CC-chemokine receptor 5 polymorphism and age of onset in familial multiple sclerosis. Multiple Sclerosis Genetics Group.

abstract：:The HLA-A2 antigen expressed by donor OZB can be distinguished from the main HLA-A2.1 subtype by isoelectric focusing - it is one charge unit more acidic - and by some alloreactive T-cell clones but not by cytolytic T lymphocyte lines. The structure of variant OZB has been examined by comparative peptide mapping with ...

journal_title：Immunogenetics

authors： Castaño R,Ezquerra A,Doménech N,López de Castro JA

更新日期：1988-01-01 00:00:00

abstract：:As part of an investigation of the immune system in the developing zebrafish, Danio rerio, we cloned and characterized a genomic V(H) segment and a number of cDNAs encoding IgM heavy chains. The genomic V(H) has the characteristic features of V(H) in other vertebrates, including a leader segment interrupted by a short...

journal_title：Immunogenetics

authors： Danilova N,Hohman VS,Kim EH,Steiner LA

更新日期：2000-11-01 00:00:00

abstract：:The restricted diversity of the major histocompatibility complex (MHC) of Mauritian cynomolgus macaques provides powerful opportunities for insight into host-viral interactions and cellular immune responses that restrict lentiviral infections. However, little is known about the effects of Mhc haplotypes on control of ...

journal_title：Immunogenetics

authors： Mee ET,Berry N,Ham C,Sauermann U,Maggiorella MT,Martinon F,Verschoor EJ,Heeney JL,Le Grand R,Titti F,Almond N,Rose NJ

更新日期：2009-05-01 00:00:00

abstract：:Two new C57BL/6 H-2 mutants, B6.C-H-2bm13 and B6.C-H-2bm14 are described. They arose independently in C57BL/6 as spontaneous mutations of the gain and loss type. Complementation studies map the mutations in both bm13 and bm14 to the H-2Db gene. However, these two mutant strains are not identical, but occurred as indep...

journal_title：Immunogenetics

authors： Morgan GM,Dellos H,McKenzie IF,Melvold RW,Bailey DW

更新日期：1980-01-01 00:00:00

abstract：:Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...

journal_title：Immunogenetics

authors： Tartakovsky B,De Baetselier P,Segal S

更新日期：1980-01-01 00:00:00

abstract：:Nova Scotia duck tolling retrievers are predisposed to a SLE-related disease complex including immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). IMRD involves symptoms that resemble those seen in systemic autoimmune rheumatic diseases, such as systemic lupus erythematosus, SL...

journal_title：Immunogenetics

authors： Wilbe M,Jokinen P,Hermanrud C,Kennedy LJ,Strandberg E,Hansson-Hamlin H,Lohi H,Andersson G

更新日期：2009-08-01 00:00:00

abstract：:Immunogenicity for T cell-independent B-cell response assessed by splenic plaque-forming cell (PFC) response and cell-surface expression measured by laser flow cytometry of various class I H-2 antigens on mouse red blood cells (RBC) were compared. It was found that the order of magnitude of both immunogenicity and cel...

journal_title：Immunogenetics

authors： Nakashima I,Yoshida T,Yokochi T,Ohashi K,Nagase F,Isobe K,Hasegawa Y,Ando K,Inagi R

更新日期：1986-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules are responsible for the antigen presentation to T lymphocytes. High recombination rates in the MHC genes, as observed in humans, are believed to serve the evolutionary goal to achieve a high genetic diversity, allowing for a broad and efficient immune response. In a coh...

journal_title：Immunogenetics

authors： Gimsa U,Ho CS,Hammer SE

更新日期：2017-01-01 00:00:00

abstract：:Hepatic granulomatous lesions were induced in mice by a single intraperitoneal injection of 3 mg of disrupted Streptococcus pyogenes cell-wall material. Mice carrying the H-2b or H-2k haplotypes were highly susceptible to the induction and three weeks after the injection produced numerous granulomas. In contrast, mice...

journal_title：Immunogenetics

authors： Chen CY,Cohen SA,Zaleski MB,Albini B

更新日期：1992-01-01 00:00:00

abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...

journal_title：Immunogenetics

authors： van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JG

更新日期：2003-07-01 00:00:00

abstract：:In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides (ODN) specifically prom...

journal_title：Immunogenetics

authors： Spirig R,Peduzzi E,Patarroyo ME,Pluschke G,Daubenberger CA

更新日期：2005-05-01 00:00:00

abstract：:To analyze how many D-region-encoded molecules could be detected in H-2q, we produced a panel of nine monoclonal antibodies from AKR (KkDk) anti-AKR.M (KkDq) immunizations. All of the Dq region antibodies cross-reacted on Dd and/or Ld, and all except one cross-reacted on Db, confirming the previously observed serologi...

journal_title：Immunogenetics

authors： Chatterjee-Das S,Lillehoj EP,Hernandez DM,Coligan JE,Sachs DH

更新日期：1987-01-01 00:00:00

abstract：:Genes encoding the immunoglobulin heavy-chain variable region (Ig VH) in rainbow trout (Oncorhynchus mykiss) have been grouped into 11 families. While obtaining a baseline assessment of the various gene families utilized by trout in the production of secreted antibody, we discovered two new families. These proposed Ig...

journal_title：Immunogenetics

authors： Brown GD,Kaattari IM,Kaattari SL

更新日期：2006-11-01 00:00:00

abstract：:A new H-2 mutant involving the H-2d haplotype is described--C.B6-H-2dm4 (dm4). This mutant strain carries a gain and loss mutation which maps to the Kd gene of the H-2 complex. Serological testing comparing the mutant and the parental BALB/cKh strain failed to detect any difference between the two strains and no antib...

journal_title：Immunogenetics

authors： Morgan G,Dellos H,McKenzie IF,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes ar...

journal_title：Immunogenetics

authors： de Groot NG,Heijmans CM,de Ru AH,Hassan C,Otting N,Doxiadis GG,Koning F,van Veelen PA,Bontrop RE

更新日期：2013-12-01 00:00:00

abstract：:We recently demonstrated that vaccinated rhesus macaques controlled viral replication of a heterologous SIV challenge. Here, we analyzed anamnestic SIV-specific CD4+ T-cell responses expanding immediately after challenge and show that successful vaccinees consistently targeted a short region of the Gag-p27 Capsid (ami...

journal_title：Immunogenetics

authors： Giraldo-Vela JP,Bean AT,Rudersdorf R,Wallace LT,Loffredo JT,Erickson P,Wilson NA,Watkins DI

更新日期：2010-10-01 00:00:00

abstract：:Immunofluorescent and immunoelectron-microscopic staining methods were utilized to investigate the localization of Ia antigens in murine keratinizing epithelia. Approximately 3-5% of epidermal cells were shown to be Ia positive. Only dendritic Langerhans cells in the interfollicular epidermis and outer root sheaths we...

journal_title：Immunogenetics

authors： Rowden G,Phillips TM,Delovitch TL

更新日期：1978-12-01 00:00:00

abstract：:The membrane immunoglobulin M (mIgM) of a B lymphocyte serves as a receptor for its cognate antigen. Our aim is to elucidate the structure and function of this membrane-bound receptor. The first step is to determine the requirements for proper membrane placement of IgM. We have used mIgM-positive B lymphocyte tumors f...

journal_title：Immunogenetics

authors： Sibley CH,Andrews-Wagner R

更新日期：1983-01-01 00:00:00

abstract：:Previous studies demonstrated that the diversity of the antibody response of mice to the inulin (In) determinant of bacterial levan is regulated by the gene Spectrotype Regulation 1 ( Sr1). BALB/c mice produce a monoclonal anti-In response as shown by isoelectric focusing analysis. In contrast, the anti-In antibody re...

journal_title：Immunogenetics

authors： Jones Tiffany L,Riblet R,Stein KE

更新日期：2003-05-01 00:00:00

abstract：:Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, a...

journal_title：Immunogenetics

authors： Ballingall KT,Waibochi L,Holmes EC,Woelk CH,MacHugh ND,Lutje V,McKeever DJ

更新日期：2001-01-01 00:00:00

abstract：:Endemic pemphigus foliaceus (EPF), is an autoimmune disease associated with production of IgG antibodies against epidermal antigens. We have tested 38 patients and 50 control subjects living in endemic areas to investigate whether HLA genes are associated with host factors that determine whether or not exposed individ...

journal_title：Immunogenetics

authors： Moraes JR,Moraes ME,Fernandez-Vina M,Diaz LA,Friedman H,Campbell IT,Alvarez RR,Sampaio SA,Rivitti EA,Stastny P

更新日期：1991-01-01 00:00:00

abstract：:Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...

journal_title：Immunogenetics

authors： Kuroda N,Uinuk-ool TS,Sato A,Samonte IE,Figueroa F,Mayer WE,Klein J

更新日期：2003-03-01 00:00:00

abstract：:A healthy adult having no serologically detectable HLA class I A locus antigens was identified. The parents of the individual are consanguineous. Results of a family study indicated that the individual is homozygous for the B46-Cw1-DR8.1 haplotype, which was shown to be positively associated with A*0207 in our previou...

journal_title：Immunogenetics

authors： Ishikawa Y,Tokunaga K,Tanaka H,Nishimura M,Muraoka M,Fujii Y,Akaza T,Tadokoro K,Juji T

更新日期：1996-01-01 00:00:00

abstract：:The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...

journal_title：Immunogenetics

authors： Martin MP,Single RM,Wilson MJ,Trowsdale J,Carrington M

更新日期：2008-12-01 00:00:00

abstract：:CD99, the product of the MIC2 gene, exhibits an erythroid-specific quantitative polymorphism co-regulated with the Xga blood group polymorphism. The co-expression of X-linked MIC2 and XG genes is presumably controlled at the transcriptional level by a single XGR locus in the pseudoautosomal region of sexual chromosome...

journal_title：Immunogenetics

authors： Fouchet C,Gane P,Cartron JP,Lopez C

更新日期：2000-07-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:Cytotoxic CD8+ T-cell immunosurveillance for intracellular pathogens, such as viruses, is controlled by classical major histocompatibility complex (MHC) class Ia molecules, and ideally, these antiviral T-cell populations are defined by the specific peptide and restricting MHC allele. Surprisingly, despite the utility ...

journal_title：Immunogenetics

authors： Holmes JC,Holmer SG,Ross P,Buntzman AS,Frelinger JA,Hess PR

更新日期：2013-09-01 00:00:00

abstract：:The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...

journal_title：Immunogenetics

authors： Nguyen VK,Su C,Muyldermans S,van der Loo W

更新日期：2002-04-01 00:00:00

abstract：:We cloned the cDNAs and genes of two different types of toll-like receptors from Japanese flounder. The results of homology searches suggested that these genes (designated JF-TLR2 and JF-TLR22) are homologues of human TLR2 and fugu TLR22, respectively. The cDNAs of JF-TLR2 and JF-TLR22 encoded 818 and 961 amino acid r...

journal_title：Immunogenetics

authors： Hirono I,Takami M,Miyata M,Miyazaki T,Han HJ,Takano T,Endo M,Aoki T

更新日期：2004-04-01 00:00:00

abstract：:Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccharomyces cerevisiae, Dictyostelium discoideum, and Drosophila melanogaster, and ...

journal_title：Immunogenetics

authors： Pruvot B,Laurens V,Salvadori F,Solary E,Pichon L,Chluba J

更新日期：2010-10-01 00:00:00