当前位置： SCI文献检索 > IMMUNOGENETICS期刊下所有文献 > The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively.

The production of two Th2 cytokines, interleukin-4 and interleukin-10, is controlled independently by locus Cypr1 and by loci Cypr2 and Cypr3, respectively.

Abstract：

:The strains BALB/cHeA (BALB/c) and STS/A (STS) differ in production of IL-4 and IL-10, two Th2 cytokines, after stimulation of spleen cells with Concanavalin A, STS being a low and BALB/c a high producer. We analyzed the genetic basis of this strain difference using the recombinant congenic (RC) strains of the BALB/c-c-STS/Dem (CcS/Dem) series. This series comprises 20 homozygous strains. Each CcS/Dem strain contains a different, random set of approximately 12. 5% genes of the "donor" strain STS and approximately 87.5% of the "background" strain BALB/c. We selected for further analysis the RC strain production intermediate between BALB/c and STS. In (CcS-20xBALB/c)F2 hybrids we found that different loci control expression of IL-4 and IL-10. Cypr1 (cytokine production 1) on chromosome 16 near D16Mit15 controls IL-4 production, whereas the production of IL-10 is influenced by loci Cypr2 near D1Mit14 and D1Mit227 on chromosome 1 and Cypr3 marked by D5Mit20 on chromosome 5. In addition, the relationship between the level of these two cytokines depends on the genotype of the F2 hybrids at a locus cora1 (correlation 1) on chromosome 5. This differential genetic regulation may be relevant for the understanding of biological effects of T-helper cells in mice of different genotypes.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Kosarová M,Havelková H,Krulová M,Demant P,Lipoldová M

doi

10.1007/s002510050472

subject

Has Abstract

pub_date

1999-02-01 00:00:00

pages

134-41

issue

2

eissn

0093-7711

issn

1432-1211

journal_volume

49

pub_type

杂志文章

相关文献

IMMUNOGENETICS文献大全
  • Fine mapping of the Bmgr5 quantitative trait locus for allogeneic bone marrow engraftment in mice.

    abstract：:To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we used forward genetics and previously described identification, in mice, of a bone marrow (BM) engraftment quantitative trait locus (QTL), termed Bmgr5. This QTL confers dominant and large allele effects for engraftment susceptibility...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-013-0709-6

    authors： Wang Y,Chen X,Tsai S,Thomas A,Shizuru JA,Cao TM

    更新日期：2013-08-01 00:00:00

  • Immunoglobulin JH rearrangement in a T-cell line reflects fusion to the DH locus at a sequence lacking the nonamer recognition signal.

    abstract：:Rearrangements of the immunoglobulin heavy chain joining region (JH) genes occur in some T lymphocytes, probably because the mechanism for assembly of T-cell receptor encoded genes is very similar to that for immunoglobulins. Two such rearrangements described previously represented proper fusion of a DH and JH gene. W...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00345502

    authors： Gerondakis S,Bernard O,Cory S,Adams JM

    更新日期：1988-01-01 00:00:00

  • High antibody response to autologous type II collagen is restricted to H-2q.

    abstract：:The incidence of arthritis and the antibody response to mouse and to rat type II collagen after immunization with native rat type II collagen was studied in different mouse strains, including wild mouse-derived strains belonging to the H-2p/H-2q family. High serum levels of antibodies to mouse and rat type II collagen...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00373114

    authors： Holmdahl R,Klareskog L,Andersson M,Hansen C

    更新日期：1986-01-01 00:00:00

  • H-2 influences phenytoin binding and inhibition of prostaglandin synthesis.

    abstract：:We have reported that susceptibility to glucocorticoid- and phenytoin-induced cleft palate and glucocorticoid receptor levels in mice are influenced by the H-2 histocompatibility complex on chromosome 17. Phenytoin competes with glucocorticoids for the glucocorticoid receptor and inhibits production of prostaglandins ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00430325

    authors： Gupta C,Katsumata M,Goldman AS

    更新日期：1984-01-01 00:00:00

  • Copy number variation and association over T-cell receptor genes--influence of DNA source.

    abstract：:Genomic copy number variants (CNVs) are a common, heritable source of inter-individual differences in genomic sequence. Their influence on phenotypic variability and their involvement in the pathogenesis of several common diseases is well established and the object of many current studies. In the course of examining C...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-010-0459-7

    authors： Schwienbacher C,De Grandi A,Fuchsberger C,Facheris MF,Svaldi M,Wjst M,Pramstaller PP,Hicks AA

    更新日期：2010-08-01 00:00:00

  • Molecular cloning, gene structure, and expression pattern of pig immunoreceptor DAP12.

    abstract：:Natural killer (NK) cells express receptors for MHC class I that contain immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic domain. Whereas these receptors inhibit NK cell cytotoxicity, certain isoforms of these NK receptors (e.g., KIR2DS, CD94/NKG2C, and Ly49D) do not have ITIMs, but...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050642

    authors： Yim D,Jie HB,Lanier LL,Kim YB

    更新日期：2000-05-01 00:00:00

  • Polymorphism at expressed DQ and DR loci in five common equine MHC haplotypes.

    abstract：:The polymorphism of major histocompatibility complex (MHC) class II DQ and DR genes in five common equine leukocyte antigen (ELA) haplotypes was determined through sequencing of mRNA transcripts isolated from lymphocytes of eight ELA homozygous horses. Ten expressed MHC class II genes were detected in horses of the EL...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-016-0964-4

    authors： Miller D,Tallmadge RL,Binns M,Zhu B,Mohamoud YA,Ahmed A,Brooks SA,Antczak DF

    更新日期：2017-03-01 00:00:00

  • Sequence polymorphism in the HLA-B promoter region.

    abstract：:Transcription of major histocompatibility complex class I genes is controlled by the class I regulatory complex in the 5' flanking region. To investigate the molecular basis of this region, we studied the polymorphism of the promoter of the HLA-B locus extending from the ATG transcription initiation signal to -284 bas...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00163991

    authors： Yao Z,Volgger A,Scholz S,Albert ED

    更新日期：1995-01-01 00:00:00

  • MIC-A polymorphism in Japanese and a MIC-A-MIC-B null haplotype.

    abstract：:A polymorphic gene, MIC-A, is one of the MIC family of genes which is composed of a group of homologous genes interspersed in the class III and class I regions of the major histocompatibility complex. MIC-A is located 46 kilobases (kb) centromeric of HLA-B, and is preferentially expressed in the epithelial cells and i...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050658

    authors： Komatsu-Wakui M,Tokunaga K,Ishikawa Y,Kashiwase K,Moriyama S,Tsuchiya N,Ando H,Shiina T,Geraghty DE,Inoko H,Juji T

    更新日期：1999-07-01 00:00:00

  • Structure and diversity of Mexican axolotl lambda light chains.

    abstract：:We report here the structure of cDNA clones encoding axolotl light chains of the lambda type. A single IGLC gene and eight different potential IGLV genes belonging to four different families were detected. The axolotl Cgamma domain has several residues or stretches of residues that are typically conserved in mammalian...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510000264

    authors： André S,Guillet F,Charlemagne J,Fellah JS

    更新日期：2000-11-01 00:00:00

  • Identification and characterization of Fugu orthologues of mammalian interleukin-12 subunits.

    abstract：:We have isolated and characterized cDNAs and genes for pufferfish, Fugu rubripes, (Fugu) orthologues of mammalian interleukin (IL)-12 subunits (IL-12 p35 and IL-12 p40). The deduced amino acid sequences of the Fugu IL-12 subunits showed homology with mammalian IL-12 subunits (p35: 50.4-58.0% similarity; p40: 51.2-55.4...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-003-0582-9

    authors： Yoshiura Y,Kiryu I,Fujiwara A,Suetake H,Suzuki Y,Nakanishi T,Ototake M

    更新日期：2003-08-01 00:00:00

  • The chicken CD4 gene has remained conserved in evolution.

    abstract：:CD4 has a central role in thymocyte differentiation and cell-mediated immunity. We isolated and analyzed chicken CD4. The gene spans 11.5 kb and is composed of ten exons. The promoter is TATA-less and similar to the mouse and human CD4 promoters, with two transcription start sites as determined by 5'RACE analysis. In ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-002-0490-4

    authors： Koskinen R,Salomonsen J,Tregaskes CA,Young JR,Goodchild M,Bumstead N,Vainio O

    更新日期：2002-10-01 00:00:00

  • P1 and cosmid clones define the organization of 280 kb of the mouse H-2 complex containing the Cps-1 and Hsp70 loci.

    abstract：:A 280 kilobase (kb) contig was isolated from mouse genomic P1 and cosmid libraries, using as probes human cDNA and genomic DNA fragments that map in the interval between the second component of complement and tumor necrosis factor genes of the HLA complex. The clone contig demonstrates synteny of eleven mouse genes th...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00171796

    authors： Gasser DL,Sternberg NL,Pierce JC,Goldner-Sauve A,Feng H,Haq AK,Spies T,Hunt C,Buetow KH,Chaplin DD

    更新日期：1994-01-01 00:00:00

  • Polymorphism of IL-10 gene promoter region: association with T cell proliferative responses after acellular pertussis vaccination in adults.

    abstract：:Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-1...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-016-0923-0

    authors： Gröndahl-Yli-Hannuksela K,Vahlberg T,Ilonen J,Mertsola J,He Q

    更新日期：2016-10-01 00:00:00

  • Association of human NK cell surface receptors NKR-P1 and CD94 with Src-family protein kinases.

    abstract：:Human natural killer (NK) cells express on their surface several members of the C-type lectin family such as NKR-P1, CD94, and NKG2 that are probably involved in recognition of target cells and delivery of signals modulating NK cell cytotoxicity. To elucidate the mechanisms involved in signaling via these receptors, w...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050267

    authors： Cerný J,Fiserová A,Horváth O,Bezouska K,Pospísil M,Horejsí V

    更新日期：1997-01-01 00:00:00

  • Identification and characterization of the lamprey cathepsin genes.

    abstract：:Cathepsins are key mammalian proteases that play an important role in the immune response. Several studies have revealed the versatile and critical functions of cathepsins. Here, we obtained ten kinds of cathepsin homologs and identified seven homologs with complete coding sequences. Phylogenetic analysis verified the...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-019-01117-w

    authors： Wang D,Su P,Wang X,Liu K,Li C,Gao X,Lu J,Sun F,Li Q,Pang Y

    更新日期：2019-05-01 00:00:00

  • Thirty allele-level haplotypes centered around KIR2DL5 define the diversity in an African American population.

    abstract：:KIR2DL5 alleles were physically linked to alleles at adjacent KIR loci to define this region of KIR haplotypes in 55 gene-positive random African Americans. The majority carried KIR2DL5B. Three KIR2DL5A and six KIR2DL5B alleles that have been previously described and 11 novel KIR2DL5 alleles were identified by DNA seq...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-010-0458-8

    authors： Hou L,Chen M,Jiang B,Wu D,Ng J,Hurley CK

    更新日期：2010-08-01 00:00:00

  • Physical mapping of the E/C and grc regions of the rat major histocompatibility complex.

    abstract：:Alignment of class I-hybridizing cosmids from an R21 (AlBlDlEugrc+) genomic DNA library gave two contigs: one [150 kilobases (kb)] encompassed the E/C region, or a large part thereof, and the other (110 kb) contained the grc region which has genes influencing resistance to chemical carcinogens (rcc), fertility (ft), a...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF02602652

    authors： Yuan XJ,Salgar SK,Hassett AL,McHugh KP,Kunz HW,Gill TJ 3rd

    更新日期：1996-01-01 00:00:00

  • Gene duplication, allelic diversity, selection processes and adaptive value of MHC class II DRB genes of the bank vole, Clethrionomys glareolus.

    abstract：:The generation and maintenance of allelic polymorphism in genes of the major histocompatibility complex (MHC) is a central issue in evolutionary genetics. Recently, the focus has changed from ex situ to in situ populations to understand the mechanisms that determine adaptive MHC polymorphism under natural selection. B...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-007-0205-y

    authors： Axtner J,Sommer S

    更新日期：2007-05-01 00:00:00

  • The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6.

    abstract：:One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00373021

    authors： D'Hoostelaere LA,Gibson DM

    更新日期：1986-01-01 00:00:00

  • Analysis of three distinct Ly6-A-related cDNA sequences isolated from rat kidney.

    abstract：:Mouse Ly6A and Ly6C cDNA probes were hybridized to total RNA of rat tissues and, as in mouse, the highest level of Ly6-related transcripts was detected in kidney. Therefore, Ly6-related cDNA clones were isolated from a commercial rat kidney cDNA library in lambda gt11. Four of these (RK3, RK6, RK10, and RK11) have bee...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00661220

    authors： Friedman S,Palfree RG,Sirlin S,Hämmerling U

    更新日期：1990-01-01 00:00:00

  • Polymorphism, natural selection, and structural modeling of class Ia MHC in the African clawed frog (Xenopus laevis).

    abstract：:In the African clawed frog (Xenopus laevis), two deeply divergent allelic lineages of multiple genes of the class I MHC region have been discovered. For the MHC class I UAA locus, functional differences and the molecular basis for lineages maintenance are unknown. Alleles of linked class I region genes also exhibit st...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-006-0114-5

    authors： Bos DH,Waldman B

    更新日期：2006-06-01 00:00:00

  • The diversity of the HLA-E-restricted peptide repertoire explains the immunological impact of the Arg107Gly mismatch.

    abstract：:Human leukocyte antigen (HLA)-E molecules are potent inhibitors of NK cell-mediated killing. Low in polymorphisms, two alleles are widely expressed among diverse populations: HLA-E*01:01 and HLA-E*01:03. Both alleles are distinguished by one SNP resulting in the substitution Arg107Gly. Both alleles present a limited s...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-015-0880-z

    authors： Celik AA,Kraemer T,Huyton T,Blasczyk R,Bade-Döding C

    更新日期：2016-01-01 00:00:00

  • Two genes controlling acute phase responses by the antitumor polysacch aride, lentinan.

    abstract：:Lentinan, a beta-1,6;1,3-glucan, is tumor-specific for transplantable mouse solid-type tumors and it also stimulates the production of acute phase proteins (APPs). The APP response to lentinan is of the delayed type (DT-APR) and differs from that to lipopolysaccharide, which is acute. We found that the responses were ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00587302

    authors： Maeda YY,Takahama S,Kohara Y,Yonekawa H

    更新日期：1996-01-01 00:00:00

  • Evidence for non-random distribution of Fcgamma receptor genotype combinations.

    abstract：:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. L...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-003-0574-9

    authors： van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JG

    更新日期：2003-07-01 00:00:00

  • MICA, a new polymorphic HLA-related antigen, is expressed mainly by keratinocytes, endothelial cells, and monocytes.

    abstract：:MICA is a new polymorphic gene in the HLA region expressed in epithelial cell lines and gastrointestinal epithelium. Little is yet known about the MICA protein, and the pattern of its expression by freshly isolated cells has not been established. In the present experiments, we used antibodies raised in rabbits against...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s002510050339

    authors： Zwirner NW,Fernández-Viña MA,Stastny P

    更新日期：1998-01-01 00:00:00

  • Mapping of susceptibility and protective loci for acute GVHD in unrelated HLA-matched bone marrow transplantation donors and recipients using 155 microsatellite markers on chromosome 22.

    abstract：:Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gen...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-006-0186-2

    authors： Kikuchi T,Naruse TK,Onizuka M,Li S,Kimura T,Oka A,Morishima Y,Kulski JK,Ichimiya S,Sato N,Inoko H

    更新日期：2007-02-01 00:00:00

  • Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion.

    abstract：:Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority ...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-011-0589-6

    authors： Schwartz JC,Lefranc MP,Murtaugh MP

    更新日期：2012-04-01 00:00:00

  • Rearrangement of 21-hydroxylase genes in disease-associated MHC supratypes.

    abstract：:Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/BF00377968

    authors： Garlepp MJ,Wilton AN,Dawkins RL,White PC

    更新日期：1986-01-01 00:00:00

  • NetCTLpan: pan-specific MHC class I pathway epitope predictions.

    abstract：:Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates predictions of proteaso...

    journal_title：Immunogenetics

    pub_type： 杂志文章

    doi：10.1007/s00251-010-0441-4

    authors： Stranzl T,Larsen MV,Lundegaard C,Nielsen M

    更新日期：2010-06-01 00:00:00