An epitope on C4 beta light (L) chains detected by human anti-Rg; its relationship with beta chain polymorphism and MHC associations.

abstract：:The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...

journal_title：Immunogenetics

authors： Martin MP,Single RM,Wilson MJ,Trowsdale J,Carrington M

更新日期：2008-12-01 00:00:00

abstract：:In order to determine the extent of the repertoire of the immunoglobulin light chain V-region locus (Igl-V) in the laboratory rat (Rattus norvegicus), we constructed a specifically primed cDNA library from lipopolysaccharide-stimulated DA strain rat spleens. The library was screened with a rat Igl-C2-specific probe, a...

journal_title：Immunogenetics

authors： Aguilar BA,Gutman GA

更新日期：1992-01-01 00:00:00

abstract：:Previous studies demonstrated that the diversity of the antibody response of mice to the inulin (In) determinant of bacterial levan is regulated by the gene Spectrotype Regulation 1 ( Sr1). BALB/c mice produce a monoclonal anti-In response as shown by isoelectric focusing analysis. In contrast, the anti-In antibody re...

journal_title：Immunogenetics

authors： Jones Tiffany L,Riblet R,Stein KE

更新日期：2003-05-01 00:00:00

abstract：:Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological re...

journal_title：Immunogenetics

authors： Sette A,Sidney J

更新日期：1999-11-01 00:00:00

abstract：:In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides (ODN) specifically prom...

journal_title：Immunogenetics

authors： Spirig R,Peduzzi E,Patarroyo ME,Pluschke G,Daubenberger CA

更新日期：2005-05-01 00:00:00

abstract：:Although major histocompatibility complex (MHC) class I molecules are, as a rule, highly polymorphic in mammalian species, those of the New World primate Saguinus oedipus (cotton-top tamarin) exhibit limited polymorphism. We have cloned and sequenced twelve MHC class I cDNAs from this species. Since cloned cotton-top ...

journal_title：Immunogenetics

authors： Watkins DI,Garber TL,Chen ZW,Toukatly G,Hughes AL,Letvin NL

更新日期：1991-01-01 00:00:00

abstract：:Type 1 diabetes is a multigenic autoimmune disease, the genetic basis for which is perhaps best characterized in the nonobese diabetic (NOD) mouse model. We previously located a NOD diabetes susceptibility locus, designated Idd11, on mouse Chromosome (Chr) 4 by analyzing diabetic backcross mice produced after crossing...

journal_title：Immunogenetics

authors： Brodnicki TC,McClive P,Couper S,Morahan G

更新日期：2000-01-01 00:00:00

abstract：:Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by microsatellites reve...

journal_title：Immunogenetics

authors： Aarnink A,Dereuddre-Bosquet N,Vaslin B,Le Grand R,Winterton P,Apoil PA,Blancher A

更新日期：2011-05-01 00:00:00

abstract：:Cichlid fishes of the East African Rift Valley lakes constitute an important model of adaptive radiation. Explosive speciation in the Great Lakes, in some cases as recently as 12 400 years ago, generated large species flocks that have been the focus of evolutionary studies for some time. The studies have, however, bee...

journal_title：Immunogenetics

authors： Sato A,Klein D,Sültmann H,Figueroa F,O'hUigin C,Klein J

更新日期：1997-01-01 00:00:00

abstract：:Mouse Ly6A and Ly6C cDNA probes were hybridized to total RNA of rat tissues and, as in mouse, the highest level of Ly6-related transcripts was detected in kidney. Therefore, Ly6-related cDNA clones were isolated from a commercial rat kidney cDNA library in lambda gt11. Four of these (RK3, RK6, RK10, and RK11) have bee...

journal_title：Immunogenetics

authors： Friedman S,Palfree RG,Sirlin S,Hämmerling U

更新日期：1990-01-01 00:00:00

abstract：:The vertebrate complement system is composed of about 30 serum and cell surface proteins that make up three activation pathways, a lytic pathway, and a set of proteins that regulate complement. Regulatory proteins are required for host protection against autologous complement attack and to control the amplification fe...

journal_title：Immunogenetics

authors： Multerer KA,Smith LC

更新日期：2004-05-01 00:00:00

abstract：:The genes of the major histocompatibility complex (MHC) are amongst the most variable in vertebrates and represent some of the best candidates to study processes of adaptive evolution. However, despite the number of studies available, most of the information on the structure and function of these genes come from studi...

journal_title：Immunogenetics

authors： Gómez D,Conejeros P,Marshall SH,Consuegra S

更新日期：2010-08-01 00:00:00

abstract：:The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...

journal_title：Immunogenetics

authors： Su J,Luscher MA,MacDonald KS

更新日期：2004-03-01 00:00:00

abstract：:Immunity-related genes are a suitable model for studying effects of selection at the genomic level. Some of them are highly conserved due to functional constraints and purifying selection, while others are variable and change quickly to cope with the variation of pathogens. The SLC11A1 gene encodes a transporter prote...

journal_title：Immunogenetics

authors： Bayerova Z,Janova E,Matiasovic J,Orlando L,Horin P

更新日期：2016-05-01 00:00:00

abstract：:Indian and Chinese rhesus macaques are often used in biomedical research. Genetic analyses of the major histocompatibility class I region have revealed that these macaques display a substantial level of polymorphism at Mamu-A and Mamu-B loci, which have been subject to duplication. Only a few Mamu class I allotypes ar...

journal_title：Immunogenetics

authors： de Groot NG,Heijmans CM,de Ru AH,Hassan C,Otting N,Doxiadis GG,Koning F,van Veelen PA,Bontrop RE

更新日期：2013-12-01 00:00:00

abstract：:We report here the structure of cDNA clones encoding axolotl light chains of the lambda type. A single IGLC gene and eight different potential IGLV genes belonging to four different families were detected. The axolotl Cgamma domain has several residues or stretches of residues that are typically conserved in mammalian...

journal_title：Immunogenetics

authors： André S,Guillet F,Charlemagne J,Fellah JS

更新日期：2000-11-01 00:00:00

abstract：:The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...

journal_title：Immunogenetics

authors： Easterfield AJ,Bradley JA,Bolton EM

更新日期：2003-08-01 00:00:00

abstract：:Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

journal_title：Immunogenetics

authors： Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

更新日期：1995-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease. Although the pathogenesis of RA is poorly understood, progress ...

journal_title：Immunogenetics

authors： Bax M,van Heemst J,Huizinga TW,Toes RE

更新日期：2011-08-01 00:00:00

abstract：:The only avian major histocompatibility complex (Mhc) genes thus far identified are from species of the relatively small order of Galliformes, while by far the largest order of Passeriformes (songbirds), containing some 60% of extant bird species, has not been studied at all in this regard. The Galliformes emerged mor...

journal_title：Immunogenetics

authors： Vincek V,Klein D,Graser RT,Figueroa F,O'hUigin C,Klein J

更新日期：1995-01-01 00:00:00

abstract：:Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...

journal_title：Immunogenetics

authors： Lamont SJ,Bolin C,Cheville N

更新日期：1987-01-01 00:00:00

abstract：:The locus for human immunoglobulin heavy chain constant region genes (IgCH) is characterized by a significant frequency of deleted or duplicated haplotypes, due to unequal crossing-over events. Four types of deletions and one duplication have been reported so far. We describe here a molecular study of four cases of Ig...

journal_title：Immunogenetics

authors： Bottaro A,De Marchi M,De Lange G,Boccazzi C,Caldesi F,Gallina R,Carbonara AO

更新日期：1989-01-01 00:00:00

abstract：:To determine the nucleotide polymorphism of activating killer-cell immunoglobulin-like receptors (aKIR) 3DS1 and 2DS3, we developed a novel direct-sequencing method and analyzed DNA samples of 175 KIR3DS1(+) individuals and 72 KIR2DS3(+) individuals from the white population. The putative ligand-binding extracellular ...

journal_title：Immunogenetics

authors： Luo L,Du Z,Sharma SK,Cullen R,Spellman S,Reed EF,Rajalingam R

更新日期：2007-10-01 00:00:00

abstract：:Severe combined immune deficiency (scid) mice are assumed to have two types of abnormalities: one is high radiosensitivity and the other is abnormal recombination in immunoglobulin and T-cell receptor genes. The human chromosome 8 q1.1 region has an ability to complement the scid aberrations. Moreover, the localizatio...

journal_title：Immunogenetics

authors： Hamatani K,Matsuda Y,Araki R,Itoh M,Abe M

更新日期：1996-01-01 00:00:00

abstract：:Development of an accurate and efficient molecular-based equine MHC class I typing method would facilitate the study of T lymphocyte immune responses in horses. Here, a DNA microarray was designed to detect expressed classical MHC class I genes comprising serologically defined equine leukocyte antigen (ELA)-A haplotyp...

journal_title：Immunogenetics

authors： Ramsay JD,Leib SR,Orfe L,Call DR,Tallmadge RL,Fraser DG,Mealey RH

更新日期：2010-09-01 00:00:00

abstract：:Two new C57BL/6 H-2 mutants, B6.C-H-2bm13 and B6.C-H-2bm14 are described. They arose independently in C57BL/6 as spontaneous mutations of the gain and loss type. Complementation studies map the mutations in both bm13 and bm14 to the H-2Db gene. However, these two mutant strains are not identical, but occurred as indep...

journal_title：Immunogenetics

authors： Morgan GM,Dellos H,McKenzie IF,Melvold RW,Bailey DW

更新日期：1980-01-01 00:00:00

abstract：:A strong correlation between the TT(-889) genotype over CC(-889) of the interleukin-1 alpha (IL-1 alpha) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region a...

journal_title：Immunogenetics

authors： Dominici R,Cattaneo M,Malferrari G,Archi D,Mariani C,Grimaldi LM,Biunno I

更新日期：2002-05-01 00:00:00

abstract：:Immunofluorescent and immunoelectron-microscopic staining methods were utilized to investigate the localization of Ia antigens in murine keratinizing epithelia. Approximately 3-5% of epidermal cells were shown to be Ia positive. Only dendritic Langerhans cells in the interfollicular epidermis and outer root sheaths we...

journal_title：Immunogenetics

authors： Rowden G,Phillips TM,Delovitch TL

更新日期：1978-12-01 00:00:00

abstract：:Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein composed of two ex...

journal_title：Immunogenetics

authors： Tovar V,del Valle J,Zapater N,Martin M,Romero X,Pizcueta P,Bosch J,Terhorst C,Engel P

更新日期：2002-09-01 00:00:00

abstract：:Cattle in Africa are a genetically diverse population that has resulted from successive introduction of Asian Bos indicus and European B. taurus cattle. However, analysis of mitochondrial genetic diversity in African cattle identified three lineages, one associated with Asian B. indicus, one with European B. taurus, a...

journal_title：Immunogenetics

authors： Ballingall KT,Waibochi L,Holmes EC,Woelk CH,MacHugh ND,Lutje V,McKeever DJ

更新日期：2001-01-01 00:00:00