Polymorphism in the regulatory region of HLA-DRB genes correlating with haplotype evolution.

abstract：:An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...

journal_title：Immunogenetics

authors： Eardley DD,Murphy DB,Kemp JD,Shen FW,Cantor H,Gershon RK

更新日期：1980-01-01 00:00:00

abstract：:The mouse Fcgr1 gene encoding the high-affinity IgG receptor (FcgammaRI) exists as two known alleles, FcgammaRI-BALB and FcgammaRI-NOD, and these alleles exhibit functional differences. To determine whether other alleles exist in mouse strains, Fcgr1 coding regions from 35 strains of mice were sequenced and a further ...

journal_title：Immunogenetics

authors： Gavin AL,Leiter EH,Hogarth PM

更新日期：2000-03-01 00:00:00

abstract：:A cDNA clone, designated IL-8nL, was obtained by suppression subtractive hybridisation between lipopolysaccharide-stimulated and non-stimulated populations of the rainbow trout macrophage-like cell line, RTS11. IL-8nL was similar but not identical to a recently published sequence of the gene encoding rainbow trout int...

journal_title：Immunogenetics

authors： Fujiki K,Gauley J,Bols NC,Dixon B

更新日期：2003-05-01 00:00:00

abstract：:The common fruit fly Drosophila melanogaster is a powerful model for studying signaling pathway regulation. Conserved signaling pathways underlying physiological processes signify evolutionary relationship between organisms and the nature of the mechanisms they control. This study explores the cross-talk between the w...

journal_title：Immunogenetics

authors： Patrnogic J,Heryanto C,Ozakman Y,Eleftherianos I

更新日期：2019-07-01 00:00:00

abstract：:One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...

journal_title：Immunogenetics

authors： D'Hoostelaere LA,Gibson DM

更新日期：1986-01-01 00:00:00

abstract：:The human major histocompatibility complex (MHC) is located within a 4 megabase segment on chromosome 6p21.3. Recently, a highly divergent MHC class I chain-related gene family, MIC was identified within the class I region. The MICA and MICB genes in this family have unique patterns of tissue expression. The MICA gene...

journal_title：Immunogenetics

authors： Ando H,Mizuki N,Ota M,Yamazaki M,Ohno S,Goto K,Miyata Y,Wakisaka K,Bahram S,Inoko H

更新日期：1997-01-01 00:00:00

abstract：:The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp i...

journal_title：Immunogenetics

authors： Yu CQ,Na L,Lv XL,Liu JD,Liu XM,Ji F,Zheng YH,Du HL,Kong XG,Zhou JH

更新日期：2013-03-01 00:00:00

abstract：:The human leukocyte receptor complex (LRC) at Chromosome 19q13.4 encodes Ig superfamily proteins which regulate the function of various hematopoietic cell types. We investigated characteristics of the Ig-like transcript (ILT)/leukocyte Ig-like receptor (LIR) group of LRC genes in comparison with the other major LRC lo...

journal_title：Immunogenetics

authors： Young NT,Canavez F,Uhrberg M,Shum BP,Parham P

更新日期：2001-05-01 00:00:00

abstract：:The sheep immunoglobulin heavy chain Igh-J locus has been characterized in order to determine the genomic organization of JH segments and their contribution to heavy chain diversity. The locus contains six segments, of which two are functional and four are apparently pseudogenes. These segments span a 1.8 kilobase (kb...

journal_title：Immunogenetics

authors： Dufour V,Nau F

更新日期：1997-01-01 00:00:00

abstract：:The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...

journal_title：Immunogenetics

authors： Nguyen VK,Su C,Muyldermans S,van der Loo W

更新日期：2002-04-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through ...

journal_title：Immunogenetics

authors： Bashirova AA,Apps R,Vince N,Mochalova Y,Yu XG,Carrington M

更新日期：2014-01-01 00:00:00

abstract：:Macrophages (mϕ) from pre-diseased mice of the major murine inbred models of spontaneous autoimmunity (AI), including multiple lupus-prone strains and the type I diabetes-prone NOD (non-obese diabetic) strain, have identical apoptotic target-dependent abnormalities. This characteristic feature of mϕ from AI-prone mice...

journal_title：Immunogenetics

authors： Antoni A,Patel VA,Fan H,Lee DJ,Graham LH,Rosch CL,Spiegel DS,Rauch J,Levine JS

更新日期：2011-05-01 00:00:00

abstract：:Among the genes with the highest allelic polymorphism and sequence diversity are those encoding the classical class I and class II molecules of the major histocompatibility complex (MHC). Although many thousands of MHC sequences have been deposited in general sequence databases like GenBank, the availability of curate...

journal_title：Immunogenetics

authors： Afrache H,Tregaskes CA,Kaufman J

更新日期：2020-02-01 00:00:00

abstract：:Irradiation with UVB (290-320 nm) initiates a systemic immunosuppression detectable as suppression of contact hypersensitivity (CHS). We investigated susceptibility to UV suppression in reciprocal F1-hybrid and backcross mice derived from BALB/c (low susceptibility) and C57BL/6 (high susceptibility) inbred strains. CB...

journal_title：Immunogenetics

authors： Noonan FP,Hoffman HA

更新日期：1994-01-01 00:00:00

abstract：:Macaques are the most widely used experimental nonhuman primate (NHP) species. Rhesus (Macaca mulatta, Macmul), cynomolgus (Macaca fascicularis, Macfas), and pigtail (Macaca nemestrina, Macnem) macaques continue to be popular models for vaccine and infectious diseases research, especially HIV infection and AIDS, and f...

journal_title：Immunogenetics

authors： Nguyen DC,Sanghvi R,Scinicariello F,Pulit-Penaloza J,Hill N,Attanasio R

更新日期：2014-06-01 00:00:00

abstract：:Nova Scotia duck tolling retrievers are predisposed to a SLE-related disease complex including immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). IMRD involves symptoms that resemble those seen in systemic autoimmune rheumatic diseases, such as systemic lupus erythematosus, SL...

journal_title：Immunogenetics

authors： Wilbe M,Jokinen P,Hermanrud C,Kennedy LJ,Strandberg E,Hansson-Hamlin H,Lohi H,Andersson G

更新日期：2009-08-01 00:00:00

abstract：:The human T-cell receptor gamma (TCRG) locus comprises 14 variable genes (TRGV), five joining segments (TRGJ), and two constant region genes (TRGC). The constant gamma 1 gene, TRGC1, consists of three exons, whereas the TRGC2 gene contains four or five exons due to the duplication or triplication of exon 2 and spans 9...

journal_title：Immunogenetics

authors： Buresi C,Ghanem N,Huck S,Lefranc G,Lefranc MP

更新日期：1989-01-01 00:00:00

abstract：:Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...

journal_title：Immunogenetics

authors： Tartakovsky B,De Baetselier P,Segal S

更新日期：1980-01-01 00:00:00

abstract：:The cell-surface expression of the class I alloantigen Qa-2 was analyzed on resting and activated spleen and thymus cells using cytotoxic elimination and immunofluorescence and flow cytometry. Spleen cells activated by mitogens or alloantigen were homogeneously positive for cell surface Qa-2, but activated splenic T c...

journal_title：Immunogenetics

authors： Rabinowitz R,Sharrow SO,Chatterjee-Das S,Rogers MJ,Sachs DH

更新日期：1986-01-01 00:00:00

abstract：:A healthy adult having no serologically detectable HLA class I A locus antigens was identified. The parents of the individual are consanguineous. Results of a family study indicated that the individual is homozygous for the B46-Cw1-DR8.1 haplotype, which was shown to be positively associated with A*0207 in our previou...

journal_title：Immunogenetics

authors： Ishikawa Y,Tokunaga K,Tanaka H,Nishimura M,Muraoka M,Fujii Y,Akaza T,Tadokoro K,Juji T

更新日期：1996-01-01 00:00:00

abstract：:Nonaspanins constitute a family of proteins, also called TM9SF, characterized by a large non-cytoplasmic domain and nine putative transmembrane domains. This family is highly conserved through evolution and comprises three members in Saccharomyces cerevisiae, Dictyostelium discoideum, and Drosophila melanogaster, and ...

journal_title：Immunogenetics

authors： Pruvot B,Laurens V,Salvadori F,Solary E,Pichon L,Chluba J

更新日期：2010-10-01 00:00:00

abstract：:The interaction between 9-mer peptides and HLA-B51 molecules was investigated by quantitative peptide binding assay using RMA-S cells expressing human beta2-microglobulin and HLA-B51 molecules. Of 147 chemically synthesized 9-mer peptides possessing two anchor residues corresponding to the motif of HLA-B*5101 binding ...

journal_title：Immunogenetics

authors： Kikuchi A,Sakaguchi T,Miwa K,Takamiya Y,Rammensee HG,Kaneko Y,Takiguchi M

更新日期：1996-01-01 00:00:00

abstract：:Codon bias and base composition in major histocompatibility complex (MHC) sequences have been studied for both class I and II loci in Homo sapiens and Pan troglodytes. There is low to moderate codon bias for the MHC of humans and chimpanzees. In the class I loci, the same level of moderate codon bias is seen for HLA-B...

journal_title：Immunogenetics

authors： McWeeney SK,Valdes AM

更新日期：1999-04-01 00:00:00

abstract：:Cichlid fishes of the East African Rift Valley lakes constitute an important model of adaptive radiation. Explosive speciation in the Great Lakes, in some cases as recently as 12 400 years ago, generated large species flocks that have been the focus of evolutionary studies for some time. The studies have, however, bee...

journal_title：Immunogenetics

authors： Sato A,Klein D,Sültmann H,Figueroa F,O'hUigin C,Klein J

更新日期：1997-01-01 00:00:00

abstract：:In three families with an apparent non-expressed factor B (BF) allele (BF*Q0), advanced methods of isoelectric focusing for the determination of BF F subtypes revealed different hypomorphic BF products (BF QL) with functional hemolytic activity expressed by the assumed BF*Q0 allele. A Taq I and a Msp I restriction fra...

journal_title：Immunogenetics

authors： Siemens I,Brenden M,Mauff G,Abbal M,Du Toit E,Bertrams J,Geserick G

更新日期：1992-01-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...

journal_title：Immunogenetics

authors： Pilarski LM,Wegmann TG

更新日期：1984-01-01 00:00:00

abstract：:The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequences showed the expected evolutionary...

journal_title：Immunogenetics

authors： Grossberger D,Parham P

更新日期：1992-01-01 00:00:00

abstract：:To assess the role interleukins and mitogens play in regulating immunoglobulin (Ig) gene expression via the Ig enhancer and promoter, transgenic mice carrying two different Ig gene regulatory regions were generated. One, EmukCAT, contains the Ig heavy chain enhancer (Emu) and the kappa light chain promoter driving the...

journal_title：Immunogenetics

authors： Miller AE,Ennist DL,Ozato K,Westphal H

更新日期：1992-01-01 00:00:00

abstract：:Transcription of major histocompatibility complex class I genes is controlled by the class I regulatory complex in the 5' flanking region. To investigate the molecular basis of this region, we studied the polymorphism of the promoter of the HLA-B locus extending from the ATG transcription initiation signal to -284 bas...

journal_title：Immunogenetics

authors： Yao Z,Volgger A,Scholz S,Albert ED

更新日期：1995-01-01 00:00:00