Abstract：
:The CCL4 chemokine is secreted by a variety of cells following stimulation. CCL4 affects several different types of cells that are important for acute inflammatory responses and are critical for the development of specific immune responses to foreign antigens. The human genome contains two genes for the CCL4 chemokine. Although highly homologous, the two genes encode slightly different proteins. We analyzed the mRNA expressed in monocytes and B lymphocytes and found that while monocytes express predominantly one CCL4 gene, known as ACT-2, peripheral blood B lymphocytes express a mixture of ACT-2 and the second CCL4 gene, lymphocyte activating gene-1 ( LAG-1). Although peripheral blood B cells, CD27(-) B cells, and CD27(+) B cells all express a mixture of LAG-1 and ACT-2, the B-cell lines that were studied regulate the two genes independently. RL, SU-DHL-6, and REH cells predominantly express LAG-1. These studies demonstrate that monocytes and B cells utilize different mechanisms to regulate expression of the two CCL4 genes and suggest that the two genes may not have identical activities.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Lu J,Honczarenko M,Sloan SRdoi
10.1007/s00251-003-0636-zsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
706-11issue
10eissn
0093-7711issn
1432-1211journal_volume
55pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract：:The immune systems of all mammals include populations of B cells producing antibodies with incredibly diverse specificities. Repertoire diversity has been described as the "miracle of immunology," and it was long thought to be the result of essentially stochastic processes. Recently, however, analysis of high throughp...
journal_title：Immunogenetics
pub_type： 杂志文章,评审
doi：10.1007/s00251-017-1049-8
更新日期：2018-03-01 00:00:00
abstract：:The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00621950
更新日期：1982-01-01 00:00:00
abstract：:The single nucleotide polymorphism (SNP)-derived Epitope Prediction program (SNEP) is now available to the public. It predicts minor histocompatibility antigens (miHAgs), which are T-cell epitopes containing polymorphic spots, from proteins listed in the SWISS-PROT database. SNEP recognizes polymorphisms (termed VARIA...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-005-0054-5
更新日期：2005-12-01 00:00:00
abstract：:In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides (ODN) specifically prom...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-005-0789-z
更新日期：2005-05-01 00:00:00
abstract：:The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s002510100355
更新日期：2001-09-01 00:00:00
abstract：:The organization of the major histocompatibility complex (MHC) class II region in cattle was investigated by Southern blot analysis using human probes corresponding to DO, DP, DQ, and DR genes. Exon-specific probes were also employed to facilitate the assessment of the number of different bovine class II genes. The re...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00351084
更新日期：1988-01-01 00:00:00
abstract：:In order to determine the extent of the repertoire of the immunoglobulin light chain V-region locus (Igl-V) in the laboratory rat (Rattus norvegicus), we constructed a specifically primed cDNA library from lipopolysaccharide-stimulated DA strain rat spleens. The library was screened with a rat Igl-C2-specific probe, a...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00223543
更新日期：1992-01-01 00:00:00
abstract：:Natural killer (NK) cells constitute the third major population of lymphocytes. They possess the inherent capacity to kill various tumor and virally infected cells and mediate the rejection of bone-marrow grafts in lethally irradiated animals. A large family of NK cell receptors belong to the C-type lectin superfamily...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s002510050679
更新日期：1999-10-01 00:00:00
abstract：:Earlier studies suggest that end-stage renal disease (ESRD) is associated with inflammatory state and have become a major cause of morbidity and mortality worldwide. This study speculated the role of interleukins (IL)-2, -4, and -6 cytokines gene polymorphism with risk of susceptibility to ESRD. Polymorphism in IL-2 (...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-006-0182-6
更新日期：2007-02-01 00:00:00
abstract：:Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-002-0531-z
更新日期：2003-03-01 00:00:00
abstract：:The aim of this study was to evaluate the intra- and inter-population variability of the Gm/Km system in the Madonie Mountains, one of the main geographical barriers in north-central Sicily. We analysed 392 samples: 145 from Alia, 128 from Valledolmo, 25 from Cerda and 94 from Palermo. Serum samples were tested for G1...
journal_title：Immunogenetics
pub_type： 历史文章,杂志文章
doi：10.1007/s00251-003-0628-z
更新日期：2004-01-01 00:00:00
abstract：:Stable cell surface presentation of HLA class I molecules requires active transport of antigenic peptides across the endoplasmic reticulum by products of two genes, TAP1 and TAP2, which map in the major histocompatibility complex class II region. Alleles of each gene are derived from a combination of variable sites at...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00187452
更新日期：1993-01-01 00:00:00
abstract：:The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The nucleotide sequence...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00188786
更新日期：1994-01-01 00:00:00
abstract：:Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of diseases have been the subject of research for decades. In particular, the associations of autoimmune disorders to allelic variants and candidate genes encoding the MHC are we...
journal_title：Immunogenetics
pub_type： 杂志文章,评审
doi：10.1007/s00251-021-01204-x
更新日期：2021-02-02 00:00:00
abstract：:Loss of major histocompatibility complex class II (MHCII) antigen expression on diffuse large B cell lymphoma (DLBCL) corresponds closely with significant decreases in patient survival. However, the mechanisms accounting for MHCII loss in DLBCL have not been thoroughly characterized to date. In this report, we demonst...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-009-0418-3
更新日期：2010-02-01 00:00:00
abstract：:Six IgA allotypes are serologically identifiable in inbred mice. The sequences of the PCR-amplified C alpha 1, C alpha 2 and C alpha 3 exons from the genomic DNA of mice of four previously unsequenced allotypes already have been compared with those of BALB/c and of a wild mouse, Mus pahari, in the literature. Sporadic...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-002-0434-z
更新日期：2002-03-01 00:00:00
abstract：:Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein composed of two ex...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-002-0483-3
更新日期：2002-09-01 00:00:00
abstract：:TAP1 and TAP2 are two major histocompatibility complex (MHC) genes, located between HLA-DP and -DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in both genes and, in this study, we have identified another polymorphic site within the ade...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00216802
更新日期：1993-01-01 00:00:00
abstract：:The structure of the DRB1*03 gene has been interpreted as the product of a gene conversion event involving a DRB3 gene as donor and resulting in the introduction of two short segments of the DRB3 sequence into the DRB1 locus. The serological counterpart of this double insertion is the TR81 specificity. Consequently, t...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00717905
更新日期：1989-01-01 00:00:00
abstract：:Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF01561675
更新日期：1981-01-01 00:00:00
abstract：:The potential association between integration or deletion of mouse mammary tumor virus (MMTV) retroviral sequences and the appearance of non-H-2 histocompatibility (H) antigen mutations was investigated. Genomic blots from inbred strains carrying 22 loss, gain-loss, and gain mutations on the BALB/c and C57BL/6 backgro...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00345461
更新日期：1987-01-01 00:00:00
abstract：:Natural killer T (NKT) cells play an important role in controlling cancers, infectious diseases and autoimmune diseases. Although the rhesus macaque is a useful primate model for many human diseases such as infectious and autoimmune diseases, little is known about their NKT cells. We analyzed V alpha 24TCR+ T cells fr...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-002-0527-8
更新日期：2003-02-01 00:00:00
abstract：:Mouse Ly6A and Ly6C cDNA probes were hybridized to total RNA of rat tissues and, as in mouse, the highest level of Ly6-related transcripts was detected in kidney. Therefore, Ly6-related cDNA clones were isolated from a commercial rat kidney cDNA library in lambda gt11. Four of these (RK3, RK6, RK10, and RK11) have bee...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00661220
更新日期：1990-01-01 00:00:00
abstract：:Mice bearing the H-2w7 haplotype have five C4-related genes, one C4, one Slp, and three C4/Slp hybrid genes. The expression of these five genes in the liver of H-2w7 mice was estimated at the steady state level of their respective mRNA. We have amplified by the polymerase chain reaction (PCR) three regions of the C4/S...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00216695
更新日期：1991-01-01 00:00:00
abstract：:Immunoprecipitation of NP-40 lysates of 125I-labeled lymph-node cells with different anti-H-2 sera and with anti-Qa-2 serum has shown that the BALB/cByA strain (H-2d, Qa-2-negative) expresses, besides H-2Ld, another molecule that is not detectable in the BALB/c-H-2dm2 strain. Electrophoresis in SDS polyacrylamide gels...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00345905
更新日期：1982-01-01 00:00:00
abstract：:The polymorphism of major histocompatibility complex class I chain-related gene B (MICB) and variations in MICB alleles in a variety of populations have been characterized using several genotyping approaches. In the present study, a novel polymerase chain reaction sequence-based typing (PCR-SBT) method was established...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-013-0699-4
更新日期：2013-07-01 00:00:00
abstract：:In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. To investigate the origin of the Ig-like domains encoded by the LRC genes, a subset of C2-type Ig-like domain s...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-004-0764-0
更新日期：2005-04-01 00:00:00
abstract：:Mammalian interleukin-4 (IL-4) and IL-13 are T helper type 2 (Th2) cytokines with pleiotropic functions in immunity. They signal through receptors containing IL-4Rα and IL-2Rγ or IL-13Rα1. In addition, a decoy receptor, IL-13Rα2, is known to exist and modulates the function of IL-13. The existence of fish orthologues ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-010-0508-2
更新日期：2011-04-01 00:00:00
abstract：:We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-001-0426-4
更新日期：2002-02-01 00:00:00
abstract：:The heavy and light chain subunits of the DC1 antigen from several cell lines expressing different DR specificities were compared by two-dimensional (2-D) gel electrophoresis. The DC1 light chains from cell lines typed as DR1, DR2, or DRw6 differed in their isoelectric points. No difference in charge was observed for ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00345970
更新日期：1983-01-01 00:00:00
