Abstract:
:The cattle major histocompatibility complex (MHC) region contains a variable number of classical class I genes encoding polymorphic molecules involved in antigen presentation. Six classical class I genes have been described, but assigning sequences to these genes has proved problematic. We propose a refinement of the existing nomenclature, which currently names the 97 known classical class I sequences in a single series. Phylogenetic analysis of the 3' portion of the coding region allows segregation of these into six groups; thus, we have prefixed existing names with the appropriate number. Although it is clear that some of these groups correspond to discrete genes, it is currently not possible to state definitively that all do. However, the main groupings are consistent, and in conjunction with other evidence, we feel it is now appropriate to rename the sequences accordingly. Segregation of sequences into groups in this way will facilitate ongoing research and future use of the cattle MHC section of the Immuno Polymorphism Database.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Hammond JA,Marsh SG,Robinson J,Davies CJ,Stear MJ,Ellis SAdoi
10.1007/s00251-012-0611-7subject
Has Abstractpub_date
2012-06-01 00:00:00pages
475-80issue
6eissn
0093-7711issn
1432-1211journal_volume
64pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0664-3
更新日期:2004-04-01 00:00:00
abstract::Ranatuerins are antimicrobial peptides of the innate immune system found in ranid frogs. We previously presented evidence that a positive selective sweep had fixed a single allele at the Ranatuerin2 locus in the northern leopard frog (Rana pipiens). In this paper, we further investigate the evolutionary history of ran...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0430-7
更新日期:2010-05-01 00:00:00
abstract::In a series of newly isolated AKR leukemias, some tumors expressed large amounts of both H-2K and H-2D molecules, while others had reduced levels of both antigens. The number of H-2 antigens expressed in steady state showed a consistent correlation with the rate of synthesis of the H-2 class I heavy chain and the beta...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00418093
更新日期:1985-01-01 00:00:00
abstract::Footpad swelling response was used to measure the alloantigenicity of epidermal cells (ECs) in delayed-type hypersensitivity (DTH). Strong footpad swelling was observed 3 h after the challenge, and it continued for 48 h after the challenge. Genetical incompatibility between the recipients and the ECs was required to i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372666
更新日期:1986-01-01 00:00:00
abstract::We have evaluated the ability of certain inbred strains of mice to develop a delayed-type hypersensitivity response to the male H-Y antigen. It was found that C57BL/10, B10.GD and B10.A(5R) female mice responded to syngeneic male cells. B10.A(4R) females also responded to B10.A(4R) male cells although the reactivity w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567793
更新日期:1980-01-01 00:00:00
abstract::Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0122-5
更新日期:2006-08-01 00:00:00
abstract::Natural killer (NK) cells express receptors for MHC class I that contain immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic domain. Whereas these receptors inhibit NK cell cytotoxicity, certain isoforms of these NK receptors (e.g., KIR2DS, CD94/NKG2C, and Ly49D) do not have ITIMs, but...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050642
更新日期:2000-05-01 00:00:00
abstract::The CCL4 chemokine is secreted by a variety of cells following stimulation. CCL4 affects several different types of cells that are important for acute inflammatory responses and are critical for the development of specific immune responses to foreign antigens. The human genome contains two genes for the CCL4 chemokine...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0636-z
更新日期:2004-01-01 00:00:00
abstract::We analyzed the genetic regulation of spontaneous autoimmune thyroiditis (SAT) by means of crosses between Obese strain (OS) chickens with the disease, and healthy inbred chicken of line CB. Mononuclear cell infiltration of the thyroid was used as a criterion for the disease. We confirmed the existence of one recessiv...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-001-0388-6
更新日期:2001-12-01 00:00:00
abstract::Dendritic cells (DC) are specialist antigen presenting cells which capture antigens in the periphery, migrate centrally, and present the processed antigens in the context of major histocompatibility complex and appropriate co-stimulatory molecules to T lymphocytes for the initiation of an immune response. DEC-205 has ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050381
更新日期:1998-05-01 00:00:00
abstract::Mouse lymphocyte alloantigens Ly-19 and Ly-32 are controlled by the genes tightly linked to the Lyb-2 locus on chromosome 4. Despite the similarity in mouse strain distribution patterns, Ly-19 and Ly-32 antigens which have been detected on both B- and T-cell lineages are distinct from Lyb-2 antigen whose expression is...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364229
更新日期:1988-01-01 00:00:00
abstract::The major histocompatibility complex (MHC) class I-related molecule, MR1, presents vitamin B metabolites from bacteria and yeast to mucosal-associated invariant T (MAIT) cells. Despite the evolutionary conservation of MR1, we do not know whether different allele variants of MR1 exist within the nonhuman primate (NHP) ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-018-1091-1
更新日期:2019-02-01 00:00:00
abstract::The immune response of the rat to group A streptococcal carbohydrate (SACHO) and an associated idiotype, Id-1, was used to examine the effect of paternal immunity on Id-1 and SACHO-specific antibody expression by the offspring. First litters, conceived before immunization of the father, had significantly higher Id-1 l...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372236
更新日期:1985-01-01 00:00:00
abstract::Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell tolerance to self and to recognition of foreign antigens. Antigen uptake and processing pathways as well as expression of the peptide exchange factors HLA-DM and HLA-DO differ among the various professional and non-professional...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-018-1095-x
更新日期:2019-03-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease. Although the pathogenesis of RA is poorly understood, progress ...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-011-0528-6
更新日期:2011-08-01 00:00:00
abstract::Ataxia-telangiectasia (A-T), a rare inherited disorder, usually affects the nervous and immune systems, and occasionally other organs. A-T is associated mainly with mutations in the ataxia telangiectasia mutated (ATM) gene, which encodes a protein kinase that has a major role in the cellular response to DNA damage. We...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-017-0983-9
更新日期:2017-07-01 00:00:00
abstract::Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216831
更新日期:1993-01-01 00:00:00
abstract::Codon bias and base composition in major histocompatibility complex (MHC) sequences have been studied for both class I and II loci in Homo sapiens and Pan troglodytes. There is low to moderate codon bias for the MHC of humans and chimpanzees. In the class I loci, the same level of moderate codon bias is seen for HLA-B...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050493
更新日期:1999-04-01 00:00:00
abstract::Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] wa...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0077-y
更新日期:2006-02-01 00:00:00
abstract::MICA is a new polymorphic gene in the HLA region expressed in epithelial cell lines and gastrointestinal epithelium. Little is yet known about the MICA protein, and the pattern of its expression by freshly isolated cells has not been established. In the present experiments, we used antibodies raised in rabbits against...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050339
更新日期:1998-01-01 00:00:00
abstract::Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00404420
更新日期:1987-01-01 00:00:00
abstract::Human natural killer (NK) cells express on their surface several members of the C-type lectin family such as NKR-P1, CD94, and NKG2 that are probably involved in recognition of target cells and delivery of signals modulating NK cell cytotoxicity. To elucidate the mechanisms involved in signaling via these receptors, w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050267
更新日期:1997-01-01 00:00:00
abstract::The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0584-7
更新日期:2003-08-01 00:00:00
abstract::The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00343312
更新日期:1982-01-01 00:00:00
abstract::The level of HLA-B27 transgene expression on the cell surface is dependent on the host H-2 haplotype. Mice homozygous for the H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes express B27 at high levels. An intermediate level of B27 expression is observed in H-2v mice whereas low levels of B27 are expressed in H-2q an...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00185114
更新日期:1992-01-01 00:00:00
abstract::In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00223541
更新日期:1992-01-01 00:00:00
abstract::Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0644-7
更新日期:2004-02-01 00:00:00
abstract::Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0275-5
更新日期:2008-04-01 00:00:00
abstract::Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC genomic region (called HLA) is extremely polymorphic comprising several thousand alleles, each encoding a distinct MHC molecule. The pot...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0341-z
更新日期:2009-01-01 00:00:00
abstract::Immunoglobulin E (IgE) provides important information on the humoral immune status, and the IgE level is routinely detected in clinical practice. There are many diseases associated with IgE, such as atopic disease, autoimmune diseases, and so on. IgE is a genetically complex trait, but comprehensive genetic assessment...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0706-9
更新日期:2013-08-01 00:00:00