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Diversifying selection in a parasitoid's symbiotic virus among genes involved in inhibiting host immunity.

Abstract：

:During parasitization of their hosts some insect parasitoids deliver resident viruses which encode genes that must be expressed in the host for successful parasitization. Among these viruses the Campoletis sonorensis Ichnovirus has been well studied and encodes a cys-motif gene family implicated in disruption of host immunity and other physiological systems. Members of this gene family encode one or more intercystine-knot structural motifs in which the non-cysteine residues of the motif are variable. We analyzed patterns of synonymous and non-synonymous substitution within the cys-motif to investigate the evolution of this gene family and the likelihood of virus-host gene coevolution. Maximum likelihood techniques suggest positive selection acts on 8 of 51 codons in the aligned cysteine-rich region. Although the detected positive selection was not strong, it likely contributes to the diversification of this gene family. Comparison of selection pressure relative to tertiary structure of the VHv1.1 cys-motif protein suggests that the hypervariable sites are exposed. Furthermore, invariant residues in the motif exhibit a region-specific pattern of codon bias, suggesting there are unusual mechanisms of effecting selection pressure at work in this system, though the mechanism has yet to be studied. The positive selection and duplication of both the gene family and the cys-motif implies either selection is driving the molecular radiation of immune suppressive genes toward novel hosts, or molecular coevolution with host targets.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Dupas S,Turnbull MW,Webb BA

doi

10.1007/s00251-003-0595-4

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

351-61

issue

6

eissn

0093-7711

issn

1432-1211

journal_volume

55

pub_type

杂志文章

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