Abstract:
:The susceptibility to cell-mediated cytolysis of cells of the recently developed C57BL/Ka(H-2 ( b )) lymphoma cell line, BL/VL(3), was investigated in allogeneic assays with thymus-dependent lymphocytes (T cells). Compared to EL4, the widely used C57BL/6(H-2 ( b )) lymphoma cell line, BL/VL(3) cells were found to be insensitive to T-cell-mediated lysis as detected by the use of(51)Crrelease methods. When used as immunogens in alloreactive combinations with BALB/c(H-2 ( d )) splenocytes as responder cells, BL/VL(3) cells failed to elicit sensitization. Serological tests showed that this cell line had profoundly reduced levels of H-2(b) antigens on its surface. When BL/VL(3) cells were reinjected into C57BL/Ka and BALB/c mice, full recovery of H-2(b) antigen expression at the cell surface was observed in both syngeneic and allogeneic hosts after only 11 days of in vivo growth. Concomitantly, they acquired the ability to induce cytotoxic responses in allogeneic T cells and became susceptible to their lytic activity. The expression of H-2 antigens on the surface of BL/VL(3) cells is a reversibly modulated function that depends on in vivo growth conditions and is lost in vitro in the absence of immunoselective pressure.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Finn OJ,Lieberman M,Kaplan HSdoi
10.1007/BF01843991subject
Has Abstractpub_date
1978-12-01 00:00:00pages
79-88issue
1eissn
0093-7711issn
1432-1211journal_volume
7pub_type
杂志文章相关文献
IMMUNOGENETICS文献大全abstract::The Mep-1 gene on chromosome 17 in mice controls the activity of meprin, a kidney brush border metalloendopeptidase. Most inbred mouse strains of the k haplotype (e.g., CBA, C3H, AKR) are markedly deficient in meprin activity; these mice carry the Mep-1b allele. Mouse strains in which meprin activity levels are normal...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00430310
更新日期:1985-01-01 00:00:00
abstract::Individual mice were tested for their proliferation T-cell response to H-Y- and H-3-incompatible stimulator cells in secondary mixed lymphocyte culture. Responders expressing the H-2b haplotype were restricted in their response to stimulators presenting H-Y and H-3 in the context of H-2b. Lymphocytes from individual B...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00342193
更新日期:1981-01-01 00:00:00
abstract::The immune capacity of young and adult axolotls (Ambystoma mexicanum) was evaluated by examining the combinatorial and junctional diversity of the VH chain. A large number of VDJ rearrangements isolated from 2.5-, 3.5-, 10-, and 24-month-old animals were sequenced. Six JH segments were identified with the canonical st...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050294
更新日期:1997-01-01 00:00:00
abstract::Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00377968
更新日期:1986-01-01 00:00:00
abstract::Described here is a new, more efficient method for defining major histocompatibility complex-Y (MHC-Y) genotypes in chickens. The MHC-Y region is genetically independent from the classical MHC (MHC-B) region. MHC-Y is highly polymorphic and potentially important in the genetics of disease resistance. MHC-Y haplotypes ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-020-01166-6
更新日期:2020-07-01 00:00:00
abstract::Protein tyrosine phosphorylation is an important regulatory mechanism in cell physiology. While the protein tyrosine kinase (PTKase) family has been extensively studied, only six protein tyrosine phosphatases (PTPases) have been described. By Southern blot analysis, genomic DNA from several different phyla were found ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00211693
更新日期:1991-01-01 00:00:00
abstract::The genetic control of natural resistance in vivo to four natural killer (NK) cell-resistant H-2 homozygous lymphoid tumor cell lines was investigated by following the survival and organ distribution of cells prelabeled with radioactive iododeoxyuridine. Backcross mice derived from DBA/2J and CBA/J parents were inject...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364210
更新日期:1984-01-01 00:00:00
abstract::The recombination activating genes RAG-1 and RAG-2 are adjacent genes that act synergistically to activate variable-diversity-joining (V(D)J) recombination. Southern analysis of hybrid cell lines derived from patients with the Wilms tumor-aniridia-genitourinary defects-mental retardation (WAGR) syndrome and from mutag...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00189518
更新日期:1992-01-01 00:00:00
abstract::We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitt...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02115010
更新日期:1990-01-01 00:00:00
abstract::Immunogenicity of allogeneic immunoglobulins in mice were studied, measuring the allotype-specific antibody activity by agglutination of allogeneic antibody-coated red blood cells. It was found that the serum from C.B-20 mice (Ighb, BALB/c-congenic) was uniquely immunogenic in BALB/c mice for allotype antibody respons...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02421533
更新日期:1989-01-01 00:00:00
abstract::Class I-like molecules have been immunoprecipitated from Xenopus leukocytes and erythrocytes with alloantisera directed against major histocompatibility complex (MHC)-linked antigens. The heavy chains, depending on the allele examined, have molecular weights of 40 000-44 000 of which 3000 daltons are asparagine-linked...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345617
更新日期:1984-01-01 00:00:00
abstract::Observations have frequently been interpreted as showing that the helper T cells which collaborate with alloantigen-specific cytotoxic T-cell precursors can only recognize antigens encoded in the I region of the H-2 gene complex. An experimental system is described here that allows analysis of the recognition repertoi...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345403
更新日期:1984-01-01 00:00:00
abstract::Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 0.5-1% of the population worldwide. The disease has a heterogeneous character, including clinical subsets of anti-citrullinated protein antibody (ACPA)-positive and APCA-negative disease. Although the pathogenesis of RA is poorly understood, progress ...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-011-0528-6
更新日期:2011-08-01 00:00:00
abstract::The heavy and light chain subunits of the DC1 antigen from several cell lines expressing different DR specificities were compared by two-dimensional (2-D) gel electrophoresis. The DC1 light chains from cell lines typed as DR1, DR2, or DRw6 differed in their isoelectric points. No difference in charge was observed for ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00345970
更新日期:1983-01-01 00:00:00
abstract::The killer cell immunoglobulin-like receptor (KIR) gene cluster exhibits extensive allelic and haplotypic diversity. Variation at the locus is associated with an increasing number of human diseases, reminiscent of the HLA loci. Characterization of diversity at the KIR locus has progressed over the past several years, ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-008-0334-y
更新日期:2008-12-01 00:00:00
abstract::A healthy adult having no serologically detectable HLA class I A locus antigens was identified. The parents of the individual are consanguineous. Results of a family study indicated that the individual is homozygous for the B46-Cw1-DR8.1 haplotype, which was shown to be positively associated with A*0207 in our previou...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00186597
更新日期:1996-01-01 00:00:00
abstract::Leukocyte immunoglobulin-like receptor (LILR)B3 and LILRA6 represent a pair of inhibitory/activating receptors with identical extracellular domains and unknown ligands. LILRB3 can mediate inhibitory signaling via immunoreceptor tyrosine-based inhibition motifs in its cytoplasmic tail whereas LILRA6 can signal through ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-013-0730-9
更新日期:2014-01-01 00:00:00
abstract::The complexity and polymorphism of sequences related to the class I and class II genes of mammalian major histocompatibility complexes (MHCs) were investigated in the tassel-eared squirrel subspecies Sciurus aberti kaibabensis or Kaibab squirrel. Kaibab squirrels are geographically isolated on the Kaibab plateau north...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00364527
更新日期:1986-01-01 00:00:00
abstract::We have isolated and characterized cDNAs and genes for pufferfish, Fugu rubripes, (Fugu) orthologues of mammalian interleukin (IL)-12 subunits (IL-12 p35 and IL-12 p40). The deduced amino acid sequences of the Fugu IL-12 subunits showed homology with mammalian IL-12 subunits (p35: 50.4-58.0% similarity; p40: 51.2-55.4...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-003-0582-9
更新日期:2003-08-01 00:00:00
abstract::The Ly49 family of natural killer (NK) cell receptors is encoded by a polygenic genetic locus. Allelic forms have been described and their expression appears to be regulated. The best-characterized Ly49 molecule, the C57BL/6 form of Ly49A, is an NK cell inhibitory receptor that binds H2Dd. To determine whether differe...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510100355
更新日期:2001-09-01 00:00:00
abstract::Antigen-specific CD4+ T cells play a critical role in protective immunity to many infectious pathogens. Although the antigen-specific CD4+ T cells can be measured by functional assays such as proliferation or cytokine enzyme-linked immunospot, such assays are limited to a specific function and cannot quantify anergic ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-006-0140-3
更新日期:2006-09-01 00:00:00
abstract::Sixteen microsatellite markers, including two described here, were used to construct a high-resolution map of the 1q32 region encompassing the regulator of the complement activation (RCA) gene cluster. The RCA genes are a group of related genes coding for plasma and membrane associated proteins that collectively contr...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s002510050224
更新日期:1997-01-01 00:00:00
abstract::The polymorphic major histocompatibility complex (MHC) has gained a specific relevance in pathogen resistance and mate choice. Particularly the antigen-binding site (ABS), encoded by exon 2 of the DRB class II gene, exhibits numerous alleles and extensive sequence variations between alleles. A lack of MHC variability ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-009-0362-2
更新日期:2009-04-01 00:00:00
abstract::As the only native insular Newfoundland canid between the extinction of the wolf in the 1930s and the recent arrival of coyotes, the red fox (Vulpes vulpes deletrix Bangs 1898) poses interesting questions about genetic distinctiveness and the post-glacial colonization history of the island's depauperate mammalian faun...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-016-0907-0
更新日期:2016-05-01 00:00:00
abstract::We used rabbit antisera to the chicken MHC erythrocyte molecule B-G and to the class I alpha chain (B-F) to screen lambda gt11 cDNA expression libraries made with RNA selected by oligo-dT from bone marrow cells of anemic B19 homozygous chickens. Eight clones were found to encode B-G molecules which hybridize with sequ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF02421176
更新日期:1989-01-01 00:00:00
abstract::Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...
journal_title:Immunogenetics
pub_type: 杂志文章,评审
doi:10.1007/s00251-018-1090-2
更新日期:2019-03-01 00:00:00
abstract::The glycosyl phosphatidylinositol (GPI)-linked antigen recognized by monoclonal antibody (mAb) MEM-102 is expressed on all peripheral blood lymphocytes, both resting and activated. Its properties are very similar to a previously described activation antigen, Blast-1. The amino acid sequence deduced from the structure ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/BF00210823
更新日期:1991-01-01 00:00:00
abstract::Killer cell immunoglobulin-like receptors (KIRs) represent the most polymorphic genes responsible for natural killer cell function, while human leukocyte antigen (HLA) class I molecules define and restrict cytotoxic T lymphocyte responses. Specific KIR, HLA, or KIR-HLA combinations have been implicated in the outcome ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-016-0920-3
更新日期:2016-10-01 00:00:00
abstract::MICA and MICB genes encode MHC class I chain-related proteins, which are polymorphic, do not appear to present peptides or associate with beta(2)-microglobulin, and are expressed predominantly in epithelial cells, endothelial cells, fibroblasts and several cultured cell lines. Alternatively spliced isoforms are known ...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0496-y
更新日期:2002-12-01 00:00:00
abstract::Human CS1, also known as novel Ly9, 19A24, or CRACC, is a member of the immunoglobulin gene superfamily (IgSF) expressed on natural killer cells and other leukocytes. Here we describe the cloning of the mouse homologue of this gene. The mouse novel Ly9 gene is shown to encode a transmembrane protein composed of two ex...
journal_title:Immunogenetics
pub_type: 杂志文章
doi:10.1007/s00251-002-0483-3
更新日期:2002-09-01 00:00:00