Abstract:
:The immune response of the rat to group A streptococcal carbohydrate (SACHO) and an associated idiotype, Id-1, was used to examine the effect of paternal immunity on Id-1 and SACHO-specific antibody expression by the offspring. First litters, conceived before immunization of the father, had significantly higher Id-1 levels than litters conceived by the same parental pairs after hyperimmunization of the father (P greater than 0.01). Total anti-SACHO levels were not affected. The effect appeared to be independent of the level of Id-1 expressed by the father or grandfather. No significant difference in Id-1 production was found between offspring of actively immune, neonatally Id-1 suppressed fathers and fathers expressing high levels of Id-1. We suggest that the paternal immunoregulatory influence acts via the maternal immune system to modify the idiotype repertoire expressed in the immune response of the offspring, and is not the result of genetic transmission of a trait acquired by the father. Some possible mechanisms of transmission are discussed.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Cooper-Willis CA,Olson JC,Brewer ME,Leslie GAdoi
10.1007/BF00372236subject
Has Abstractpub_date
1985-01-01 00:00:00pages
1-10issue
1eissn
0093-7711issn
1432-1211journal_volume
21pub_type
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