From transcription to cell surface expression, the induction of MHC class II I-A alpha by interferon-gamma in macrophages is regulated at different levels.

abstract：:Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles w...

journal_title：Immunogenetics

authors： Hill A,Takiguchi M,McMichael A

更新日期：1993-01-01 00:00:00

abstract：:Monoclonal antibodies reacting with TL-like class I antigens expressed on the surface of human thymocytes and some T leukemia lines were found to define three independent epitopic clusters, two of which could be shown to reside on serologically distinct molecular subsets by a solid-phase radioimmunoassay as well as by...

journal_title：Immunogenetics

authors： Olive D,Dubreuil P,Mawas C

更新日期：1984-01-01 00:00:00

abstract：:Immunoglobulin E (IgE) provides important information on the humoral immune status, and the IgE level is routinely detected in clinical practice. There are many diseases associated with IgE, such as atopic disease, autoimmune diseases, and so on. IgE is a genetically complex trait, but comprehensive genetic assessment...

journal_title：Immunogenetics

authors： Liao M,Shi D,Wang Y,Zhang K,Chen X,Gao Y,Tan A,Xuan Q,Yang X,Hu Y,Qin X,Zhang H,Mo Z

更新日期：2013-08-01 00:00:00

abstract：:Recombinant inbred strains were used to demonstrate the existence of a major locus on chromosome 1, designated Sap, which controls the endogenous concentration of the mouse acute phase reactant, serum amyloid P-component (SAP). Levels of SAP were associated with alleles at the Ly-9 locus in two sets of RI strains: BXD...

journal_title：Immunogenetics

authors： Mortensen RF,Le PT,Taylor BA

更新日期：1985-01-01 00:00:00

abstract：:We report here the structure of cDNA clones encoding axolotl light chains of the lambda type. A single IGLC gene and eight different potential IGLV genes belonging to four different families were detected. The axolotl Cgamma domain has several residues or stretches of residues that are typically conserved in mammalian...

journal_title：Immunogenetics

authors： André S,Guillet F,Charlemagne J,Fellah JS

更新日期：2000-11-01 00:00:00

abstract：:We cloned the cDNAs and genes of two different types of toll-like receptors from Japanese flounder. The results of homology searches suggested that these genes (designated JF-TLR2 and JF-TLR22) are homologues of human TLR2 and fugu TLR22, respectively. The cDNAs of JF-TLR2 and JF-TLR22 encoded 818 and 961 amino acid r...

journal_title：Immunogenetics

authors： Hirono I,Takami M,Miyata M,Miyazaki T,Han HJ,Takano T,Endo M,Aoki T

更新日期：2004-04-01 00:00:00

abstract：:The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The nucleotide sequence...

journal_title：Immunogenetics

authors： Isono T,Isegawa Y,Seto A

更新日期：1994-01-01 00:00:00

abstract：:An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...

journal_title：Immunogenetics

authors： Eardley DD,Murphy DB,Kemp JD,Shen FW,Cantor H,Gershon RK

更新日期：1980-01-01 00:00:00

abstract：:Almost 10,000 single nucleotide polymorphisms (SNPs) had been identified in the RT1 complex, the major histocompatibility complex of the rat, but less than approximately 0.5% have been characterized. In the context of the incomplete characterization of most SNPs, simple sequence length polymorphism (SSLP) marker devel...

journal_title：Immunogenetics

authors： Takagi Y,Kuramoto T,Voigt B,Tsurumi T,Nakanishi S,Mashimo T,Masui N,Serikawa T

更新日期：2009-03-01 00:00:00

abstract：:Eleven new C4d genomic primate sequences of the fourth complement factor (C4) have been obtained. Seven of them belong to five species not yet explored for this gene: Pan paniscus (pygmy chimpanzee), Cercopithecus aethiops (green monkey), Macaca mulatta (rhesus monkey), Macaca fascicularis (cynomolgus), and Saguinus o...

journal_title：Immunogenetics

authors： Paz-Artal E,Corell A,Alvarez M,Varela P,Allende L,Madroño A,Rosal M,Arnaiz-Villena A

更新日期：1994-01-01 00:00:00

abstract：:T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...

journal_title：Immunogenetics

authors： Li J,Li J,You Y,Chen S

更新日期：2012-05-01 00:00:00

abstract：:Cytotoxic CD8+ T-cell immunosurveillance for intracellular pathogens, such as viruses, is controlled by classical major histocompatibility complex (MHC) class Ia molecules, and ideally, these antiviral T-cell populations are defined by the specific peptide and restricting MHC allele. Surprisingly, despite the utility ...

journal_title：Immunogenetics

authors： Holmes JC,Holmer SG,Ross P,Buntzman AS,Frelinger JA,Hess PR

更新日期：2013-09-01 00:00:00

abstract：:IgM and IgD genes of the Japanese flounder were cloned and characterized from a genomic bacterial artificial chromosome (BAC) library. The micro gene contained four constant region exons (Cmi1-Cmi4), and two transmembrane exons (miTM1 and miTM2), which conforms to the organizational pattern of all other vertebrate mic...

journal_title：Immunogenetics

authors： Srisapoome P,Ohira T,Hirono I,Aoki T

更新日期：2004-07-01 00:00:00

abstract：:We report on the analyses of genes encoding immunoglobulin heavy and light chains in the rabbit 6.51× whole genome assembly. This OryCun2.0 assembly confirms previous mapping of the duplicated IGK1 and IGK2 loci to chromosome 2 and the IGL lambda light chain locus to chromosome 21. The most frequently rearranged and e...

journal_title：Immunogenetics

authors： Gertz EM,Schäffer AA,Agarwala R,Bonnet-Garnier A,Rogel-Gaillard C,Hayes H,Mage RG

更新日期：2013-10-01 00:00:00

abstract：:Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccharomyces cerevisiae, Dictyostelium discoideum, and Drosophila melanogaster, and ...

journal_title：Immunogenetics

authors： Pruvot B,Laurens V,Salvadori F,Solary E,Pichon L,Chluba J

更新日期：2010-10-01 00:00:00

abstract：:The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequences showed the expected evolutionary...

journal_title：Immunogenetics

authors： Grossberger D,Parham P

更新日期：1992-01-01 00:00:00

abstract：:The H-2K glycoprotein from the MHC mutant bm10 was analyzed biochemically to determine where primary structural differences distinguished it from the parental standard molecule, Kb. Comparative peptide maps showed differences in two peptides known to be part of the parental CNBr fragment spanning amino acids 139 to 22...

journal_title：Immunogenetics

authors： Pease LR,Ewenstein BM,McGovern D,Melvold RW,Nisizawa T,Nathenson SG

更新日期：1983-01-01 00:00:00

abstract：:In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...

journal_title：Immunogenetics

authors： Bade-Doeding C,Elsner HA,Eiz-Vesper B,Seltsam A,Holtkamp U,Blasczyk R

更新日期：2004-05-01 00:00:00

abstract：:We studied the relationship between human leukocyte antigen (HLA) class I alleles and cervical cancer among Indian women. Seventy-five cervical cancer cases were compared with 175 noncancer controls. Cervical biopsy tissue specimen from cancer cases and cervical swab specimen from controls were collected for HPV detec...

journal_title：Immunogenetics

authors： Gokhale P,Mania-Pramanik J,Sonawani A,Idicula-Thomas S,Kerkar S,Tongaonkar H,Chaudhari H,Warke H,Salvi V

更新日期：2014-12-01 00:00:00

abstract：:Retinoid X receptors (RXRs) are zinc finger-containing nuclear transcription factors. They belong to the nuclear receptor superfamily that contains retinoid receptors, vitamin D receptors, thyroid hormone receptors, and steroid hormone receptors as well as the so-called orphan receptors. We previously mapped all three...

journal_title：Immunogenetics

authors： Nagata T,Weiss EH,Abe K,Kitagawa K,Ando A,Yara-Kikuti Y,Seldin MF,Ozato K,Inoko H,Taketo M

更新日期：1995-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a common disease of the central nervous system characterized by myelin loss and progressive neurological dysfunction. An underlying genetic susceptibility plays a clear role in the etiology of MS, likely acting in concert with an undefined environmental exposure. Full-genome screenings in mu...

journal_title：Immunogenetics

authors： Barcellos LF,Schito AM,Rimmler JB,Vittinghoff E,Shih A,Lincoln R,Callier S,Elkins MK,Goodkin DE,Haines JL,Pericak-Vance MA,Hauser SL,Oksenberg JR

更新日期：2000-04-01 00:00:00

abstract：:We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitt...

journal_title：Immunogenetics

authors： Webber LM,Garson OM,Tate B,McKenzie IF,Hogarth PM

更新日期：1990-01-01 00:00:00

abstract：:The mouse Fcgr1 gene encoding the high-affinity IgG receptor (FcgammaRI) exists as two known alleles, FcgammaRI-BALB and FcgammaRI-NOD, and these alleles exhibit functional differences. To determine whether other alleles exist in mouse strains, Fcgr1 coding regions from 35 strains of mice were sequenced and a further ...

journal_title：Immunogenetics

authors： Gavin AL,Leiter EH,Hogarth PM

更新日期：2000-03-01 00:00:00

abstract：:Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] wa...

journal_title：Immunogenetics

authors： Racila E,Racila DM,Ritchie JM,Taylor C,Dahle C,Weiner GJ

更新日期：2006-02-01 00:00:00

abstract：:Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes ar...

journal_title：Immunogenetics

authors： de Groot NG,Heijmans CM,de Ru AH,Hassan C,Otting N,Doxiadis GG,Koning F,van Veelen PA,Bontrop RE

更新日期：2013-12-01 00:00:00

abstract：:Mouse leukosialin, previously known as the 3E8 antigen, is expressed primarily on cells of the hematopoietic and lymphoid lineages and is shown to be the mouse homologue to the human leukosialin/sialophorin and rat W3/13 molecules. A partial leukosialin cDNA clone was isolated via cross-species hybridization with a po...

journal_title：Immunogenetics

authors： Baecher CM,Dorfman KS,Mattei MG,Frelinger JG

更新日期：1990-01-01 00:00:00

abstract：:To search for host genes for resistance/susceptibility to cancer metastasis, mutation analysis was employed. Ten putative mutants of resistance to lymphoma EL4 and four putative mutants of resistance to sarcoma MCA/77-23 of C57BL/6J (B6) mice were produced. These mutants were designated S (for "survivor") mutants; the...

journal_title：Immunogenetics

authors： Egorov OS,Liu Y,Sargent EE,Drizlikh GI,Egorov IK

更新日期：1992-01-01 00:00:00

abstract：:Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, a...

journal_title：Immunogenetics

authors： Ballingall KT,Waibochi L,Holmes EC,Woelk CH,MacHugh ND,Lutje V,McKeever DJ

更新日期：2001-01-01 00:00:00

abstract：:Natural resistance-associated macrophage protein 1 (NRAMP1) has an important role in regulating macrophage functions that affect innate resistance as well as immune responses. We analyzed the microsatellite polymorphism in the promoter region of the human NRAMP1 gene in 206 type 1 diabetes patients and 200 normal chil...

journal_title：Immunogenetics

authors： Bassuny WM,Ihara K,Matsuura N,Ahmed S,Kohno H,Kuromaru R,Miyako K,Hara T

更新日期：2002-07-01 00:00:00

abstract：:The MHC class I gene family of rhesus macaques is characterised by considerable gene duplications. While a HLA-C-orthologous gene is absent, the Mamu-A and in particular the Mamu-B genes have expanded, giving rise to plastic haplotypes with differential gene content. Although some of the rhesus macaque MHC class I gen...

journal_title：Immunogenetics

authors： Rosner C,Kruse PH,Lübke T,Walter L

更新日期：2010-03-01 00:00:00