Abstract:
:Human IgG receptors (FcgammaR) display considerable heterogeneity, and are crucial immune response modulating molecules. FcgammaRIIA, FcgammaRIIIA, and FcgammaRIIIB display functional biallelic polymorphisms. FcgammaR polymorphisms have been found associated with susceptibility to infectious and autoimmune diseases. Linked transmission of FcgammaR alleles was studied by determining the distribution of FcgammaRIIA-FcgammaRIIIA-FcgammaRIIIB genotype combinations in 514 Dutch Caucasian, and 149 Japanese blood donors. The structure of the FcgammaR locus was studied by radiation hybrid mapping of FcgammaRIA, FcgammaRIIA, FcgammaRIIB, FcgammaRIIIA, FcgammaRIIIB, and adjacent genes from the pentraxin family. In addition, crossing-over frequencies within the FcgammaR locus were determined in 63 Dutch Caucasian families, encompassing 183 individuals. FcgammaRII and FcgammaRIII subclasses were mapped in close proximity (0.47-3.14 cR). Accordingly, crossing-over frequencies within the FcgammaRII-III locus in Dutch families were low. Analysis of combined FcgammaR genotypes strongly suggested non-random distribution of FcgammaRIIA-FcgammaRIIIA-, and FcgammaRIIIA-FcgammaRIIIB genotypes in Dutch donors (P<0.001 and P<0.00001, respectively), and of FcgammaRIIA-FcgammaRIIIb genotypes in Japanese blood donors (P<0.02). Frequencies of FcgammaRII-FcgammaRIII haplotypes differed significantly between Dutch and Japanese (P<0.00001). This study provides important information for the interpretation of studies reporting associations of FcgammaR alleles with disease, and underscores the apparent differences in FcgammaR heterogeneity between ethnic groups.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
van der Pol WL,Jansen MD,Sluiter WJ,van de Sluis B,Leppers-van de Straat FG,Kobayashi T,Westendorp RG,Huizinga TW,van de Winkel JGdoi
10.1007/s00251-003-0574-9subject
Has Abstractpub_date
2003-07-01 00:00:00pages
240-6issue
4eissn
0093-7711issn
1432-1211journal_volume
55pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::A segment comprising 307,078 nucleotides of the pig major histocompatibility complex (SLA) was completely sequenced. The segment corresponded to the entire SLA classical class I-containing region of the serologically defined SLA H01 haplotype. In all, 11 genes were characterized, comprising 7 class I genes located on ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510100348
更新日期:2001-08-01 00:00:00
abstract::Immunity-related genes are a suitable model for studying effects of selection at the genomic level. Some of them are highly conserved due to functional constraints and purifying selection, while others are variable and change quickly to cope with the variation of pathogens. The SLC11A1 gene encodes a transporter prote...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-016-0905-2
更新日期:2016-05-01 00:00:00
abstract::The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0334-y
更新日期:2008-12-01 00:00:00
abstract::Polymorphic insertion frequencies of the retrotransposons known as the "SVA" elements were investigated at four loci in the MHC class I genomic region to determine their allele and haplotype frequencies and associations with the HLA-A, -B or -C genes for 100 Japanese, 100 African Americans, 174 Australian Caucasians a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0427-2
更新日期:2010-04-01 00:00:00
abstract::Footpad swelling response was used to measure the alloantigenicity of epidermal cells (ECs) in delayed-type hypersensitivity (DTH). Strong footpad swelling was observed 3 h after the challenge, and it continued for 48 h after the challenge. Genetical incompatibility between the recipients and the ECs was required to i...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00372666
更新日期:1986-01-01 00:00:00
abstract::In the African clawed frog (Xenopus laevis), two deeply divergent allelic lineages of multiple genes of the class I MHC region have been discovered. For the MHC class I UAA locus, functional differences and the molecular basis for lineages maintenance are unknown. Alleles of linked class I region genes also exhibit st...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0114-5
更新日期:2006-06-01 00:00:00
abstract::Rearrangements of the immunoglobulin heavy chain joining region (JH) genes occur in some T lymphocytes, probably because the mechanism for assembly of T-cell receptor encoded genes is very similar to that for immunoglobulins. Two such rearrangements described previously represented proper fusion of a DH and JH gene. W...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345502
更新日期:1988-01-01 00:00:00
abstract::We investigated the Nco I restriction fragment length polymorphism (RFLP) of the tumor necrosis factor beta (TNFB) gene in 173 patients with systemic lupus erythematosus (SLE), 192 unrelated healthy controls, and eleven panel families, all of German origin. The phenotype frequency of the TNFB*1 allele was significantl...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00222469
更新日期:1993-01-01 00:00:00
abstract::The polymorphism of feline MHC antigens was examined using biochemical methods. The following observations were made: (1) feline class I and II antigens are polymorphic. Their biochemical features were established using rabbit and mouse reagents directed against human MHC products; they resemble those observed for oth...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00398799
更新日期:1986-01-01 00:00:00
abstract::The cell-surface expression of the class I alloantigen Qa-2 was analyzed on resting and activated spleen and thymus cells using cytotoxic elimination and immunofluorescence and flow cytometry. Spleen cells activated by mitogens or alloantigen were homogeneously positive for cell surface Qa-2, but activated splenic T c...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00377958
更新日期:1986-01-01 00:00:00
abstract::Segregation distortion was found for a haplotype of the equine lymphocyte antigen (ELA) system in an extended family of American Standardbred horses. In one sire family, consisting of a stallion and his 17 sons and grandsons, the gene for ELA-A10 (A10) was transmitted to 57.7% of 638 offspring scored (P = 0.001). Sign...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364526
更新日期:1986-01-01 00:00:00
abstract::A 280 kilobase (kb) contig was isolated from mouse genomic P1 and cosmid libraries, using as probes human cDNA and genomic DNA fragments that map in the interval between the second component of complement and tumor necrosis factor genes of the HLA complex. The clone contig demonstrates synteny of eleven mouse genes th...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00171796
更新日期:1994-01-01 00:00:00
abstract::Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345403
更新日期:1984-01-01 00:00:00
abstract::Although major histocompatibility complex (MHC) class I molecules are, as a rule, highly polymorphic in mammalian species, those of the New World primate Saguinus oedipus (cotton-top tamarin) exhibit limited polymorphism. We have cloned and sequenced twelve MHC class I cDNAs from this species. Since cloned cotton-top ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00210819
更新日期:1991-01-01 00:00:00
abstract::CD99, the product of the MIC2 gene, exhibits an erythroid-specific quantitative polymorphism co-regulated with the Xga blood group polymorphism. The co-expression of X-linked MIC2 and XG genes is presumably controlled at the transcriptional level by a single XGR locus in the pseudoautosomal region of sexual chromosome...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000193
更新日期:2000-07-01 00:00:00
abstract::Two out of ten Rg-specific antisera tested contain a third antibody specific for the beta chain of C4. Analysis of the beta chains of 66 unrelated individuals by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that the epitope detected is located exclusively on the light (L) beta chain. A strong, bu...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02425274
更新日期:1989-01-01 00:00:00
abstract::Mice bearing the H-2b haplotype are susceptible to the development of experimental autoimmune myasthenia gravis (EAMG), induced by acetylcholine receptor (AChR) autoimmunity. One of the genes influencing EAMG susceptibility has been mapped to the Ab locus of the major histocompatibility complex, and the A beta chain h...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00204895
更新日期:1990-01-01 00:00:00
abstract::In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00223541
更新日期:1992-01-01 00:00:00
abstract::On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00368537
更新日期:1983-01-01 00:00:00
abstract::Wild mice captured in Texas, Scotland, Federal Republic of Germany, Denmark, Spain, Greece, Israel, Egypt, and Chile were mated to inbred strains and through successive backcross matings and H-2 typing lines homozygous for wild-derived H-2, haplotypes were established. The lines, which are neither congenic nor inbred,...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00952959
更新日期:1983-01-01 00:00:00
abstract::Rh and its homologous Rh50 gene products are considered to form heterotetramers on erythrocyte membranes. Rh protein has Rh blood group antigen sites, while Rh50 protein does not, and is more conserved than Rh protein. We previously determined both Rh and Rh50 gene cDNA coding regions from mouse and rat, and carried o...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000202
更新日期:2000-08-01 00:00:00
abstract::The KIR gene cluster exhibits a high degree of polymorphism in terms of gene content as well as allelic polymorphism, and data suggest that it is evolving rapidly. The KIR3DL1 locus is one of the most polymorphic loci within this cluster and is unique in that it encodes an activating receptor KIR3DS1, as well as multi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-007-0240-8
更新日期:2007-10-01 00:00:00
abstract::Almost 10,000 single nucleotide polymorphisms (SNPs) had been identified in the RT1 complex, the major histocompatibility complex of the rat, but less than approximately 0.5% have been characterized. In the context of the incomplete characterization of most SNPs, simple sequence length polymorphism (SSLP) marker devel...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0352-9
更新日期:2009-03-01 00:00:00
abstract::In an effort to generate an A.CA mouse expressing Ed, the Ead gene has been introduced into A.CA mice which lack the major histocompatibility complex (MHC) class II E molecule. Flow cytometric analysis shows cell surface expression of the E alpha chain on lymphocytes and macrophages in the transgenic mice. Analysis of...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01719237
更新日期:1991-01-01 00:00:00
abstract::Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510000276
更新日期:2001-01-01 00:00:00
abstract::Genes encoding the horse (Equus caballus) T-cell receptor beta chain (TCRB) were cloned and characterized. Of 33 cDNA clones isolated from the mesenteric lymph node, 30 had functionally rearranged gene segments, and three contained germline sequences. Sixteen unique variable segments (TCRBV), 14 joining genes (TCRBJ),...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188177
更新日期:1994-01-01 00:00:00
abstract::The human Lutheran (Lu) blood group antigens are carried by two glycoproteins (gps) that belong to the immunoglobulin (Ig) superfamily. These gps represent adhesion molecules that function as the unique erythroid receptors for laminin. We report here the cloning and functional expression of the orthologous mouse Lu mR...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050602
更新日期:1999-12-01 00:00:00
abstract::The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02440994
更新日期:1996-01-01 00:00:00
abstract::In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-gamma these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when com...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00172153
更新日期:1995-01-01 00:00:00
abstract::The nucleotide sequences of 11 variable gene segments coding for rabbit T-cell receptor beta (Tcrb-V) chains were determined by directly sequencing fragments amplified by the cassette-ligation mediated polymerase chain reaction (CLM-PCR) and by modified anchor PCR without the cloning procedure. The nucleotide sequence...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188786
更新日期:1994-01-01 00:00:00