Abstract：
:Assembly of HLA class I molecules was studied using pulse-chase labeling of B-lymphoblastoid cell lines with 35S-methionine, immunoprecipitation with antibodies detecting free or beta 2-microglobulin-associated heavy chain and isoelectric focusing. Marked differences between the products of different class I alleles were noted. HLA-B51 assembled very inefficiently, with considerable free heavy chain still detected in an unsialated form after a four hour chase. The closely related molecule HLA-B35 was in contrast rapidly assembled, all newly synthesized heavy chain being detected in a beta 2m-associated sialated form within 30 minutes. Analysis of naturally occurring variants related to HLA-B35 and HLA-B51 localized the region determining assembly efficiency to the alpha 2 domain, in which these molecules differ at eight amino acid residues. The effect was not due to a linked dominant gene, as both patterns of assembly were observed in a single cell line.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Hill A,Takiguchi M,McMichael Adoi
10.1007/BF00216831subject
Has Abstractpub_date
1993-01-01 00:00:00pages
95-101issue
2eissn
0093-7711issn
1432-1211journal_volume
37pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract：:The level of HLA-B27 transgene expression on the cell surface is dependent on the host H-2 haplotype. Mice homozygous for the H-2b, H-2f, H-2s, H-2p, H-2r, and H-2k haplotypes express B27 at high levels. An intermediate level of B27 expression is observed in H-2v mice whereas low levels of B27 are expressed in H-2q an...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00185114
更新日期：1992-01-01 00:00:00
abstract：:Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic re...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00210476
更新日期：1993-01-01 00:00:00
abstract：:Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00404420
更新日期：1987-01-01 00:00:00
abstract：:Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-008-0275-5
更新日期：2008-04-01 00:00:00
abstract：:The J chain is a component of polymeric immunoglobulin (Ig) molecules and may play an important role in their polymerization and the transport of polymeric Ig across epithelial cells. In this study, the primary structure of the chicken J chain was determined by sequencing cDNA clones. The cDNA had an open reading fram...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s002510050016
更新日期：2000-02-01 00:00:00
abstract：:The complexity and polymorphism of sequences related to the class I and class II genes of mammalian major histocompatibility complexes (MHCs) were investigated in the tassel-eared squirrel subspecies Sciurus aberti kaibabensis or Kaibab squirrel. Kaibab squirrels are geographically isolated on the Kaibab plateau north...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00364527
更新日期：1986-01-01 00:00:00
abstract：:A healthy adult having no serologically detectable HLA class I A locus antigens was identified. The parents of the individual are consanguineous. Results of a family study indicated that the individual is homozygous for the B46-Cw1-DR8.1 haplotype, which was shown to be positively associated with A*0207 in our previou...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00186597
更新日期：1996-01-01 00:00:00
abstract：:The protein kinase, interferon-inducible double-stranded (ds)RNA-dependent activator (PRKRA) is a dsRNA-binding protein which activates a protein kinase participating in the antiviral activity of interferon. Our previous studies indicated that the nucleotide sequence encoding PRKRA, which appeared to be an intronless ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s002510000270
更新日期：2001-01-01 00:00:00
abstract：:Hepatic granulomatous lesions were induced in mice by a single intraperitoneal injection of 3 mg of disrupted Streptococcus pyogenes cell-wall material. Mice carrying the H-2b or H-2k haplotypes were highly susceptible to the induction and three weeks after the injection produced numerous granulomas. In contrast, mice...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00209289
更新日期：1992-01-01 00:00:00
abstract：:A new H-2 mutant involving the H-2d haplotype is described--C.B6-H-2dm4 (dm4). This mutant strain carries a gain and loss mutation which maps to the Kd gene of the H-2 complex. Serological testing comparing the mutant and the parental BALB/cKh strain failed to detect any difference between the two strains and no antib...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF01561695
更新日期：1981-03-01 00:00:00
abstract：:The human complement C4 genes in the HLA exhibit an unusual, dichotomous size polymorphism and a four-gene, modular variation involving novel gene RP, complement C4, steroid 21-hydroxylase (CYP21), and tenascin-like Gene X (RCCX). The C4 gene size dichotomy is mediated by an endogenous retrovirus, HERV-K(C4). Nearly i...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00177825
更新日期：1994-01-01 00:00:00
abstract：:The genetic control of natural resistance in vivo to four natural killer (NK) cell-resistant H-2 homozygous lymphoid tumor cell lines was investigated by following the survival and organ distribution of cells prelabeled with radioactive iododeoxyuridine. Backcross mice derived from DBA/2J and CBA/J parents were inject...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00364210
更新日期：1984-01-01 00:00:00
abstract：:Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates predictions of proteaso...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-010-0441-4
更新日期：2010-06-01 00:00:00
abstract：:The aim of this study was to evaluate the intra- and inter-population variability of the Gm/Km system in the Madonie Mountains, one of the main geographical barriers in north-central Sicily. We analysed 392 samples: 145 from Alia, 128 from Valledolmo, 25 from Cerda and 94 from Palermo. Serum samples were tested for G1...
journal_title：Immunogenetics
pub_type： 历史文章,杂志文章
doi：10.1007/s00251-003-0628-z
更新日期：2004-01-01 00:00:00
abstract：:Many immunoglobulin variable region (IgV) genes are present in the vertebrate genome and provide a basis for antibody diversity. IgV genes have been classified into distinct families according to DNA sequence similarity. Comparisons of VH and VL genes from two mammalian species (mouse and human) have led to the conclu...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00188428
更新日期：1995-01-01 00:00:00
abstract：:Killer cell immunoglobulin-like receptors (KIRs) represent the most polymorphic genes responsible for natural killer cell function, while human leukocyte antigen (HLA) class I molecules define and restrict cytotoxic T lymphocyte responses. Specific KIR, HLA, or KIR-HLA combinations have been implicated in the outcome ...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-016-0920-3
更新日期：2016-10-01 00:00:00
abstract：:The generation and maintenance of allelic polymorphism in genes of the major histocompatibility complex (MHC) is a central issue in evolutionary genetics. Recently, the focus has changed from ex situ to in situ populations to understand the mechanisms that determine adaptive MHC polymorphism under natural selection. B...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-007-0205-y
更新日期：2007-05-01 00:00:00
abstract：:The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequences showed the expected evolutionary...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00661093
更新日期：1992-01-01 00:00:00
abstract：:In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-004-0677-y
更新日期：2004-05-01 00:00:00
abstract：:The evolution of the mouse immunoglobulin heavy chain variable region (Igh-V) locus was investigated by the comprehensive analysis of variable region (Vh) gene family content and restriction fragment polymorphism in the genus Mus. The examination of natural Mus domesticus populations suggests an important role for rec...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF02425271
更新日期：1989-01-01 00:00:00
abstract：:The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-004-0649-2
更新日期：2004-03-01 00:00:00
abstract：:Mouse lymphocyte alloantigens Ly-19 and Ly-32 are controlled by the genes tightly linked to the Lyb-2 locus on chromosome 4. Despite the similarity in mouse strain distribution patterns, Ly-19 and Ly-32 antigens which have been detected on both B- and T-cell lineages are distinct from Lyb-2 antigen whose expression is...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00364229
更新日期：1988-01-01 00:00:00
abstract：:Control of HIV-1 viremia and progression to AIDS has been associated with specific HLA genes. The tumor necrosis factor ( TNF) and the non-classical major histocompatibility (MHC) class I chain-related A ( MICA) genes are located in the genomic segment between the HLA class I and II genes and variants of both genes ha...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-003-0604-7
更新日期：2003-10-01 00:00:00
abstract：:The ability of local ultraviolet B (UVB) irradiation to impair the induction of dinitrofluorobenzene (DNFB)-specific contact hypersensitivity (CH) in mice has been shown to be genetically determined. We have explored the possibility that the mouse Tnfa and Lps loci are involved. We demonstrate that C3H/HeN (Lpsn) stra...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF00241633
更新日期：1990-01-01 00:00:00
abstract：:An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF01567824
更新日期：1980-01-01 00:00:00
abstract：:Sixteen microsatellite markers, including two described here, were used to construct a high-resolution map of the 1q32 region encompassing the regulator of the complement activation (RCA) gene cluster. The RCA genes are a group of related genes coding for plasma and membrane associated proteins that collectively contr...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s002510050224
更新日期：1997-01-01 00:00:00
abstract：:Two out of ten Rg-specific antisera tested contain a third antibody specific for the beta chain of C4. Analysis of the beta chains of 66 unrelated individuals by sodium dodecyl sulfate polyacrylamide gel electrophoresis revealed that the epitope detected is located exclusively on the light (L) beta chain. A strong, bu...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/BF02425274
更新日期：1989-01-01 00:00:00
abstract：:Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-1...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-016-0923-0
更新日期：2016-10-01 00:00:00
abstract：:Cathepsins are key mammalian proteases that play an important role in the immune response. Several studies have revealed the versatile and critical functions of cathepsins. Here, we obtained ten kinds of cathepsin homologs and identified seven homologs with complete coding sequences. Phylogenetic analysis verified the...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-019-01117-w
更新日期：2019-05-01 00:00:00
abstract：:UV-inactivated GCHV (grass carp hemorrhage virus) is able to induce an antiviral state in cultured CAB cells (crucian carp Carassius auratus blastulae embryonic cells) via the production of interferon (IFN). In the current work, the full-length cDNAs of two Mx genes, termed CaMx1 and CaMx2, have been cloned and sequen...
journal_title：Immunogenetics
pub_type： 杂志文章
doi：10.1007/s00251-004-0658-1
更新日期：2004-04-01 00:00:00
