Apparently non-expressed alleles of factor B (BF) code for hypomorphic proteins.

abstract：:Immunogenicity of allogeneic immunoglobulins in mice were studied, measuring the allotype-specific antibody activity by agglutination of allogeneic antibody-coated red blood cells. It was found that the serum from C.B-20 mice (Ighb, BALB/c-congenic) was uniquely immunogenic in BALB/c mice for allotype antibody respons...

journal_title：Immunogenetics

authors： Inagi R,Yoshida T,Isobe K,Nakashima I

更新日期：1989-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...

journal_title：Immunogenetics

authors： Dijkstra JM,Yamaguchi T

更新日期：2019-03-01 00:00:00

abstract：:Early and late primary IgM antibody responses of mice to Thy-1.1 antigens showed different antigenic and cellular requirements. We studied genetic controls of the early primary responses, which could be induced by subcellular thymocyte antigens independently of host T-cell activity. All Thy-1.2 mouse strains of Igha (...

journal_title：Immunogenetics

authors： Isobe K,Nakashima I,Nagase F,Yoshida T,Ando K,Inagi R,Kato N,Ohashi K

更新日期：1984-01-01 00:00:00

abstract：:A mouse monoclonal antibody, Mo. Ab. 108.45, detecting cell-surface determinants associated with the T-cell receptor for alloantigen was produced by immunizing mice with an alloreactive human T-cell clone and fusing the splenocytes with the NS1 plasmocytoma. This Mo. Ab. reacts with the immunizing T-cell clone but not...

journal_title：Immunogenetics

authors： Haars R,Rohowsky-Kochan C,Reed E,King DW,Suciu-Foca N

更新日期：1984-01-01 00:00:00

abstract：:Mutants of the EB virus-transformed cell line T5-1 (HLA-A1, 2; B8, 27), bearing well-characterized alterations in HLA-A2 antigen expression and unable to bind the HLA-A2-specific monoclonal antibody BB7.2, have been tested for their susceptibility to EB virus-specific cytolysis using effector T-cell preparations funct...

journal_title：Immunogenetics

authors： Gaston JS,Wallace LE,Rickinson AB,Epstein MA,Pious D

更新日期：1984-01-01 00:00:00

abstract：:We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequ...

journal_title：Immunogenetics

authors： Kaufman J,Salomonsen J,Skjødt K

更新日期：1989-01-01 00:00:00

abstract：:The polymorphic major histocompatibility complex (MHC) has gained a specific relevance in pathogen resistance and mate choice. Particularly the antigen-binding site (ABS), encoded by exon 2 of the DRB class II gene, exhibits numerous alleles and extensive sequence variations between alleles. A lack of MHC variability ...

journal_title：Immunogenetics

authors： Becker L,Nieberg C,Jahreis K,Peters E

更新日期：2009-04-01 00:00:00

abstract：:C3, C4, and C5 are thiolester-containing proteins (TEPs) of vertebrate complement. The identification of the molecular origin of the TEP family, and more specifically the ancestor protein of complement components C3, C4, and C5, remains a fundamental question. The prevailing paradigm suggests that duplication and dive...

journal_title：Immunogenetics

authors： Dishaw LJ,Smith SL,Bigger CH

更新日期：2005-08-01 00:00:00

abstract：:Rh-related transcripts present in bone marrow samples from several species of nonhuman primates (chimpanzee, gorilla, gibbon, crab-eating macaque) have been amplified by RT-polymerase chain reaction using primers deduced from the sequence of human RH genes. Nucleotide sequence analysis of the nonhuman transcripts reve...

journal_title：Immunogenetics

authors： Salvignol I,Calvas P,Socha WW,Colin Y,Le Van Kim C,Bailly P,Ruffié J,Cartron JP,Blancher A

更新日期：1995-01-01 00:00:00

abstract：:The aim of this study was to evaluate the intra- and inter-population variability of the Gm/Km system in the Madonie Mountains, one of the main geographical barriers in north-central Sicily. We analysed 392 samples: 145 from Alia, 128 from Valledolmo, 25 from Cerda and 94 from Palermo. Serum samples were tested for G1...

journal_title：Immunogenetics

authors： Cerutti N,Dugoujon JM,Guitard E,Rabino Massa E

更新日期：2004-01-01 00:00:00

abstract：:As genetically engineered mutant mice deficient in single genes are usually generated on a C57BL/6 background, to study mast cell trafficking in mutant mice, we initially investigated whether mast cells accumulated in bronchi in C57BL/6 mice challenged with OVA allergen acutely or chronically for 1 to 3 months. The to...

journal_title：Immunogenetics

authors： Pae S,Cho JY,Dayan S,Miller M,Pemberton AD,Broide DH

更新日期：2010-08-01 00:00:00

abstract：:Mechanisms to account for the unusual properties of a DR1 alpha beta complex (designated DRgp50) that is resistant to dissociation under normal conditions utilized were investigated. Expression of this DRgp50 complex is highly correlated with the failure of cells from certain DR1 individuals (DR1x) to stimulate specif...

journal_title：Immunogenetics

authors： Davis JE,Cook RG,Van M,Rich RR

更新日期：1988-01-01 00:00:00

abstract：:Class I-like molecules have been immunoprecipitated from Xenopus leukocytes and erythrocytes with alloantisera directed against major histocompatibility complex (MHC)-linked antigens. The heavy chains, depending on the allele examined, have molecular weights of 40 000-44 000 of which 3000 daltons are asparagine-linked...

journal_title：Immunogenetics

authors： Flajnik MF,Kaufman JF,Riegert P,Du Pasquier L

更新日期：1984-01-01 00:00:00

abstract：:We report the sequence of a cDNA encoding a rabbit immunoglobulin gamma heavy chain of d12 and e14 allotypes with high homology to partial cDNA sequences from rabbits of d11 and e15 allotypes. The encoded rabbit protein shows homologies with human (68-70%) and mouse (60-63%) gamma chains. The nucleotide sequence homol...

journal_title：Immunogenetics

authors： Bernstein KE,Alexander CB,Mage RG

更新日期：1983-01-01 00:00:00

abstract：:The genetic factors that determine the size of lymphocyte populations are largely unknown. We studied the genetic control of variations in the size of the CD4 thymic compartment in unmanipulated mouse strains. A time-course experiment showed that the C57BL/6 mouse strain has a consistently reduced proportion of thymic...

journal_title：Immunogenetics

authors： Duarte N,Penha-Gonçalves C

更新日期：2001-10-01 00:00:00

abstract：:Since the discovery of human leukocyte antigens (HLAs), the function of major histocompatibility complex (MHC) gene families in a wide range of diseases have been the subject of research for decades. In particular, the associations of autoimmune disorders to allelic variants and candidate genes encoding the MHC are we...

journal_title：Immunogenetics

authors： Al Naqbi H,Mawart A,Alshamsi J,Al Safar H,Tay GK

更新日期：2021-02-02 00:00:00

abstract：:Immunoglobulin-A deficiency (IgA-D) is the most common human Ig class deficiency with an estimated frequency of approximately 1 in 500 in the Swedish population. We investigated the immunoglobulin heavy chain constant region gene segments (IGHC) in 103 individuals with IgA-D and the immunoglobulin heavy chain variable...

journal_title：Immunogenetics

authors： Olsson PG,Hammarström L,Cox DW,Smith CI

更新日期：1992-01-01 00:00:00

abstract：:A cDNA library screening using the conserved exon 4 of Atlantic salmon Mhc class I as probe provided the basis for a study on Mhc class I polymorphism in a breeding population. Twelve different alleles were identified in the 82 dams and sires studied. No individual expressed more than two alleles, which corresponded t...

journal_title：Immunogenetics

authors： Grimholt U,Drabløs F,Jørgensen SM,Høyheim B,Stet RJ

更新日期：2002-11-01 00:00:00

abstract：:The major histocompatibility complex (MHC) class I-related molecule, MR1, presents vitamin B metabolites from bacteria and yeast to mucosal-associated invariant T (MAIT) cells. Despite the evolutionary conservation of MR1, we do not know whether different allele variants of MR1 exist within the nonhuman primate (NHP) ...

journal_title：Immunogenetics

authors： Ellis-Connell AL,Kannal NM,Balgeman AJ,O'Connor SL

更新日期：2019-02-01 00:00:00

abstract：:Coeliac disease is strongly associated with HLA-DQ2, but it is possible that additional major histocompatibility complex genes also confer disease susceptibility. Encoded close to HLA-DQ are two genes, TAP1 and TAP2, whose products are believed to transport antigenic peptides from the cytoplasm into the endoplasmic re...

journal_title：Immunogenetics

authors： Powis SH,Rosenberg WM,Hall M,Mockridge I,Tonks S,Ivinson A,Ciclitira PJ,Jewell DP,Lanchbury JS,Bell JI

更新日期：1993-01-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through ...

journal_title：Immunogenetics

authors： Bashirova AA,Apps R,Vince N,Mochalova Y,Yu XG,Carrington M

更新日期：2014-01-01 00:00:00

abstract：:Type II natural killer T cells (NKT) are a subset of the innate-like CD1d-restricted lymphocytes that are reactive to lipid antigens. Unlike the type I NKT cells, which express a semi-invariant TCR, type II NKT cells express a broader TCR repertoire. Additionally, other features, such as their predominance over type I...

journal_title：Immunogenetics

authors： Dasgupta S,Kumar V

更新日期：2016-08-01 00:00:00

abstract：:Position 45 represents a highly polymorphic residue within HLA class I alleles, which contacts the p2 position of bound peptides in 85% of the peptide-HLA structures analyzed, while the neighboring residues 41 and 46 are not involved in peptide binding. To investigate the influence of residue 45 at the functional leve...

journal_title：Immunogenetics

authors： Badrinath S,Huyton T,Schumacher H,Blasczyk R,Bade-Doeding C

更新日期：2012-03-01 00:00:00

abstract：:Direct immunoprecipitation and two-dimensional (2D) gel electrophoresis have been used to identify and characterize genetic variation of the H-2K and H-2D regions. Using inbred strains of mice and alloantisera, haplotype-specific polypeptides were defined for five different H-2 haplotypes. Specific immunoprecipitates ...

journal_title：Immunogenetics

authors： Sawicki JA,Epstein CJ

更新日期：1981-01-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:The genealogy of 14 H-2Kb mutations arising spontaneously in the C57BL/6Kh colony is presented together with data from skin-graft monitoring and husbandry procedures. Eight of the 14 mutations have phenotypic and structural similarities, but the pedigree analysis and evaluation of the histocompatibility genetics of th...

journal_title：Immunogenetics

authors： Melvold RW,Kohn HI,Dunn GR

更新日期：1982-01-01 00:00:00

abstract：:Mouse lymphocyte alloantigens Ly-19 and Ly-32 are controlled by the genes tightly linked to the Lyb-2 locus on chromosome 4. Despite the similarity in mouse strain distribution patterns, Ly-19 and Ly-32 antigens which have been detected on both B- and T-cell lineages are distinct from Lyb-2 antigen whose expression is...

journal_title：Immunogenetics

authors： Nakamura S,Ikegami S,Dairiki K,Kochiya M,Fujimori T,Tamaoki N,Tada N

更新日期：1988-01-01 00:00:00

abstract：:A strong correlation between the TT(-889) genotype over CC(-889) of the interleukin-1 alpha (IL-1 alpha) transcription regulatory region and age of Alzheimer's disease onset has recently been reported. To determine the functional effects of the genetic variants on plasma protein levels, we cloned the promoter region a...

journal_title：Immunogenetics

authors： Dominici R,Cattaneo M,Malferrari G,Archi D,Mariani C,Grimaldi LM,Biunno I

更新日期：2002-05-01 00:00:00

abstract：:Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...

journal_title：Immunogenetics

authors： Kuroda N,Uinuk-ool TS,Sato A,Samonte IE,Figueroa F,Mayer WE,Klein J

更新日期：2003-03-01 00:00:00

abstract：:Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44- supertype alleles, and biological data demonstrating their immunological re...

journal_title：Immunogenetics

authors： Sette A,Sidney J

更新日期：1999-11-01 00:00:00