Biochemical studies on the H-2K mutant B6.C-H-2bm10.

abstract：:A contribution of allelic variation of T-cell receptor (Tcr) genes to the immune response has not been studied. Here we report that the presence of insertion-deletion-related polymorphisms (IDRP) of the Tcr beta chain (Tcrb) can be utilized to distinguish the parental origin of the gene complex that undergoes rearrang...

journal_title：Immunogenetics

authors： Seboun E,Joshi N,Hauser SL

更新日期：1992-01-01 00:00:00

abstract：:The Mep-1 gene on chromosome 17 in mice controls the activity of meprin, a kidney brush border metalloendopeptidase. Most inbred mouse strains of the k haplotype (e.g., CBA, C3H, AKR) are markedly deficient in meprin activity; these mice carry the Mep-1b allele. Mouse strains in which meprin activity levels are normal...

journal_title：Immunogenetics

authors： Reckelhoff JF,Bond JS,Beynon RJ,Savarirayan S,David CS

更新日期：1985-01-01 00:00:00

abstract：:The genetic factors that determine the size of lymphocyte populations are largely unknown. We studied the genetic control of variations in the size of the CD4 thymic compartment in unmanipulated mouse strains. A time-course experiment showed that the C57BL/6 mouse strain has a consistently reduced proportion of thymic...

journal_title：Immunogenetics

authors： Duarte N,Penha-Gonçalves C

更新日期：2001-10-01 00:00:00

abstract：:Human cDNA probes for 21-hydroxylase (21-OH) and for complement component C4 are used on restriction digests of the members of several families with interesting supratypes. The presence of two Taq I fragments of 3.7 kb and 3.2 kb in size with a 21-OH probe is confirmed in most individuals who show no evidence of C4 de...

journal_title：Immunogenetics

authors： Garlepp MJ,Wilton AN,Dawkins RL,White PC

更新日期：1986-01-01 00:00:00

abstract：:Human natural killer (NK) cells express on their surface several members of the C-type lectin family such as NKR-P1, CD94, and NKG2 that are probably involved in recognition of target cells and delivery of signals modulating NK cell cytotoxicity. To elucidate the mechanisms involved in signaling via these receptors, w...

journal_title：Immunogenetics

authors： Cerný J,Fiserová A,Horváth O,Bezouska K,Pospísil M,Horejsí V

更新日期：1997-01-01 00:00:00

abstract：:The evolution of the mouse immunoglobulin heavy chain variable region (Igh-V) locus was investigated by the comprehensive analysis of variable region (Vh) gene family content and restriction fragment polymorphism in the genus Mus. The examination of natural Mus domesticus populations suggests an important role for rec...

journal_title：Immunogenetics

authors： Tutter A,Riblet R

更新日期：1989-01-01 00:00:00

abstract：:The cell-surface expression of the class I alloantigen Qa-2 was analyzed on resting and activated spleen and thymus cells using cytotoxic elimination and immunofluorescence and flow cytometry. Spleen cells activated by mitogens or alloantigen were homogeneously positive for cell surface Qa-2, but activated splenic T c...

journal_title：Immunogenetics

authors： Rabinowitz R,Sharrow SO,Chatterjee-Das S,Rogers MJ,Sachs DH

更新日期：1986-01-01 00:00:00

abstract：:Transcription of major histocompatibility complex class I genes is controlled by the class I regulatory complex in the 5' flanking region. To investigate the molecular basis of this region, we studied the polymorphism of the promoter of the HLA-B locus extending from the ATG transcription initiation signal to -284 bas...

journal_title：Immunogenetics

authors： Yao Z,Volgger A,Scholz S,Albert ED

更新日期：1995-01-01 00:00:00

abstract：:Antibody diversity, as measured by isoelectric focusing of dinitrophenol-specific antibodies, was compared in different polyploid species of the clawed toad Xenopus. Antibody heterogeneity increased with chromosome number and DNA content from Xenopus tropicalis (2n = 20 chromosome) to Xenopus ruwenzoriensis (2n = 108 ...

journal_title：Immunogenetics

authors： Du Pasquier L,Blomberg B

更新日期：1982-03-01 00:00:00

abstract：:The N-terminal domain of the chemokine CCL5/regulated upon activation normal T cell expressed and secreted (RANTES) has been shown to be critical for its biological activity on leukocytes. Several N-terminus-modified CCL5/RANTES derivatives, such as N-Terminal truncated CCL5/RANTES, Met-RANTES, and amino-oxypentane (A...

journal_title：Immunogenetics

authors： Capoulade-Métay C,Ayouba A,Kfutwah A,Lole K,Pêtres S,Dudoit Y,Deterre P,Menu E,Barré-Sinoussi F,Debré P,Theodorou I

更新日期：2006-07-01 00:00:00

abstract：:The region inclusive of the thioester and the isotype-determining sites of the sheep C4 genes from a single animal was amplified by polymerase chain reaction (PCR). Two bands, at 880 base pairs (bp) and 1000 bp, were resolved by agarose gel electrophoresis. Four different clones were obtained for the 880 bp (type 1) p...

journal_title：Immunogenetics

authors： Ren XD,Dodds AW,Law SK

更新日期：1993-01-01 00:00:00

abstract：:A new H-2 mutant involving the H-2d haplotype is described--C.B6-H-2dm4 (dm4). This mutant strain carries a gain and loss mutation which maps to the Kd gene of the H-2 complex. Serological testing comparing the mutant and the parental BALB/cKh strain failed to detect any difference between the two strains and no antib...

journal_title：Immunogenetics

authors： Morgan G,Dellos H,McKenzie IF,Melvold RW

更新日期：1981-03-01 00:00:00

abstract：:Asthma is a chronic inflammatory disorder of the airways, and a number of genetic loci are associated with the disease. Candidate gene association studies have been regarded as effective tools to study complex traits. Knowledge of the sequence variation and structure of the candidate genes is required for association ...

journal_title：Immunogenetics

authors： Kim JJ,Kim HH,Park JH,Ryu HJ,Kim J,Moon S,Gu H,Kim HT,Lee JY,Han BG,Park C,Kimm K,Park CS,Lee JK,Oh B

更新日期：2005-10-01 00:00:00

abstract：:The vertebrate complement system is composed of about 30 serum and cell surface proteins that make up three activation pathways, a lytic pathway, and a set of proteins that regulate complement. Regulatory proteins are required for host protection against autologous complement attack and to control the amplification fe...

journal_title：Immunogenetics

authors： Multerer KA,Smith LC

更新日期：2004-05-01 00:00:00

abstract：:The collectin surfactant protein-D (SP-D) plays a significant role in innate immunity. Epidemiological studies described associations between single nucleotide polymorphisms (SNPs) of the human gene coding surfactant protein-D (SFTPD) and infectious pulmonary diseases. Studies on twins indicated very strong genetic de...

journal_title：Immunogenetics

authors： Heidinger K,König IR,Bohnert A,Kleinsteiber A,Hilgendorff A,Gortner L,Ziegler A,Chakraborty T,Bein G

更新日期：2005-04-01 00:00:00

abstract：:The peptide repertoire presented on human leukocyte antigen (HLA) class I molecules is largely determined by the structure of the peptide binding groove. It is expected that the molecules having similar grooves (i.e., belonging to the same supertype) might present similar/overlapping peptides. However, the extent of p...

journal_title：Immunogenetics

authors： Rao X,Hoof I,Costa AI,van Baarle D,Keşmir C

更新日期：2011-11-01 00:00:00

abstract：:We have recently mapped the human FCGR2 gene to chromosome 1 bands q23-q24. In situ hybridization of FCGR2 cDNA with a cell line containing a t(1:19)(q23;p13) derived from a patient with pre-B ALL has allowed a more accurate localization of this gene to chromosome 1 band q23. Furthermore, this study indicated a splitt...

journal_title：Immunogenetics

authors： Webber LM,Garson OM,Tate B,McKenzie IF,Hogarth PM

更新日期：1990-01-01 00:00:00

abstract：:The major histocompatibility complex (MHC) is critical to host-pathogen interactions. Class II MHC is a heterodimer, with α and β subunits encoded by different genes. The peptide-binding groove is formed by the first domain of both subunits (α1 and β1), but studies of class II variation or natural selection focus prim...

journal_title：Immunogenetics

authors： Rand LM,Woodward C,May R,Ackerman RA,Tweedie B,Zicarelli TB,Dearborn DC

更新日期：2019-09-01 00:00:00

abstract：:The rhesus macaque ( Macaca mulatta) has become a popular animal model for several human infectious diseases, such as HIV (modeled by SIV infection), hepatitis, and malaria. Investigation of T-cell responses in experimental infectious diseases in rhesus macaques has benefited from an expanding understanding of the div...

journal_title：Immunogenetics

authors： Su J,Luscher MA,MacDonald KS

更新日期：2004-03-01 00:00:00

abstract：:The present experiments were performed to study whether the genes responsible for the expression of T-idiotypes and allotypes could be mapped in relation to immunoglobulin (Ig) heavy chain V- and C-genes. Use was made of our antiserum 5936, which detects idiotypes in B6 and anti-B10.BR sera and on Lyt-1+, 2.3-B6 anti-...

journal_title：Immunogenetics

authors： Suzan M,Valsted F,Boned A,Rubin B

更新日期：1982-01-01 00:00:00

abstract：:Resistance to two cultured lines of murine embryonal carcinoma was studied in F1 hybrids constructed between the tumor-syngeneic mouse strain 129/J and several allogeneic strains. Three of four such hybrid strains were significantly more resistant to the multipotent embryonal carcinoma line PCC3 than the tumor-syngene...

journal_title：Immunogenetics

authors： Bishop GA,Dove WF

更新日期：1980-01-01 00:00:00

abstract：:Major histocompatibility complex (MHC) molecules are only found in jawed vertebrates and not in more primitive species. MHC class II type structures likely represent the ancestral structure of MHC molecules. Efficient MHC class II transport to endosomal compartments depends on association with a specialized chaperone,...

journal_title：Immunogenetics

authors： Dijkstra JM,Yamaguchi T

更新日期：2019-03-01 00:00:00

abstract：:CD4 has a central role in thymocyte differentiation and cell-mediated immunity. We isolated and analyzed chicken CD4. The gene spans 11.5 kb and is composed of ten exons. The promoter is TATA-less and similar to the mouse and human CD4 promoters, with two transcription start sites as determined by 5'RACE analysis. In ...

journal_title：Immunogenetics

authors： Koskinen R,Salomonsen J,Tregaskes CA,Young JR,Goodchild M,Bumstead N,Vainio O

更新日期：2002-10-01 00:00:00

abstract：:The KIR gene cluster exhibits a high degree of polymorphism in terms of gene content as well as allelic polymorphism, and data suggest that it is evolving rapidly. The KIR3DL1 locus is one of the most polymorphic loci within this cluster and is unique in that it encodes an activating receptor KIR3DS1, as well as multi...

journal_title：Immunogenetics

authors： Martin MP,Pascal V,Yeager M,Phair J,Kirk GD,Hoots K,O'Brien SJ,Anderson SK,Carrington M

更新日期：2007-10-01 00:00:00

abstract：:MHC class II deficiency provokes a severe immunodeficiency characterized by a lack of antigen-specific immune response. In the absence of bone marrow transplantation (the only curative treatment), patients affected by this genetic recessive disease die in early childhood. However, others and we have recently described...

journal_title：Immunogenetics

authors： Prod'homme T,Dekel B,Barbieri G,Lisowska-Grospierre B,Katz R,Charron D,Alcaide-Loridan C,Pollack S

更新日期：2003-11-01 00:00:00

abstract：:The sheep immunoglobulin heavy chain Igh-J locus has been characterized in order to determine the genomic organization of JH segments and their contribution to heavy chain diversity. The locus contains six segments, of which two are functional and four are apparently pseudogenes. These segments span a 1.8 kilobase (kb...

journal_title：Immunogenetics

authors： Dufour V,Nau F

更新日期：1997-01-01 00:00:00

abstract：:We have studied the MICA alleles of 196 unrelated subjects from three South American Indian tribes (Toba, Wichi and Terena). They are members of isolated tribes located in the Gran Chaco area in northeastern Argentina and in Mato Grosso do Sul in South Central Brazil. Of 55 previously known alleles, nine were observed...

journal_title：Immunogenetics

authors： Zhang Y,Lazaro AM,Zou Y,Lavingia B,Moraes EM,Moraes RJ,Stastny P

更新日期：2002-02-01 00:00:00

abstract：:The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequences showed the expected evolutionary...

journal_title：Immunogenetics

authors： Grossberger D,Parham P

更新日期：1992-01-01 00:00:00

abstract：:Almost 10,000 single nucleotide polymorphisms (SNPs) had been identified in the RT1 complex, the major histocompatibility complex of the rat, but less than approximately 0.5% have been characterized. In the context of the incomplete characterization of most SNPs, simple sequence length polymorphism (SSLP) marker devel...

journal_title：Immunogenetics

authors： Takagi Y,Kuramoto T,Voigt B,Tsurumi T,Nakanishi S,Mashimo T,Masui N,Serikawa T

更新日期：2009-03-01 00:00:00

abstract：:T-bet is a key regulator for the lineage commitment in CD4+ T helper (Th) 1 cells by activating the hallmark production of interferon-γ. Previously, two single nucleotide polymorphisms (SNPs) in the TBX21 promoter, T-1993C and T-1514C, have been shown by statistic studies to associate with systemic lupus erythematosus...

journal_title：Immunogenetics

authors： Li J,Li J,You Y,Chen S

更新日期：2012-05-01 00:00:00