Abstract:
:In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Comparison of KIR data with that from other genomic regions allows control for strictly demographic factors; over 500,000 additional genomic markers have been typed in this panel by other investigators and the data made publicly available. Presence/absence frequencies and haplotypic associations for the KIR region are analyzed in the 52 populations comprising the panel and in accordance with major world regions (Africa, Middle East, Central Asia, East Asia, Europe, Americas, and Oceania). These data represent the first overview of KIR population genetics in the well-documented HGDP-CEPH panel and suggest different evolutionary histories and recent selection in the KIR gene cluster.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Hollenbach JA,Nocedal I,Ladner MB,Single RM,Trachtenberg EAdoi
10.1007/s00251-012-0629-xsubject
Has Abstractpub_date
2012-10-01 00:00:00pages
719-37issue
10eissn
0093-7711issn
1432-1211journal_volume
64pub_type
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