Abstract:
:Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts revealed a high degree of similarity to human blood group Rh sequences, suggesting a great conservation of the RH genes throughout evolution. Full-length transcripts, potentially encoding 417 amino acid long proteins homologous to Rh polypeptides, were characterized, as well as mRNA isoforms which harbored nucleotide deletions or insertions and potentially encode truncated proteins. Proteins of 30-40,000 M(r), immunologically related to human Rh proteins, were detected by western blot analysis with antipeptide antibodies, indicating that Rh-like transcripts are translated into membrane proteins. Comparison of human and nonhuman protein sequences was pivotal in clarifying the molecular basis of the blood group C/c polymorphism, showing that only the Pro103Ser substitution was correlated with C/c polymorphism. In addition, it was shown that a proline residue at position 102 was critical in the expression of C and c epitopes, most likely by providing an appropriate conformation of Rh polypeptides. From these data a phylogenetic reconstruction of the RH locus evolution has been calculated from which an unrooted phylogenetic tree could be proposed, indicating that African ape Rh-like genes would be closer to the human RhD gene than to the human RhCE gene.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Salvignol I,Calvas P,Socha WW,Colin Y,Le Van Kim C,Bailly P,Ruffié J,Cartron JP,Blancher Adoi
10.1007/BF00172151subject
Has Abstractpub_date
1995-01-01 00:00:00pages
271-81issue
5eissn
0093-7711issn
1432-1211journal_volume
41pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::HLA-B and C are related class I genes which are believed to have arisen by duplication of a common ancestor. Previous study showed the presence of orthologues for both HLA-B and C in African apes but only for HLA-B in Asian apes. These observations suggested that the primate C locus evolved subsequent to the divergenc...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050566
更新日期:1999-09-01 00:00:00
abstract::We investigated the genetic control of heterotopic heart allograft rejection using a family of standard inbred, major histocompatibility complex (MHC)-congenic, and intra-MHC recombinant rat strains. Gene products of the various regions within the rat MHC differed markedly in their capacity to induce rejection. Isolat...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02421535
更新日期:1989-01-01 00:00:00
abstract::With the use of monospecific rabbit anti-G protein and mouse monoclonal anti-H-2Kk, we have analyzed the spatial relationship of the serologically defined H-2Kk antigens and the major surface glycoprotein (G protein) of vesicular stomatitis virus (VSV) to those antigens recognized by B10.A (k, d) anti-VSV cytotoxic T ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01572582
更新日期:1980-01-01 00:00:00
abstract::Because of the role major histocompatibility complex (MHC) class I b molecules may play during mouse embryonic development, we thought it would be interesting to search for additional MHC class I b molecules that might be expressed in preimplantation embryos, and in particular in the trophoblastic lineage. We therefor...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050178
更新日期:1996-01-01 00:00:00
abstract::The rabbit has long been a model for studies of the immune system. Work using rabbits contributed both to the battle against infectious diseases such as rabies and syphilis, and to our knowledge, of antibodies' structure, function, and regulated expression. With the description of rabbit Ig allotypes, the discovery of...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-011-0533-9
更新日期:2011-07-01 00:00:00
abstract::The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0433-0
更新日期:2002-04-01 00:00:00
abstract::Protein tyrosine phosphorylation is an important regulatory mechanism in cell physiology. While the protein tyrosine kinase (PTKase) family has been extensively studied, only six protein tyrosine phosphatases (PTPases) have been described. By Southern blot analysis, genomic DNA from several different phyla were found ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00211693
更新日期:1991-01-01 00:00:00
abstract::Class II genes of the human major histocompatibility complex (MHC) are polymorphic. Allelic variation of the coding region of these genes is involved in the antigen presentation and is associated with susceptibility to certain autoimmune diseases. The DR region is unique among human class II regions in that multiple D...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216386
更新日期:1993-01-01 00:00:00
abstract::The glycosyl phosphatidylinositol (GPI)-linked antigen recognized by monoclonal antibody (mAb) MEM-102 is expressed on all peripheral blood lymphocytes, both resting and activated. Its properties are very similar to a previously described activation antigen, Blast-1. The amino acid sequence deduced from the structure ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00210823
更新日期:1991-01-01 00:00:00
abstract::The Hawaiian monk seal population has experienced precipitous declines in the last 50 years. In this study, we provide evidence that individuals from remaining endangered population exhibit alarming uniformity in class I major histocompatibility (MHC) genes. The peripheral blood leukocyte-derived mRNA of six captive a...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0069-y
更新日期:2006-04-01 00:00:00
abstract::The locus for human immunoglobulin heavy chain constant region genes (IgCH) is characterized by a significant frequency of deleted or duplicated haplotypes, due to unequal crossing-over events. Four types of deletions and one duplication have been reported so far. We describe here a molecular study of four cases of Ig...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02341612
更新日期:1989-01-01 00:00:00
abstract::The genetic control of natural resistance in vivo to four natural killer (NK) cell-resistant H-2 homozygous lymphoid tumor cell lines was investigated by following the survival and organ distribution of cells prelabeled with radioactive iododeoxyuridine. Backcross mice derived from DBA/2J and CBA/J parents were inject...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364210
更新日期:1984-01-01 00:00:00
abstract::Five sets of cytotoxic effector cells were generated, using haplo-identical, first degree relatives in five different families, against the HLA-A3; B7 serological determinants combined with different DR antigens. When tested against a panel of cells bearing combinations of the HLA-A, -B and -DR antigens it was shown t...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364495
更新日期:1981-01-01 00:00:00
abstract::Phenotypic variability is often observed in cynomolgus monkeys on preclinical studies and may, in part, be driven by genetic variability. However, the role of monkey genetic variation remains largely unexplored in the context of drug response. This study evaluated genetic variation in cynomolgus monkey FcγR3A and TAP1...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-017-0970-1
更新日期:2017-04-01 00:00:00
abstract::To evaluate the effects of the transcription factor GATA-1 on determining cell fate between dendritic cell (DC) and mast cell (MC) lineages, GATA-1 was exogenously expressed in bone marrow-derived (BM) DCs. Exogenous expression of GATA-1 by a retrovirus in BMDCs inhibited expression of CD11c, CD80, CD86, and major his...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-010-0444-1
更新日期:2010-07-01 00:00:00
abstract::Lentinan, a beta-1,6;1,3-glucan, is tumor-specific for transplantable mouse solid-type tumors and it also stimulates the production of acute phase proteins (APPs). The APP response to lentinan is of the delayed type (DT-APR) and differs from that to lipopolysaccharide, which is acute. We found that the responses were ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00587302
更新日期:1996-01-01 00:00:00
abstract::Genetic effects on spontaneous autoimmune thyroiditis in chickens were assessed by measuring phenotypic symptoms, the titer of circulating antibody to thyroglobulin, and the pathological change in the thyroids of young chicks. One or more loci within the B complex (the major histocompatibility complex of the chicken) ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF01561675
更新日期:1981-01-01 00:00:00
abstract::On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00368537
更新日期:1983-01-01 00:00:00
abstract::We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4. We also studied the distribution of MICA ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-001-0413-9
更新日期:2002-02-01 00:00:00
abstract::Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-014-0775-4
更新日期:2014-06-01 00:00:00
abstract::Knowledge about the magnitude of individual polymorphism is a critical part in understanding the complexity of comprehensive mismatching. HLA-B*44:09 differs from the highly frequent HLA-B*44:02 allele by amino acid exchanges at residues 77, 80, 81, 82 and 83. We aimed to identify the magnitude of these mismatches on ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-012-0625-1
更新日期:2012-09-01 00:00:00
abstract::Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] wa...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-005-0077-y
更新日期:2006-02-01 00:00:00
abstract::Early and late primary IgM antibody responses of mice to Thy-1.1 antigens showed different antigenic and cellular requirements. We studied genetic controls of the early primary responses, which could be induced by subcellular thymocyte antigens independently of host T-cell activity. All Thy-1.2 mouse strains of Igha (...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364214
更新日期:1984-01-01 00:00:00
abstract::We have previously demonstrated a genetic predisposition among mice regarding their ability to be protected against vaginal candidiasis after peripheral immunization. Both BALB/c and (BALB/cx C57BL/6) F1 mice are protected against vaginal candidiasis after subcutaneous immunization with Candida albicans extract and C5...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050581
更新日期:1999-10-01 00:00:00
abstract::The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-004-0649-2
更新日期:2004-03-01 00:00:00
abstract::Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles w...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00216831
更新日期:1993-01-01 00:00:00
abstract::Codon bias and base composition in major histocompatibility complex (MHC) sequences have been studied for both class I and II loci in Homo sapiens and Pan troglodytes. There is low to moderate codon bias for the MHC of humans and chimpanzees. In the class I loci, the same level of moderate codon bias is seen for HLA-B...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050493
更新日期:1999-04-01 00:00:00
abstract::The interaction of bacterial pathogens with their hosts' innate immune systems can be extremely complex and is often difficult to disentangle experimentally. Using mouse models of bacterial infections, several laboratories have successfully applied genetic approaches to identify novel host genes required for innate im...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-007-0248-0
更新日期:2007-10-01 00:00:00
abstract::Genes encoding the horse (Equus caballus) T-cell receptor beta chain (TCRB) were cloned and characterized. Of 33 cDNA clones isolated from the mesenteric lymph node, 30 had functionally rearranged gene segments, and three contained germline sequences. Sixteen unique variable segments (TCRBV), 14 joining genes (TCRBJ),...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00188177
更新日期:1994-01-01 00:00:00
abstract::Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-020-01166-6
更新日期:2020-07-01 00:00:00