Abstract:
:Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes are characterised for their peptide-binding motifs, although more information of this nature would contribute to a better interpretation of T cell-mediated immune responses. Here, we present the results of the characterisation of the functional properties of Mamu-B*037:01, an allotype commonly encountered in rhesus macaques of Indian and Chinese origin. Mamu-B*037:01 is seen to have a strong preference for acidic amino acids at the third residue, and for arginine, lysine, and tyrosine at the carboxyl terminus. This peptide-binding motif is not described in the human population.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
de Groot NG,Heijmans CM,de Ru AH,Hassan C,Otting N,Doxiadis GG,Koning F,van Veelen PA,Bontrop REdoi
10.1007/s00251-013-0734-5subject
Has Abstractpub_date
2013-12-01 00:00:00pages
897-900issue
12eissn
0093-7711issn
1432-1211journal_volume
65pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::Polymorphic insertion frequencies of the retrotransposons known as the "SVA" elements were investigated at four loci in the MHC class I genomic region to determine their allele and haplotype frequencies and associations with the HLA-A, -B or -C genes for 100 Japanese, 100 African Americans, 174 Australian Caucasians a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0427-2
更新日期:2010-04-01 00:00:00
abstract::Severe combined immune deficiency (scid) mice are assumed to have two types of abnormalities: one is high radiosensitivity and the other is abnormal recombination in immunoglobulin and T-cell receptor genes. The human chromosome 8 q1.1 region has an ability to complement the scid aberrations. Moreover, the localizatio...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050159
更新日期:1996-01-01 00:00:00
abstract::In the African clawed frog (Xenopus laevis), two deeply divergent allelic lineages of multiple genes of the class I MHC region have been discovered. For the MHC class I UAA locus, functional differences and the molecular basis for lineages maintenance are unknown. Alleles of linked class I region genes also exhibit st...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0114-5
更新日期:2006-06-01 00:00:00
abstract::The class I genes of the major histocompatibility complex (Mhc) are here investigated for the first time in a passerine bird. The great reed warbler is a rare species in Sweden with a few semi-isolated populations. Yet, we found extensive Mhc class I variation in the study population. The variable exon 3, correspondin...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050477
更新日期:1999-03-01 00:00:00
abstract::Immunoglobulin-A deficiency (IgA-D) is the most common human Ig class deficiency with an estimated frequency of approximately 1 in 500 in the Swedish population. We investigated the immunoglobulin heavy chain constant region gene segments (IGHC) in 103 individuals with IgA-D and the immunoglobulin heavy chain variable...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00218046
更新日期:1992-01-01 00:00:00
abstract::The hallmark of the classical major histocompatibility complex (MHC) class I molecules is their astonishing level of polymorphism, a characteristic not shared by the nonclassical MHC class I genes. A distinct family of MHC class I genes has been recently identified within the human MHC class I region. The MICA (MHC cl...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02602779
更新日期:1996-01-01 00:00:00
abstract::The A15, L6, and S5.7(TAPA1) proteins are members of the transmembrane 4 superfamily (TM4SF). The A15 is expressed in immature human T cells and in the human brain. The MXS1(CCG-B7) gene which codes for A15 contains triplet nucleotide repeats which have been associated with neuropsychiatric diseases such as Huntington...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00189229
更新日期:1994-01-01 00:00:00
abstract::Development of an accurate and efficient molecular-based equine MHC class I typing method would facilitate the study of T lymphocyte immune responses in horses. Here, a DNA microarray was designed to detect expressed classical MHC class I genes comprising serologically defined equine leukocyte antigen (ELA)-A haplotyp...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0463-y
更新日期:2010-09-01 00:00:00
abstract::Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0664-3
更新日期:2004-04-01 00:00:00
abstract::The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510100355
更新日期:2001-09-01 00:00:00
abstract::The level of HLA-B27 transgene expression on the cell surface is dependent on the host H-2 haplotype. Mice homozygous for the H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes express B27 at high levels. An intermediate level of B27 expression is observed in H-2v mice whereas low levels of B27 are expressed in H-2q an...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00185114
更新日期:1992-01-01 00:00:00
abstract::The CCL4 chemokine is secreted by a variety of cells following stimulation. CCL4 affects several different types of cells that are important for acute inflammatory responses and are critical for the development of specific immune responses to foreign antigens. The human genome contains two genes for the CCL4 chemokine...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0636-z
更新日期:2004-01-01 00:00:00
abstract::We reported previously that human gene MAGE-1 directs the expression of a tumor antigen recognized on a melanoma by autologous cytolytic T lymphocytes. Probing cosmid libraries with a MAGE-1 sequence, we identified 11 closely related genes. The analysis of hamster-human somatic cell hybrids indicated that the 12 MAGE ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01246677
更新日期:1994-01-01 00:00:00
abstract::The region inclusive of the thioester and the isotype-determining sites of the sheep C4 genes from a single animal was amplified by polymerase chain reaction (PCR). Two bands, at 880 base pairs (bp) and 1000 bp, were resolved by agarose gel electrophoresis. Four different clones were obtained for the 880 bp (type 1) p...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216835
更新日期:1993-01-01 00:00:00
abstract::We have evaluated the ability of certain inbred strains of mice to develop a delayed-type hypersensitivity response to the male H-Y antigen. It was found that C57BL/10, B10.GD and B10.A(5R) female mice responded to syngeneic male cells. B10.A(4R) females also responded to B10.A(4R) male cells although the reactivity w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01567793
更新日期:1980-01-01 00:00:00
abstract::Loss of major histocompatibility complex class II (MHCII) antigen expression on diffuse large B cell lymphoma (DLBCL) corresponds closely with significant decreases in patient survival. However, the mechanisms accounting for MHCII loss in DLBCL have not been thoroughly characterized to date. In this report, we demonst...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0418-3
更新日期:2010-02-01 00:00:00
abstract::Genes encoding the immunoglobulin heavy-chain variable region (Ig VH) in rainbow trout (Oncorhynchus mykiss) have been grouped into 11 families. While obtaining a baseline assessment of the various gene families utilized by trout in the production of secreted antibody, we discovered two new families. These proposed Ig...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0149-7
更新日期:2006-11-01 00:00:00
abstract::The recombination activating genes RAG-1 and RAG-2 are adjacent genes that act synergistically to activate variable-diversity-joining (V(D)J) recombination. Southern analysis of hybrid cell lines derived from patients with the Wilms tumor-aniridia-genitourinary defects-mental retardation (WAGR) syndrome and from mutag...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00189518
更新日期:1992-01-01 00:00:00
abstract::Leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0730-9
更新日期:2014-01-01 00:00:00
abstract::The gray short-tailed opossum Monodelphis domestica is one of the few marsupial species for which a high quality whole genome sequence is available and the major histocompatibility complex (MHC) region has been annotated. Previous analyses revealed only a single locus within the opossum MHC region, designated Modo-UA1...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-015-0826-5
更新日期:2015-04-01 00:00:00
abstract::A cDNA clone, designated IL-8nL, was obtained by suppression subtractive hybridisation between lipopolysaccharide-stimulated and non-stimulated populations of the rainbow trout macrophage-like cell line, RTS11. IL-8nL was similar but not identical to a recently published sequence of the gene encoding rainbow trout int...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0556-y
更新日期:2003-05-01 00:00:00
abstract::Early and late primary IgM antibody responses of mice to Thy-1.1 antigens showed different antigenic and cellular requirements. We studied genetic controls of the early primary responses, which could be induced by subcellular thymocyte antigens independently of host T-cell activity. All Thy-1.2 mouse strains of Igha (...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364214
更新日期:1984-01-01 00:00:00
abstract::The T- and B-cell surface polypeptides detected by an international workshop panel of 100 mouse monoclonal antibodies (M.Ab) were biochemically defined by radioimmunoprecipitation. Eight T-cell-associated molecules and eight B-cell-associated molecules were identified by multiple antibodies in the panel. Clusters of a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345968
更新日期:1983-01-01 00:00:00
abstract::The major histocompatibility complex (MHC) is critical to host-pathogen interactions. Class II MHC is a heterodimer, with α and β subunits encoded by different genes. The peptide-binding groove is formed by the first domain of both subunits (α1 and β1), but studies of class II variation or natural selection focus prim...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-019-01130-z
更新日期:2019-09-01 00:00:00
abstract::Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0275-5
更新日期:2008-04-01 00:00:00
abstract::Macrophages (mϕ) from pre-diseased mice of the major murine inbred models of spontaneous autoimmunity (AI), including multiple lupus-prone strains and the type I diabetes-prone NOD (non-obese diabetic) strain, have identical apoptotic target-dependent abnormalities. This characteristic feature of mϕ from AI-prone mice...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0507-3
更新日期:2011-05-01 00:00:00
abstract::Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell tolerance to self and to recognition of foreign antigens. Antigen uptake and processing pathways as well as expression of the peptide exchange factors HLA-DM and HLA-DO differ among the various professional and non-professional...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-018-1095-x
更新日期:2019-03-01 00:00:00
abstract::The factors which influence expression of autoimmune disease in the central nervous system are still poorly understood. We determined the characteristics of experimental autoimmune encephalomyelitis (EAE) in twelve different inbred strains of mice using either mouse spinal cord homogenate or synthetic peptides as the ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02602559
更新日期:1996-01-01 00:00:00
abstract::A polymorphic gene, MIC-A, is one of the MIC family of genes which is composed of a group of homologous genes interspersed in the class III and class I regions of the major histocompatibility complex. MIC-A is located 46 kilobases (kb) centromeric of HLA-B, and is preferentially expressed in the epithelial cells and i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050658
更新日期:1999-07-01 00:00:00
abstract::Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-1...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-016-0923-0
更新日期:2016-10-01 00:00:00