Polymorphism of the tumor necrosis factor beta gene in systemic lupus erythematosus: TNFB-MHC haplotypes.

abstract：:Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...

journal_title：Immunogenetics

authors： Kuroda N,Uinuk-ool TS,Sato A,Samonte IE,Figueroa F,Mayer WE,Klein J

更新日期：2003-03-01 00:00:00

abstract：:A cDNA library screening using the conserved exon 4 of Atlantic salmon Mhc class I as probe provided the basis for a study on Mhc class I polymorphism in a breeding population. Twelve different alleles were identified in the 82 dams and sires studied. No individual expressed more than two alleles, which corresponded t...

journal_title：Immunogenetics

authors： Grimholt U,Drabløs F,Jørgensen SM,Høyheim B,Stet RJ

更新日期：2002-11-01 00:00:00

abstract：:We report here the structure of cDNA clones encoding axolotl light chains of the lambda type. A single IGLC gene and eight different potential IGLV genes belonging to four different families were detected. The axolotl Cgamma domain has several residues or stretches of residues that are typically conserved in mammalian...

journal_title：Immunogenetics

authors： André S,Guillet F,Charlemagne J,Fellah JS

更新日期：2000-11-01 00:00:00

abstract：:Avian influenza is a serious threat to the poultry industry and, as the potential source of a human pandemic virus, to public health. Different Mx alleles have been reported to confer resistance or susceptibility to influenza virus replication, and so knowledge of their frequencies is important when considering the po...

journal_title：Immunogenetics

authors： Balkissoon D,Staines K,McCauley J,Wood J,Young J,Kaufman J,Butter C

更新日期：2007-08-01 00:00:00

abstract：:The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp i...

journal_title：Immunogenetics

authors： Yu CQ,Na L,Lv XL,Liu JD,Liu XM,Ji F,Zheng YH,Du HL,Kong XG,Zhou JH

更新日期：2013-03-01 00:00:00

abstract：:A segment comprising 307,078 nucleotides of the pig major histocompatibility complex (SLA) was completely sequenced. The segment corresponded to the entire SLA classical class I-containing region of the serologically defined SLA H01 haplotype. In all, 11 genes were characterized, comprising 7 class I genes located on ...

journal_title：Immunogenetics

authors： Renard C,Vaiman M,Chiannilkulchai N,Cattolico L,Robert C,Chardon P

更新日期：2001-08-01 00:00:00

abstract：:Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] wa...

journal_title：Immunogenetics

authors： Racila E,Racila DM,Ritchie JM,Taylor C,Dahle C,Weiner GJ

更新日期：2006-02-01 00:00:00

abstract：:Immunoglobulin-A deficiency (IgA-D) is the most common human Ig class deficiency with an estimated frequency of approximately 1 in 500 in the Swedish population. We investigated the immunoglobulin heavy chain constant region gene segments (IGHC) in 103 individuals with IgA-D and the immunoglobulin heavy chain variable...

journal_title：Immunogenetics

authors： Olsson PG,Hammarström L,Cox DW,Smith CI

更新日期：1992-01-01 00:00:00

abstract：:We studied the relationship between human leukocyte antigen (HLA) class I alleles and cervical cancer among Indian women. Seventy-five cervical cancer cases were compared with 175 noncancer controls. Cervical biopsy tissue specimen from cancer cases and cervical swab specimen from controls were collected for HPV detec...

journal_title：Immunogenetics

authors： Gokhale P,Mania-Pramanik J,Sonawani A,Idicula-Thomas S,Kerkar S,Tongaonkar H,Chaudhari H,Warke H,Salvi V

更新日期：2014-12-01 00:00:00

abstract：:Codon bias and base composition in major histocompatibility complex (MHC) sequences have been studied for both class I and II loci in Homo sapiens and Pan troglodytes. There is low to moderate codon bias for the MHC of humans and chimpanzees. In the class I loci, the same level of moderate codon bias is seen for HLA-B...

journal_title：Immunogenetics

authors： McWeeney SK,Valdes AM

更新日期：1999-04-01 00:00:00

abstract：:The human major histocompatibility complex (MHC) is located within a 4 megabase segment on chromosome 6p21.3. Recently, a highly divergent MHC class I chain-related gene family, MIC was identified within the class I region. The MICA and MICB genes in this family have unique patterns of tissue expression. The MICA gene...

journal_title：Immunogenetics

authors： Ando H,Mizuki N,Ota M,Yamazaki M,Ohno S,Goto K,Miyata Y,Wakisaka K,Bahram S,Inoko H

更新日期：1997-01-01 00:00:00

abstract：:Two out of ten Rg-specific antisera tested contain a third antibody specific for the beta chain of C4. Analysis of the beta chains of 66 unrelated individuals by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that the epitope detected is located exclusively on the light (L) beta chain. A strong, bu...

journal_title：Immunogenetics

authors： Robson T,Heard RN,Giles CM

更新日期：1989-01-01 00:00:00

abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

journal_title：Immunogenetics

authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

更新日期：2006-08-01 00:00:00

abstract：:In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...

journal_title：Immunogenetics

authors： Bade-Doeding C,Elsner HA,Eiz-Vesper B,Seltsam A,Holtkamp U,Blasczyk R

更新日期：2004-05-01 00:00:00

abstract：:A strong correlation between the TT(-889) genotype over CC(-889) of the interleukin-1 alpha (IL-1 alpha) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region a...

journal_title：Immunogenetics

authors： Dominici R,Cattaneo M,Malferrari G,Archi D,Mariani C,Grimaldi LM,Biunno I

更新日期：2002-05-01 00:00:00

abstract：:Virus-specific CD8(+) T cells play an important role in controlling HIV/SIV replication. These T cells recognize intracellular pathogen-derived peptides displayed on the cell surface by individual MHC class I molecules. In the SIV-infected rhesus macaque model, five Mamu class I alleles have been thoroughly characteri...

journal_title：Immunogenetics

authors： Reed JS,Sidney J,Piaskowski SM,Glidden CE,León EJ,Burwitz BJ,Kolar HL,Eernisse CM,Furlott JR,Maness NJ,Walsh AD,Rudersdorf RA,Bardet W,McMurtrey CP,O'Connor DH,Hildebrand WH,Sette A,Watkins DI,Wilson NA

更新日期：2011-12-01 00:00:00

abstract：:Mice bearing the H-2w7 haplotype have five C4-related genes, one C4, one Slp, and three C4/Slp hybrid genes. The expression of these five genes in the liver of H-2w7 mice was estimated at the steady state level of their respective mRNA. We have amplified by the polymerase chain reaction (PCR) three regions of the C4/S...

journal_title：Immunogenetics

authors： Huang ZM,Takahashi M,Nonaka M

更新日期：1991-01-01 00:00:00

abstract：:To describe the polymorphism of the DRA gene in Macaca fascicularis, we have studied 141 animals either at cDNA level (78 animals from Mauritius, the Philippines, and Vietnam) or genomic level (63 animals from the Philippines, Indonesia, and Vietnam). In total, we characterized 22 cDNA DRA alleles, 13 of which had not...

journal_title：Immunogenetics

authors： Aarnink A,Estrade L,Apoil PA,Kita YF,Saitou N,Shiina T,Blancher A

更新日期：2010-03-01 00:00:00

abstract：:Monoclonal antibodies reacting with TL-like class I antigens expressed on the surface of human thymocytes and some T leukemia lines were found to define three independent epitopic clusters, two of which could be shown to reside on serologically distinct molecular subsets by a solid-phase radioimmunoassay as well as by...

journal_title：Immunogenetics

authors： Olive D,Dubreuil P,Mawas C

更新日期：1984-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) includes highly polymorphic gene families encoding proteins crucial to the vertebrate acquired immune system. Classical MHC class I (MHCI) genes code for molecules expressed on the surfaces of most nucleated cells and are associated with defense against intracellular pathogen...

journal_title：Immunogenetics

authors： Buehler DM,Verkuil YI,Tavares ES,Baker AJ

更新日期：2013-03-01 00:00:00

abstract：:TAP1 and TAP2 are two major histocompatibility complex (MHC) genes, located between HLA-DP and -DQ, whose products form a transporter molecule involved in endogenous antigen processing. Polymorphic residues have been described in both genes and, in this study, we have identified another polymorphic site within the ade...

journal_title：Immunogenetics

authors： Powis SH,Tonks S,Mockridge I,Kelly AP,Bodmer JG,Trowsdale J

更新日期：1993-01-01 00:00:00

abstract：:Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...

journal_title：Immunogenetics

authors： Pilarski LM,Wegmann TG

更新日期：1984-01-01 00:00:00

abstract：:In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. To investigate the origin of the Ig-like domains encoded by the LRC genes, a subset of C2-type Ig-like domain s...

journal_title：Immunogenetics

authors： Nikolaidis N,Klein J,Nei M

更新日期：2005-04-01 00:00:00

abstract：:An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...

journal_title：Immunogenetics

authors： Eardley DD,Murphy DB,Kemp JD,Shen FW,Cantor H,Gershon RK

更新日期：1980-01-01 00:00:00

abstract：:The human Lutheran (Lu) blood group antigens are carried by two glycoproteins (gps) that belong to the immunoglobulin (Ig) superfamily. These gps represent adhesion molecules that function as the unique erythroid receptors for laminin. We report here the cloning and functional expression of the orthologous mouse Lu mR...

journal_title：Immunogenetics

authors： Rahuel C,Colin Y,Goossens D,Gane P,El Nemer W,Cartron JP,Le Van Kim C

更新日期：1999-12-01 00:00:00

abstract：:The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus, HERV-K(C4). Nearly i...

journal_title：Immunogenetics

authors： Dangel AW,Mendoza AR,Baker BJ,Daniel CM,Carroll MC,Wu LC,Yu CY

更新日期：1994-01-01 00:00:00

abstract：:Eleven new C4d genomic primate sequences of the fourth complement factor (C4) have been obtained. Seven of them belong to five species not yet explored for this gene: Pan paniscus (pygmy chimpanzee), Cercopithecus aethiops (green monkey), Macaca mulatta (rhesus monkey), Macaca fascicularis (cynomolgus), and Saguinus o...

journal_title：Immunogenetics

authors： Paz-Artal E,Corell A,Alvarez M,Varela P,Allende L,Madroño A,Rosal M,Arnaiz-Villena A

更新日期：1994-01-01 00:00:00

abstract：:Probes for loci situated near one end of the proximal (Tcp-1) and distal (Qa-2, 3) inversions of the mouse t complex have been hybridized to chromosomes of mice with and without t complexes and with morphologically distinguishable chromosome 17s. Both the probe for Tcp-1 and that for Qa-2, 3 hybridized to clearly diff...

journal_title：Immunogenetics

authors： Lyon MF,Zenthon J,Evans EP,Burtenshaw MD,Willison KR

更新日期：1988-01-01 00:00:00

abstract：:A cDNA clone, designated IL-8nL, was obtained by suppression subtractive hybridisation between lipopolysaccharide-stimulated and non-stimulated populations of the rainbow trout macrophage-like cell line, RTS11. IL-8nL was similar but not identical to a recently published sequence of the gene encoding rainbow trout int...

journal_title：Immunogenetics

authors： Fujiki K,Gauley J,Bols NC,Dixon B

更新日期：2003-05-01 00:00:00

abstract：:To assess the role interleukins and mitogens play in regulating immunoglobulin (Ig) gene expression via the Ig enhancer and promoter, transgenic mice carrying two different Ig gene regulatory regions were generated. One, EmukCAT, contains the Ig heavy chain enhancer (Emu) and the kappa light chain promoter driving the...

journal_title：Immunogenetics

authors： Miller AE,Ennist DL,Ozato K,Westphal H

更新日期：1992-01-01 00:00:00