Abstract:
:By determining the nucleotide sequences of more than 700 cDNA clones isolated from 16 cynomolgus monkeys, we identified 26 Mafa-B alleles. In addition, nine sequences with similarity to Mamu-I alleles were identified. Since multiple Mafa-B alleles were found in each individual, it was strongly suggested that the cynomolgus MHC class I B locus might be duplicated and that the Mafa-I locus was derived from the B locus by gene duplication, as in the case of the Mamu-I locus of rhesus monkeys.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Uda A,Tanabayashi K,Fujita O,Hotta A,Terao K,Yamada Adoi
10.1007/s00251-005-0782-6subject
Has Abstractpub_date
2005-05-01 00:00:00pages
189-97issue
3-4eissn
0093-7711issn
1432-1211journal_volume
57pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::Type 1 diabetes is a multigenic autoimmune disease, the genetic basis for which is perhaps best characterized in the nonobese diabetic (NOD) mouse model. We previously located a NOD diabetes susceptibility locus, designated Idd11, on mouse Chromosome (Chr) 4 by analyzing diabetic backcross mice produced after crossing...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050006
更新日期:2000-01-01 00:00:00
abstract::The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIA...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0054-5
更新日期:2005-12-01 00:00:00
abstract::The region inclusive of the thioester and the isotype-determining sites of the sheep C4 genes from a single animal was amplified by polymerase chain reaction (PCR). Two bands, at 880 base pairs (bp) and 1000 bp, were resolved by agarose gel electrophoresis. Four different clones were obtained for the 880 bp (type 1) p...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216835
更新日期:1993-01-01 00:00:00
abstract::Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0644-7
更新日期:2004-02-01 00:00:00
abstract::Monoclonal antibodies reacting with TL-like class I antigens expressed on the surface of human thymocytes and some T leukemia lines were found to define three independent epitopic clusters, two of which could be shown to reside on serologically distinct molecular subsets by a solid-phase radioimmunoassay as well as by...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364207
更新日期:1984-01-01 00:00:00
abstract::Antigen-specific CD4+ T cells play a critical role in protective immunity to many infectious pathogens. Although the antigen-specific CD4+ T cells can be measured by functional assays such as proliferation or cytokine enzyme-linked immunospot, such assays are limited to a specific function and cannot quantify anergic ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0140-3
更新日期:2006-09-01 00:00:00
abstract::Major histocompatibility complex (MHC) molecules are responsible for the antigen presentation to T lymphocytes. High recombination rates in the MHC genes, as observed in humans, are believed to serve the evolutionary goal to achieve a high genetic diversity, allowing for a broad and efficient immune response. In a coh...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-016-0946-6
更新日期:2017-01-01 00:00:00
abstract::On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00368537
更新日期:1983-01-01 00:00:00
abstract::The vertebrate complement system is composed of about 30 serum and cell surface proteins that make up three activation pathways, a lytic pathway, and a set of proteins that regulate complement. Regulatory proteins are required for host protection against autologous complement attack and to control the amplification fe...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0665-2
更新日期:2004-05-01 00:00:00
abstract::We have isolated and characterized cDNAs and genes for pufferfish, Fugu rubripes, (Fugu) orthologues of mammalian interleukin (IL)-12 subunits (IL-12 p35 and IL-12 p40). The deduced amino acid sequences of the Fugu IL-12 subunits showed homology with mammalian IL-12 subunits (p35: 50.4-58.0% similarity; p40: 51.2-55.4...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0582-9
更新日期:2003-08-01 00:00:00
abstract::As part of an investigation of the immune system in the developing zebrafish, Danio rerio, we cloned and characterized a genomic V(H) segment and a number of cDNAs encoding IgM heavy chains. The genomic V(H) has the characteristic features of V(H) in other vertebrates, including a leader segment interrupted by a short...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000255
更新日期:2000-11-01 00:00:00
abstract::Cytotoxic CD8+ T-cell immunosurveillance for intracellular pathogens, such as viruses, is controlled by classical major histocompatibility complex (MHC) class Ia molecules, and ideally, these antiviral T-cell populations are defined by the specific peptide and restricting MHC allele. Surprisingly, despite the utility ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0711-z
更新日期:2013-09-01 00:00:00
abstract::T cell receptor genes are assembled in developing T lymphocytes from discrete V, D, and J genes by a site-specific somatic rearrangement mechanism. A flanking recombination signal, composed of a conserved heptamer and a semiconserved nonamer separated by 12 or 23 variable nucleotides, targets the activity of the rearr...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0150-1
更新日期:2006-11-01 00:00:00
abstract::The structure of the DRB1*03 gene has been interpreted as the product of a gene conversion event involving a DRB3 gene as donor and resulting in the introduction of two short segments of the DRB3 sequence into the DRB1 locus. The serological counterpart of this double insertion is the TR81 specificity. Consequently, t...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00717905
更新日期:1989-01-01 00:00:00
abstract::The class I genes of the major histocompatibility complex (Mhc) are here investigated for the first time in a passerine bird. The great reed warbler is a rare species in Sweden with a few semi-isolated populations. Yet, we found extensive Mhc class I variation in the study population. The variable exon 3, correspondin...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050477
更新日期:1999-03-01 00:00:00
abstract::Zaïre ebolavirus (ZEBOV) infection rapidly outruns the host's immunity and leads to death within a week. Fatal cases have been associated with an aberrant innate, proinflammatory immune response followed by a suppressed adaptive response leading to the rapid depletion of peripheral NK cells and lymphocytes. A critical...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0480-x
更新日期:2010-12-01 00:00:00
abstract::We describe a bioinformatic analysis of germline and rearranged immunoglobulin kappa chain (IGK) gene sequences, performed in order to assess the completeness and reliability of the reported IGK repertoire. In contrast to the reported heavy-chain gene repertoire, which includes many dubious sequences, only five IGK va...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0325-z
更新日期:2008-11-01 00:00:00
abstract::With the use of monospecific rabbit anti-G protein and mouse monoclonal anti-H-2Kk, we have analyzed the spatial relationship of the serologically defined H-2Kk antigens and the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) to those antigens recognized by B10.A (k, d) anti-VSV cytotoxic T ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01572582
更新日期:1980-01-01 00:00:00
abstract::Immunogenicity of allogeneic immunoglobulins in mice were studied, measuring the allotype-specific antibody activity by agglutination of allogeneic antibody-coated red blood cells. It was found that the serum from C.B-20 mice (Ighb, BALB/c-congenic) was uniquely immunogenic in BALB/c mice for allotype antibody respons...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02421533
更新日期:1989-01-01 00:00:00
abstract::Loss of major histocompatibility complex class II (MHCII) antigen expression on diffuse large B cell lymphoma (DLBCL) corresponds closely with significant decreases in patient survival. However, the mechanisms accounting for MHCII loss in DLBCL have not been thoroughly characterized to date. In this report, we demonst...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0418-3
更新日期:2010-02-01 00:00:00
abstract::The interaction of bacterial pathogens with their hosts' innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate im...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-007-0248-0
更新日期:2007-10-01 00:00:00
abstract::Antibody diversity, as measured by isoelectric focusing of dinitrophenol-specific antibodies, was compared in different polyploid species of the clawed toad Xenopus. Antibody heterogeneity increased with chromosome number and DNA content from Xenopus tropicalis (2n = 20 chromosome) to Xenopus ruwenzoriensis (2n = 108 ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364333
更新日期:1982-03-01 00:00:00
abstract::MHC genes are key components in disease resistance and an excellent system for studying selection acting on genetic variation in natural populations. Current patterns of variation in MHC genes are likely to be influenced by past and ongoing selection as well as demographic fluctuations in population size such as those...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-017-1051-1
更新日期:2018-07-01 00:00:00
abstract::Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0574-9
更新日期:2003-07-01 00:00:00
abstract::The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0334-y
更新日期:2008-12-01 00:00:00
abstract::The HLA-A2 antigen expressed by donor OZB can be distinguished from the main HLA-A2.1 subtype by isoelectric focusing - it is one charge unit more acidic - and by some alloreactive T-cell clones but not by cytolytic T lymphocyte lines. The structure of variant OZB has been examined by comparative peptide mapping with ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00395130
更新日期:1988-01-01 00:00:00
abstract::Using cDNA hybridization selection techniques, we identified seven new genes in a 280 kilobase YAC covering the HLA-F locus. The new genes were mapped back to the YAC by a combination of optical restriction mapping and pulse field gel electrophoresis. Northern analysis of individual clones demonstrated the presence of...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02660056
更新日期:1996-01-01 00:00:00
abstract::The Mep-1 gene on chromosome 17 in mice controls the activity of meprin, a kidney brush border metalloendopeptidase. Most inbred mouse strains of the k haplotype (e.g., CBA, C3H, AKR) are markedly deficient in meprin activity; these mice carry the Mep-1b allele. Mouse strains in which meprin activity levels are normal...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430310
更新日期:1985-01-01 00:00:00
abstract::The polymorphism of feline MHC antigens was examined using biochemical methods. The following observations were made: (1) feline class I and II antigens are polymorphic. Their biochemical features were established using rabbit and mouse reagents directed against human MHC products; they resemble those observed for oth...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00398799
更新日期:1986-01-01 00:00:00
abstract::The cattle major histocompatibility complex (MHC) region contains a variable number of classical class I genes encoding polymorphic molecules involved in antigen presentation. Six classical class I genes have been described, but assigning sequences to these genes has proved problematic. We propose a refinement of the ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0611-7
更新日期:2012-06-01 00:00:00