Abstract:
:An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percent of Ly-1 or Ly-1,2 T cells are killed by anti-I-J plus complement treatment, the I-J determinant demarcates functionally distinct subsets of both the Ly-1 and Ly-1,2 T-cell sets. This I-J determinant is not expressed on a detectable number of Ly-1 helper T cells which induce B lymphocytes to produce anti-sheep red cell antibody in tissue culture.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Eardley DD,Murphy DB,Kemp JD,Shen FW,Cantor H,Gershon RKdoi
10.1007/BF01567824subject
Has Abstractpub_date
1980-01-01 00:00:00pages
549-57issue
6eissn
0093-7711issn
1432-1211journal_volume
11pub_type
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