Position 45 influences the peptide binding motif of HLA-B*44:08.

Abstract:

:Position 45 represents a highly polymorphic residue within HLA class I alleles, which contacts the p2 position of bound peptides in 85% of the peptide-HLA structures analyzed, while the neighboring residues 41 and 46 are not involved in peptide binding. To investigate the influence of residue 45 at the functional level, we sequenced peptides eluted from recombinant HLA-B*44:08(41Ala/45Met/46Ala) molecules and compared their features with known peptides from B*44:02(41Thr/45Lys/46Glu). While HLA-B*44:02 has an anchor motif of E at the p2 anchor position, HLA-B*44:08 exhibits Q and L as anchor motif. The 45(Met/Lys) polymorphism contributes to the alteration in the peptide-binding motif and provides further evidence that mismatches at position 45 should be considered as nonpermissive in a transplantation setting.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Badrinath S,Huyton T,Schumacher H,Blasczyk R,Bade-Doeding C

doi

10.1007/s00251-011-0583-z

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

245-9

issue

3

eissn

0093-7711

issn

1432-1211

journal_volume

64

pub_type

杂志文章
  • Identical genetic control of MLC reactivity to different MHC incompatibilities, independent of production of and response to IL-2.

    abstract::The inbred strain STS/A exhibits a higher proliferative response in the mixed lymphocyte culture (MLC) to stimulator cells of all 11 tested inbred mouse strains with 10 different major histocompatibility complex (MHC) haplotypes, as well as to stimulation with IL-2 than does the strain BALB/cHeA. However, alloantigen-...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF02602654

    authors: Holán V,Lipoldová M,Demant P

    更新日期:1996-01-01 00:00:00

  • Sixteen new H-2 haplotypes derived from wild mice.

    abstract::Wild mice captured in Texas, Scotland, Federal Republic of Germany, Denmark, Spain, Greece, Israel, Egypt, and Chile were mated to inbred strains and through successive backcross matings and H-2 typing lines homozygous for wild-derived H-2, haplotypes were established. The lines, which are neither congenic nor inbred,...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00952959

    authors: Zaleska-Rutczynska Z,Figueroa F,Klein J

    更新日期:1983-01-01 00:00:00

  • Influence of the MHC genotype on the progression of experimental SIV infection in the Mauritian cynomolgus macaque.

    abstract::Experimental infection of Mauritian cynomolgus macaques by simian immunodeficiency virus is a representative model of HIV infection, currently in favour for evaluating the efficacy of new preventive or curative treatments. Extensive studies of major histocompatibility complex (MHC) polymorphism by microsatellites reve...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s00251-010-0504-6

    authors: Aarnink A,Dereuddre-Bosquet N,Vaslin B,Le Grand R,Winterton P,Apoil PA,Blancher A

    更新日期:2011-05-01 00:00:00

  • Haplotypic origin of beta-chain genes expressed by human T-cell clones.

    abstract::A contribution of allelic variation of T-cell receptor (Tcr) genes to the immune response has not been studied. Here we report that the presence of insertion-deletion-related polymorphisms (IDRP) of the Tcr beta chain (Tcrb) can be utilized to distinguish the parental origin of the gene complex that undergoes rearrang...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00218043

    authors: Seboun E,Joshi N,Hauser SL

    更新日期:1992-01-01 00:00:00

  • Large-scale identification and characterization of genetic variants in asthma candidate genes.

    abstract::Asthma is a chronic inflammatory disorder of the airways, and a number of genetic loci are associated with the disease. Candidate gene association studies have been regarded as effective tools to study complex traits. Knowledge of the sequence variation and structure of the candidate genes is required for association ...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s00251-005-0024-y

    authors: Kim JJ,Kim HH,Park JH,Ryu HJ,Kim J,Moon S,Gu H,Kim HT,Lee JY,Han BG,Park C,Kimm K,Park CS,Lee JK,Oh B

    更新日期:2005-10-01 00:00:00

  • A method for making alignments of related protein sequences that share very little similarity; shark interleukin 2 as an example.

    abstract::An optimized alignment of related protein sequences helps to see their important shared features and to deduce their phylogenetic relationships. At low levels of sequence similarity, there are no suitable computer programs for making the best possible alignment. This review summarizes some guidelines for how in such i...

    journal_title:Immunogenetics

    pub_type: 杂志文章,评审

    doi:10.1007/s00251-020-01191-5

    authors: Dijkstra JM

    更新日期:2021-01-29 00:00:00

  • Isolation of Mhc class I cDNAs from the axolotl Ambystoma mexicanum.

    abstract::Class I major histocompatibility complex (Mhc) cDNA clones were isolated from axolotl mRNA by polymerase chain reaction (PCR) and by screening a cDNA phage library. The nucleotide and predicted amino acid sequences show definite similarities to the Mhc class Ialpha molecules of higher vertebrates. Most of the amino ac...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s002510050207

    authors: Sammut B,Laurens V,Tournefier A

    更新日期:1997-01-01 00:00:00

  • A directed miniscreen for genes involved in the Drosophila anti-parasitoid immune response.

    abstract::Drosophila larvae react against eggs from the endoparasitoid wasp Leptopilina boulardi by surrounding them in a multilayered cellular capsule. Once a wasp egg is recognized as foreign, circulating macrophage-like cells, known as plasmatocytes, adhere to the invader. After spreading around the wasp egg, plasmatocytes f...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s00251-011-0571-3

    authors: Howell L,Sampson CJ,Xavier MJ,Bolukbasi E,Heck MM,Williams MJ

    更新日期:2012-02-01 00:00:00

  • Positive correlation between oligonucleotide typing and T-cell recognition of HLA-DP molecules.

    abstract::The identification of 19 different HLA-DPB1 sequences implicates the existence of more DP specificities than can be typed for with cellular methods. How many of the DP beta sequences can be specifically recognized by T cells, and which of the polymorphic regions can contribute to the specificity of allorecognition, is...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00212307

    authors: de Koster HS,Kenter MJ,D'Amaro J,Luiten RM,Schroeijers WE,Giphart MJ,Termijtelen A

    更新日期:1991-01-01 00:00:00

  • The role of MHC class I allele Mamu-A*07 during SIV(mac)239 infection.

    abstract::Virus-specific CD8(+) T cells play an important role in controlling HIV/SIV replication. These T cells recognize intracellular pathogen-derived peptides displayed on the cell surface by individual MHC class I molecules. In the SIV-infected rhesus macaque model, five Mamu class I alleles have been thoroughly characteri...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s00251-011-0541-9

    authors: Reed JS,Sidney J,Piaskowski SM,Glidden CE,León EJ,Burwitz BJ,Kolar HL,Eernisse CM,Furlott JR,Maness NJ,Walsh AD,Rudersdorf RA,Bardet W,McMurtrey CP,O'Connor DH,Hildebrand WH,Sette A,Watkins DI,Wilson NA

    更新日期:2011-12-01 00:00:00

  • Structure and diversity of the heavy chain VDJ junctions in the developing Mexican axolotl.

    abstract::The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified with the canonical st...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s002510050294

    authors: Golub R,Fellah JS,Charlemagne J

    更新日期:1997-01-01 00:00:00

  • Identification of major histocompatibility complex genes in the guppy, Poecilia reticulata.

    abstract::The guppy, Poecilia reticulata, a teleostean fish of the order Cyprinodontiformes, has been used extensively in studies of host-parasite interactions, courtship behavior, and mating preference, as well as in ecological and evolutionary genetics. A related species was among the first poikilotherm vertebrates to be used...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00186602

    authors: Sato A,Figueroa F,O'hUigin C,Reznick DN,Klein J

    更新日期:1996-01-01 00:00:00

  • Rearrangement of 21-hydroxylase genes in disease-associated MHC supratypes.

    abstract::Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00377968

    authors: Garlepp MJ,Wilton AN,Dawkins RL,White PC

    更新日期:1986-01-01 00:00:00

  • Ancient features of the MHC class II presentation pathway, and a model for the possible origin of MHC molecules.

    abstract::Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...

    journal_title:Immunogenetics

    pub_type: 杂志文章,评审

    doi:10.1007/s00251-018-1090-2

    authors: Dijkstra JM,Yamaguchi T

    更新日期:2019-03-01 00:00:00

  • Membrane expression of HLA-Cw4 free chains in activated T cells of transgenic mice.

    abstract::Transgenic mice were produced in which human HLA-Cw4 is stably integrated, behaves as a single Mendelian trait, and, being under the transcriptional control of human CD2, is selectively and efficiently expressed in T lymphocytes. These mice were used as a model system to determine whether HLA-type C molecules can be e...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00179398

    authors: Aiuti A,Forte P,Simeoni L,Lino M,Pozzi L,Fattorossi A,Giacomini P,Ginelli E,Beretta A,Siccardi A

    更新日期:1995-01-01 00:00:00

  • Definition of a novel complementation group in MHC class II deficiency.

    abstract::In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-gamma these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when com...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00172153

    authors: Peijnenburg A,Godthelp B,van Boxel-Dezaire A,van den Elsen PJ

    更新日期:1995-01-01 00:00:00

  • Evolution of the porcine (Sus scrofa domestica) immunoglobulin kappa locus through germline gene conversion.

    abstract::Immunoglobulin (IG) gene rearrangement and expression are central to disease resistance and health maintenance in animals. The IG kappa (IGK) locus in swine (Sus scrofa domestica) contributes to approximately half of all antibody molecules, in contrast to many other Cetartiodactyla, whose members provide the majority ...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s00251-011-0589-6

    authors: Schwartz JC,Lefranc MP,Murtaugh MP

    更新日期:2012-04-01 00:00:00

  • Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis.

    abstract::We have previously reported that autoimmune pancreatitis (AIP) is a bioclinical entity characterized by high serum immunoglobulin G4 concentrations and association with the HLA-DRB1*0405-DQB1*0401 haplotype. However, the precise identity of gene(s) within this haplotype directly responsible for AIP pathogenesis is yet...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s00251-006-0178-2

    authors: Ota M,Katsuyama Y,Hamano H,Umemura T,Kimura A,Yoshizawa K,Kiyosawa K,Fukushima H,Bahram S,Inoko H,Kawa S

    更新日期:2007-01-01 00:00:00

  • The gene encoding the Ia-associated invariant chain is located on chromosome 18 in the mouse.

    abstract::The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (Ia) was determined by Southern blot analysis of DNA from a panel of mouse X Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse li cDNA as a hybridization probe, ...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00372244

    authors: Yamamoto K,Floyd-Smith G,Francke U,Koch N,Lauer W,Dobberstein B,Schäfer R,Hämmerling GJ

    更新日期:1985-01-01 00:00:00

  • Class I mhc genes of cichlid fishes: identification, expression, and polymorphism.

    abstract::Cichlid fishes of the East African Rift Valley lakes constitute an important model of adaptive radiation. Explosive speciation in the Great Lakes, in some cases as recently as 12 400 years ago, generated large species flocks that have been the focus of evolutionary studies for some time. The studies have, however, bee...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s002510050243

    authors: Sato A,Klein D,Sültmann H,Figueroa F,O'hUigin C,Klein J

    更新日期:1997-01-01 00:00:00

  • Serological detection of H-2K- and H-2D-gene products. I. Principal difference between T and B lymphocytes in expression of H-2D-encoded alloantigens.

    abstract::Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF01567827

    authors: Tartakovsky B,De Baetselier P,Segal S

    更新日期:1980-01-01 00:00:00

  • "Natural" antibodies to chicken MHC antigens are present in mice, rats, humans, alligators and allogeneic chickens.

    abstract::In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is direct...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF01567795

    authors: Longenecker BM,Mosmann TR

    更新日期:1980-01-01 00:00:00

  • Screening mouse mutations for resistance to cancer metastasis.

    abstract::To search for host genes for resistance/susceptibility to cancer metastasis, mutation analysis was employed. Ten putative mutants of resistance to lymphoma EL4 and four putative mutants of resistance to sarcoma MCA/77-23 of C57BL/6J (B6) mice were produced. These mutants were designated S (for "survivor") mutants; the...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00215051

    authors: Egorov OS,Liu Y,Sargent EE,Drizlikh GI,Egorov IK

    更新日期:1992-01-01 00:00:00

  • Genomic organization of the sheep immunoglobulin JH segments and their contribution to heavy chain variable region diversity.

    abstract::The sheep immunoglobulin heavy chain Igh-J locus has been characterized in order to determine the genomic organization of JH segments and their contribution to heavy chain diversity. The locus contains six segments, of which two are functional and four are apparently pseudogenes. These segments span a 1.8 kilobase (kb...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s002510050274

    authors: Dufour V,Nau F

    更新日期:1997-01-01 00:00:00

  • The expression of antibody diversity in natural and laboratory-made polyploid individuals of the clawed toad Xenopus.

    abstract::Antibody diversity, as measured by isoelectric focusing of dinitrophenol-specific antibodies, was compared in different polyploid species of the clawed toad Xenopus. Antibody heterogeneity increased with chromosome number and DNA content from Xenopus tropicalis (2n = 20 chromosome) to Xenopus ruwenzoriensis (2n = 108 ...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00364333

    authors: Du Pasquier L,Blomberg B

    更新日期:1982-03-01 00:00:00

  • The organization of immunoglobulin variable kappa chain genes on mouse chromosome 6.

    abstract::One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00373021

    authors: D'Hoostelaere LA,Gibson DM

    更新日期:1986-01-01 00:00:00

  • Transcript analysis reveals the involvement of NF-κB transcription factors for the activation of TGF-β signaling in nematode-infected Drosophila.

    abstract::The common fruit fly Drosophila melanogaster is a powerful model for studying signaling pathway regulation. Conserved signaling pathways underlying physiological processes signify evolutionary relationship between organisms and the nature of the mechanisms they control. This study explores the cross-talk between the w...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s00251-019-01119-8

    authors: Patrnogic J,Heryanto C,Ozakman Y,Eleftherianos I

    更新日期:2019-07-01 00:00:00

  • Lyb-8.2: A new B cell antigen defined and characterized with a monoclonal antibody.

    abstract::A DBA/1 B10.D2-specific monoclonal antibody (CY34) is described which defines a new murine B lymphocyte differentiation antigen designated Lyb-8.2. The ontogeny, strain distribution, and cell-surface density of the antigen were studied by radioimmunoassay and by fluorescence-activated cell sorter (FACS) analysis. Lyb-...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00372098

    authors: Symington FW,Subbarao B,Mosier DE,Sprent J

    更新日期:1982-01-01 00:00:00

  • Differential behavior of cytotoxic effector cells against HLA antigens in strong genetic linkage disequilibrium.

    abstract::Five sets of cytotoxic effector cells were generated, using haplo-identical, first degree relatives in five different families, against the HLA-A3; B7 serological determinants combined with different DR antigens. When tested against a panel of cells bearing combinations of the HLA-A, -B and -DR antigens it was shown t...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/BF00364495

    authors: Kim SJ,Christiansen FT,Silver DM,Dupont B

    更新日期:1981-01-01 00:00:00

  • Patterns of MHC-DRB1 polymorphism in a post-glacial island canid, the Newfoundland red fox (Vulpes vulpes deletrix), suggest balancing selection at species and population timescales.

    abstract::As the only native insular Newfoundland canid between the extinction of the wolf in the 1930s and the recent arrival of coyotes, the red fox (Vulpes vulpes deletrix Bangs 1898) poses interesting questions about genetic distinctiveness and the post-glacial colonization history of the island's depauperate mammalian faun...

    journal_title:Immunogenetics

    pub_type: 杂志文章

    doi:10.1007/s00251-016-0907-0

    authors: Marshall HD,Langille BL,Hann CA,Whitney HG

    更新日期:2016-05-01 00:00:00