Genetic basis of the effects of ultraviolet light B on cutaneous immunity. Evidence that polymorphism at the Tnfa and Lps loci governs susceptibility.

abstract：:Genes of the major histocompatibility complex (MHC) have been characterized in all extant lineages of mammals. The tammar wallaby (Macropus eugenii) is well established as a model marsupial species; however, no classical MHC sequences have been described from this species. We have isolated two MHC class II beta-chain ...

journal_title：Immunogenetics

authors： Browning TL,Belov K,Miller RD,Eldridge MD

更新日期：2004-02-01 00:00:00

abstract：:Severe combined immune deficiency (scid) mice are assumed to have two types of abnormalities: one is high radiosensitivity and the other is abnormal recombination in immunoglobulin and T-cell receptor genes. The human chromosome 8 q1.1 region has an ability to complement the scid aberrations. Moreover, the localizatio...

journal_title：Immunogenetics

authors： Hamatani K,Matsuda Y,Araki R,Itoh M,Abe M

更新日期：1996-01-01 00:00:00

abstract：:In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between different formulations before conducting expensive human clinical trials. CpG oligonucleotides (ODN) specifically prom...

journal_title：Immunogenetics

authors： Spirig R,Peduzzi E,Patarroyo ME,Pluschke G,Daubenberger CA

更新日期：2005-05-01 00:00:00

abstract：:A DBA/1 B10.D2-specific monoclonal antibody (CY34) is described which defines a new murine B lymphocyte differentiation antigen designated Lyb-8.2. The ontogeny, strain distribution, and cell-surface density of the antigen were studied by radioimmunoassay and by fluorescence-activated cell sorter (FACS) analysis. Lyb-...

journal_title：Immunogenetics

authors： Symington FW,Subbarao B,Mosier DE,Sprent J

更新日期：1982-01-01 00:00:00

abstract：:Mouse Ly6A and Ly6C cDNA probes were hybridized to total RNA of rat tissues and, as in mouse, the highest level of Ly6-related transcripts was detected in kidney. Therefore, Ly6-related cDNA clones were isolated from a commercial rat kidney cDNA library in lambda gt11. Four of these (RK3, RK6, RK10, and RK11) have bee...

journal_title：Immunogenetics

authors： Friedman S,Palfree RG,Sirlin S,Hämmerling U

更新日期：1990-01-01 00:00:00

abstract：:We have analyzed genomic DNA in a large number of independent examples of five HLA-DQw2-bearing extended haplotypes for their associated subtypes by restriction fragment length polymorphism (RFLP) using DRB, DQA, and DQB probes after Taq I and Pst I digestion and Southern blotting. In addition to three previously desc...

journal_title：Immunogenetics

authors： Yunis JJ,Wescott M,Lechin SJ,Alosco SM,Awdeh Z,Alper CA,Yunis EJ

更新日期：1990-01-01 00:00:00

abstract：:Mutants of the EB virus-transformed cell line T5-1 (HLA-A1, 2; B8, 27), bearing well-characterized alterations in HLA-A2 antigen expression and unable to bind the HLA-A2-specific monoclonal antibody BB7.2, have been tested for their susceptibility to EB virus-specific cytolysis using effector T-cell preparations funct...

journal_title：Immunogenetics

authors： Gaston JS,Wallace LE,Rickinson AB,Epstein MA,Pious D

更新日期：1984-01-01 00:00:00

abstract：:Immunoglobulin E (IgE) provides important information on the humoral immune status, and the IgE level is routinely detected in clinical practice. There are many diseases associated with IgE, such as atopic disease, autoimmune diseases, and so on. IgE is a genetically complex trait, but comprehensive genetic assessment...

journal_title：Immunogenetics

authors： Liao M,Shi D,Wang Y,Zhang K,Chen X,Gao Y,Tan A,Xuan Q,Yang X,Hu Y,Qin X,Zhang H,Mo Z

更新日期：2013-08-01 00:00:00

abstract：:The tripartite motif protein (TRIM)5α/CypA fusion protein TRIMCyp in Old World monkeys is generally considered unable to restrict HIV-1 replication. Monkeys with TRIMCyp can serve as a unique animal model for studies of HIV-1 infection. The present study investigated the distribution and expression status of TRIMCyp i...

journal_title：Immunogenetics

authors： Yu CQ,Na L,Lv XL,Liu JD,Liu XM,Ji F,Zheng YH,Du HL,Kong XG,Zhou JH

更新日期：2013-03-01 00:00:00

abstract：:Protein tyrosine phosphorylation is an important regulatory mechanism in cell physiology. While the protein tyrosine kinase (PTKase) family has been extensively studied, only six protein tyrosine phosphatases (PTPases) have been described. By Southern blot analysis, genomic DNA from several different phyla were found ...

journal_title：Immunogenetics

authors： Matthews RJ,Flores E,Thomas ML

更新日期：1991-01-01 00:00:00

abstract：:We report on the analyses of genes encoding immunoglobulin heavy and light chains in the rabbit 6.51× whole genome assembly. This OryCun2.0 assembly confirms previous mapping of the duplicated IGK1 and IGK2 loci to chromosome 2 and the IGL lambda light chain locus to chromosome 21. The most frequently rearranged and e...

journal_title：Immunogenetics

authors： Gertz EM,Schäffer AA,Agarwala R,Bonnet-Garnier A,Rogel-Gaillard C,Hayes H,Mage RG

更新日期：2013-10-01 00:00:00

abstract：:Hepatic granulomatous lesions were induced in mice by a single intraperitoneal injection of 3 mg of disrupted Streptococcus pyogenes cell-wall material. Mice carrying the H-2b or H-2k haplotypes were highly susceptible to the induction and three weeks after the injection produced numerous granulomas. In contrast, mice...

journal_title：Immunogenetics

authors： Chen CY,Cohen SA,Zaleski MB,Albini B

更新日期：1992-01-01 00:00:00

abstract：:In mammals, there are MHC class II molecules with distinctive sequence features, such as the classical isotypes DR, DQ and DP. These particular isotypes have not been reported in non-mammalian vertebrates. We have isolated the class II (B-L) alpha chain from outbred chickens as the basis for the cloning and sequencing...

journal_title：Immunogenetics

authors： Salomonsen J,Marston D,Avila D,Bumstead N,Johansson B,Juul-Madsen H,Olesen GD,Riegert P,Skjødt K,Vainio O,Wiles MV,Kaufman J

更新日期：2003-12-01 00:00:00

abstract：:We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed...

journal_title：Immunogenetics

authors： Zhang Y,Lazaro AM,Zou Y,Lavingia B,Moraes EM,Moraes RJ,Stastny P

更新日期：2002-02-01 00:00:00

abstract：:The mouse Fcgr1 gene encoding the high-affinity IgG receptor (FcgammaRI) exists as two known alleles, FcgammaRI-BALB and FcgammaRI-NOD, and these alleles exhibit functional differences. To determine whether other alleles exist in mouse strains, Fcgr1 coding regions from 35 strains of mice were sequenced and a further ...

journal_title：Immunogenetics

authors： Gavin AL,Leiter EH,Hogarth PM

更新日期：2000-03-01 00:00:00

abstract：:Natural resistance-associated macrophage protein 1 (NRAMP1) has an important role in regulating macrophage functions that affect innate resistance as well as immune responses. We analyzed the microsatellite polymorphism in the promoter region of the human NRAMP1 gene in 206 type 1 diabetes patients and 200 normal chil...

journal_title：Immunogenetics

authors： Bassuny WM,Ihara K,Matsuura N,Ahmed S,Kohno H,Kuromaru R,Miyako K,Hara T

更新日期：2002-07-01 00:00:00

abstract：:In the absence of any deliberate immunization, mice, rats, humans and alligators all have detectable titers of antibody against chicken red blood cells (CRBC's). Remarkably, this antibody is directed predominantly against private or public determinants of MHC proteins on the CRBC's, and little or no antibody is direct...

journal_title：Immunogenetics

authors： Longenecker BM,Mosmann TR

更新日期：1980-01-01 00:00:00

abstract：:Celiac disease is a chronic inflammatory condition of the small intestine caused by aberrant adaptive immune response to gluten protein from wheat and related cereal plants. Over 90% of celiac disease patients carry the HLA-DQ2.5 allotype and HLA-DQ2.5 presents gluten peptides to gluten-reactive CD4+ T cells in celiac...

journal_title：Immunogenetics

authors： Qiao SW,Sollid LM

更新日期：2019-11-01 00:00:00

abstract：:Almost 10,000 single nucleotide polymorphisms (SNPs) had been identified in the RT1 complex, the major histocompatibility complex of the rat, but less than approximately 0.5% have been characterized. In the context of the incomplete characterization of most SNPs, simple sequence length polymorphism (SSLP) marker devel...

journal_title：Immunogenetics

authors： Takagi Y,Kuramoto T,Voigt B,Tsurumi T,Nakanishi S,Mashimo T,Masui N,Serikawa T

更新日期：2009-03-01 00:00:00

abstract：:In this study we analyzed fibroblasts derived from an MHC class II deficiency patient (type III bare lymphocyte syndrome). Northern blot analysis showed that upon induction with IFN-gamma these fibroblasts did not express HLA class II genes and displayed a strongly reduced level of HLA class I gene expression when com...

journal_title：Immunogenetics

authors： Peijnenburg A,Godthelp B,van Boxel-Dezaire A,van den Elsen PJ

更新日期：1995-01-01 00:00:00

abstract：:Drosophila larvae react against eggs from the endoparasitoid wasp Leptopilina boulardi by surrounding them in a multilayered cellular capsule. Once a wasp egg is recognized as foreign, circulating macrophage-like cells, known as plasmatocytes, adhere to the invader. After spreading around the wasp egg, plasmatocytes f...

journal_title：Immunogenetics

authors： Howell L,Sampson CJ,Xavier MJ,Bolukbasi E,Heck MM,Williams MJ

更新日期：2012-02-01 00:00:00

abstract：:On a B10 (Lshs) genetic background the development of acquired T-cell-mediated immunity to Leishmania donovani infection in mice is under H-2-linked genetic control. Three phenotypic patterns of recovery were previously observed: "early cure" (H-2s, H-2r), "cure" (H-2b) and "noncure" (H-2d, H-2q, H-2f), with cure beha...

journal_title：Immunogenetics

authors： Blackwell JM

更新日期：1983-01-01 00:00:00

abstract：:Lentinan, a beta-1,6;1,3-glucan, is tumor-specific for transplantable mouse solid-type tumors and it also stimulates the production of acute phase proteins (APPs). The APP response to lentinan is of the delayed type (DT-APR) and differs from that to lipopolysaccharide, which is acute. We found that the responses were ...

journal_title：Immunogenetics

authors： Maeda YY,Takahama S,Kohara Y,Yonekawa H

更新日期：1996-01-01 00:00:00

abstract：:Using the fluorescence-activated cell sorter (FACS II), we have analyzed the expression of H-2K- and H-2D-gene products on the membrane of various cellular components of the murine immune system. Using this serological technique we show a basic difference between T and B lymphocytes. Whereas all cellular components an...

journal_title：Immunogenetics

authors： Tartakovsky B,De Baetselier P,Segal S

更新日期：1980-01-01 00:00:00

abstract：:The characterization of genes involved in the generation of the immune repertoire is an active area of research in lower vertebrate taxa. The recombination activating genes (RAG) have been shown to be essential for V (D) J recombination of T-cell antigen receptor (TCR) and immunoglobulin (Ig) genes, leading to the gen...

journal_title：Immunogenetics

authors： Hansen JD,Kaattari SL

更新日期：1995-01-01 00:00:00

abstract：:In this study we have sequenced peptides eluted from a truncated recombinant HLA-A*6602 molecule, and compared their features with data reported for peptides presented in the A*6601 molecule. A striking change in the amino-acid binding preferences was observed at peptide position P1, which interacts with pocket A of t...

journal_title：Immunogenetics

authors： Bade-Doeding C,Elsner HA,Eiz-Vesper B,Seltsam A,Holtkamp U,Blasczyk R

更新日期：2004-05-01 00:00:00

abstract：:A cDNA library prepared from lymphocytes of a cow (E98), homozygous at major histocompatibility complex (MHC) loci (BoLA phenotype w10, KN104), was screened with a bovine MHC class I probe. Of the cDNA clones isolated, two, (2.1 and 5.1) were selected and showed divergence at both 5' and 3' termini. E98 DNA was digest...

journal_title：Immunogenetics

authors： Bensaid A,Kaushal A,Baldwin CL,Clevers H,Young JR,Kemp SJ,MacHugh ND,Toye PG,Teale AJ

更新日期：1991-01-01 00:00:00

abstract：:Chytridiomycosis, caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd), has been implicated in population declines and species extinctions of amphibians around the world. Susceptibility to the disease varies both within and among species, most likely attributable to heritable immunogenetic variation. Anal...

journal_title：Immunogenetics

authors： Fu M,Waldman B

更新日期：2017-08-01 00:00:00

abstract：:We have previously reported that autoimmune pancreatitis (AIP) is a bioclinical entity characterized by high serum immunoglobulin G4 concentrations and association with the HLA-DRB1*0405-DQB1*0401 haplotype. However, the precise identity of gene(s) within this haplotype directly responsible for AIP pathogenesis is yet...

journal_title：Immunogenetics

authors： Ota M,Katsuyama Y,Hamano H,Umemura T,Kimura A,Yoshizawa K,Kiyosawa K,Fukushima H,Bahram S,Inoko H,Kawa S

更新日期：2007-01-01 00:00:00

abstract：:The guppy, Poecilia reticulata, a teleostean fish of the order Cyprinodontiformes, has been used extensively in studies of host-parasite interactions, courtship behavior, and mating preference, as well as in ecological and evolutionary genetics. A related species was among the first poikilotherm vertebrates to be used...

journal_title：Immunogenetics

authors： Sato A,Figueroa F,O'hUigin C,Reznick DN,Klein J

更新日期：1996-01-01 00:00:00