Abstract：
:Class I major histocompatibility complex (Mhc) cDNA clones were isolated from axolotl mRNA by polymerase chain reaction (PCR) and by screening a cDNA phage library. The nucleotide and predicted amino acid sequences show definite similarities to the Mhc class Ialpha molecules of higher vertebrates. Most of the amino acids in the peptide binding region that dock peptides at their N and C termini in mammals are conserved. Several amino acids considered to be important for the interaction of beta2-microglobulin with the Mhc alpha chain are also conserved in the axolotl sequence. The fact that axolotl class I A cDNAs are ubiquitously expressed and highly polymorphic in the alpha1 and alpha2 domains suggests the classical nature of axolotl class I A genes.
journal_name
Immunogeneticsjournal_title
Immunogeneticsauthors
Sammut B,Laurens V,Tournefier Adoi
10.1007/s002510050207subject
Has Abstractpub_date
1997-01-01 00:00:00pages
285-94issue
5eissn
0093-7711issn
1432-1211journal_volume
45pub_type
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