Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2.

abstract：:The immune systems of all mammals include populations of B cells producing antibodies with incredibly diverse specificities. Repertoire diversity has been described as the "miracle of immunology," and it was long thought to be the result of essentially stochastic processes. Recently, however, analysis of high throughp...

journal_title：Immunogenetics

authors： Collins AM,Jackson KJL

更新日期：2018-03-01 00:00:00

abstract：:By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynom...

journal_title：Immunogenetics

authors： Uda A,Tanabayashi K,Fujita O,Hotta A,Terao K,Yamada A

更新日期：2005-05-01 00:00:00

abstract：:Recurrent pregnancy loss (RPL) is a common problem during early gestation. The aim of our study was to investigate the association of IL-17 F( rs763780), IL-17 A (rs2275913), and leptin (2548 G/A) gene polymorphisms with RPL in obese and lean Egyptian females, and to find out whether these gene polymorphisms affect th...

journal_title：Immunogenetics

authors： Zidan HE,Rezk NA,Alnemr AA,Moniem MI

更新日期：2015-11-01 00:00:00

abstract：:Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-1...

journal_title：Immunogenetics

authors： Gröndahl-Yli-Hannuksela K,Vahlberg T,Ilonen J,Mertsola J,He Q

更新日期：2016-10-01 00:00:00

abstract：:The T- and B-cell surface polypeptides detected by an international workshop panel of 100 mouse monoclonal antibodies (M.Ab) were biochemically defined by radioimmunoprecipitation. Eight T-cell-associated molecules and eight B-cell-associated molecules were identified by multiple antibodies in the panel. Clusters of a...

journal_title：Immunogenetics

authors： Clark EA,Martin PJ,Hansen JA,Ledbetter JA

更新日期：1983-01-01 00:00:00

abstract：:Several lines of evidence have confirmed the importance of Nod2 mutations for disease susceptibility in Crohn's disease. For tracing Nod2 evolution, exons 4a, 4e, 8, and 12 mutations were screened in a collection of 1,064 DNA samples from 52 worldwide populations. The overall allele frequency was 7.5% for single nucle...

journal_title：Immunogenetics

authors： Gasche C,Nemeth M,Grundtner P,Willheim-Polli C,Ferenci P,Schwarzenbacher R

更新日期：2008-02-01 00:00:00

abstract：:Recombinant inbred strains were used to demonstrate the existence of a major locus on chromosome 1, designated Sap, which controls the endogenous concentration of the mouse acute phase reactant, serum amyloid P-component (SAP). Levels of SAP were associated with alleles at the Ly-9 locus in two sets of RI strains: BXD...

journal_title：Immunogenetics

authors： Mortensen RF,Le PT,Taylor BA

更新日期：1985-01-01 00:00:00

abstract：:MHC genes are key components in disease resistance and an excellent system for studying selection acting on genetic variation in natural populations. Current patterns of variation in MHC genes are likely to be influenced by past and ongoing selection as well as demographic fluctuations in population size such as those...

journal_title：Immunogenetics

authors： Cortázar-Chinarro M,Meyer-Lucht Y,Laurila A,Höglund J

更新日期：2018-07-01 00:00:00

abstract：:Rh and its homologous Rh50 gene products are considered to form heterotetramers on erythrocyte membranes. Rh protein has Rh blood group antigen sites, while Rh50 protein does not, and is more conserved than Rh protein. We previously determined both Rh and Rh50 gene cDNA coding regions from mouse and rat, and carried o...

journal_title：Immunogenetics

authors： Kitano T,Saitou N

更新日期：2000-08-01 00:00:00

abstract：:The human major histocompatibility complex (MHC) is located within a 4 megabase segment on chromosome 6p21.3. Recently, a highly divergent MHC class I chain-related gene family, MIC was identified within the class I region. The MICA and MICB genes in this family have unique patterns of tissue expression. The MICA gene...

journal_title：Immunogenetics

authors： Ando H,Mizuki N,Ota M,Yamazaki M,Ohno S,Goto K,Miyata Y,Wakisaka K,Bahram S,Inoko H

更新日期：1997-01-01 00:00:00

abstract：:The potential value of in vitro cytotoxic T lymphocyte (CTL) assays for predicting the occurrence of graft vs host disease (GVHD) following allogeneic bone marrow transplantation was evaluated in 12 mouse donor-host combinations associated with various degrees of GVHD. These donor-host combinations were selected after...

journal_title：Immunogenetics

authors： Fontaine P,Langlais J,Perreault C

更新日期：1991-01-01 00:00:00

abstract：:Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

journal_title：Immunogenetics

authors： Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

更新日期：1995-01-01 00:00:00

abstract：:The effect of the H-2dm1 mutation on Qa-m2 expression was examined. The mutant strain B10.D2-H-2dm1 showed a fourfold increase in Qa-m2 expression when compared with the parental strain B10.D2. Qa-m2 molecules immunoprecipitated from B10.D2-H-2dm1, C57BL/10, and B10.D2 spleen cells were identical by two-dimensional (2...

journal_title：Immunogenetics

authors： Hogarth PM,Walker ID,Rigby AJ,McKenzie IF

更新日期：1983-01-01 00:00:00

abstract：:A cDNA library screening using the conserved exon 4 of Atlantic salmon Mhc class I as probe provided the basis for a study on Mhc class I polymorphism in a breeding population. Twelve different alleles were identified in the 82 dams and sires studied. No individual expressed more than two alleles, which corresponded t...

journal_title：Immunogenetics

authors： Grimholt U,Drabløs F,Jørgensen SM,Høyheim B,Stet RJ

更新日期：2002-11-01 00:00:00

abstract：:A graft-vs-host reaction (GVHR) develops after major histocompatibility complex (MHC)-compatible bone marrow-transplantation. In the genetic combination studied, B10.D2 donor cells differed from those of (DBA/2 x B10.D2)F1 mice for multiple DBA/2 minor histocompatibility antigens (mHAg) and minor lymphocyte stimulatin...

journal_title：Immunogenetics

authors： Miconnet I,de la Selle V,Tucek C,Huchet R,Bonardelle D,Bruley-Rosset M

更新日期：1994-01-01 00:00:00

abstract：:Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has been implicated in population declines and species extinctions of amphibians around the world. Susceptibility to the disease varies both within and among species, most likely attributable to heritable immunogenetic variation. Anal...

journal_title：Immunogenetics

authors： Fu M,Waldman B

更新日期：2017-08-01 00:00:00

abstract：:Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gen...

journal_title：Immunogenetics

authors： Kikuchi T,Naruse TK,Onizuka M,Li S,Kimura T,Oka A,Morishima Y,Kulski JK,Ichimiya S,Sato N,Inoko H

更新日期：2007-02-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILR) are cell surface molecules that regulate the activities of myelomonocytic cells through the balance of inhibitory and activation signals. LILR genes are located within the leukocyte receptor complex (LRC) on chromosome 19q13.4 adjacent to KIR genes, which are subject to a...

journal_title：Immunogenetics

authors： López-Álvarez MR,Jones DC,Jiang W,Traherne JA,Trowsdale J

更新日期：2014-02-01 00:00:00

abstract：:We investigated the genetic control of heterotopic heart allograft rejection using a family of standard inbred, major histocompatibility complex (MHC)-congenic, and intra-MHC recombinant rat strains. Gene products of the various regions within the rat MHC differed markedly in their capacity to induce rejection. Isolat...

journal_title：Immunogenetics

authors： Klempnauer J,Steiniger B,Lück R,Günther E

更新日期：1989-01-01 00:00:00

abstract：:The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...

journal_title：Immunogenetics

authors： Mehta IK,Wang J,Roland J,Margulies DH,Yokoyama WM

更新日期：2001-09-01 00:00:00

abstract：:The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...

journal_title：Immunogenetics

authors： Easterfield AJ,Bradley JA,Bolton EM

更新日期：2003-08-01 00:00:00

abstract：:We have previously demonstrated a genetic predisposition among mice regarding their ability to be protected against vaginal candidiasis after peripheral immunization. Both BALB/c and (BALB/cx C57BL/6) F1 mice are protected against vaginal candidiasis after subcutaneous immunization with Candida albicans extract and C5...

journal_title：Immunogenetics

authors： Mulero-Marchese RD,Blank KJ,Sieck TG

更新日期：1999-10-01 00:00:00

abstract：:The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified with the canonical st...

journal_title：Immunogenetics

authors： Golub R,Fellah JS,Charlemagne J

更新日期：1997-01-01 00:00:00

abstract：:Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...

journal_title：Immunogenetics

authors： Schwienbacher C,De Grandi A,Fuchsberger C,Facheris MF,Svaldi M,Wjst M,Pramstaller PP,Hicks AA

更新日期：2010-08-01 00:00:00

abstract：:Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccharomyces cerevisiae, Dictyostelium discoideum, and Drosophila melanogaster, and ...

journal_title：Immunogenetics

authors： Pruvot B,Laurens V,Salvadori F,Solary E,Pichon L,Chluba J

更新日期：2010-10-01 00:00:00

abstract：:Mouse Ly6A and Ly6C cDNA probes were hybridized to total RNA of rat tissues and, as in mouse, the highest level of Ly6-related transcripts was detected in kidney. Therefore, Ly6-related cDNA clones were isolated from a commercial rat kidney cDNA library in lambda gt11. Four of these (RK3, RK6, RK10, and RK11) have bee...

journal_title：Immunogenetics

authors： Friedman S,Palfree RG,Sirlin S,Hämmerling U

更新日期：1990-01-01 00:00:00

abstract：:Analysis of a Japanese population by oligonucleotide genotyping revealed that one Japanese HLA-DRw14 allele had a DRB1 genotype different from that of the known HLA-DRw14-related alleles, DRB1*1401 (DRw14-Dw9) and DRB1*1402 (DRw14-Dw16). The second exon of the DRB1 gene of the novel DRw14 allele (designated DRB1-14c) ...

journal_title：Immunogenetics

authors： Obata F,Ito I,Ito K,Abe A,Ohkubo M,Onda K,Yang YG,Watanabe K,Kashiwagi N

更新日期：1990-01-01 00:00:00

abstract：:Polymorphic insertion frequencies of the retrotransposons known as the "SVA" elements were investigated at four loci in the MHC class I genomic region to determine their allele and haplotype frequencies and associations with the HLA-A, -B or -C genes for 100 Japanese, 100 African Americans, 174 Australian Caucasians a...

journal_title：Immunogenetics

authors： Kulski JK,Shigenari A,Inoko H

更新日期：2010-04-01 00:00:00

abstract：:The cell-surface expression of the class I alloantigen Qa-2 was analyzed on resting and activated spleen and thymus cells using cytotoxic elimination and immunofluorescence and flow cytometry. Spleen cells activated by mitogens or alloantigen were homogeneously positive for cell surface Qa-2, but activated splenic T c...

journal_title：Immunogenetics

authors： Rabinowitz R,Sharrow SO,Chatterjee-Das S,Rogers MJ,Sachs DH

更新日期：1986-01-01 00:00:00

abstract：:Because of the role major histocompatibility complex (MHC) class I b molecules may play during mouse embryonic development, we thought it would be interesting to search for additional MHC class I b molecules that might be expressed in preimplantation embryos, and in particular in the trophoblastic lineage. We therefor...

journal_title：Immunogenetics

authors： Sipes SL,Medaglia MV,Stabley DL,DeBruyn CS,Alden MS,Catenacci V,Landel CP

更新日期：1996-01-01 00:00:00