Localization of Idd11 using NOD congenic mouse strains: elimination of Slc9a1 as a candidate gene.

abstract：:Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates predictions of proteaso...

journal_title：Immunogenetics

authors： Stranzl T,Larsen MV,Lundegaard C,Nielsen M

更新日期：2010-06-01 00:00:00

abstract：:The restricted diversity of the major histocompatibility complex (MHC) of Mauritian cynomolgus macaques provides powerful opportunities for insight into host-viral interactions and cellular immune responses that restrict lentiviral infections. However, little is known about the effects of Mhc haplotypes on control of ...

journal_title：Immunogenetics

authors： Mee ET,Berry N,Ham C,Sauermann U,Maggiorella MT,Martinon F,Verschoor EJ,Heeney JL,Le Grand R,Titti F,Almond N,Rose NJ

更新日期：2009-05-01 00:00:00

abstract：:Two proteasome activators PA28alpha and beta, which have been implicated in antigen processing for loading class I MHC molecules, are synthesized in response to Ifn-gamma. The human genes encoding these activators (PSME1 and PSME2, respectively) were analyzed by sequencing. Each gene comprised 11 exons, consistent wit...

journal_title：Immunogenetics

authors： McCusker D,Wilson M,Trowsdale J

更新日期：1999-05-01 00:00:00

abstract：:To search for host genes for resistance/susceptibility to cancer metastasis, mutation analysis was employed. Ten putative mutants of resistance to lymphoma EL4 and four putative mutants of resistance to sarcoma MCA/77-23 of C57BL/6J (B6) mice were produced. These mutants were designated S (for "survivor") mutants; the...

journal_title：Immunogenetics

authors： Egorov OS,Liu Y,Sargent EE,Drizlikh GI,Egorov IK

更新日期：1992-01-01 00:00:00

abstract：:Eleven new C4d genomic primate sequences of the fourth complement factor (C4) have been obtained. Seven of them belong to five species not yet explored for this gene: Pan paniscus (pygmy chimpanzee), Cercopithecus aethiops (green monkey), Macaca mulatta (rhesus monkey), Macaca fascicularis (cynomolgus), and Saguinus o...

journal_title：Immunogenetics

authors： Paz-Artal E,Corell A,Alvarez M,Varela P,Allende L,Madroño A,Rosal M,Arnaiz-Villena A

更新日期：1994-01-01 00:00:00

abstract：:C3, C4, and C5 are thiolester-containing proteins (TEPs) of vertebrate complement. The identification of the molecular origin of the TEP family, and more specifically the ancestor protein of complement components C3, C4, and C5, remains a fundamental question. The prevailing paradigm suggests that duplication and dive...

journal_title：Immunogenetics

authors： Dishaw LJ,Smith SL,Bigger CH

更新日期：2005-08-01 00:00:00

abstract：:The ability of NK cells to specifically recognize cells lacking expression of self-MHC class I molecules was discovered over 30 years ago. It provided the foundation for the "missing self" hypothesis. Research in the two past decades has contributed to a detailed understanding of the molecular mechanisms that determin...

journal_title：Immunogenetics

authors： Malmberg KJ,Sohlberg E,Goodridge JP,Ljunggren HG

更新日期：2017-08-01 00:00:00

abstract：:The cluster of differentiation 4 (CD4) molecule functions as a co-receptor for MHC class II binding to TCR in T helper cells. A CD4 epitope deficiency was identified in the swine MeLiM (melanoblastoma-bearing Libechov minipig) strain, a model for spontaneous cutaneous melanoma development and regression. Extensive seq...

journal_title：Immunogenetics

authors： Blanc F,Créchet F,Bruneau N,Piton G,Leplat JJ,Andréoletti F,Egidy G,Vincent-Naulleau S,Bourneuf E

更新日期：2018-04-01 00:00:00

abstract：:Despite matching donors and recipients for the human leukocyte antigens (HLAs) expressed by the major histocompatibility genomic region of the short arm of chromosome 6, several recipients still develop acute graft-versus-host disease (aGVHD) after bone marrow transplantation (BMT). This is possibly due to non-HLA gen...

journal_title：Immunogenetics

authors： Kikuchi T,Naruse TK,Onizuka M,Li S,Kimura T,Oka A,Morishima Y,Kulski JK,Ichimiya S,Sato N,Inoko H

更新日期：2007-02-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through ...

journal_title：Immunogenetics

authors： Bashirova AA,Apps R,Vince N,Mochalova Y,Yu XG,Carrington M

更新日期：2014-01-01 00:00:00

abstract：:Ataxia-telangiectasia (A-T), a rare inherited disorder, usually affects the nervous and immune systems, and occasionally other organs. A-T is associated mainly with mutations in the ataxia telangiectasia mutated (ATM) gene, which encodes a protein kinase that has a major role in the cellular response to DNA damage. We...

journal_title：Immunogenetics

authors： Mortaz E,Marashian SM,Ghaffaripour H,Varahram M,Mehrian P,Dorudinia A,Garssen J,Adcock IM,Taylor M,Mahdaviani SA

更新日期：2017-07-01 00:00:00

abstract：:Individual variation in immune responses is always encountered after vaccination. This phenomenon is also seen after acellular pertussis vaccination. The aim of this present study was to investigate whether single nucleotide polymorphisms (SNPs) in the IL-10 gene promoter region (rs1800890, rs1800896, rs1800871), IL-1...

journal_title：Immunogenetics

authors： Gröndahl-Yli-Hannuksela K,Vahlberg T,Ilonen J,Mertsola J,He Q

更新日期：2016-10-01 00:00:00

abstract：:T cell receptor genes are assembled in developing T lymphocytes from discrete V, D, and J genes by a site-specific somatic rearrangement mechanism. A flanking recombination signal, composed of a conserved heptamer and a semiconserved nonamer separated by 12 or 23 variable nucleotides, targets the activity of the rearr...

journal_title：Immunogenetics

authors： Touvrey C,Cowell LG,Lieberman AE,Marche PN,Jouvin-Marche E,Candéias SM

更新日期：2006-11-01 00:00:00

abstract：:In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is direct...

journal_title：Immunogenetics

authors： Longenecker BM,Mosmann TR

更新日期：1980-01-01 00:00:00

abstract：:The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...

journal_title：Immunogenetics

authors： Nguyen VK,Su C,Muyldermans S,van der Loo W

更新日期：2002-04-01 00:00:00

abstract：:The genomic organisation of the major histocompatibility complex (MHC) seems to vary considerably between different bird species. In order to understand this variation it is important to gather information from different species. We have, for the first time, investigated MHC class II polymorphism in a wader species, t...

journal_title：Immunogenetics

authors： Ekblom R,Grahn M,Höglund J

更新日期：2003-01-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILR) are cell surface molecules that regulate the activities of myelomonocytic cells through the balance of inhibitory and activation signals. LILR genes are located within the leukocyte receptor complex (LRC) on chromosome 19q13.4 adjacent to KIR genes, which are subject to a...

journal_title：Immunogenetics

authors： López-Álvarez MR,Jones DC,Jiang W,Traherne JA,Trowsdale J

更新日期：2014-02-01 00:00:00

abstract：:We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitt...

journal_title：Immunogenetics

authors： Webber LM,Garson OM,Tate B,McKenzie IF,Hogarth PM

更新日期：1990-01-01 00:00:00

abstract：:Virus-specific CD8(+) T cells play an important role in controlling HIV/SIV replication. These T cells recognize intracellular pathogen-derived peptides displayed on the cell surface by individual MHC class I molecules. In the SIV-infected rhesus macaque model, five Mamu class I alleles have been thoroughly characteri...

journal_title：Immunogenetics

authors： Reed JS,Sidney J,Piaskowski SM,Glidden CE,León EJ,Burwitz BJ,Kolar HL,Eernisse CM,Furlott JR,Maness NJ,Walsh AD,Rudersdorf RA,Bardet W,McMurtrey CP,O'Connor DH,Hildebrand WH,Sette A,Watkins DI,Wilson NA

更新日期：2011-12-01 00:00:00

abstract：:Immunoglobulin E (IgE) provides important information on the humoral immune status, and the IgE level is routinely detected in clinical practice. There are many diseases associated with IgE, such as atopic disease, autoimmune diseases, and so on. IgE is a genetically complex trait, but comprehensive genetic assessment...

journal_title：Immunogenetics

authors： Liao M,Shi D,Wang Y,Zhang K,Chen X,Gao Y,Tan A,Xuan Q,Yang X,Hu Y,Qin X,Zhang H,Mo Z

更新日期：2013-08-01 00:00:00

abstract：:An analysis of mRNA structures as deduced from the amino acid sequences of immunoglobulin heavy chains reveals possible base-paired regions within the sequences coding for the 20 C-terminal amino acids of the human μ and α chains. The two regions are similar in structure and contain a palindrome which might serve as a...

journal_title：Immunogenetics

authors： Melcher U

更新日期：1978-12-01 00:00:00

abstract：:In order to further our understanding of major histocompatibility complex (MHC) class I gene organization, we began a comparative analysis of the large scale organization of the class I region in diverse haplotypes. For these studies, the MHC in healthy Japanese donors who have the predominant MHC haplotypes and/or HL...

journal_title：Immunogenetics

authors： Watanabe Y,Tokunaga K,Geraghty DE,Tadokoro K,Juji T

更新日期：1997-01-01 00:00:00

abstract：:MICA and MICB genes encode MHC class I chain-related proteins, which are polymorphic, do not appear to present peptides or associate with beta(2)-microglobulin, and are expressed predominantly in epithelial cells, endothelial cells, fibroblasts and several cultured cell lines. Alternatively spliced isoforms are known ...

journal_title：Immunogenetics

authors： Zou Y,Stastny P

更新日期：2002-12-01 00:00:00

abstract：:Complement is one of primary defense mechanisms against intravascular microorganisms and could play a role in the immune response to malignancy and hence its clinical behavior. We evaluated if the sole coding polymorphism of C1qA associates with outcome in patients with breast carcinoma. Genotyping for C1qA[276A/G] wa...

journal_title：Immunogenetics

authors： Racila E,Racila DM,Ritchie JM,Taylor C,Dahle C,Weiner GJ

更新日期：2006-02-01 00:00:00

abstract：:We selected 38 consecutive celiac disease (CD) patients (from a group of 316 consecutive CD patients) and 91 healthy blood donors, all of whom were HLA-DQ2 (DQA1*0501/DQB1*0201) negative, and investigated the presence of the classically associated alleles HLA-DQ8 and HLA-DRB4. We also studied the distribution of MICA ...

journal_title：Immunogenetics

authors： Lopez-Vazquez A,Rodrigo L,Fuentes D,Riestra S,Bousoño C,Garcia-Fernandez S,Martinez-Borra J,Gonzalez S,Lopez-Larrea C

更新日期：2002-02-01 00:00:00

abstract：:The rat major histocompatibility complex loci RT1-B and RT1-D are equivalent to the human leucocyte antigens HLA-DQ and HLA-DR respectively. Here we describe the complementary DNA (cDNA) sequence encoding the alpha and beta chains of both the RT1-B and RT1-D locus genes of the rat RT1u haplotype. We have found entire ...

journal_title：Immunogenetics

authors： Easterfield AJ,Bradley JA,Bolton EM

更新日期：2003-08-01 00:00:00

abstract：:T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...

journal_title：Immunogenetics

authors： Li J,Li J,You Y,Chen S

更新日期：2012-05-01 00:00:00

abstract：:The inbred strain STS/A exhibits a higher proliferative response in the mixed lymphocyte culture (MLC) to stimulator cells of all 11 tested inbred mouse strains with 10 different major histocompatibility complex (MHC) haplotypes, as well as to stimulation with IL-2 than does the strain BALB/cHeA. However, alloantigen-...

journal_title：Immunogenetics

authors： Holán V,Lipoldová M,Demant P

更新日期：1996-01-01 00:00:00

abstract：:We cloned the cDNAs and genes of two different types of toll-like receptors from Japanese flounder. The results of homology searches suggested that these genes (designated JF-TLR2 and JF-TLR22) are homologues of human TLR2 and fugu TLR22, respectively. The cDNAs of JF-TLR2 and JF-TLR22 encoded 818 and 961 amino acid r...

journal_title：Immunogenetics

authors： Hirono I,Takami M,Miyata M,Miyazaki T,Han HJ,Takano T,Endo M,Aoki T

更新日期：2004-04-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00