Evolution of immunoglobulin heavy chain variable region genes: a VH family can last for 150-200 million years or longer.

abstract：:Mouse leukosialin, previously known as the 3E8 antigen, is expressed primarily on cells of the hematopoietic and lymphoid lineages and is shown to be the mouse homologue to the human leukosialin/sialophorin and rat W3/13 molecules. A partial leukosialin cDNA clone was isolated via cross-species hybridization with a po...

journal_title：Immunogenetics

authors： Baecher CM,Dorfman KS,Mattei MG,Frelinger JG

更新日期：1990-01-01 00:00:00

abstract：:The characterization of genes involved in the generation of the immune repertoire is an active area of research in lower vertebrate taxa. The recombination activating genes (RAG) have been shown to be essential for V (D) J recombination of T-cell antigen receptor (TCR) and immunoglobulin (Ig) genes, leading to the gen...

journal_title：Immunogenetics

authors： Hansen JD,Kaattari SL

更新日期：1995-01-01 00:00:00

abstract：:Recent genome-wide association studies (GWAs) have identified several new genetic risk factors for asthma; however, their influence on disease behavior and treatment response is still unclear. The aim of our study was the association analysis of the most significant single nucleotide polymorphisms (SNPs) recently repo...

journal_title：Immunogenetics

authors： Perin P,Potočnik U

更新日期：2014-03-01 00:00:00

abstract：:TAP1 and TAP2 are two major histocompatibility complex (MHC) genes, located between HLA-DP and -DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in both genes and, in this study, we have identified another polymorphic site within the ade...

journal_title：Immunogenetics

authors： Powis SH,Tonks S,Mockridge I,Kelly AP,Bodmer JG,Trowsdale J

更新日期：1993-01-01 00:00:00

abstract：:Several lines of evidence have confirmed the importance of Nod2 mutations for disease susceptibility in Crohn's disease. For tracing Nod2 evolution, exons 4a, 4e, 8, and 12 mutations were screened in a collection of 1,064 DNA samples from 52 worldwide populations. The overall allele frequency was 7.5% for single nucle...

journal_title：Immunogenetics

authors： Gasche C,Nemeth M,Grundtner P,Willheim-Polli C,Ferenci P,Schwarzenbacher R

更新日期：2008-02-01 00:00:00

abstract：:The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity. Epidemiological studies described associations between single nucleotide polymorphisms (SNPs) of the human gene coding surfactant protein-D (SFTPD) and infectious pulmonary diseases. Studies on twins indicated very strong genetic de...

journal_title：Immunogenetics

authors： Heidinger K,König IR,Bohnert A,Kleinsteiber A,Hilgendorff A,Gortner L,Ziegler A,Chakraborty T,Bein G

更新日期：2005-04-01 00:00:00

abstract：:Genetically anemic W/Wv mice and lethally irradiated wild-type mice were cured and populated by grafted marrow cells from donor mice of three congenic lines that differed at non-H-2 histocompatibility loci. Tail skin from mice of the same congenic lines was grafted 3-4 weeks later. In two cases, the recipients behaved...

journal_title：Immunogenetics

authors： Harrison DE,Mobraaten LE

更新日期：1984-01-01 00:00:00

abstract：:In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...

journal_title：Immunogenetics

authors： Hollenbach JA,Nocedal I,Ladner MB,Single RM,Trachtenberg EA

更新日期：2012-10-01 00:00:00

abstract：:Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...

journal_title：Immunogenetics

authors： Schwienbacher C,De Grandi A,Fuchsberger C,Facheris MF,Svaldi M,Wjst M,Pramstaller PP,Hicks AA

更新日期：2010-08-01 00:00:00

abstract：:Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...

journal_title：Immunogenetics

authors： Zhang J,Goto RM,Miller MM

更新日期：2020-07-01 00:00:00

abstract：:Alignment of class I-hybridizing cosmids from an R21 (AlBlDlEugrc+) genomic DNA library gave two contigs: one [150 kilobases (kb)] encompassed the E/C region, or a large part thereof, and the other (110 kb) contained the grc region which has genes influencing resistance to chemical carcinogens (rcc), fertility (ft), a...

journal_title：Immunogenetics

authors： Yuan XJ,Salgar SK,Hassett AL,McHugh KP,Kunz HW,Gill TJ 3rd

更新日期：1996-01-01 00:00:00

abstract：:Dendritic cells (DC) are specialist antigen presenting cells which capture antigens in the periphery, migrate centrally, and present the processed antigens in the context of major histocompatibility complex and appropriate co-stimulatory molecules to T lymphocytes for the initiation of an immune response. DEC-205 has ...

journal_title：Immunogenetics

authors： Kato M,Neil TK,Clark GJ,Morris CM,Sorg RV,Hart DN

更新日期：1998-05-01 00:00:00

abstract：:A contribution of allelic variation of T-cell receptor (Tcr) genes to the immune response has not been studied. Here we report that the presence of insertion-deletion-related polymorphisms (IDRP) of the Tcr beta chain (Tcrb) can be utilized to distinguish the parental origin of the gene complex that undergoes rearrang...

journal_title：Immunogenetics

authors： Seboun E,Joshi N,Hauser SL

更新日期：1992-01-01 00:00:00

abstract：:T cell receptor genes are assembled in developing T lymphocytes from discrete V, D, and J genes by a site-specific somatic rearrangement mechanism. A flanking recombination signal, composed of a conserved heptamer and a semiconserved nonamer separated by 12 or 23 variable nucleotides, targets the activity of the rearr...

journal_title：Immunogenetics

authors： Touvrey C,Cowell LG,Lieberman AE,Marche PN,Jouvin-Marche E,Candéias SM

更新日期：2006-11-01 00:00:00

abstract：:We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequ...

journal_title：Immunogenetics

authors： Kaufman J,Salomonsen J,Skjødt K

更新日期：1989-01-01 00:00:00

abstract：:The mouse Fcgr1 gene encoding the high-affinity IgG receptor (FcgammaRI) exists as two known alleles, FcgammaRI-BALB and FcgammaRI-NOD, and these alleles exhibit functional differences. To determine whether other alleles exist in mouse strains, Fcgr1 coding regions from 35 strains of mice were sequenced and a further ...

journal_title：Immunogenetics

authors： Gavin AL,Leiter EH,Hogarth PM

更新日期：2000-03-01 00:00:00

abstract：:The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus, HERV-K(C4). Nearly i...

journal_title：Immunogenetics

authors： Dangel AW,Mendoza AR,Baker BJ,Daniel CM,Carroll MC,Wu LC,Yu CY

更新日期：1994-01-01 00:00:00

abstract：:The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...

journal_title：Immunogenetics

authors： Mehta IK,Wang J,Roland J,Margulies DH,Yokoyama WM

更新日期：2001-09-01 00:00:00

abstract：:Codon bias and base composition in major histocompatibility complex (MHC) sequences have been studied for both class I and II loci in Homo sapiens and Pan troglodytes. There is low to moderate codon bias for the MHC of humans and chimpanzees. In the class I loci, the same level of moderate codon bias is seen for HLA-B...

journal_title：Immunogenetics

authors： McWeeney SK,Valdes AM

更新日期：1999-04-01 00:00:00

abstract：:Nova Scotia duck tolling retrievers are predisposed to a SLE-related disease complex including immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). IMRD involves symptoms that resemble those seen in systemic autoimmune rheumatic diseases, such as systemic lupus erythematosus, SL...

journal_title：Immunogenetics

authors： Wilbe M,Jokinen P,Hermanrud C,Kennedy LJ,Strandberg E,Hansson-Hamlin H,Lohi H,Andersson G

更新日期：2009-08-01 00:00:00

abstract：:The human Lutheran (Lu) blood group antigens are carried by two glycoproteins (gps) that belong to the immunoglobulin (Ig) superfamily. These gps represent adhesion molecules that function as the unique erythroid receptors for laminin. We report here the cloning and functional expression of the orthologous mouse Lu mR...

journal_title：Immunogenetics

authors： Rahuel C,Colin Y,Goossens D,Gane P,El Nemer W,Cartron JP,Le Van Kim C

更新日期：1999-12-01 00:00:00

abstract：:The immune systems of all mammals include populations of B cells producing antibodies with incredibly diverse specificities. Repertoire diversity has been described as the "miracle of immunology," and it was long thought to be the result of essentially stochastic processes. Recently, however, analysis of high throughp...

journal_title：Immunogenetics

authors： Collins AM,Jackson KJL

更新日期：2018-03-01 00:00:00

abstract：:An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...

journal_title：Immunogenetics

authors： Eardley DD,Murphy DB,Kemp JD,Shen FW,Cantor H,Gershon RK

更新日期：1980-01-01 00:00:00

abstract：:The interaction of bacterial pathogens with their hosts' innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate im...

journal_title：Immunogenetics

authors： Persson J,Vance RE

更新日期：2007-10-01 00:00:00

abstract：:MHC class II deficiency provokes a severe immunodeficiency characterized by a lack of antigen-specific immune response. In the absence of bone marrow transplantation (the only curative treatment), patients affected by this genetic recessive disease die in early childhood. However, others and we have recently described...

journal_title：Immunogenetics

authors： Prod'homme T,Dekel B,Barbieri G,Lisowska-Grospierre B,Katz R,Charron D,Alcaide-Loridan C,Pollack S

更新日期：2003-11-01 00:00:00

abstract：:Immunogenicity for T cell-independent B-cell response assessed by splenic plaque-forming cell (PFC) response and cell-surface expression measured by laser flow cytometry of various class I H-2 antigens on mouse red blood cells (RBC) were compared. It was found that the order of magnitude of both immunogenicity and cel...

journal_title：Immunogenetics

authors： Nakashima I,Yoshida T,Yokochi T,Ohashi K,Nagase F,Isobe K,Hasegawa Y,Ando K,Inagi R

更新日期：1986-01-01 00:00:00

abstract：:One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...

journal_title：Immunogenetics

authors： D'Hoostelaere LA,Gibson DM

更新日期：1986-01-01 00:00:00

abstract：:TL antigens are class I glycoproteins which are expressed on thymocytes and which are coded by the Tla region of the major histocompatibility complex of the mouse. Biochemical analysis of TL molecules from different strains of mice revealed structural variation determined by the Tla region which is detectable by pepti...

journal_title：Immunogenetics

authors： Michaelson J,Boyse EA,Ciccia L,Flaherty L,Fleissner E,Garnick E,Hämmerling U,Lawrence M,Mauch P,Shen FW

更新日期：1986-01-01 00:00:00

abstract：:Footpad swelling response was used to measure the alloantigenicity of epidermal cells (ECs) in delayed-type hypersensitivity (DTH). Strong footpad swelling was observed 3 h after the challenge, and it continued for 48 h after the challenge. Genetical incompatibility between the recipients and the ECs was required to i...

journal_title：Immunogenetics

authors： Ishii N,Nakajima H,Aoki I,Ishii T,Takahashi T,Okuda K

更新日期：1986-01-01 00:00:00

abstract：:To determine the nucleotide polymorphism of activating killer-cell immunoglobulin-like receptors (aKIR) 3DS1 and 2DS3, we developed a novel direct-sequencing method and analyzed DNA samples of 175 KIR3DS1(+) individuals and 72 KIR2DS3(+) individuals from the white population. The putative ligand-binding extracellular ...

journal_title：Immunogenetics

authors： Luo L,Du Z,Sharma SK,Cullen R,Spellman S,Reed EF,Rajalingam R

更新日期：2007-10-01 00:00:00