The MHC locus controls size variations in the CD4 compartment of the mouse thymus.

abstract：:Several lines of evidence have confirmed the importance of Nod2 mutations for disease susceptibility in Crohn's disease. For tracing Nod2 evolution, exons 4a, 4e, 8, and 12 mutations were screened in a collection of 1,064 DNA samples from 52 worldwide populations. The overall allele frequency was 7.5% for single nucle...

journal_title：Immunogenetics

authors： Gasche C,Nemeth M,Grundtner P,Willheim-Polli C,Ferenci P,Schwarzenbacher R

更新日期：2008-02-01 00:00:00

abstract：:The anti-HLA-DQ3 monoclonal antibodies (mAb) KS13, SO1, SO2, SO3, SO4, and SO5 recognize spatially close but distinct antigenic determinants, since they crossinhibit each other in their binding to HLA-DQ3 antigens, but do not share idiotopes recognized in their antigen combining site by syngeneic and anti-id antisera ...

journal_title：Immunogenetics

authors： Iwasaki Y,Takabatake H,Monestier M,Ferrone S

更新日期：1995-01-01 00:00:00

abstract：:Human leucocyte antigen (HLA)-DRB1*15 is associated with predisposition to multiple sclerosis (MS), although conjecture surrounds the possible involvement of an alternate risk locus in the class I region of the HLA complex. We have shown previously that an alternate MS risk allele(s) may be encompassed by the telomeri...

journal_title：Immunogenetics

authors： Rubio JP,Bahlo M,Stankovich J,Burfoot RK,Johnson LJ,Huxtable S,Butzkueven H,Lin L,Taylor BV,Speed TP,Kilpatrick TJ,Mignot E,Foote SJ

更新日期：2007-03-01 00:00:00

abstract：:The emergence in Camelidae species of functional antibodies devoid of light chains (referred to as heavy-chain antibodies or HCAbs) is an intriguing evolutionary event. Homodimeric HCAbs have also been documented in spotted ratfish ( Cos5-Abs) and nurse shark (NAR). To reveal the evolutionary history of HCAbs, we eval...

journal_title：Immunogenetics

authors： Nguyen VK,Su C,Muyldermans S,van der Loo W

更新日期：2002-04-01 00:00:00

abstract：:To identify novel mechanisms regulating allogeneic hematopoietic cell engraftment, we used forward genetics and previously described identification, in mice, of a bone marrow (BM) engraftment quantitative trait locus (QTL), termed Bmgr5. This QTL confers dominant and large allele effects for engraftment susceptibility...

journal_title：Immunogenetics

authors： Wang Y,Chen X,Tsai S,Thomas A,Shizuru JA,Cao TM

更新日期：2013-08-01 00:00:00

abstract：:Ruminant gammadelta T cells are divided into subpopulations based on the presence or absence of WC1 co-receptors (scavenger-receptor-cysteine-rich family members uniquely expressed on gammadelta T cells). Evidence suggests WC1+ are inflammatory while WC1- are regulatory and that they also differ in their tissue distri...

journal_title：Immunogenetics

authors： Blumerman SL,Herzig CT,Rogers AN,Telfer JC,Baldwin CL

更新日期：2006-08-01 00:00:00

abstract：:Parasites exert a selection pressure on their hosts and are accountable for driving diversity within gene families and immune gene polymorphisms in a host population. The overwhelming response of regulatory T cells during infectious challenges directs the host immune system to lose the ability to mount parasite specif...

journal_title：Immunogenetics

authors： Hanel SA,Velavan TP,Kremsner PG,Kun JF

更新日期：2011-07-01 00:00:00

abstract：:Mechanisms to account for the unusual properties of a DR1 alpha beta complex (designated DRgp50) that is resistant to dissociation under normal conditions utilized were investigated. Expression of this DRgp50 complex is highly correlated with the failure of cells from certain DR1 individuals (DR1x) to stimulate specif...

journal_title：Immunogenetics

authors： Davis JE,Cook RG,Van M,Rich RR

更新日期：1988-01-01 00:00:00

abstract：:The inbred strain STS/A exhibits a higher proliferative response in the mixed lymphocyte culture (MLC) to stimulator cells of all 11 tested inbred mouse strains with 10 different major histocompatibility complex (MHC) haplotypes, as well as to stimulation with IL-2 than does the strain BALB/cHeA. However, alloantigen-...

journal_title：Immunogenetics

authors： Holán V,Lipoldová M,Demant P

更新日期：1996-01-01 00:00:00

abstract：:A segment comprising 307,078 nucleotides of the pig major histocompatibility complex (SLA) was completely sequenced. The segment corresponded to the entire SLA classical class I-containing region of the serologically defined SLA H01 haplotype. In all, 11 genes were characterized, comprising 7 class I genes located on ...

journal_title：Immunogenetics

authors： Renard C,Vaiman M,Chiannilkulchai N,Cattolico L,Robert C,Chardon P

更新日期：2001-08-01 00:00:00

abstract：:Reliable predictions of immunogenic peptides are essential in rational vaccine design and can minimize the experimental effort needed to identify epitopes. In this work, we describe a pan-specific major histocompatibility complex (MHC) class I epitope predictor, NetCTLpan. The method integrates predictions of proteaso...

journal_title：Immunogenetics

authors： Stranzl T,Larsen MV,Lundegaard C,Nielsen M

更新日期：2010-06-01 00:00:00

abstract：:The class I genes of the major histocompatibility complex (Mhc) are here investigated for the first time in a passerine bird. The great reed warbler is a rare species in Sweden with a few semi-isolated populations. Yet, we found extensive Mhc class I variation in the study population. The variable exon 3, correspondin...

journal_title：Immunogenetics

authors： Westerdahl H,Wittzell H,von Schantz T

更新日期：1999-03-01 00:00:00

abstract：:Type II natural killer T cells (NKT) are a subset of the innate-like CD1d-restricted lymphocytes that are reactive to lipid antigens. Unlike the type I NKT cells, which express a semi-invariant TCR, type II NKT cells express a broader TCR repertoire. Additionally, other features, such as their predominance over type I...

journal_title：Immunogenetics

authors： Dasgupta S,Kumar V

更新日期：2016-08-01 00:00:00

abstract：:In this report we present data demonstrating the endogenous expression of I-region associated (Ia) antigens on a cloned line of mouse T cells, CTLL, as well as transcription of the invariant chain gene in these cells. We demonstrate further that this Ia-bearing T-cell clone, CTLL, can utilize the expressed Ia molecule...

journal_title：Immunogenetics

authors： Ben-Nun A,Strauss W,Leeman SA,Cohn LE,Murre C,Duby A,Seidman JG,Glimcher LH

更新日期：1985-01-01 00:00:00

abstract：:Multiple sclerosis (MS) is a common disease of the central nervous system characterized by myelin loss and progressive neurological dysfunction. An underlying genetic susceptibility plays a clear role in the etiology of MS, likely acting in concert with an undefined environmental exposure. Full-genome screenings in mu...

journal_title：Immunogenetics

authors： Barcellos LF,Schito AM,Rimmler JB,Vittinghoff E,Shih A,Lincoln R,Callier S,Elkins MK,Goodkin DE,Haines JL,Pericak-Vance MA,Hauser SL,Oksenberg JR

更新日期：2000-04-01 00:00:00

abstract：:Leukocyte immunoglobulin-like receptors (LILR) are cell surface molecules that regulate the activities of myelomonocytic cells through the balance of inhibitory and activation signals. LILR genes are located within the leukocyte receptor complex (LRC) on chromosome 19q13.4 adjacent to KIR genes, which are subject to a...

journal_title：Immunogenetics

authors： López-Álvarez MR,Jones DC,Jiang W,Traherne JA,Trowsdale J

更新日期：2014-02-01 00:00:00

abstract：:Nova Scotia duck tolling retrievers are predisposed to a SLE-related disease complex including immune-mediated rheumatic disease (IMRD) and steroid-responsive meningitis-arteritis (SRMA). IMRD involves symptoms that resemble those seen in systemic autoimmune rheumatic diseases, such as systemic lupus erythematosus, SL...

journal_title：Immunogenetics

authors： Wilbe M,Jokinen P,Hermanrud C,Kennedy LJ,Strandberg E,Hansson-Hamlin H,Lohi H,Andersson G

更新日期：2009-08-01 00:00:00

abstract：:Virus-specific CD8(+) T cells play an important role in controlling HIV/SIV replication. These T cells recognize intracellular pathogen-derived peptides displayed on the cell surface by individual MHC class I molecules. In the SIV-infected rhesus macaque model, five Mamu class I alleles have been thoroughly characteri...

journal_title：Immunogenetics

authors： Reed JS,Sidney J,Piaskowski SM,Glidden CE,León EJ,Burwitz BJ,Kolar HL,Eernisse CM,Furlott JR,Maness NJ,Walsh AD,Rudersdorf RA,Bardet W,McMurtrey CP,O'Connor DH,Hildebrand WH,Sette A,Watkins DI,Wilson NA

更新日期：2011-12-01 00:00:00

abstract：:Immunoglobulin-A deficiency (IgA-D) is the most common human Ig class deficiency with an estimated frequency of approximately 1 in 500 in the Swedish population. We investigated the immunoglobulin heavy chain constant region gene segments (IGHC) in 103 individuals with IgA-D and the immunoglobulin heavy chain variable...

journal_title：Immunogenetics

authors： Olsson PG,Hammarström L,Cox DW,Smith CI

更新日期：1992-01-01 00:00:00

abstract：:Ia antigens coded by genes of the murine major histocompatibility complex are expressed on the surface of a population of cells critical to the proliferative response of murine spleen cells to the oxidative mitogen neuraminidase/galactose oxidase. By selective depletion with antiserum and complement, Ia antigens coded...

journal_title：Immunogenetics

authors： Phillips ML,Hill SW,Parker JW,O'Brien RL,Frelinger JA

更新日期：1980-01-01 00:00:00

abstract：:Chemokines are small, inducible, structurally related proteins that guide cells expressing the right chemokine receptors to sites of immune response. They have been identified and studied extensively in mammals, but little is known about their presence in other vertebrate groups. Here we describe seven new chemokines ...

journal_title：Immunogenetics

authors： Kuroda N,Uinuk-ool TS,Sato A,Samonte IE,Figueroa F,Mayer WE,Klein J

更新日期：2003-03-01 00:00:00

abstract：:Antibody diversity, as measured by isoelectric focusing of dinitrophenol-specific antibodies, was compared in different polyploid species of the clawed toad Xenopus. Antibody heterogeneity increased with chromosome number and DNA content from Xenopus tropicalis (2n = 20 chromosome) to Xenopus ruwenzoriensis (2n = 108 ...

journal_title：Immunogenetics

authors： Du Pasquier L,Blomberg B

更新日期：1982-03-01 00:00:00

abstract：:In the present study, we investigate patterns of variation in the KIR cluster in a large and well-characterized sample of worldwide human populations in the Human Genome Diversity Project-Centre d'Etude du Polymorphisme Humain (HGDP-CEPH) panel in order to better understand the patterns of diversity in the region. Com...

journal_title：Immunogenetics

authors： Hollenbach JA,Nocedal I,Ladner MB,Single RM,Trachtenberg EA

更新日期：2012-10-01 00:00:00

abstract：:The human major histocompatibility complex (MHC) is located within a 4 megabase segment on chromosome 6p21.3. Recently, a highly divergent MHC class I chain-related gene family, MIC was identified within the class I region. The MICA and MICB genes in this family have unique patterns of tissue expression. The MICA gene...

journal_title：Immunogenetics

authors： Ando H,Mizuki N,Ota M,Yamazaki M,Ohno S,Goto K,Miyata Y,Wakisaka K,Bahram S,Inoko H

更新日期：1997-01-01 00:00:00

abstract：:Recent genome-wide association studies (GWAs) have identified several new genetic risk factors for asthma; however, their influence on disease behavior and treatment response is still unclear. The aim of our study was the association analysis of the most significant single nucleotide polymorphisms (SNPs) recently repo...

journal_title：Immunogenetics

authors： Perin P,Potočnik U

更新日期：2014-03-01 00:00:00

abstract：:Asthma is a chronic inflammatory disorder of the airways, and a number of genetic loci are associated with the disease. Candidate gene association studies have been regarded as effective tools to study complex traits. Knowledge of the sequence variation and structure of the candidate genes is required for association ...

journal_title：Immunogenetics

authors： Kim JJ,Kim HH,Park JH,Ryu HJ,Kim J,Moon S,Gu H,Kim HT,Lee JY,Han BG,Park C,Kimm K,Park CS,Lee JK,Oh B

更新日期：2005-10-01 00:00:00

abstract：:We have used seven HLA-D homozygous typing cells (HTC) in a comparative study of the DRw8 antigen complex in three racial groups. Three distinct HLA-D specificities were recognized, each associated with HLA-DRw8. Four of the HTC defined a DRw8-associated HLA-D specificity designated 8.1, one defined a specificity desi...

journal_title：Immunogenetics

authors： Mickelson EM,Nisperos B,Layrisse Z,Kim SJ,Thomas ED,Hansen JA

更新日期：1983-01-01 00:00:00

abstract：:The chromosomal assignment of the gene encoding the invariant (Ii) chain associated with the mouse immune response antigens (Ia) was determined by Southern blot analysis of DNA from a panel of mouse X Chinese hamster somatic cell hybrids cleaved with Hind III or Eco RI. Using a mouse li cDNA as a hybridization probe, ...

journal_title：Immunogenetics

authors： Yamamoto K,Floyd-Smith G,Francke U,Koch N,Lauer W,Dobberstein B,Schäfer R,Hämmerling GJ

更新日期：1985-01-01 00:00:00

abstract：:The polymerase chain reaction was used to isolate clones with class I major histocompatibility complex sequences from fish (carp), amphibian (axolotl), and two species of reptile (lizard and snake). The lizard and snake clones were used to isolate class I cDNA clones. All the sequences showed the expected evolutionary...

journal_title：Immunogenetics

authors： Grossberger D,Parham P

更新日期：1992-01-01 00:00:00

abstract：:The ability of NK cells to specifically recognize cells lacking expression of self-MHC class I molecules was discovered over 30 years ago. It provided the foundation for the "missing self" hypothesis. Research in the two past decades has contributed to a detailed understanding of the molecular mechanisms that determin...

journal_title：Immunogenetics

authors： Malmberg KJ,Sohlberg E,Goodridge JP,Ljunggren HG

更新日期：2017-08-01 00:00:00