Tissue distribution and polymorphism of minor histocompatibility antigens involved in GVHR.

abstract：:Mice bearing the H-2b haplotype are susceptible to the development of experimental autoimmune myasthenia gravis (EAMG), induced by acetylcholine receptor (AChR) autoimmunity. One of the genes influencing EAMG susceptibility has been mapped to the Ab locus of the major histocompatibility complex, and the A beta chain h...

journal_title：Immunogenetics

authors： Christadoss P,David CS,Shenoy M,Keve S

更新日期：1990-01-01 00:00:00

abstract：:The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIA...

journal_title：Immunogenetics

authors： Schuler MM,Dönnes P,Nastke MD,Kohlbacher O,Rammensee HG,Stevanovic S

更新日期：2005-12-01 00:00:00

abstract：:Mouse leukosialin, previously known as the 3E8 antigen, is expressed primarily on cells of the hematopoietic and lymphoid lineages and is shown to be the mouse homologue to the human leukosialin/sialophorin and rat W3/13 molecules. A partial leukosialin cDNA clone was isolated via cross-species hybridization with a po...

journal_title：Immunogenetics

authors： Baecher CM,Dorfman KS,Mattei MG,Frelinger JG

更新日期：1990-01-01 00:00:00

abstract：:We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German origin. The phenotype frequency of the TNFB*1 allele was significantl...

journal_title：Immunogenetics

authors： Bettinotti MP,Hartung K,Deicher H,Messer G,Keller E,Weiss EH,Albert ED

更新日期：1993-01-01 00:00:00

abstract：:The Hawaiian monk seal population has experienced precipitous declines in the last 50 years. In this study, we provide evidence that individuals from remaining endangered population exhibit alarming uniformity in class I major histocompatibility (MHC) genes. The peripheral blood leukocyte-derived mRNA of six captive a...

journal_title：Immunogenetics

authors： Aldridge BM,Bowen L,Smith BR,Antonelis GA,Gulland F,Stott JL

更新日期：2006-04-01 00:00:00

abstract：:We report here the structure of cDNA clones encoding axolotl light chains of the lambda type. A single IGLC gene and eight different potential IGLV genes belonging to four different families were detected. The axolotl Cgamma domain has several residues or stretches of residues that are typically conserved in mammalian...

journal_title：Immunogenetics

authors： André S,Guillet F,Charlemagne J,Fellah JS

更新日期：2000-11-01 00:00:00

abstract：:The immune response of the rat to group A streptococcal carbohydrate (SACHO) and an associated idiotype, Id-1, was used to examine the effect of paternal immunity on Id-1 and SACHO-specific antibody expression by the offspring. First litters, conceived before immunization of the father, had significantly higher Id-1 l...

journal_title：Immunogenetics

authors： Cooper-Willis CA,Olson JC,Brewer ME,Leslie GA

更新日期：1985-01-01 00:00:00

abstract：:One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...

journal_title：Immunogenetics

authors： D'Hoostelaere LA,Gibson DM

更新日期：1986-01-01 00:00:00

abstract：:The inbred strain STS/A exhibits a higher proliferative response in the mixed lymphocyte culture (MLC) to stimulator cells of all 11 tested inbred mouse strains with 10 different major histocompatibility complex (MHC) haplotypes, as well as to stimulation with IL-2 than does the strain BALB/cHeA. However, alloantigen-...

journal_title：Immunogenetics

authors： Holán V,Lipoldová M,Demant P

更新日期：1996-01-01 00:00:00

abstract：:Natural killer (NK) cells express receptors for MHC class I that contain immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic domain. Whereas these receptors inhibit NK cell cytotoxicity, certain isoforms of these NK receptors (e.g., KIR2DS, CD94/NKG2C, and Ly49D) do not have ITIMs, but...

journal_title：Immunogenetics

authors： Yim D,Jie HB,Lanier LL,Kim YB

更新日期：2000-05-01 00:00:00

abstract：:Rh and its homologous Rh50 gene products are considered to form heterotetramers on erythrocyte membranes. Rh protein has Rh blood group antigen sites, while Rh50 protein does not, and is more conserved than Rh protein. We previously determined both Rh and Rh50 gene cDNA coding regions from mouse and rat, and carried o...

journal_title：Immunogenetics

authors： Kitano T,Saitou N

更新日期：2000-08-01 00:00:00

abstract：:Cathepsins are key mammalian proteases that play an important role in the immune response. Several studies have revealed the versatile and critical functions of cathepsins. Here, we obtained ten kinds of cathepsin homologs and identified seven homologs with complete coding sequences. Phylogenetic analysis verified the...

journal_title：Immunogenetics

authors： Wang D,Su P,Wang X,Liu K,Li C,Gao X,Lu J,Sun F,Li Q,Pang Y

更新日期：2019-05-01 00:00:00

abstract：:Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...

journal_title：Immunogenetics

authors： Schwienbacher C,De Grandi A,Fuchsberger C,Facheris MF,Svaldi M,Wjst M,Pramstaller PP,Hicks AA

更新日期：2010-08-01 00:00:00

abstract：:The ability of local ultraviolet B (UVB) irradiation to impair the induction of dinitrofluorobenzene (DNFB)-specific contact hypersensitivity (CH) in mice has been shown to be genetically determined. We have explored the possibility that the mouse Tnfa and Lps loci are involved. We demonstrate that C3H/HeN (Lpsn) stra...

journal_title：Immunogenetics

authors： Yoshikawa T,Streilein JW

更新日期：1990-01-01 00:00:00

abstract：:Genes encoding the horse (Equus caballus) T-cell receptor beta chain (TCRB) were cloned and characterized. Of 33 cDNA clones isolated from the mesenteric lymph node, 30 had functionally rearranged gene segments, and three contained germline sequences. Sixteen unique variable segments (TCRBV), 14 joining genes (TCRBJ),...

journal_title：Immunogenetics

authors： Schrenzel MD,Watson JL,Ferrick DA

更新日期：1994-01-01 00:00:00

abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

journal_title：Immunogenetics

authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

更新日期：2006-08-01 00:00:00

abstract：:In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...

journal_title：Immunogenetics

authors： Hollenbach JA,Nocedal I,Ladner MB,Single RM,Trachtenberg EA

更新日期：2012-10-01 00:00:00

abstract：:Knowledge about the magnitude of individual polymorphism is a critical part in understanding the complexity of comprehensive mismatching. HLA-B*44:09 differs from the highly frequent HLA-B*44:02 allele by amino acid exchanges at residues 77, 80, 81, 82 and 83. We aimed to identify the magnitude of these mismatches on ...

journal_title：Immunogenetics

authors： Huyton T,Schumacher H,Blasczyk R,Bade-Doeding C

更新日期：2012-09-01 00:00:00

abstract：:Endemic pemphigus foliaceus (EPF), is an autoimmune disease associated with production of IgG antibodies against epidermal antigens. We have tested 38 patients and 50 control subjects living in endemic areas to investigate whether HLA genes are associated with host factors that determine whether or not exposed individ...

journal_title：Immunogenetics

authors： Moraes JR,Moraes ME,Fernandez-Vina M,Diaz LA,Friedman H,Campbell IT,Alvarez RR,Sampaio SA,Rivitti EA,Stastny P

更新日期：1991-01-01 00:00:00

abstract：:We analyzed the genetic regulation of spontaneous autoimmune thyroiditis (SAT) by means of crosses between Obese strain (OS) chickens with the disease, and healthy inbred chicken of line CB. Mononuclear cell infiltration of the thyroid was used as a criterion for the disease. We confirmed the existence of one recessiv...

journal_title：Immunogenetics

authors： Vasícek D,Vasícková K,Kaiser P,Drozenová R,Cítek J,Hala K

更新日期：2001-12-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I-related molecule, MR1, presents vitamin B metabolites from bacteria and yeast to mucosal-associated invariant T (MAIT) cells. Despite the evolutionary conservation of MR1, we do not know whether different allele variants of MR1 exist within the nonhuman primate (NHP) ...

journal_title：Immunogenetics

authors： Ellis-Connell AL,Kannal NM,Balgeman AJ,O'Connor SL

更新日期：2019-02-01 00:00:00

abstract：:Mouse lymphocyte alloantigens Ly-19 and Ly-32 are controlled by the genes tightly linked to the Lyb-2 locus on chromosome 4. Despite the similarity in mouse strain distribution patterns, Ly-19 and Ly-32 antigens which have been detected on both B- and T-cell lineages are distinct from Lyb-2 antigen whose expression is...

journal_title：Immunogenetics

authors： Nakamura S,Ikegami S,Dairiki K,Kochiya M,Fujimori T,Tamaoki N,Tada N

更新日期：1988-01-01 00:00:00

abstract：:Although major histocompatibility complex (MHC) class I molecules are, as a rule, highly polymorphic in mammalian species, those of the New World primate Saguinus oedipus (cotton-top tamarin) exhibit limited polymorphism. We have cloned and sequenced twelve MHC class I cDNAs from this species. Since cloned cotton-top ...

journal_title：Immunogenetics

authors： Watkins DI,Garber TL,Chen ZW,Toukatly G,Hughes AL,Letvin NL

更新日期：1991-01-01 00:00:00

abstract：:Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates predictions of proteaso...

journal_title：Immunogenetics

authors： Stranzl T,Larsen MV,Lundegaard C,Nielsen M

更新日期：2010-06-01 00:00:00

abstract：:Killer cell immunoglobulin-like receptors (KIRs) represent the most polymorphic genes responsible for natural killer cell function, while human leukocyte antigen (HLA) class I molecules define and restrict cytotoxic T lymphocyte responses. Specific KIR, HLA, or KIR-HLA combinations have been implicated in the outcome ...

journal_title：Immunogenetics

authors： Garrido-Rodríguez D,Ávila-Ríos S,García-Morales C,Valenzuela-Ponce H,Ormsby C,Reyes-Gopar H,Fernandez-Lopez JC,Reyes-Terán G

更新日期：2016-10-01 00:00:00

abstract：:Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes ha...

journal_title：Immunogenetics

authors： Delgado JC,Leung JY,Baena A,Clavijo OP,Vittinghoff E,Buchbinder S,Wolinsky S,Addo M,Walker BD,Yunis EJ,Goldfeld AE

更新日期：2003-10-01 00:00:00

abstract：:Mutation rates of H2 and non-H2 histocompatibility genes in the mouse are examined over a 25-year period. Detected by skin graft rejections, the mutations were screened in inbred and hybrid mice from a continuously maintained and monitored colony and from a regularly supplied set of mice provided from the National Can...

journal_title：Immunogenetics

authors： Melvold RW,Wang K,Kohn HI

更新日期：1997-01-01 00:00:00

abstract：:Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

journal_title：Immunogenetics

authors： Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

更新日期：1995-01-01 00:00:00

abstract：:The recent identification of a large and diverse family of leukocyte immune-type receptors (IpLITRs) in channel catfish (Ictalurus punctatus) indicates that immunoglobulin superfamily (IgSF) members related to both mammalian Fc receptors (FcRs) and leukocyte receptor complex (LRC)-encoded proteins exist in fish. In th...

journal_title：Immunogenetics

authors： Stafford JL,Bengtén E,Du Pasquier L,Miller NW,Wilson M

更新日期：2007-01-01 00:00:00

abstract：:Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has been implicated in population declines and species extinctions of amphibians around the world. Susceptibility to the disease varies both within and among species, most likely attributable to heritable immunogenetic variation. Anal...

journal_title：Immunogenetics

authors： Fu M,Waldman B

更新日期：2017-08-01 00:00:00