Abstract：
:The hallmark of the classical major histocompatibility complex (MHC) class I molecules is their astonishing level of polymorphism, a characteristic not shared by the nonclassical MHC class I genes. A distinct family of MHC class I genes has been recently identified within the human MHC class I region. The MICA (MHC class I chain-related A) gene in this family is a highly divergent member of the MHC class I family and has a unique pattern of tissue expression. We have sequenced exons encoding the extracellular alpha1, alpha2, and alpha3 domains of the MICA gene from twenty HLA homozygous typing cell lines and four unrelated individuals. We report the identification of eleven new alleles defined by a total of twenty-two amino acid substitutions. Thus, the total number of MICA alleles is sixteen. Interestingly, a tentative superimposition of MICA variable residues on the HLA-A2 structure reveals a unique pattern of distribution, concentrated primarily on the outer edge of the MICA putative antigen binding cleft, apparently bordering an invariant ligand binding site.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Fodil N,Laloux L,Wanner V,Pellet P,Hauptmann G,Mizuki N,Inoko H,Spies T,Theodorou I,Bahram Sdoi
10.1007/BF02602779subject
Has Abstractpub_date
1996-01-01 00:00:00pages
351-7issue
5eissn
0093-7711issn
1432-1211journal_volume
44pub_type
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