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Sequence analysis and HLA-DR genotyping of a novel HLA-DRw14 allele.

Abstract：

:Analysis of a Japanese population by oligonucleotide genotyping revealed that one Japanese HLA-DRw14 allele had a DRB1 genotype different from that of the known HLA-DRw14-related alleles, DRB1*1401 (DRw14-Dw9) and DRB1*1402 (DRw14-Dw16). The second exon of the DRB1 gene of the novel DRw14 allele (designated DRB1-14c) was amplified enzymatically and sequenced after cloning into a plasmid vector. The amino acid sequence of the first domain in the DR beta 1 chain encoded in the DRB1-14c allele was more similar to that of the DRB1*1401 allele (three amino acid substitutions) than to that of the DRB1*1402 allele (six amino acid substitutions). No polymorphic amino acid residue that could explain the common serologic HLA-DRw14 specificity was identified among the sequences of the three DRw14-related alleles. Sequence-specific oligonucleotides (SSOs) were synthesized on the basis of the DRB1-14c nucleotide sequence and used for genotyping of the Japanese population. These SSOs served as useful probes for identifying the DRB1-14c allele in a wide range of donors.

journal_name

Immunogenetics

journal_title

Immunogenetics

authors

Obata F,Ito I,Ito K,Abe A,Ohkubo M,Onda K,Yang YG,Watanabe K,Kashiwagi N

doi

10.1007/BF00211645

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

313-20

issue

5

eissn

0093-7711

issn

1432-1211

journal_volume

32

pub_type

杂志文章

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