Abstract:
:Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded (or determined) by the I-A and I-J, E, C subregions of the Ir region can be detected on the surface of cells required for the response. In addition, I-A-subregion products have a functional significance in cellular activation which can be demonstrated by blocking experiments with anti-Ia serum in the absence of complement.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Phillips ML,Hill SW,Parker JW,O'Brien RL,Frelinger JAdoi
10.1007/BF01561562subject
Has Abstractpub_date
1980-01-01 00:00:00pages
133-40issue
2eissn
0093-7711issn
1432-1211journal_volume
10pub_type
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