenetics

authors： Tartakovsky B,De Baetselier P,Segal S

更新日期：1980-01-01 00:00:00

abstract：:Codon bias and base composition in major histocompatibility complex (MHC) sequences have been studied for both class I and II loci in Homo sapiens and Pan troglodytes. There is low to moderate codon bias for the MHC of humans and chimpanzees. In the class I loci, the same level of moderate codon bias is seen for HLA-B...

journal_title：Immunogenetics

authors： McWeeney SK,Valdes AM

更新日期：1999-04-01 00:00:00

abstract：:Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological re...

journal_title：Immunogenetics

authors： Sette A,Sidney J

更新日期：1999-11-01 00:00:00

abstract：:Genes encoded by the major histocompatibility complex (MHC) play key roles in the vertebrate immune system. However, our understanding of the evolutionary processes and underlying genetic mechanisms shaping these genes is limited in many taxa, including amphibians, a group currently impacted by emerging infectious dis...

journal_title：Immunogenetics

authors： Kiemnec-Tyburczy KM,Richmond JQ,Savage AE,Zamudio KR

更新日期：2010-12-01 00:00:00

abstract：:The only avian major histocompatibility complex (Mhc) genes thus far identified are from species of the relatively small order of Galliformes, while by far the largest order of Passeriformes (songbirds), containing some 60% of extant bird species, has not been studied at all in this regard. The Galliformes emerged mor...

journal_title：Immunogenetics

authors： Vincek V,Klein D,Graser RT,Figueroa F,O'hUigin C,Klein J

更新日期：1995-01-01 00:00:00

abstract：:Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response leading to the rapid depletion of peripheral NK cells and lymphocytes. A critical...

journal_title：Immunogenetics

authors： Wauquier N,Padilla C,Becquart P,Leroy E,Vieillard V

更新日期：2010-12-01 00:00:00

abstract：:Stable cell surface presentation of HLA class I molecules requires active transport of antigenic peptides across the endoplasmic reticulum by products of two genes, TAP1 and TAP2, which map in the major histocompatibility complex class II region. Alleles of each gene are derived from a combination of variable sites at...

journal_title：Immunogenetics

authors： Carrington M,Colonna M,Spies T,Stephens JC,Mann DL

更新日期：1993-01-01 00:00:00

abstract：:The serological reactivities of HLA-A3, -B7, and -CW3 heavy chains associated with either mouse, bovine, or human beta-2-microglobulin (beta 2m) and expressed on the surface of transfected mouse fibroblasts were analyzed. All reactivities associated with one cluster (defined by monoclonal antibody W6/32) of antigenic ...

journal_title：Immunogenetics

authors： Ferrier P,Fontecilla-Camps JC,Bucchini D,Caillol DH,Jordan BR,Lemonnier FA

更新日期：1985-01-01 00:00:00

abstract：:The human leukocyte receptor complex (LRC) at Chromosome 19q13.4 encodes Ig superfamily proteins which regulate the function of various hematopoietic cell types. We investigated characteristics of the Ig-like transcript (ILT)/leukocyte Ig-like receptor (LIR) group of LRC genes in comparison with the other major LRC lo...

journal_title：Immunogenetics

authors： Young NT,Canavez F,Uhrberg M,Shum BP,Parham P

更新日期：2001-05-01 00:00:00

abstract：:The ability of NK cells to specifically recognize cells lacking expression of self-MHC class I molecules was discovered over 30 years ago. It provided the foundation for the "missing self" hypothesis. Research in the two past decades has contributed to a detailed understanding of the molecular mechanisms that determin...

journal_title：Immunogenetics

authors： Malmberg KJ,Sohlberg E,Goodridge JP,Ljunggren HG

更新日期：2017-08-01 00:00:00

abstract：:To search for host genes for resistance/susceptibility to cancer metastasis, mutation analysis was employed. Ten putative mutants of resistance to lymphoma EL4 and four putative mutants of resistance to sarcoma MCA/77-23 of C57BL/6J (B6) mice were produced. These mutants were designated S (for "survivor") mutants; the...

journal_title：Immunogenetics

authors： Egorov OS,Liu Y,Sargent EE,Drizlikh GI,Egorov IK

更新日期：1992-01-01 00:00:00

abstract：:In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...

journal_title：Immunogenetics

authors： Hollenbach JA,Nocedal I,Ladner MB,Single RM,Trachtenberg EA

更新日期：2012-10-01 00:00:00

abstract：:Mice bearing the H-2b haplotype are susceptible to the development of experimental autoimmune myasthenia gravis (EAMG), induced by acetylcholine receptor (AChR) autoimmunity. One of the genes influencing EAMG susceptibility has been mapped to the Ab locus of the major histocompatibility complex, and the A beta chain h...

journal_title：Immunogenetics

authors： Christadoss P,David CS,Shenoy M,Keve S

更新日期：1990-01-01 00:00:00

abstract：:A segment comprising 307,078 nucleotides of the pig major histocompatibility complex (SLA) was completely sequenced. The segment corresponded to the entire SLA classical class I-containing region of the serologically defined SLA H01 haplotype. In all, 11 genes were characterized, comprising 7 class I genes located on ...

journal_title：Immunogenetics

authors： Renard C,Vaiman M,Chiannilkulchai N,Cattolico L,Robert C,Chardon P

更新日期：2001-08-01 00:00:00

abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

journal_title：Immunogenetics

authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

更新日期：2006-08-01 00:00:00

abstract：:Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...

journal_title：Immunogenetics

authors： Herrmann-Hoesing LM,White SN,Kappmeyer LS,Herndon DR,Knowles DP

更新日期：2008-04-01 00:00:00

abstract：:Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccharomyces cerevisiae, Dictyostelium discoideum, and Drosophila melanogaster, and ...

journal_title：Immunogenetics

authors： Pruvot B,Laurens V,Salvadori F,Solary E,Pichon L,Chluba J

更新日期：2010-10-01 00:00:00

abstract：:Using mouse bone marrow-derived macrophages we determined the role of interferon (IFN)-gamma at the different steps in expression of the I-A alpha chain of MHC class II molecules, from transcription to the cell surface. Levels of transcription, RNA, and protein were low in cells not stimulated with IFN-gamma. Treatmen...

journal_title：Immunogenetics

authors： Cullell-Young M,Barrachina M,López-López C,Goñalons E,Lloberas J,Soler C,Celada A

更新日期：2001-03-01 00:00:00

abstract：:Probes for loci situated near one end of the proximal (Tcp-1) and distal (Qa-2, 3) inversions of the mouse t complex have been hybridized to chromosomes of mice with and without t complexes and with morphologically distinguishable chromosome 17s. Both the probe for Tcp-1 and that for Qa-2, 3 hybridized to clearly diff...

journal_title：Immunogenetics

authors： Lyon MF,Zenthon J,Evans EP,Burtenshaw MD,Willison KR

更新日期：1988-01-01 00:00:00

abstract：:The structure of the DRB1*03 gene has been interpreted as the product of a gene conversion event involving a DRB3 gene as donor and resulting in the introduction of two short segments of the DRB3 sequence into the DRB1 locus. The serological counterpart of this double insertion is the TR81 specificity. Consequently, t...

journal_title：Immunogenetics

authors： Sorrentino R,Iannicola C,Botti S,Costanzi S,Tanigaki N,Tosi R

更新日期：1989-01-01 00:00:00

abstract：:Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...

journal_title：Immunogenetics

authors： Pilarski LM,Wegmann TG

更新日期：1984-01-01 00:00:00

abstract：:In order to further our understanding of major histocompatibility complex (MHC) class I gene organization, we began a comparative analysis of the large scale organization of the class I region in diverse haplotypes. For these studies, the MHC in healthy Japanese donors who have the predominant MHC haplotypes and/or HL...

journal_title：Immunogenetics

authors： Watanabe Y,Tokunaga K,Geraghty DE,Tadokoro K,Juji T

更新日期：1997-01-01 00:00:00