The pattern of clinical breast cancer metastasis correlates with a single nucleotide polymorphism in the C1qA component of complement.

abstract：:The sheep immunoglobulin heavy chain Igh-J locus has been characterized in order to determine the genomic organization of JH segments and their contribution to heavy chain diversity. The locus contains six segments, of which two are functional and four are apparently pseudogenes. These segments span a 1.8 kilobase (kb...

journal_title：Immunogenetics

authors： Dufour V,Nau F

更新日期：1997-01-01 00:00:00

abstract：:Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...

journal_title：Immunogenetics

authors： Vasilescu A,Heath SC,Diop G,Do H,Hirtzig T,Hendel H,Bertin-Maghit S,Rappaport J,Therwath A,Lathrop GM,Matsuda F,Zagury JF

更新日期：2004-04-01 00:00:00

abstract：:We cloned the cDNAs and genes of two different types of toll-like receptors from Japanese flounder. The results of homology searches suggested that these genes (designated JF-TLR2 and JF-TLR22) are homologues of human TLR2 and fugu TLR22, respectively. The cDNAs of JF-TLR2 and JF-TLR22 encoded 818 and 961 amino acid r...

journal_title：Immunogenetics

authors： Hirono I,Takami M,Miyata M,Miyazaki T,Han HJ,Takano T,Endo M,Aoki T

更新日期：2004-04-01 00:00:00

abstract：:Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts reve...

journal_title：Immunogenetics

authors： Salvignol I,Calvas P,Socha WW,Colin Y,Le Van Kim C,Bailly P,Ruffié J,Cartron JP,Blancher A

更新日期：1995-01-01 00:00:00

abstract：:Alpha-2-macroglobulin (A2M) binds proteases, thereby acting as defense barriers against pathogens in the plasma and tissues of vertebrates and invertebrates. Quantitative real-time polymerase chain reaction (PCR) and the isobaric tags for relative and absolute quantitation method were used to determine the expression ...

journal_title：Immunogenetics

authors： Wang X,Huang J,Zhao L,Wang C,Ju Z,Li Q,Qi C,Zhang Y,Zhang Z,Zhang W,Hou M,Yuan J,Zhong J

更新日期：2012-11-01 00:00:00

abstract：:Probes for loci situated near one end of the proximal (Tcp-1) and distal (Qa-2, 3) inversions of the mouse t complex have been hybridized to chromosomes of mice with and without t complexes and with morphologically distinguishable chromosome 17s. Both the probe for Tcp-1 and that for Qa-2, 3 hybridized to clearly diff...

journal_title：Immunogenetics

authors： Lyon MF,Zenthon J,Evans EP,Burtenshaw MD,Willison KR

更新日期：1988-01-01 00:00:00

abstract：:We have used seven HLA-D homozygous typing cells (HTC) in a comparative study of the DRw8 antigen complex in three racial groups. Three distinct HLA-D specificities were recognized, each associated with HLA-DRw8. Four of the HTC defined a DRw8-associated HLA-D specificity designated 8.1, one defined a specificity desi...

journal_title：Immunogenetics

authors： Mickelson EM,Nisperos B,Layrisse Z,Kim SJ,Thomas ED,Hansen JA

更新日期：1983-01-01 00:00:00

abstract：:A polymorphic gene, MIC-A, is one of the MIC family of genes which is composed of a group of homologous genes interspersed in the class III and class I regions of the major histocompatibility complex. MIC-A is located 46 kilobases (kb) centromeric of HLA-B, and is preferentially expressed in the epithelial cells and i...

journal_title：Immunogenetics

authors： Komatsu-Wakui M,Tokunaga K,Ishikawa Y,Kashiwase K,Moriyama S,Tsuchiya N,Ando H,Shiina T,Geraghty DE,Inoko H,Juji T

更新日期：1999-07-01 00:00:00

abstract：:In mammals many natural killer (NK) cell receptors, encoded by the leukocyte receptor complex (LRC), regulate the cytotoxic activity of NK cells and provide protection against virus-infected and tumor cells. To investigate the origin of the Ig-like domains encoded by the LRC genes, a subset of C2-type Ig-like domain s...

journal_title：Immunogenetics

authors： Nikolaidis N,Klein J,Nei M

更新日期：2005-04-01 00:00:00

abstract：:Macrophages (mϕ) from pre-diseased mice of the major murine inbred models of spontaneous autoimmunity (AI), including multiple lupus-prone strains and the type I diabetes-prone NOD (non-obese diabetic) strain, have identical apoptotic target-dependent abnormalities. This characteristic feature of mϕ from AI-prone mice...

journal_title：Immunogenetics

authors： Antoni A,Patel VA,Fan H,Lee DJ,Graham LH,Rosch CL,Spiegel DS,Rauch J,Levine JS

更新日期：2011-05-01 00:00:00

abstract：:The rabbit has long been a model for studies of the immune system. Work using rabbits contributed both to the battle against infectious diseases such as rabies and syphilis, and to our knowledge, of antibodies' structure, function, and regulated expression. With the description of rabbit Ig allotypes, the discovery of...

journal_title：Immunogenetics

authors： Pinheiro A,Lanning D,Alves PC,Mage RG,Knight KL,van der Loo W,Esteves PJ

更新日期：2011-07-01 00:00:00

abstract：:The locus for human immunoglobulin heavy chain constant region genes (IgCH) is characterized by a significant frequency of deleted or duplicated haplotypes, due to unequal crossing-over events. Four types of deletions and one duplication have been reported so far. We describe here a molecular study of four cases of Ig...

journal_title：Immunogenetics

authors： Bottaro A,De Marchi M,De Lange G,Boccazzi C,Caldesi F,Gallina R,Carbonara AO

更新日期：1989-01-01 00:00:00

abstract：:The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...

journal_title：Immunogenetics

authors： Nguyen VK,Su C,Muyldermans S,van der Loo W

更新日期：2002-04-01 00:00:00

abstract：:The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...

journal_title：Immunogenetics

authors： Su J,Luscher MA,MacDonald KS

更新日期：2004-03-01 00:00:00

abstract：:A cDNA clone, designated IL-8nL, was obtained by suppression subtractive hybridisation between lipopolysaccharide-stimulated and non-stimulated populations of the rainbow trout macrophage-like cell line, RTS11. IL-8nL was similar but not identical to a recently published sequence of the gene encoding rainbow trout int...

journal_title：Immunogenetics

authors： Fujiki K,Gauley J,Bols NC,Dixon B

更新日期：2003-05-01 00:00:00

abstract：:Resistance to two cultured lines of murine embryonal carcinoma was studied in F1 hybrids constructed between the tumor-syngeneic mouse strain 129/J and several allogeneic strains. Three of four such hybrid strains were significantly more resistant to the multipotent embryonal carcinoma line PCC3 than the tumor-syngene...

journal_title：Immunogenetics

authors： Bishop GA,Dove WF

更新日期：1980-01-01 00:00:00

abstract：:The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity. Epidemiological studies described associations between single nucleotide polymorphisms (SNPs) of the human gene coding surfactant protein-D (SFTPD) and infectious pulmonary diseases. Studies on twins indicated very strong genetic de...

journal_title：Immunogenetics

authors： Heidinger K,König IR,Bohnert A,Kleinsteiber A,Hilgendorff A,Gortner L,Ziegler A,Chakraborty T,Bein G

更新日期：2005-04-01 00:00:00

abstract：:The glycosyl phosphatidylinositol (GPI)-linked antigen recognized by monoclonal antibody (mAb) MEM-102 is expressed on all peripheral blood lymphocytes, both resting and activated. Its properties are very similar to a previously described activation antigen, Blast-1. The amino acid sequence deduced from the structure ...

journal_title：Immunogenetics

authors： Korínek V,Stefanová I,Angelisová P,Hilgert I,Horejsí V

更新日期：1991-01-01 00:00:00

abstract：:Alignment of class I-hybridizing cosmids from an R21 (AlBlDlEugrc+) genomic DNA library gave two contigs: one [150 kilobases (kb)] encompassed the E/C region, or a large part thereof, and the other (110 kb) contained the grc region which has genes influencing resistance to chemical carcinogens (rcc), fertility (ft), a...

journal_title：Immunogenetics

authors： Yuan XJ,Salgar SK,Hassett AL,McHugh KP,Kunz HW,Gill TJ 3rd

更新日期：1996-01-01 00:00:00

abstract：:Binding of peptides to major histocompatibility complex (MHC) molecules is the single most selective step in the recognition of pathogens by the cellular immune system. The human MHC genomic region (called HLA) is extremely polymorphic comprising several thousand alleles, each encoding a distinct MHC molecule. The pot...

journal_title：Immunogenetics

authors： Hoof I,Peters B,Sidney J,Pedersen LE,Sette A,Lund O,Buus S,Nielsen M

更新日期：2009-01-01 00:00:00

abstract：:Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and dou...

journal_title：Immunogenetics

authors： Reveille JD,Arnett FC,Wilson RW,Bias WB,McLean RH

更新日期：1985-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I-related molecule, MR1, presents vitamin B metabolites from bacteria and yeast to mucosal-associated invariant T (MAIT) cells. Despite the evolutionary conservation of MR1, we do not know whether different allele variants of MR1 exist within the nonhuman primate (NHP) ...

journal_title：Immunogenetics

authors： Ellis-Connell AL,Kannal NM,Balgeman AJ,O'Connor SL

更新日期：2019-02-01 00:00:00

abstract：:Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles w...

journal_title：Immunogenetics

authors： Hill A,Takiguchi M,McMichael A

更新日期：1993-01-01 00:00:00

abstract：:Natural killer (NK) cells express receptors for MHC class I that contain immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic domain. Whereas these receptors inhibit NK cell cytotoxicity, certain isoforms of these NK receptors (e.g., KIR2DS, CD94/NKG2C, and Ly49D) do not have ITIMs, but...

journal_title：Immunogenetics

authors： Yim D,Jie HB,Lanier LL,Kim YB

更新日期：2000-05-01 00:00:00

abstract：:Wild mice captured in Texas, Scotland, Federal Republic of Germany, Denmark, Spain, Greece, Israel, Egypt, and Chile were mated to inbred strains and through successive backcross matings and H-2 typing lines homozygous for wild-derived H-2, haplotypes were established. The lines, which are neither congenic nor inbred,...

journal_title：Immunogenetics

authors： Zaleska-Rutczynska Z,Figueroa F,Klein J

更新日期：1983-01-01 00:00:00

abstract：:The major histocompatibility complex of the rat (RT1) encodes the class II molecules involved with antigen presentation and cell to cell communication. The organization of these class II genes has been studied by Southern blot hybridization using genomic DNA from inbred and recombinant rat strains digested with variou...

journal_title：Immunogenetics

authors： Watters JW,Locker JD,Kunz HW,Gill TJ 3rd

更新日期：1987-01-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T), a rare inherited disorder, usually affects the nervous and immune systems, and occasionally other organs. A-T is associated mainly with mutations in the ataxia telangiectasia mutated (ATM) gene, which encodes a protein kinase that has a major role in the cellular response to DNA damage. We...

journal_title：Immunogenetics

authors： Mortaz E,Marashian SM,Ghaffaripour H,Varahram M,Mehrian P,Dorudinia A,Garssen J,Adcock IM,Taylor M,Mahdaviani SA

更新日期：2017-07-01 00:00:00

abstract：:We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitt...

journal_title：Immunogenetics

authors： Webber LM,Garson OM,Tate B,McKenzie IF,Hogarth PM

更新日期：1990-01-01 00:00:00

abstract：:Several lines of evidence have confirmed the importance of Nod2 mutations for disease susceptibility in Crohn's disease. For tracing Nod2 evolution, exons 4a, 4e, 8, and 12 mutations were screened in a collection of 1,064 DNA samples from 52 worldwide populations. The overall allele frequency was 7.5% for single nucle...

journal_title：Immunogenetics

authors： Gasche C,Nemeth M,Grundtner P,Willheim-Polli C,Ferenci P,Schwarzenbacher R

更新日期：2008-02-01 00:00:00

abstract：:The factors which influence expression of autoimmune disease in the central nervous system are still poorly understood. We determined the characteristics of experimental autoimmune encephalomyelitis (EAE) in twelve different inbred strains of mice using either mouse spinal cord homogenate or synthetic peptides as the ...

journal_title：Immunogenetics

authors： Lindsey JW

更新日期：1996-01-01 00:00:00