Molecular cloning and characterization of the polymorphic MHC class II DBB from the tammar wallaby (Macropus eugenii).

abstract：:The susceptibility to cell-mediated cytolysis of cells of the recently developed C57BL/Ka(H-2 ( b )) lymphoma cell line, BL/VL(3), was investigated in allogeneic assays with thymus-dependent lymphocytes (T cells). Compared to EL4, the widely used C57BL/6(H-2 ( b )) lymphoma cell line, BL/VL(3) cells were found to be i...

journal_title：Immunogenetics

authors： Finn OJ,Lieberman M,Kaplan HS

更新日期：1978-12-01 00:00:00

abstract：:The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...

journal_title：Immunogenetics

authors： Mehta IK,Wang J,Roland J,Margulies DH,Yokoyama WM

更新日期：2001-09-01 00:00:00

abstract：:The genes of the major histocompatibility complex (MHC) are amongst the most variable in vertebrates and represent some of the best candidates to study processes of adaptive evolution. However, despite the number of studies available, most of the information on the structure and function of these genes come from studi...

journal_title：Immunogenetics

authors： Gómez D,Conejeros P,Marshall SH,Consuegra S

更新日期：2010-08-01 00:00:00

abstract：:The major histocompatibility complex (MHC) is critical to host-pathogen interactions. Class II MHC is a heterodimer, with α and β subunits encoded by different genes. The peptide-binding groove is formed by the first domain of both subunits (α1 and β1), but studies of class II variation or natural selection focus prim...

journal_title：Immunogenetics

authors： Rand LM,Woodward C,May R,Ackerman RA,Tweedie B,Zicarelli TB,Dearborn DC

更新日期：2019-09-01 00:00:00

abstract：:In mammals, there are MHC class II molecules with distinctive sequence features, such as the classical isotypes DR, DQ and DP. These particular isotypes have not been reported in non-mammalian vertebrates. We have isolated the class II (B-L) alpha chain from outbred chickens as the basis for the cloning and sequencing...

journal_title：Immunogenetics

authors： Salomonsen J,Marston D,Avila D,Bumstead N,Johansson B,Juul-Madsen H,Olesen GD,Riegert P,Skjødt K,Vainio O,Wiles MV,Kaufman J

更新日期：2003-12-01 00:00:00

abstract：:Eight families (121 individuals) with two or more members affected with systemic lupus erythematosus (SLE) were analyzed for histocompatibility antigens (HLA-A, B, C, DR, MT, and MB) and complement antigens (C4A, C4B, and BF). These data were correlated with serological markers (antinuclear antibodies, single- and dou...

journal_title：Immunogenetics

authors： Reveille JD,Arnett FC,Wilson RW,Bias WB,McLean RH

更新日期：1985-01-01 00:00:00

abstract：:The ability of NK cells to specifically recognize cells lacking expression of self-MHC class I molecules was discovered over 30 years ago. It provided the foundation for the "missing self" hypothesis. Research in the two past decades has contributed to a detailed understanding of the molecular mechanisms that determin...

journal_title：Immunogenetics

authors： Malmberg KJ,Sohlberg E,Goodridge JP,Ljunggren HG

更新日期：2017-08-01 00:00:00

abstract：:Infection of humans and chimpanzees with Hepatitis C virus (HCV) results in either the resolution of the acute infection or its progression to a persistent infection associated with chronic liver disease. In cohorts of human patients, resolution of HCV infection has been associated with homozygosity for both C1(+)HLA-...

journal_title：Immunogenetics

authors： Abi-Rached L,Guethlein LA,Norman PJ,Parham P

更新日期：2015-10-01 00:00:00

abstract：:We report the sequence of a cDNA encoding a rabbit immunoglobulin gamma heavy chain of d12 and e14 allotypes with high homology to partial cDNA sequences from rabbits of d11 and e15 allotypes. The encoded rabbit protein shows homologies with human (68-70%) and mouse (60-63%) gamma chains. The nucleotide sequence homol...

journal_title：Immunogenetics

authors： Bernstein KE,Alexander CB,Mage RG

更新日期：1983-01-01 00:00:00

abstract：:Apoptosis has been suggested as a major mechanism for the CD4(+) T-lymphocyte depletion observed in patients infected with human immunodeficiency virus 1 (HIV-1). To evaluate the impact of genetic variations to apoptosis during progression of acquired immunodeficiency syndrome (AIDS), we have performed an extensive ge...

journal_title：Immunogenetics

authors： Vasilescu A,Heath SC,Diop G,Do H,Hirtzig T,Hendel H,Bertin-Maghit S,Rappaport J,Therwath A,Lathrop GM,Matsuda F,Zagury JF

更新日期：2004-04-01 00:00:00

abstract：:The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...

journal_title：Immunogenetics

authors： Su J,Luscher MA,MacDonald KS

更新日期：2004-03-01 00:00:00

abstract：:One mouse with a known recombination (NAK) at the Igk locus on chromosome 6 and two new recombinants [B6.PL (75NS) and B6.PL (85NS)] were examined using a series of probes, each of which is specific for a set of immunoglobulin (Ig) Vk genes. Under high stringency conditions, each probe detects from 1 to 19 Bam HI rest...

journal_title：Immunogenetics

authors： D'Hoostelaere LA,Gibson DM

更新日期：1986-01-01 00:00:00

abstract：:The organization of the major histocompatibility complex (MHC) class II region in cattle was investigated by Southern blot analysis using human probes corresponding to DO, DP, DQ, and DR genes. Exon-specific probes were also employed to facilitate the assessment of the number of different bovine class II genes. The re...

journal_title：Immunogenetics

authors： Andersson L,Rask L

更新日期：1988-01-01 00:00:00

abstract：:The interleukin-1 gene family encodes a group of related proteins that exhibit a remarkable pleiotropy in the context of health and disease. The set of indispensable functions they control suggests that these genes should be found in all eukaryotic species. The ligands and receptors of this family have been primarily ...

journal_title：Immunogenetics

authors： Gibson MS,Kaiser P,Fife M

更新日期：2014-08-01 00:00:00

abstract：:Natural killer (NK) cells express receptors for MHC class I that contain immunoreceptor tyrosine-based inhibitory motif (ITIM) sequences in their cytoplasmic domain. Whereas these receptors inhibit NK cell cytotoxicity, certain isoforms of these NK receptors (e.g., KIR2DS, CD94/NKG2C, and Ly49D) do not have ITIMs, but...

journal_title：Immunogenetics

authors： Yim D,Jie HB,Lanier LL,Kim YB

更新日期：2000-05-01 00:00:00

abstract：:Mice bearing the H-2b haplotype are susceptible to the development of experimental autoimmune myasthenia gravis (EAMG), induced by acetylcholine receptor (AChR) autoimmunity. One of the genes influencing EAMG susceptibility has been mapped to the Ab locus of the major histocompatibility complex, and the A beta chain h...

journal_title：Immunogenetics

authors： Christadoss P,David CS,Shenoy M,Keve S

更新日期：1990-01-01 00:00:00

abstract：:The common fruit fly Drosophila melanogaster is a powerful model for studying signaling pathway regulation. Conserved signaling pathways underlying physiological processes signify evolutionary relationship between organisms and the nature of the mechanisms they control. This study explores the cross-talk between the w...

journal_title：Immunogenetics

authors： Patrnogic J,Heryanto C,Ozakman Y,Eleftherianos I

更新日期：2019-07-01 00:00:00

abstract：:Retinoid X receptors (RXRs) are zinc finger-containing nuclear transcription factors. They belong to the nuclear receptor superfamily that contains retinoid receptors, vitamin D receptors, thyroid hormone receptors, and steroid hormone receptors as well as the so-called orphan receptors. We previously mapped all three...

journal_title：Immunogenetics

authors： Nagata T,Weiss EH,Abe K,Kitagawa K,Ando A,Yara-Kikuti Y,Seldin MF,Ozato K,Inoko H,Taketo M

更新日期：1995-01-01 00:00:00

abstract：:Chickens of the Iowa State S1 line have been selected for ability to regress Rous sarcoma virus-induced (RSV) tumors, humoral immune response to GAT (Ir-GAT), and erythrocyte antigen B. Sublines homozygous at the major histocompatibility complex (MHC), as well as F1 heterozygotes and F2 segregants, were tested for res...

journal_title：Immunogenetics

authors： Lamont SJ,Bolin C,Cheville N

更新日期：1987-01-01 00:00:00

abstract：:Five sets of cytotoxic effector cells were generated, using haplo-identical, first degree relatives in five different families, against the HLA-A3; B7 serological determinants combined with different DR antigens. When tested against a panel of cells bearing combinations of the HLA-A, -B and -DR antigens it was shown t...

journal_title：Immunogenetics

authors： Kim SJ,Christiansen FT,Silver DM,Dupont B

更新日期：1981-01-01 00:00:00

abstract：:A healthy adult having no serologically detectable HLA class I A locus antigens was identified. The parents of the individual are consanguineous. Results of a family study indicated that the individual is homozygous for the B46-Cw1-DR8.1 haplotype, which was shown to be positively associated with A*0207 in our previou...

journal_title：Immunogenetics

authors： Ishikawa Y,Tokunaga K,Tanaka H,Nishimura M,Muraoka M,Fujii Y,Akaza T,Tadokoro K,Juji T

更新日期：1996-01-01 00:00:00

abstract：:Analysis of a Japanese population by oligonucleotide genotyping revealed that one Japanese HLA-DRw14 allele had a DRB1 genotype different from that of the known HLA-DRw14-related alleles, DRB1*1401 (DRw14-Dw9) and DRB1*1402 (DRw14-Dw16). The second exon of the DRB1 gene of the novel DRw14 allele (designated DRB1-14c) ...

journal_title：Immunogenetics

authors： Obata F,Ito I,Ito K,Abe A,Ohkubo M,Onda K,Yang YG,Watanabe K,Kashiwagi N

更新日期：1990-01-01 00:00:00

abstract：:An I-J-subregion controlled determinant is expressed on Ly-1 inducer and Ly-1,2 acceptor T cells in the feedback suppression circuit. Ly-1 T cells absorb the I-J antibody reactive with the Ly-1,2 acceptor T cell, suggesting that both inducer and acceptor T cells have the same I-J determinant. Since less than 10 percen...

journal_title：Immunogenetics

authors： Eardley DD,Murphy DB,Kemp JD,Shen FW,Cantor H,Gershon RK

更新日期：1980-01-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease. Although the pathogenesis of RA is poorly understood, progress ...

journal_title：Immunogenetics

authors： Bax M,van Heemst J,Huizinga TW,Toes RE

更新日期：2011-08-01 00:00:00

abstract：:Determining the genomic organization of the Ovis aries (Ovar) major histocompatibility complex class IIa region is essential for future functional studies related to antigen presentation. In this study, a bacterial artificial chromosome (BAC) library of genomic DNA from peripheral blood leukocytes (PBL) of a Rambouill...

journal_title：Immunogenetics

authors： Herrmann-Hoesing LM,White SN,Kappmeyer LS,Herndon DR,Knowles DP

更新日期：2008-04-01 00:00:00

abstract：:Rearrangements of the immunoglobulin heavy chain joining region (JH) genes occur in some T lymphocytes, probably because the mechanism for assembly of T-cell receptor encoded genes is very similar to that for immunoglobulins. Two such rearrangements described previously represented proper fusion of a DH and JH gene. W...

journal_title：Immunogenetics

authors： Gerondakis S,Bernard O,Cory S,Adams JM

更新日期：1988-01-01 00:00:00

abstract：:Among the genes with the highest allelic polymorphism and sequence diversity are those encoding the classical class I and class II molecules of the major histocompatibility complex (MHC). Although many thousands of MHC sequences have been deposited in general sequence databases like GenBank, the availability of curate...

journal_title：Immunogenetics

authors： Afrache H,Tregaskes CA,Kaufman J

更新日期：2020-02-01 00:00:00

abstract：:Alpha-2-macroglobulin (A2M) binds proteases, thereby acting as defense barriers against pathogens in the plasma and tissues of vertebrates and invertebrates. Quantitative real-time polymerase chain reaction (PCR) and the isobaric tags for relative and absolute quantitation method were used to determine the expression ...

journal_title：Immunogenetics

authors： Wang X,Huang J,Zhao L,Wang C,Ju Z,Li Q,Qi C,Zhang Y,Zhang Z,Zhang W,Hou M,Yuan J,Zhong J

更新日期：2012-11-01 00:00:00

abstract：:Dendritic cells (DC) are specialist antigen presenting cells which capture antigens in the periphery, migrate centrally, and present the processed antigens in the context of major histocompatibility complex and appropriate co-stimulatory molecules to T lymphocytes for the initiation of an immune response. DEC-205 has ...

journal_title：Immunogenetics

authors： Kato M,Neil TK,Clark GJ,Morris CM,Sorg RV,Hart DN

更新日期：1998-05-01 00:00:00

abstract：:CD99, the product of the MIC2 gene, exhibits an erythroid-specific quantitative polymorphism co-regulated with the Xga blood group polymorphism. The co-expression of X-linked MIC2 and XG genes is presumably controlled at the transcriptional level by a single XGR locus in the pseudoautosomal region of sexual chromosome...

journal_title：Immunogenetics

authors： Fouchet C,Gane P,Cartron JP,Lopez C

更新日期：2000-07-01 00:00:00